专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070082939A1 Methods and compositions for the treatment of neuropathies and related disorders 审中-公开
标题翻译：用于治疗神经病和相关疾病的方法和组合物
公开(公告)号：US20070082939A1
公开(公告)日：2007-04-12
申请号：US11492608
申请日：2006-07-24
申请人： Arnold Lippa , Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
发明人： Arnold Lippa , Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
IPC分类号： A61K31/403
CPC分类号： A61K31/403
摘要： The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.
摘要翻译：本发明提供了使用1-芳基-3-氮杂双环[3.1.0]己烷治疗与神经性疾病相关的症状的新颖的组合物和方法，所述神经性疾病例如痛觉过敏，异常性疼痛和副症状。本发明还涉及1-芳基-3-氮杂双环[3.1.0]己烷在用于治疗哺乳动物神经病症和相关症状的药物组合物和方法中的用途。根据本发明治疗的患者包括患有糖尿病性神经病，疱疹后神经痛，三叉神经痛，慢性下背痛，坐骨神经痛，特发性和创伤后神经病变，HIV相关神经性疼痛等许多其他神经病变和相关的患者症状

2. 发明申请

US20070082940A1 Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders 审中-公开
标题翻译：新型1-芳基-3-氮杂双环[3.1.0]己烷：制备和用于治疗神经精神障碍
公开(公告)号：US20070082940A1
公开(公告)日：2007-04-12
申请号：US11493431
申请日：2006-07-25
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
IPC分类号： A61K31/403
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
摘要翻译：本发明提供新的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物用于治疗和/或预防中枢的组合物和方法神经系统（CNS）障碍，包括抑郁和焦虑。

3. 发明申请

US20060223875A1 Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes 审中-公开
标题翻译：用于生产，配制和使用1-芳基-3-氮杂双环[3.1.0]己烷的方法和组合物
公开(公告)号：US20060223875A1
公开(公告)日：2006-10-05
申请号：US11371178
申请日：2006-03-07
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen
IPC分类号： A61K31/403 , C07D209/00
CPC分类号： C07D209/52
摘要： The invention provides novel 1-aryl-3-azabicyclo[3.1.0]hexanes that are active for modulating biogenic amine transport, along with compositions and methods for using these compounds to treat central nervous system disorders. Certain 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have at least one substituent on the aryl ring. In other embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided that have a substitution on the nitrogen at the ‘3’ position. In additional embodiments 1-aryl-3-azabicyclo[3.1.0]hexanes are provided which have one substitution on the aryl ring, as well as a substitution on the nitrogen at the ‘3’ position. The invention also provides novel methods of making aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, including synthetic methods that form novel intermediate compounds of the invention for producing aryl- and aza-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes.
摘要翻译：本发明提供了用于调节生物胺转运的新型1-芳基-3-氮杂双环[3.1.0]己烷，以及使用这些化合物治疗中枢神经系统疾病的组合物和方法。提供在芳基环上具有至少一个取代基的某些1-芳基-3-氮杂双环[3.1.0]己烷。在其它实施方案中，提供1-氮杂双环[3.1.0]己烷，其在“3”位上在氮上具有取代基。在另外的实施方案中，提供1-芳基-3-氮杂双环[3.1.0]己烷，其在芳基环上具有一个取代基，以及在“3”位置的氮上进行取代。本发明还提供制备芳基和氮杂取代的1-芳基-3-氮杂双环[3.1.0]己烷的新方法，包括形成本发明的新型中间体化合物的合成方法，用于制备芳基和氮杂取代的1-芳基 -3-氮杂双环[3.1.0]己烷。

4. 发明申请

US20090233978A1 Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders 审中-公开
标题翻译：新型1-芳基-3-氮杂双环[3.1.0]己烷：制备和用于治疗神经精神障碍
公开(公告)号：US20090233978A1
公开(公告)日：2009-09-17
申请号：US12334432
申请日：2008-12-12
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/40 , C07D209/02 , A61P25/00
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
摘要翻译：本发明提供新的多取代的1-芳基-3-氮杂双环[3.1.0]己烷，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物用于治疗和/或预防中枢的组合物和方法神经系统（CNS）障碍，包括抑郁和焦虑。

