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1. 发明申请

US20130231603A1 Ocular Implants and Methods for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼部植入物和将眼部植入物植入眼睛的方法
公开(公告)号：US20130231603A1
公开(公告)日：2013-09-05
申请号：US13865770
申请日：2013-04-18
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F9/007
CPC分类号： A61F9/0017 , A61F9/0026 , A61F9/00781
摘要： An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.
摘要翻译：提供眼部植入物。在一些实施例中，眼部植入物包括围绕纵向中心轴线弯曲的主体和限定包括通道开口的纵向通道的远侧主体部分。植入物的尺寸和构造使得眼睛植入物呈现出当眼部植入物置于施莱姆氏管中时通道开口邻近施莱姆管道的主侧的取向。还提供了将眼部植入物输送到施莱姆氏管中的方法。一些方法包括覆盖眼部植入物中的开口，将植入物推进到施莱姆氏管中，同时至少一些开口被覆盖，并且在植入物的远端部分设置在施莱姆管中时露出开口。

2. 发明申请

US20140114229A1 OCULAR IMPLANTS FOR DELIVERY INTO THE EYE 有权
标题翻译：用于输送到眼睛的OCULAR植入物
公开(公告)号：US20140114229A1
公开(公告)日：2014-04-24
申请号：US14139403
申请日：2013-12-23
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61K9/0051
摘要： An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. The implant includes a spine extending along a longitudinal axis of the implant, a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that each support forms a portion of a helix, the spine and supports defining a volume having a maximum width perpendicular to the longitudinal axis between 0.005 inches and 0.04 inches, the ocular implant being configured to bend preferentially in a preferential bending plane.
摘要翻译：适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。植入物包括沿着植入物的纵向轴线延伸的脊柱，从脊柱延伸的多个弯曲支撑件，每个支撑件包括从脊柱第一侧上的第一位置延伸的第一端部和从第二侧面延伸的第二端部所述第二位置靠近所述第一位置，使得每个支撑件形成螺旋的一部分，所述脊柱和支撑件限定出垂直于所述纵向轴线的最大宽度在0.005英寸和 0.04英寸，眼部植入物构造成优先弯曲在优先弯曲平面中。

3. 发明授权

US08657776B2 Ocular implants for delivery into the eye 有权
标题翻译：眼部植入物进入眼睛
公开(公告)号：US08657776B2
公开(公告)日：2014-02-25
申请号：US13160355
申请日：2011-06-14
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61K9/0051
摘要： An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. The implant includes a spine extending along a longitudinal axis of the implant, a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that each support forms a portion of a helix, the spine and supports defining a volume having a maximum width perpendicular to the longitudinal axis between 0.005 inches and 0.04 inches, the ocular implant being configured to bend preferentially in a preferential bending plane.
摘要翻译：适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。植入物包括沿着植入物的纵向轴线延伸的脊柱，从脊柱延伸的多个弯曲支撑件，每个支撑件包括从脊柱第一侧上的第一位置延伸的第一端部和从第二侧面延伸的第二端部所述第二位置靠近所述第一位置，使得每个支撑件形成螺旋的一部分，所述脊柱和支撑件限定出垂直于所述纵向轴线的最大宽度在0.005英寸和 0.04英寸，眼部植入物构造成优先弯曲在优先弯曲平面中。

4. 发明申请

US20120323159A1 Ocular Implants for Delivery Into the Eye 有权
标题翻译：眼部植入物进入眼睛
公开(公告)号：US20120323159A1
公开(公告)日：2012-12-20
申请号：US13160355
申请日：2011-06-14
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61K9/0051
摘要： An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. The implant includes a spine extending along a longitudinal axis of the implant, a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that each support forms a portion of a helix, the spine and supports defining a volume having a maximum width perpendicular to the longitudinal axis between 0.005 inches and 0.04 inches, the ocular implant being configured to bend preferentially in a preferential bending plane.
摘要翻译：适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。植入物包括沿着植入物的纵向轴线延伸的脊柱，从脊柱延伸的多个弯曲支撑件，每个支撑件包括从脊柱第一侧上的第一位置延伸的第一端部和从第二侧面延伸的第二端部所述第二位置靠近所述第一位置，使得每个支撑件形成螺旋的一部分，所述脊柱和支撑件限定出垂直于所述纵向轴线的最大宽度在0.005英寸和 0.04英寸，眼部植入物构造成优先弯曲在优先弯曲平面中。

