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1. 发明授权

US5871767A Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core 失效
标题翻译：使用具有生物相容性护套和生物相容性基质芯的免疫隔离植入式车辆治疗或预防神经变性病症的方法
公开(公告)号：US5871767A
公开(公告)日：1999-02-16
申请号：US449062
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method for treatment of a neurodegenerative condition in a patient comprising implanting in the patient at least one immunoisolatory vehicle comprising a corc comprising a volume of at least 1 .mu.l and at least 10.sup.4 living cells which secrete at least one biologically active product, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and an external jacket surrounding the core, the jacket comprising a biocompatible hydrogel or thermoplastic, the jacket being free of cells projecting externally thereof, said jacket having a molecular weight cutoff permitting the passage of the biologically active product from the core through the jacket.
摘要翻译：一种用于治疗患者神经变性病症的方法，包括在患者体内植入至少一种包含至少1μl的体积的corc和至少分泌至少一种生物活性产物的至少104个活细胞的免疫佐剂，所述细胞分散在包含水凝胶或细胞外基质组分的生物相容性基质中，以及围绕芯的外护套，所述护套包括生物相容的水凝胶或热塑性塑料，所述护套不含外部突出的细胞，所述护套具有允许生物活性产物从芯通过夹套。

2. 发明授权

US5800828A Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products 失效
标题翻译：用于递送选定治疗产品的植入式生物相容性免疫佐剂
公开(公告)号：US5800828A
公开(公告)日：1998-09-01
申请号：US179151
申请日：1994-01-10
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： Immunoisolatory vehicles having a core and a surrounding jacket are disclosed, the core having a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells capable of secreting a biologically active product or of providing a biological function to a patient, the cells dispersed in a biocompatible matrix formed of a hydrogel or an extracellular matrix component, and the external jacket being permselective, biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biological product or function.
摘要翻译：公开了具有核心和周围护套的免疫佐剂，核心具有超过1μl的体积和至少约104个能够分泌生物活性产物或者向患者提供生物学功能的活细胞，所述细胞分散在由水凝胶或细胞外基质组分形成的生物相容性基质中，并且所述外部护套是选择性选择性的，生物相容性的并且具有分子量截留允许通过所述护套在患者和核之间通过分子以提供所述生物产物或功能。

3. 发明申请

US20090162331A1 COMPOSITIONS CONTAINING SERTOLI CELLS AND MYOID CELLS AND USE THEREOF IN CELLULAR TRANSPLANTS 审中-公开
标题翻译：含有SERTOLI细胞和MYOID细胞的组合物及其在细胞运输中的应用
公开(公告)号：US20090162331A1
公开(公告)日：2009-06-25
申请号：US12118453
申请日：2008-05-09
申请人： Jannette Dufour , Craig Halberstadt , Richelle Hemendinger , Ray V. Rajotte , Alfred V. Vasconcellos , Paul Gores , Dwaine Emerich , Greg Korbutt
发明人： Jannette Dufour , Craig Halberstadt , Richelle Hemendinger , Ray V. Rajotte , Alfred V. Vasconcellos , Paul Gores , Dwaine Emerich , Greg Korbutt
IPC分类号： A61K35/12
CPC分类号： C12N5/0683 , A61K2035/122 , C12N5/0697 , C12N2502/246
摘要： The present invention relates to the use of Sertoli cells and myoid cells for creating an immunologically privileged site in a mammalian subject, thereby facilitating the transplantation of cells that produce a biological factor in the treatment of a disease that results from a deficiency of such biological factor. Pharmaceutical compositions containing Sertoli cells and myoid cells, as well as therapeutic methods relating to the use of these cells are provided by the present invention.
摘要翻译：本发明涉及用于在哺乳动物受试者中产生免疫特异性位点的Sertoli细胞和骨髓细胞的用途，从而促进产生生物因子的细胞在由这种生物因子的不足导致的疾病的治疗中的移植。含有Sertoli细胞和肌细胞的药物组合物以及与这些细胞的使用相关的治疗方法由本发明提供。

4. 发明授权

US6083523A Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products 有权
标题翻译：用于递送选定治疗产品的可植入生物相容性免疫佐剂
公开(公告)号：US6083523A
公开(公告)日：2000-07-04
申请号：US148671
申请日：1998-09-04
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.
摘要翻译：用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送，个人

