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1. 发明申请

US20040241837A1 Methods for forming normal regenerated tissues, the normal regenerated tissues, and method of calibrating sensitivity and so on 有权
标题翻译：形成正常再生组织，正常再生组织的方法和校准灵敏度等方法
公开(公告)号：US20040241837A1
公开(公告)日：2004-12-02
申请号：US10492688
申请日：2004-06-09
发明人： Shigekazu Nakatsugawa
IPC分类号： C12Q001/68 , C12N005/02 , C12N015/01
CPC分类号： C12N5/0625 , A61K35/12 , A61L27/3604 , A61L27/3813 , C12N5/0697 , C12N2502/088 , C12N2502/095 , C12N2502/246 , C12N2502/256 , C12N2502/28 , C12N2502/30 , C12N2503/00 , C12N2503/04
摘要： A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively.
摘要翻译：通过暴露于来自器官的结缔组织或支持组织从而形成饲养层，然后在其上移植上皮细胞以形成分层结构，形成正常的再生组织。通过使用人源性正常组织作为基础，通过三维培养方便且可靠地提供再生组织，可以构建用于评估诸如药物的化学物质的效果和副作用的系统，或者评估其敏感性分别使用再生组织作为相应组织的模型。

2. 发明授权

US06777230B2 Prostate cancer cell lines 失效
标题翻译：前列腺癌细胞系
公开(公告)号：US06777230B2
公开(公告)日：2004-08-17
申请号：US09919196
申请日：2001-07-31
申请人： Ming-Fong Lin
发明人： Ming-Fong Lin
IPC分类号： C12N502
CPC分类号： C12N5/0683 , C12N5/0693 , C12N2502/246 , C12N2503/00 , G01N33/57434
摘要： Novel human prostate cancer-associated neuroendocrine (NE)-like cell lines are provided that were derived via a process that resembles clinical androgen ablation therapy for advanced prostate cancer.
摘要翻译：提供了新的人前列腺癌相关神经内分泌（NE）样细胞系，其通过类似于晚期前列腺癌的临床雄激素消除治疗的过程得到。

3. 发明申请

US20020192194A1 Production and use of dopaminergic cells to treat dopaminergic deficiencies 审中-公开
标题翻译：生产和使用多巴胺能细胞治疗多巴胺能缺乏症
公开(公告)号：US20020192194A1
公开(公告)日：2002-12-19
申请号：US10000452
申请日：2001-12-04
发明人： Michael McGrogan , Gary Snable
IPC分类号： A61K048/00 , C12N005/08
CPC分类号： C12N5/0619 , A61K35/12 , C12N2500/12 , C12N2501/385 , C12N2502/246
摘要： Differentiated neuronal cells suitable for transplantation in individuals with a dopamine deficiency are derived from progenitor cells. The progenitor cells are treated with at least one inducing agent such as retinoic acid for a time period sufficient to optimize expression of tyrosine hydroxylase. The cells intended for transplantation are optionally treated with a lithium salt to enhance bcl-2 production and survival. Optionally, the progenitor cells are co-cultured with Sertoli cells, bone marrow stem cells, or a combination thereof. The transplantation-ready cells are isolated and harvested. The resulting neuronal cells are purified and have a phenotype optimized to treat a dopaminergic deficiency, such as Parkinson's Disease. Optionally the neuronal cells can be implanted with Sertoli cells, bone marrow stem cells or a combination thereof. A purified human dopaminergic cell type is obtained by culturing NT2 cells and treated for about three weeks with an inducing agent, culturing for about two weeks with growth media without an inducing agent or mitotic inhibitor, culturing for about one week with at least one mitotic inhibitor, harvesting and placing in a diluent.
摘要翻译：适合于多巴胺缺乏症患者移植的分化神经元细胞来源于祖细胞。用至少一种诱导剂如视黄酸处理祖细胞足够的时间以优化酪氨酸羟化酶的表达。用于移植的细胞任选用锂盐处理以增强bcl-2的产生和存活。任选地，祖细胞与支持细胞，骨髓干细胞或其组合共培养。分离并收获移植准备的细胞。所得神经元细胞被纯化并具有优化的表型以治疗多巴胺能缺乏症，例如帕金森病。任选地，神经元细胞可以植入支持细胞，骨髓干细胞或其组合。通过培养NT2细胞并用诱导剂处理大约三周，获得纯化的人多巴胺能细胞类型，用不含诱导剂或有丝分裂抑制剂的生长培养基培养约两周，用至少一种有丝分裂抑制剂培养约一周，收获并放入稀释剂中。