5. 发明申请

US20110009958A1 Ocular Implants and Methods for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼部植入物和将眼部植入物植入眼睛的方法
公开(公告)号：US20110009958A1
公开(公告)日：2011-01-13
申请号：US12833863
申请日：2010-07-09
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F2/14
CPC分类号： A61F9/0017 , A61F9/0026 , A61F9/00781
摘要： An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.
摘要翻译：提供眼部植入物。在一些实施例中，眼部植入物包括围绕纵向中心轴线弯曲的主体和限定包括通道开口的纵向通道的远侧主体部分。植入物的尺寸和构造使得眼睛植入物呈现出当眼部植入物置于施莱姆氏管中时通道开口邻近施莱姆管道的主侧的取向。还提供了将眼部植入物输送到施莱姆氏管中的方法。一些方法包括覆盖眼部植入物中的开口，将植入物推进到施莱姆氏管中，同时至少一些开口被覆盖，并且在植入物的远端部分设置在施莱姆管中时露出开口。

6. 发明授权

US08425449B2 Ocular implants and methods for delivering ocular implants into the eye 有权
公开(公告)号：US08425449B2
公开(公告)日：2013-04-23
申请号：US12833863
申请日：2010-07-09
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61M5/00
CPC分类号： A61F9/0017 , A61F9/0026 , A61F9/00781
摘要： An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.

7. 发明申请

US20110098809A1 Ocular Implant System and Method 审中-公开
标题翻译：眼植入系统和方法
公开(公告)号：US20110098809A1
公开(公告)日：2011-04-28
申请号：US12911451
申请日：2010-10-25
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F2/16
CPC分类号： A61F9/00781
摘要： An ocular implant and delivery system having a channel tool adapted to extend through at least a portion of Schlemm's canal of a human eye and to determine whether the Schlemm's canal portion provides a suitable location for the delivery of an ocular implant; an ocular implant adapted to be disposed within Schlemm's canal of a human eye; and a cannula comprising a distal opening adapted to deliver the channel tool and the ocular implant into Schlemm's canal of the eye. The invention also provides a method of treating glaucoma in a human eye including the steps of inserting a distal exit port of a cannula at least partially into Schlemm's canal of the eye; delivering a channel tool through the cannula into Schlemm's canal; delivering an ocular implant through the cannula into Schlemm's canal; and removing the channel tool and the cannula from the eye while leaving the ocular implant in place within Schlemm's canal.
摘要翻译：一种眼部植入物和递送系统，其具有适于延伸穿过人眼的施莱姆氏管的至少一部分的通道工具，并且确定施莱姆氏管部分是否提供用于输送眼部植入物的合适位置; 一种眼部植入物，适于放置在人眼的施莱姆氏管内; 以及套管，其包括适于将所述通道工具和所述眼部植入物输送到所述眼睛的施莱姆氏管中的远侧开口。本发明还提供了一种治疗人眼中的青光眼的方法，包括将套管的远侧出口至少部分地插入眼睛的施莱姆氏管中的步骤; 将通道工具通过套管输送到施莱姆的运河中; 通过插管将眼部植入物递送到施莱姆氏管中; 并从眼睛上移除通道工具和套管，同时将眼部植入物留在施莱姆氏管内。