5. 发明授权

US5795330A Mixing device 失效
标题翻译：混合装置
公开(公告)号：US5795330A
公开(公告)日：1998-08-18
申请号：US728440
申请日：1996-10-10
申请人： Aliassghar Tofighi , Alfred V. Vasconcellos , Katherine Jacobs , Pramod Chakravarthy
发明人： Aliassghar Tofighi , Alfred V. Vasconcellos , Katherine Jacobs , Pramod Chakravarthy
IPC分类号： A61J1/05 , A61F2/28 , A61F2/46 , A61J1/00 , A61J1/06 , A61J1/14 , A61J1/20 , A61M37/00 , B01F11/00 , B01F13/00 , B01F15/02
CPC分类号： B01F13/002 , A61F2/28 , A61F2/46 , A61F2/4601 , A61J1/067 , A61J1/2093 , B01F11/0065 , B01F15/0205 , B01F15/0212 , B01F15/026 , B65D81/3266 , A61J1/1468 , A61J1/201 , A61J1/2027 , A61J1/2086 , A61J1/2096 , B01F15/0201
摘要： A mixer for the mixing of a first and a second component, comprising a flexible pouch which contains said first component and which has an inner surface that is non-retaining to the components; means for supplying the second component to the chamber for mixing with the first component; and a neck attached to said pouch.
摘要翻译：一种用于混合第一和第二部件的混合器，包括含有所述第一部件的柔性袋，并且具有不保持在所述部件上的内表面; 用于将所述第二部件供应到所述室以与所述第一部件混合的装置; 和连接到所述袋的颈部。

6. 发明授权

US5980482A Mixing device 失效
标题翻译：混合装置
公开(公告)号：US5980482A
公开(公告)日：1999-11-09
申请号：US948435
申请日：1997-10-10
申请人： Aliassghar Tofighi , Alfred V. Vasconcellos , Katherine Jacobs , Pramod Chakravarthy
发明人： Aliassghar Tofighi , Alfred V. Vasconcellos , Katherine Jacobs , Pramod Chakravarthy
IPC分类号： A61J1/05 , A61F2/28 , A61F2/46 , A61J1/00 , A61J1/06 , A61J1/14 , A61J1/20 , A61M37/00 , B01F11/00 , B01F13/00 , B01F15/02
CPC分类号： B01F13/002 , A61F2/28 , A61F2/46 , A61F2/4601 , A61J1/067 , A61J1/2093 , B01F11/0065 , B01F15/0205 , B01F15/0212 , B01F15/026 , B65D81/3266 , A61J1/1468 , A61J1/201 , A61J1/2027 , A61J1/2086 , A61J1/2096 , B01F15/0201
摘要： A mixer for the mixing of components, comprising a continuous inner surface that is non-retaining to the components, wherein a first portion of the inner surface opposably contacts a second portion of the inner surface during mixing, and a means for supplying a component to the mixer; a kit including the mixer, and methods of using the mixer to prepare compositions.
摘要翻译：一种用于混合部件的混合器，包括不保持部件的连续内表面，其中内表面的第一部分在混合期间可相对接触内表面的第二部分，以及用于将部件供应到搅拌机包括混合器的试剂盒和使用混合器制备组合物的方法。

7. 发明授权

US5869077A Methods for treating diabetes by delivering insulin from biocompatible cell-containing devices 失效
标题翻译：通过从含生物相容性细胞的装置递送胰岛素来治疗糖尿病的方法
公开(公告)号：US5869077A
公开(公告)日：1999-02-09
申请号：US449562
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method for treating diabetes in a patient comprising subcutaneously implanting in the patient at least one immunoisolatory vehicle comprising a core comprising a volume of at least 1 .mu.l and at least about 10.sup.4 living cells which secrete insulin, said cells being dispersed in a biocompatible matrix comprising a hydrogel or extracellular matrix components, and a surrounding external jacket of a biocompatible thermoplastic or hydrogel free of said cells projecting externally thereof, said jacket being permselective and immunoisolatory, said jacket having a molecular weight cutoff permitting passage of molecules between the patient and core through said jacket wherein the insulin is released from the immunoisolatory vehicle into the patient's body to treat diabetes.
摘要翻译：一种用于治疗患者的糖尿病的方法，包括在患者体内皮下植入至少一种免疫隔离性载体，所述至少一种免疫隔离载体包含至少含有至少1μl的体积和分泌胰岛素的至少约104个活细胞的核，所述细胞分散在生物相容性基质包括水凝胶或细胞外基质组分，以及不含所述细胞从外部突出的生物相容性热塑性或水凝胶的外围护套，所述护套是选择性选择性的和免疫型的，所述护套具有分子量截留允许分子在患者和核心之间通过通过所述护套，其中将胰岛素从免疫免疫介质释放到患者体内以治疗糖尿病。