5. 发明授权

US08461196B2 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders 有权
公开(公告)号：US08461196B2
公开(公告)日：2013-06-11
申请号：US13366219
申请日：2012-02-03
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

6. 发明授权

US08138377B2 Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use 有权
标题翻译：芳基二环[3.1.0]己胺及其制备和使用的方法和组合物
公开(公告)号：US08138377B2
公开(公告)日：2012-03-20
申请号：US11936016
申请日：2007-11-06
申请人： Phil Skolnick , Zhengming Chen , Ji Yang
发明人： Phil Skolnick , Zhengming Chen , Ji Yang
IPC分类号： C07C211/00
CPC分类号： C07C211/41 , C07C2602/18
摘要： The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
摘要翻译：本发明提供新的芳基双环[3.1.0]己胺，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）障碍的组合物和方法，包括但不限于局限于抑郁和焦虑。

7. 发明申请

US20090069374A1 Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments 审中-公开
标题翻译：新型1-杂芳基-3-氮杂双环[3.1.0]己烷，其制备方法及其作为药物的用途
公开(公告)号：US20090069374A1
公开(公告)日：2009-03-12
申请号：US12135053
申请日：2008-06-06
申请人： Phil Skolnick , Zhengming Chen
发明人： Phil Skolnick , Zhengming Chen
IPC分类号： A61K31/47 , A61K31/403 , A61K31/4439 , A61K31/428
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04
摘要： The invention provides novel 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
摘要翻译：本发明提供新颖的1-杂芳基-3-氮杂双环[3.1.0]己烷，以及制备这些化合物的相关方法和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）的组合物和方法）疾病，包括但不限于抑郁和焦虑。

8. 发明申请

US20080194696A1 Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use 审中-公开
公开(公告)号：US20080194696A1
公开(公告)日：2008-08-14
申请号：US11936722
申请日：2007-11-07
申请人： Phil Skolnick , Zhengming Chen , Ji Yang
发明人： Phil Skolnick , Zhengming Chen , Ji Yang
IPC分类号： A61K31/135 , C07C211/41
CPC分类号： C07C211/41 , C07B2200/07 , C07C2602/18
摘要： The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.

9. 发明申请

US20160022634A1 NOVEL 1-HETEROARYL-3-AZABICYCLO[3.1.0]HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS 有权
标题翻译：新一代1-异噻唑啉[3.1.0] HEXANES，其制备方法及其作为药物使用
公开(公告)号：US20160022634A1
公开(公告)日：2016-01-28
申请号：US14802802
申请日：2015-07-17
申请人： Phil Skolnick , Zhengming Chen
发明人： Phil Skolnick , Zhengming Chen
IPC分类号： A61K31/403 , A61K31/4709 , A61K31/404 , A61K31/4439 , A61K31/428
CPC分类号： C07D417/04 , A61K31/00 , A61K31/403 , A61K31/404 , A61K31/428 , A61K31/4439 , A61K31/4709 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The invention provides novel 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
摘要翻译：本发明提供新颖的1-杂芳基-3-氮杂双环[3.1.0]己烷，以及制备这些化合物的相关方法和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）的组合物和方法）疾病，包括但不限于抑郁和焦虑。

10. 发明申请

US20080269348A1 Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use 审中-公开
标题翻译：新型芳基双环[3.1.0]己胺及其制备方法和组合物
公开(公告)号：US20080269348A1
公开(公告)日：2008-10-30
申请号：US11936007
申请日：2007-11-06
申请人： Phil Skolnick , Zhengming Chen
发明人： Phil Skolnick , Zhengming Chen
IPC分类号： A61K31/135 , C07C211/40 , A61P25/00
CPC分类号： C07C211/41 , C07B2200/07 , C07C2602/18
摘要： The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
摘要翻译：本发明提供新的芳基双环[3.1.0]己胺，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）障碍的组合物和方法，包括但不限于局限于抑郁和焦虑。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式