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1. 发明申请

US20170098925A1 Manually-Operated Wire Stripper 审中-公开
公开(公告)号：US20170098925A1
公开(公告)日：2017-04-06
申请号：US15240453
申请日：2016-08-18
申请人： Bartley Alan Wells
发明人： Bartley Alan Wells
IPC分类号： H02G1/12
CPC分类号： H02G1/126 , H02G1/1217 , H02G1/1224 , H02G1/1263 , H02G1/127 , H02G1/1273
摘要： A manually-operated wire stripper is a device for cutting and removing the electrical insulation from an electrical wire. The device includes a base plate onto which a first mounting plate and a second mounting plate are perpendicularly mounted. A first rod is rotatably mounted through the first mounting plate and the second mounting plate. A cutting assembly is mounted for longitudinal movement to the first rod and may be moved into position such that a blade of the cutting assembly is aligned with a selected slot from a plurality of wire slots traversing through the base plate. An electrical wire may be stripped by inserting the electrical wire through the selected slot, creating a cut in the electrical insulation with the blade, and then manually pulling the electrical wire through the selected slot to remove the electrical insulation along the length of the electrical wire.

2. 发明授权

US08734775B2 Chemokine derived peptides that bind with chemokine receptor CXCR3 and uses for chronic wound and angiogenesis inhibition treatments 有权
标题翻译：与趋化因子受体CXCR3结合并用于慢性伤口和血管发生抑制治疗的趋化因子衍生肽
公开(公告)号：US08734775B2
公开(公告)日：2014-05-27
申请号：US13219375
申请日：2011-08-26
申请人： Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
发明人： Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
IPC分类号： A61K38/19 , A61K45/00 , C07K14/435
CPC分类号： A61K38/195 , A61K47/551 , C07K14/522
摘要： Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the α-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.
摘要翻译：公开了具有针对受体CXCR3的活性的肽，其表现出在预防新血管形成中的活性和介导新形成的血管解离和在伤口愈合后期分解伤口的活性。衍生自α-螺旋部分IP-10（CXCL10）或来自IP-9（CXCL11）的优选肽是无毒的且小于天然存在的肽，使得它们可用于治疗由不想要的血管发生标记的疾病或疾病状态，包括肿瘤发生疾病如癌症，以及慢性伤口愈合。

3. 发明申请

US20200215584A1 Washing System 审中-公开
公开(公告)号：US20200215584A1
公开(公告)日：2020-07-09
申请号：US16727148
申请日：2019-12-26
申请人： Marcus Alan Wells, II
发明人： Marcus Alan Wells, II
IPC分类号： B08B3/04 , B60S3/06 , B08B1/00 , B08B1/04 , B08B3/02
摘要： Disclosed herein is a washing system, in accordance with some embodiments. Accordingly, a washing system may include a frame, at least one brush, at least one cleaning agent dispenser, a plurality of wheels, at least one actuator, a power source and a controller. a frame configured to be arranged in a plurality of frame configurations. Further, at least one operational frame configuration of the plurality of frame configurations may include a passageway. Further, the at least one brush coupled to the frame. Further, the at least one cleaning agent dispenser mounted on the frame. Further, the plurality of wheels mounted on the frame. Further, the at least one actuator operationally coupled with the at least one wheel. Further, the power source electrically coupled with the at least one actuator. Further, the controller communicatively coupled with the at least one actuator.

4. 发明授权

US10270233B2 Manually-operated wire stripper 有权
公开(公告)号：US10270233B2
公开(公告)日：2019-04-23
申请号：US15240453
申请日：2016-08-18
申请人： Bartley Alan Wells
发明人： Bartley Alan Wells
IPC分类号： H02G1/12
摘要： A manually-operated wire stripper is a device for cutting and removing the electrical insulation from an electrical wire. The device includes a base plate onto which a first mounting plate and a second mounting plate are perpendicularly mounted. A first rod is rotatably mounted through the first mounting plate and the second mounting plate. A cutting assembly is mounted for longitudinal movement to the first rod and may be moved into position such that a blade of the cutting assembly is aligned with a selected slot from a plurality of wire slots traversing through the base plate. An electrical wire may be stripped by inserting the electrical wire through the selected slot, creating a cut in the electrical insulation with the blade, and then manually pulling the electrical wire through the selected slot to remove the electrical insulation along the length of the electrical wire.

5. 发明申请

US20130014352A1 Repair Clip for Flexible Hold-down Straps 审中-公开
标题翻译：修复弹性夹紧带
公开(公告)号：US20130014352A1
公开(公告)日：2013-01-17
申请号：US13183588
申请日：2011-07-15
申请人： Bryan Alan Wells
发明人： Bryan Alan Wells
IPC分类号： F16B45/00
CPC分类号： B60J7/104 , F16B45/00 , Y10T24/4755
摘要： A device for repairing a broken elastic hold-down strap, shortening an elastic hold-down strap, or providing a third connection point therefore.
摘要翻译：因此，用于修复破碎的弹性压紧带，缩短弹性压紧带或提供第三连接点的装置。