8. 发明授权

US5800829A Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core 失效
标题翻译：用生物相容性护套和生物相容性基质芯共挤出免疫隔离植入式车辆的方法
公开(公告)号：US5800829A
公开(公告)日：1998-09-01
申请号：US449274
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61K9/00 , A61K35/12 , A61K9/50 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/0024 , A61K2035/126 , A61K2035/128 , C12N2510/00
摘要： A method of making an immunoisolatory vehicle comprised of a core comprising living cells dispersed in a biocompatible matrix is disclosed, the cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to an individual, and an external jacket surrounding said core which is a biocompatible, permselective thermoplastic or hydrogel, said jacket being free of said cells, comprising coextruding a suspension comprising said cells dispersed in a precursor matrix material comprising extracellular matrix components or a biocompatible hydrogel precursor, and a solution of a biocompatible jacket precursor from a nested dual-bore extrusion nozzle, wherein the suspension of (a) is coextruded from the inner bore and the solution of (b) is coextruded from the outer bore of the nozzle, to form said jacket as the solution of (b) and the suspension of (a) arc coextruded; and exposing the vehicle to a treatment that forms a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells and comprising a biocompatible matrix from the precursor matrix of solution (a).
摘要翻译：公开了一种制备由包含分散在生物相容性基质中的活细胞的核心组成的免疫隔离性载体的方法，所述细胞能够分泌生物活性产物或向个体提供代谢或免疫功能，以及围绕所述核心，其是生物相容的选择性热塑性或水凝胶，所述护套不含所述细胞，包括共挤出包含分散在包含细胞外基质组分或生物相容性水凝胶前体的前体基质材料中的所述细胞的悬浮液，以及生物相容性护套前体从嵌套的双孔挤出喷嘴中，其中（a）的悬浮液从内孔共挤出并且（b）的溶液从喷嘴的外孔共挤出，形成作为（b）的溶液的所述夹套，和（a）电弧共挤出的悬浮液; 并将载体暴露于形成包含体积至少为1μl和至少104个细胞并且包含来自溶液（a）的前体基质的生物相容性基质的核心的处理。

9. 发明授权

US5487739A Implantable therapy systems and methods 失效
标题翻译：植入式治疗系统和方法
公开(公告)号：US5487739A
公开(公告)日：1996-01-30
申请号：US459815
申请日：1995-06-02
申请人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
发明人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
IPC分类号： A61F2/02 , A61K9/00 , A61K9/50 , A61K35/12 , A61K35/55 , A61M31/00 , A61M39/02 , B01J13/02 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , A61K9/22
CPC分类号： A61K9/0092 , A61F2/022 , A61K35/55 , A61K9/0024 , A61K9/0085 , A61M31/002 , A61M37/0069 , A61M39/0208 , B01J13/02 , C12N11/04 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , A61K2035/126 , A61M2210/0687 , A61M2210/0693 , C12N2533/30
摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the distal end of the cannula (20b). Once the vehicle (40) is positioned near the distal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).
摘要翻译：公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有衰弱病症的受试者的脑，脊髓和其他目标区域。本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的远端。一旦车辆（40）定位在套管（20）的远端附近，则套管从通道中移除，随后是推动器，使车辆（40）位于治疗部位（12）处。

10. 发明授权

US5465712A Resuscitation mask having ribs in the air flow conduit and mask body 失效
标题翻译：在空气流动管道和面罩主体中具有肋的复苏面具
公开(公告)号：US5465712A
公开(公告)日：1995-11-14
申请号：US100592
申请日：1993-07-30
申请人： Jerry Malis , Jonathan J. Rosen , Martin T. Mortimer , Alfred V. Vasconcellos
发明人： Jerry Malis , Jonathan J. Rosen , Martin T. Mortimer , Alfred V. Vasconcellos
IPC分类号： A61M16/06 , A61M16/20 , A62B18/02 , A62B18/10
CPC分类号： A61M16/06 , A61M16/0048 , A62B18/025 , A61M16/0683 , A61M16/208 , Y10S128/912
摘要： Briefly stated, the present invention comprises a resuscitation mask for administering artificial respiration to a patient. The respiration mask has a container for defining an interior region between the container and the face of the patient. Two conduits are provided through the container wall in order to define two air flow passageways which are in fluid communication with the internal region. A valve is disposed in one air flow passageway for permitting air flow into the internal region and preventing air flow from the internal region. A vent is provided to reduce pressure within the internal region in response to an increase in pressure within the internal region. The container is generally cup-shaped and, in the preferred embodiment, it is formed with a cylindrical member coupled to the one-way air flow conduit. The other airflow passageway is adapted to be detachably coupled to an oxygen source. A pressure openable closure permits pressure within the interior region of the resuscitation mask to be released by a further conduit.
摘要翻译：简而言之，本发明包括用于向患者施用人工呼吸的复苏面罩。呼吸面罩具有用于限定容器和患者面部之间的内部区域的容器。通过容器壁设置两个管道，以限定与内部区域流体连通的两个气流通道。阀设置在一个气流通道中，用于允许空气流入内部区域并防止空气从内部区域流出。提供排气口以响应于内部区域内的压力增加而减小内部区域内的压力。容器通常为杯形，并且在优选实施例中，其形成有联接到单向空气流动导管的圆柱形构件。另一气流通道适于可拆卸地联接到氧气源。压力可打开的封闭件允许在复苏面罩的内部区域内的压力被另外的导管释放。

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