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1. 发明授权

US07368281B2 Label-free evanescent-field detection of biological and chemical agents 失效
标题翻译：无标记的生物和化学试剂的渐逝场检测
公开(公告)号：US07368281B2
公开(公告)日：2008-05-06
申请号：US10794937
申请日：2004-03-05
申请人： Eric J. Mozdy , Frederic J-Y Quan , Po Ki Yuen
发明人： Eric J. Mozdy , Frederic J-Y Quan , Po Ki Yuen
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate surface with at least a partial bio- or chemo-responsive layer, which forms a part of a serially renewable sensing region; 2) an optical interrogation apparatus for monitoring the bio- or chemo-responsive layer; and 3) an air-fluid delivery system. The optical interrogation apparatus has a light source, an optical delivery system, and a detection instrument or device. The air-fluid delivery system includes either macro or micro-fluidic passages designed to convey biological or chemical analytes to a sensing region.
摘要翻译：提供了一种消逝场传感器系统和使用该系统来检测液体或空气传播的生物病原体，化学试剂和其他有害或有毒物质的方法。传感器系统包括1）具有至少部分生物或化学响应层的衬底表面的消逝场传感器，其形成串联可再生感测区域的一部分; 2）用于监测生物或化学响应层的光学询问装置; 和3）空气流体输送系统。光学询问装置具有光源，光学传送系统和检测仪器或装置。空气流体输送系统包括设计成将生物或化学分析物传送到感测区域的宏观流路或微流体通道。

2. 发明授权

US07292333B2 Optical interrogation system and method for 2-D sensor arrays 失效
标题翻译： 2-D传感器阵列的光学询问系统和方法
公开(公告)号：US07292333B2
公开(公告)日：2007-11-06
申请号：US11100199
申请日：2005-04-05
申请人： Norman H. Fontaine , Eric J. Mozdy , Po Ki Yuen
发明人： Norman H. Fontaine , Eric J. Mozdy , Po Ki Yuen
IPC分类号： G01J3/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N21/553 , G01N21/6456 , G01N21/7743
摘要： An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (e.g., grating coupled waveguide sensors) located in a 2D specimen plate (e.g., microplate).
摘要翻译：本文描述了可以询问位于2D样本板（例如微板）中的光学传感器（例如，光栅耦合波导传感器）的二维（2D）阵列的光学询问系统和方法。

3. 发明授权

US06912342B2 Optical fiber module having reduced multi-path interference 失效
标题翻译：光纤模块具有减少的多径干扰
公开(公告)号：US06912342B2
公开(公告)日：2005-06-28
申请号：US10328553
申请日：2002-12-19
申请人： David P. Machewirth , Eric J. Mozdy , Rachel S. Mozdy , Daniel A. Nolan , V Srikant , Sergey Y. Ten
发明人： David P. Machewirth , Eric J. Mozdy , Rachel S. Mozdy , Daniel A. Nolan , V Srikant , Sergey Y. Ten
IPC分类号： G02B6/14 , G02B6/34 , G02B6/26
CPC分类号： G02B6/29376 , G02B6/14 , H01S3/06704 , H01S3/06754 , H01S3/08045 , H01S2301/02
摘要： Disclosed is a fiber optic module containing one or more optical fibers having an attenuator formed in the output end of the fibers to filter out unwanted higher order modes. The optical fibers are typically gain fibers or dispersion compensating fibers, and the attenuator consists of a coil, or a series of bends, of sufficient number and bend radius that higher order modes are reduced below a desired level.
摘要翻译：公开了一种光纤模块，其包含一根或多根光纤，该光纤具有形成在光纤的输出端的衰减器，以过滤不想要的高阶模式。光纤通常是增益光纤或色散补偿光纤，并且衰减器由具有足够数量和弯曲半径的线圈或一系列弯曲部组成，高阶模式被降低到期望的水平以下。

4. 发明申请

US20110305598A1 MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流体装置
公开(公告)号：US20110305598A1
公开(公告)日：2011-12-15
申请号：US13213744
申请日：2011-08-19
申请人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
发明人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
IPC分类号： G01N33/48
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A microfluidic device is described herein which comprises a micron-sized deep flow channel and a sensor. The micron-sized deep flow channel is configured such that a sample solution and a reference solution flow side-by-side to one another in a single sensing region of the sensor. The single sensing region is divided into a detection region and a reference region which are contiguous to one another and which are respectively interfaced with the sample solution and the reference solution that flow side-by-side to one another in a longitudinal direction within the micron-sized deep flow channel.
摘要翻译：本文描述了一种微流体装置，其包括微米级的深流动通道和传感器。微米尺寸深流通道被配置为使得样品溶液和参比溶液在传感器的单个感测区域中彼此并排流动。单个感测区域被分成彼此邻接的检测区域和参考区域，它们分别与样品溶液和在微米内沿纵向彼此并排流动的参比溶液接合。深流道。

