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1. 发明授权

US5487739A Implantable therapy systems and methods 失效
标题翻译：植入式治疗系统和方法
公开(公告)号：US5487739A
公开(公告)日：1996-01-30
申请号：US459815
申请日：1995-06-02
申请人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
发明人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
IPC分类号： A61F2/02 , A61K9/00 , A61K9/50 , A61K35/12 , A61K35/55 , A61M31/00 , A61M39/02 , B01J13/02 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , A61K9/22
CPC分类号： A61K9/0092 , A61F2/022 , A61K35/55 , A61K9/0024 , A61K9/0085 , A61M31/002 , A61M37/0069 , A61M39/0208 , B01J13/02 , C12N11/04 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , A61K2035/126 , A61M2210/0687 , A61M2210/0693 , C12N2533/30
摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the distal end of the cannula (20b). Once the vehicle (40) is positioned near the distal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).
摘要翻译：公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有衰弱病症的受试者的脑，脊髓和其他目标区域。本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的远端。一旦车辆（40）定位在套管（20）的远端附近，则套管从通道中移除，随后是推动器，使车辆（40）位于治疗部位（12）处。

2. 发明授权

US06179826B2 Implantable therapy systems and methods 失效
标题翻译：植入式治疗系统和方法
公开(公告)号：US06179826B2
公开(公告)日：2001-01-30
申请号：US08741228
申请日：1996-10-29
申请人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
发明人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
IPC分类号： A61M3100
CPC分类号： A61K9/0092 , A61F2/022 , A61K9/0024 , A61K9/0085 , A61K35/55 , A61K2035/126 , A61M31/002 , A61M37/0069 , A61M39/0208 , A61M2210/0687 , A61M2210/0693 , B01J13/02 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , C12N11/04 , C12N2533/30 , A61M2230/005
摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the proximal tip of the cannula (20b). Once the vehicle (40) is positioned near the proximal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).
摘要翻译：公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有二体化病症的受试者的脑，脊髓和其他靶区域。本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的近端处。一旦车辆（40）定位在套管（20）的近端附近，则套管从通道中移开，随后是推动器，使车辆（40）位于治疗部位（12）处。

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