4. 发明授权

US6036951A Sertoli cells as neurorecovery inducing cells for neurodegenerative disorders 失效
标题翻译： Sertoli细胞作为神经复发诱导细胞用于神经退行性疾病
公开(公告)号：US6036951A
公开(公告)日：2000-03-14
申请号：US913865
申请日：1997-09-12
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan
IPC分类号： A01K67/027 , A61K35/12 , C12N5/071 , C12N5/0793 , A61K48/00 , A61K35/00 , C12N15/85
CPC分类号： C12N5/0683 , A01K67/0271 , C12N5/0619 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into a tissue in need of trophic factors of a mammal, the cells creating trophic factors in situ.
摘要翻译： PCT No.PCT / US96 / 03335 Sec。 371日期：1997年9月12日 102（e）1997年9月12日PCT PCT 1996年3月12日PCT公布。公开号WO96 / 28030 日期1996年9月19日一种通过将Sertoli细胞移植到需要哺乳动物营养因子的组织中的原位营养因子产生的方法，该细胞原位产生营养因子。

5. 发明授权

US5843430A Methods of treating disease using sertoli cells and allografts or xenografts 失效
标题翻译：使用sertoli细胞和同种异体移植物或异种移植物治疗疾病的方法
公开(公告)号：US5843430A
公开(公告)日：1998-12-01
申请号：US467341
申请日：1995-06-06
申请人： Helena P. Selawry
发明人： Helena P. Selawry
IPC分类号： A61K38/28 , A61K35/12 , A61K35/39 , A61K35/407 , A61K35/48 , A61K38/00 , A61K38/13 , A61K48/00 , A61P3/08 , A61P3/10 , C12N5/071 , A01N63/00 , G01N33/53
CPC分类号： C12N5/0683 , A61K35/39 , A61K35/48 , A61K38/13 , A61K38/28 , C12N5/0676 , C12N5/0677 , A61K48/00 , C12N2502/246 , C12N2510/00 , C12N2510/04 , Y10S435/975
摘要： The present invention describes a method of treating a disease that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce the biological factor. In particular, the present invention describes a method of treating diabetes mellitus by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site in a mammal for cellular transplants is further described by the present invention. A pharmaceutical composition and compartmentalized kit comprising Sertoli cells and cells that produce a biological factor is also provided.
摘要翻译：本发明描述了一种治疗由生物因子缺乏引起的疾病的方法，其包括对产生生物因子的哺乳动物Sertoli细胞和细胞施用。特别地，本发明描述了通过移植胰腺细胞胰岛胰岛细胞与Sertoli细胞结合来产生免疫特异性位点来治疗糖尿病的方法。通过本发明进一步描述了在哺乳动物中为细胞移植创建免疫特异性位点的方法。还提供了包含产生生物因子的Sertoli细胞和细胞的药物组合物和分隔试剂盒。

6. 发明授权

US5830460A Sertoli cells as transplantation facilitator for cell transplantation 失效
标题翻译： Sertoli细胞作为细胞移植的移植促进剂
公开(公告)号：US5830460A
公开(公告)日：1998-11-03
申请号：US402387
申请日：1995-03-13
申请人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan , Richard Heller
发明人： Paul R. Sanberg , Don F. Cameron , Cesario V. Borlongan , Richard Heller
IPC分类号： A61K35/12 , A61K35/30 , A61K35/48 , A61P25/00 , C12N5/071 , C12N5/00
CPC分类号： C12N5/0683 , A61K35/30 , A61K35/48 , C12N5/0618 , A61K2035/122 , A61K35/12 , C12N2502/246
摘要： A method of producing a sustained localized brain immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the brain tissue.
摘要翻译：通过移植靠近脑组织的Sertoli细胞来实现在局部组织中产生持续的局部脑免疫抑制作用的方法。

7. 发明授权

US08998793B2 Feeder-free method for culture of bovine and porcine spermatogonial stem cells 有权
标题翻译：无饲养牛和猪精原干细胞培养方法
公开(公告)号：US08998793B2
公开(公告)日：2015-04-07
申请号：US13763908
申请日：2013-02-11
申请人： Washington State University Research Foundation
发明人： Jon Michael Oatley , Melissa Joan Oatley
IPC分类号： A61B17/43 , C12N5/00 , C12N5/076 , C12N5/073 , C12N5/071 , C12M1/00 , A61K35/52 , C12N5/077 , C12N15/873
CPC分类号： C12N5/061 , A01K67/0271 , A01K2207/12 , A01K2227/101 , A01K2227/108 , A01K2267/02 , A61B17/425 , A61D19/00 , A61K35/52 , C12M21/00 , C12N5/0602 , C12N5/0603 , C12N5/0656 , C12N5/0683 , C12N15/873 , C12N2500/05 , C12N2500/24 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/21 , C12N2501/727 , C12N2502/13 , C12N2502/246 , C12N2510/04 , C12N2533/90
摘要： The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.
摘要翻译：本发明涉及可以长期保持并且不含饲料的未分化精原干细胞的生产和培养。所得的无饲料种群可以用于许多方案中的任一种，包括产生后代公牛。本发明包括成功富集牛精原干细胞，新型细胞系和用于其的其它组分所需的新方法，以及所得的干细胞组合物。