5. 发明申请

US20080158570A1 Double resonance interrogation of grating-coupled waveguides 失效
标题翻译：光栅耦合波导的双共振询问
公开(公告)号：US20080158570A1
公开(公告)日：2008-07-03
申请号：US11820068
申请日：2007-06-18
申请人： Jacques Gollier , Eric J. Mozdy , Garrett A. Piech
发明人： Jacques Gollier , Eric J. Mozdy , Garrett A. Piech
IPC分类号： G01B9/02
CPC分类号： G01N21/7743 , Y10S436/805
摘要： A method for using a double resonance effect within a grating-coupled waveguide (GCW) sensor, as generated from a light beam with a given span of wavelengths or angles, is provided. The method can be used for label-independent detection of biological and chemical agents, to interrogate biological-binding events or chemical reactions within a sensing region at increased sensitivity, and with decreased sensitivity to environmental perturbations. Also described is an optical interrogation system incorporating the method.
摘要翻译：提供了从具有给定的波长或角度的光束产生的在光栅耦合波导（GCW）传感器内使用双重共振效应的方法。该方法可用于生物和化学试剂的标签无关检测，以增加的灵敏度询问感测区域内的生物结合事件或化学反应，并且对环境扰动的敏感性降低。还描述了结合该方法的光学询问系统。

6. 发明授权

US06946646B2 Method of evaluating fiber PMD using polarization optical time domain reflectometry 有权
标题翻译：使用偏振光学时域反射法评估光纤PMD的方法
公开(公告)号：US06946646B2
公开(公告)日：2005-09-20
申请号：US10287995
申请日：2002-11-05
申请人： Xin Chen , Nicol A. Heron , Timothy L. Hunt , Eric J. Mozdy , Darren A. Stainer
发明人： Xin Chen , Nicol A. Heron , Timothy L. Hunt , Eric J. Mozdy , Darren A. Stainer
IPC分类号： G01J3/447 , G01J4/00 , G01M11/00 , G02F1/01 , H04B10/00
CPC分类号： G01M11/3181
摘要： A method for screening fiber polarization mode dispersion using a polarization optical time domain reflectometer. A pulse radiation is emitted into the fiber under test, and the backscattered radiation is measured by the POTDR and used to obtain a POTDR trace. The POTDR trace is then analyzed to compare the variation of signals along the length of the fiber, the variation in signals relating to the level of PMD along the length of the fiber. Because high levels of PMD correspond to localized levels of low variability, by setting the variability of signal threshold sufficiently low, fibers having unacceptably high localized PMD can be identified and removed.
摘要翻译：一种使用偏振光学时域反射计屏蔽光纤偏振模色散的方法。脉冲辐射被发射到被测光纤中，反向散射辐射由POTDR测量并用于获得POTDR迹线。然后分析POTDR迹线以比较沿着光纤长度的信号的变化，与沿着光纤长度的PMD的水平相关的信号的变化。由于高水平的PMD对应于低变异性的局部水平，通过将信号阈值的可变性设置得足够低，可以识别和去除具有不可接受的高局部PMD的纤维。

7. 发明授权

US07998414B2 System for high throughput GPCR functional assay 失效
标题翻译：高通量GPCR功能测定系统
公开(公告)号：US07998414B2
公开(公告)日：2011-08-16
申请号：US11893506
申请日：2007-08-16
申请人： Eric J. Mozdy , Hui Su , Qi Wu
发明人： Eric J. Mozdy , Hui Su , Qi Wu
IPC分类号： G01N21/64
CPC分类号： C40B60/12 , C40B30/10
摘要： A functional assay detection system for membrane bound proteins. The system comprises a biological array including a porous substrate having a plurality of membranes adhered thereto and a first side and a second side, a fluorescent labeling reagent configured to couple to the membrane bound proteins, a pulsed light assembly configured to excite the fluorescent labeling reagent, and a time-delayed imaging device configured to capture emitted fluorescence of the fluorescent labeling reagent. The pulsed light assembly is configured to excite the fluorescent labeling reagent from at least one of the first side and the second side of the porous substrate, and the fluorescent labeling reagent comprises a fluorophore that has an emission lifetime that is in the range of microseconds.
摘要翻译：膜结合蛋白的功能测定检测系统。该系统包括生物阵列，其包括多孔基底，其具有附着于其上的多个膜，第一侧和第二侧，构造成耦合到膜结合蛋白的荧光标记试剂;脉冲光组件，其被配置为激发荧光标记试剂以及被配置为捕获荧光标记试剂的发射荧光的时间延迟成像装置。脉冲光组件被配置为从多孔基底的第一侧和第二侧中的至少一个激发荧光标记试剂，并且荧光标记试剂包含具有在微秒范围内的发光寿命的荧光团。