8. 发明授权

US06979317B2 Device for delivering non-biodegradable bulking composition to a urological site 失效
标题翻译：将不可生物降解的填充组合物递送到泌尿部位的装置
公开(公告)号：US06979317B2
公开(公告)日：2005-12-27
申请号：US10188749
申请日：2002-07-05
申请人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
发明人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61M5/178
CPC分类号： A61B17/00491 , A61B17/062 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61B17/3478 , A61B2017/00495 , A61B2017/00805 , A61B2017/1205 , A61F2/0036
摘要： A device for delivery of a biocompatible polymer composition for treatment of urinary incontinence provides for delivery of biocompatible polymer material and a solidification agent through two lumens. The delivery device provides better control of the precipitation of the polymer in the periurethral tissue and detachment of the precipitated mass from the delivery device. The medical device includes a needle having a lumen and an inner cannula positioned within the needle lumen and movable longitudinally in the needle lumen from an extended position to a withdrawn position to sheer or cut the delivered mass of polymer material away from the needle tip.
摘要翻译：用于递送用于治疗尿失禁的生物相容性聚合物组合物的装置提供通过两个流明递送生物相容性聚合物材料和固化剂。递送装置可以更好地控制聚合物在尿道周围组织中的沉淀，并将沉淀的物质与输送装置分离。医疗装置包括具有内腔和位于针内腔内的内套管的针，并且可在针内腔中从延伸位置纵向移动到撤回位置，以将输送的聚合物材料的质量远离针尖切割或切割。

9. 发明授权

US06425854B1 Method for delivering non-biodegradable bulking composition to a urological site 有权
标题翻译：将不可生物降解的填充组合物递送至泌尿部位的方法
公开(公告)号：US06425854B1
公开(公告)日：2002-07-30
申请号：US09678416
申请日：2000-10-02
申请人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
发明人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
IPC分类号： A61M500
CPC分类号： A61M5/32 , A61B17/00491 , A61B17/062 , A61B2017/00495 , A61B2017/00805 , A61F2/0036
摘要： A method for delivery of a biocompatible polymer composition for treatment of urinary incontinence provides for delivery of biocompatible polymer material and a solidification agent through two lumens of a delivery device. The delivery device provides better control of the precipitation of the polymer in the periurethral tissue and detachment of the precipitated mass from the delivery device. The medical device includes a needle having a lumen and an inner cannula positioned within the needle lumen and movable longitudinally in the needle lumen from an extended position to a withdrawn position to sheer or cut the delivered mass of polymer material away from the needle tip.
摘要翻译：递送用于治疗尿失禁的生物相容性聚合物组合物的方法提供生物相容性聚合物材料和凝固剂通过两个流明的递送装置的递送。递送装置可以更好地控制聚合物在尿道周围组织中的沉淀，并将沉淀的物质与输送装置分离。医疗装置包括具有内腔和位于针内腔内的内套管的针，并且可在针内腔中从延伸位置纵向移动到撤回位置，以将输送的聚合物材料的质量远离针尖切割或切割。

10. 发明授权

US06478775B1 Device for delivering non-biodegradable bulking composition to a urological site 有权
公开(公告)号：US06478775B1
公开(公告)日：2002-11-12
申请号：US09678431
申请日：2000-10-02
申请人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
发明人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
IPC分类号： A61M5178
CPC分类号： A61B17/00491 , A61B17/062 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61B17/3478 , A61B2017/00495 , A61B2017/00805 , A61B2017/1205 , A61F2/0036
摘要： A device for delivery of a biocompatible polymer composition for treatment of urinary incontinence provides for delivery of biocompatible polymer material and a solidification agent through two lumens. The delivery device provides better control of the precipitation of the polymer in the periurethral tissue and detachment of the precipitated mass from the delivery device. The medical device includes a needle having a lumen and an inner cannula positioned within the needle lumen and movable longitudinally in the needle lumen from an extended position to a withdrawn position to sheer or cut the delivered mass of polymer material away from the needle tip.

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