8. 发明申请

US20140147831A1 METHODS FOR FORMING NORMAL REGENERATED TISSUES, THE NORMAL REGENERATED TISSUES AND METHODS FOR ASSESSING SENSITIVITIES AND SO ON 有权
标题翻译：形成正常再生组织的方法，正常再生组织和评估敏感性的方法等
公开(公告)号：US20140147831A1
公开(公告)日：2014-05-29
申请号：US14058885
申请日：2013-10-21
申请人： JAPAN SCIENCE AND TECHNOLOGY CORPORATION
发明人： NAKATSUGAWA Shigekazu
IPC分类号： C12N5/071
CPC分类号： C12N5/0625 , A61K35/12 , A61L27/3604 , A61L27/3813 , C12N5/0697 , C12N2502/088 , C12N2502/095 , C12N2502/246 , C12N2502/256 , C12N2502/28 , C12N2502/30 , C12N2503/00 , C12N2503/04
摘要： A normal regenerated tissue is formed by exposing to radiation a connective tissue or a supporting tissue originating in an organ to thereby form a feeder layer and then transplanting epithelial cells thereon to form a stratified structure. By conveniently and surely providing regenerated tissue by the 3-dimensional culture with the use of a human-origin normal tissue as a base, it is possible to construct systems for assessing effects and side effects of chemicals such as drugs or assessing sensitivities thereof with the use of regenerated tissues as models of corresponding tissues respectively.
摘要翻译：通过暴露于来自器官的结缔组织或支持组织从而形成饲养层，然后在其上移植上皮细胞以形成分层结构，形成正常的再生组织。通过使用人源性正常组织作为基础，通过三维培养方便且可靠地提供再生组织，可以构建用于评估诸如药物的化学物质的效果和副作用的系统，或者评估其敏感性分别使用再生组织作为相应组织的模型。

9. 发明申请

US20130211186A1 FEEDER-FREE METHOD FOR CULTURE OF BOVINE AND PORCINE SPERMATOGONIAL STEM CELLS 有权
公开(公告)号：US20130211186A1
公开(公告)日：2013-08-15
申请号：US13763908
申请日：2013-02-11
申请人： WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION
发明人： Jon Michael Oatley , Melissa Joan Oatley
IPC分类号： C12N5/076 , C12N5/071 , C12M1/00 , C12N5/073
CPC分类号： C12N5/061 , A01K67/0271 , A01K2207/12 , A01K2227/101 , A01K2227/108 , A01K2267/02 , A61B17/425 , A61D19/00 , A61K35/52 , C12M21/00 , C12N5/0602 , C12N5/0603 , C12N5/0656 , C12N5/0683 , C12N15/873 , C12N2500/05 , C12N2500/24 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2500/90 , C12N2501/115 , C12N2501/125 , C12N2501/13 , C12N2501/21 , C12N2501/727 , C12N2502/13 , C12N2502/246 , C12N2510/04 , C12N2533/90
摘要： The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.

10. 发明申请

US20080254090A1 Porcine Islets Cultured With Porcine Sertoli Cells For Xenotransplantation 审中-公开
标题翻译：猪细胞培养猪胰岛细胞用于异种移植
公开(公告)号：US20080254090A1
公开(公告)日：2008-10-16
申请号：US10562246
申请日：2004-06-24
申请人： Stephen John Martin Skinner , Robert Bartlett Elliott , Livia Del Carmen Escobar Orellana
发明人： Stephen John Martin Skinner , Robert Bartlett Elliott , Livia Del Carmen Escobar Orellana
IPC分类号： A61K35/12 , C12N5/02 , C12N5/06 , A61K9/00 , A61P3/10
CPC分类号： A61K35/39 , A61K35/12 , C12N5/0676 , C12N5/0677 , C12N2502/246 , C12N2510/02
摘要： Aggregates and their method of preparation suitable for implantation into a recipient in order to produce insulin in vivo. The methods involve culturing islet cells isolated from the pancreas of donor piglets with isolated Sertoli cells from the testes of donor piglets. A preferred period of culturing is 5 days and may be followed by a purification procedure.
摘要翻译：聚集体及其制备方法适于植入受体以在体内产生胰岛素。该方法包括培养从供体仔猪胰腺分离的胰岛细胞，并从供体仔猪的睾丸中分离出Sertoli细胞。优选的培养时间为5天，然后进行纯化程序。

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