8. 发明授权

US07285420B2 System and method for self-referencing a sensor in a micron-sized deep flow chamber 失效
标题翻译：用于在微米级深流动室中自我参考传感器的系统和方法
公开(公告)号：US07285420B2
公开(公告)日：2007-10-23
申请号：US10993565
申请日：2004-11-18
申请人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
发明人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
IPC分类号： G01N21/00 , G01N35/08 , B32B5/02 , G01F25/00 , G01N31/22 , G01N27/00
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
摘要翻译：本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

9. 发明授权

US06297179B1 Transition-metal, glass-ceramic gain media 有权
标题翻译：过渡金属，玻璃陶瓷增益介质
公开(公告)号：US06297179B1
公开(公告)日：2001-10-02
申请号：US09686564
申请日：2000-10-11
申请人： George H. Beall , Nicholas F. Borrelli , Eric J. Mozdy , Linda R. Pinckney
发明人： George H. Beall , Nicholas F. Borrelli , Eric J. Mozdy , Linda R. Pinckney
IPC分类号： C03C1004
CPC分类号： G02B6/0229 , C03B32/02 , C03C4/0071 , C03C10/00 , C03C10/0009 , C03C10/0045 , C03C13/04 , C03C13/046 , C09K11/646 , C09K11/685 , H01S3/162 , H01S3/1623 , H01S3/163 , H01S3/1658 , H01S3/17
摘要： A gain medium for use in optical amplifiers or laser oscillators is disclosed. The gain medium includes a transition-metal doped glass-ceramic material having a crystal phase and a glass phase. The crystal phase is formed in situ in the glass phase, with the transition metal ions preferentially partitioning into the crystals from the glass phase. The crystals so formed have a size of less than 50 nm, and the transition metal ions within them are capable of lasing at a wavelength within the range of about 900 to 3000 nm. Also disclosed are amplifier and laser oscillator configurations, where the glass-ceramic gain medium is applied in a variety of configurations. Also disclosed is a method of amplifying a signal of light wherein the glass-ceramic gain medium is pumped with light energy so as to excite the transition metal ions, and the signal of light is transmitted through the gain medium while the transition metal ions are excited, whereby the signal of light is amplified. Also disclosed is a method of producing laser oscillation wherein the glass-ceramic gain medium is included in a laser cavity, pumped with optical energy to excite the transition metal ions, and the resulting radiation is forced to oscillate by the use of reflecting surfaces for feedback.
摘要翻译：公开了一种用于光放大器或激光振荡器的增益介质。增益介质包括具有晶相和玻璃相的过渡金属掺杂的玻璃 - 陶瓷材料。晶相在玻璃相中原位形成，过渡金属离子优先从玻璃相分配成晶体。如此形成的晶体具有小于50nm的尺寸，并且其内的过渡金属离子能够在约900至3000nm的范围内的波长下发光。还公开了放大器和激光振荡器配置，其中玻璃 - 陶瓷增益介质以各种配置应用。还公开了放大光信号的方法，其中用光能泵浦玻璃 - 陶瓷增益介质以激发过渡金属离子，并且光的信号通过增益介质传输，同时过渡金属离子被激发，由此光的信号被放大。还公开了一种产生激光振荡的方法，其中玻璃 - 陶瓷增益介质包括在激光腔中，用光能泵浦以激发过渡金属离子，并且所产生的辐射被迫使用反射表面进行振荡以进行反馈。

10. 发明授权

US08021613B2 System and method for self-referencing a sensor in a micron-sized deep flow chamber 失效
标题翻译：用于在微米级深流动室中自我参考传感器的系统和方法
公开(公告)号：US08021613B2
公开(公告)日：2011-09-20
申请号：US11900263
申请日：2007-09-11
申请人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
发明人： Norman H. Fontaine , Prantik Mazumder , Mark A. Quesada , Eric J. Mozdy , Po Ki Yuen
IPC分类号： G01N15/06 , G01N21/00 , G01N21/76
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
摘要翻译：本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

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