6. 发明申请

US20050260745A1 Perfused three-dimensional cell/tissue disease models 有权
标题翻译：灌注三维细胞/组织疾病模型
公开(公告)号：US20050260745A1
公开(公告)日：2005-11-24
申请号：US11133092
申请日：2005-05-19
申请人： Karel Domansky , Linda Griffith , Steven Tannenbaum , Alan Wells
发明人： Karel Domansky , Linda Griffith , Steven Tannenbaum , Alan Wells
IPC分类号： B01L3/00 , C12M1/00 , C12M1/32 , C12M1/34 , C12Q1/68
CPC分类号： B01L3/502715 , B01J2219/00315 , B01J2219/00743 , B01L3/50255 , B01L3/50273 , B01L3/502738 , B01L2300/0681 , B01L2300/0829 , B01L2300/0861 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M25/14 , C12M29/10
摘要： A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
摘要翻译：已经构建了通过正常人体组织重现毛细血管床特征的系统。该系统有助于在毛细血管床的长度尺度上灌注三维（3D）细胞单一培养物和异型细胞共培养物。一个主要特征是该系统可以在“多孔板”格式中使用，适合与药物开发中通常使用的机器人类型相容的高通量测定。该系统提供了进行毒理学和代谢测定的手段，并作为人类疾病（如肝脏疾病，包括肝炎，暴露相关病理和癌症）的模型。癌症应用包括原发性肝癌以及转移瘤。该系统还可用作测试基因治疗方法的手段，用于治疗疾病和先天性遗传缺陷。

7. 发明申请

US20130053319A1 CHEMOKINE DERIVED PEPTIDES AND USES FOR CHRONIC WOUND AND ANGIOGENESIS INHIBITION TREATMENTS 有权
标题翻译：化学发光肽和用于慢性创伤和血管生成抑制治疗的用途
公开(公告)号：US20130053319A1
公开(公告)日：2013-02-28
申请号：US13219375
申请日：2011-08-26
申请人： Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
发明人： Cecelia C. Yates-Binder , Jesse Jaynes , Timothy Turner , Alan Wells , Richard J. Bodnar
IPC分类号： A61K38/19 , A61P9/00 , A61P43/00 , A61P35/00
CPC分类号： A61K38/195 , A61K47/551 , C07K14/522
摘要： Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the α-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.
摘要翻译：公开了具有针对受体CXCR3的活性的肽，其表现出在预防新血管形成中的活性和介导新形成的血管解离和在伤口愈合后期分解伤口的活性。衍生自α-螺旋部分IP-10（CXCL10）或来自IP-9（CXCL11）的优选肽是无毒的且小于天然存在的肽，使得它们可用于治疗由不想要的血管发生标记的疾病或疾病状态，包括肿瘤发生疾病如癌症，以及慢性伤口愈合。

8. 发明授权

US08318479B2 Perfused three-dimensional cell/tissue disease models 有权
标题翻译：灌注三维细胞/组织疾病模型
公开(公告)号：US08318479B2
公开(公告)日：2012-11-27
申请号：US11133092
申请日：2005-05-19
申请人： Karel Domansky , Linda G. Griffith , Steven R. Tannenbaum , Alan Wells , Samuel Walker Inman
发明人： Karel Domansky , Linda G. Griffith , Steven R. Tannenbaum , Alan Wells , Samuel Walker Inman
IPC分类号： C12M1/22 , C12M3/00 , C12M1/34
CPC分类号： B01L3/502715 , B01J2219/00315 , B01J2219/00743 , B01L3/50255 , B01L3/50273 , B01L3/502738 , B01L2300/0681 , B01L2300/0829 , B01L2300/0861 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M25/14 , C12M29/10
摘要： A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a “multiwell plate” format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
摘要翻译：已经构建了通过正常人体组织重现毛细血管床特征的系统。该系统有助于在毛细血管床的长度尺度上灌注三维（3D）细胞单一培养物和异型细胞共培养物。主要特征是该系统可以在多孔板格式中使用，适合与药物开发中通常使用的机器人类型兼容的高通量测定。该系统提供了进行毒理学和代谢测定的手段，并作为人类疾病（如肝脏疾病，包括肝炎，暴露相关病理和癌症）的模型。癌症应用包括原发性肝癌以及转移瘤。该系统还可用作测试基因治疗方法的手段，用于治疗疾病和先天性遗传缺陷。

9. 发明授权

US06235729B1 Uses of phospholipase C inhibitors 失效
标题翻译：磷脂酶C抑制剂的使用
公开(公告)号：US06235729B1
公开(公告)日：2001-05-22
申请号：US08824149
申请日：1997-03-25
申请人： Philip Chen , Timothy Turner , Alan Wells
发明人： Philip Chen , Timothy Turner , Alan Wells
IPC分类号： A61K3158
CPC分类号： A61K31/685 , A61K31/15 , A61K31/27 , A61K31/58
摘要： The present invention provides a method of inhibiting tumor progression in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Also provided is a method of inhibiting metastasis in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Further provided are pharmaceutical compositions, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis and a pharmaceutically acceptable carrier and a pharmaceutical composition, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis, a antineoplastic agent and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制需要这种治疗的个体中肿瘤进展的方法，包括向所述个体施用药理学有效剂量的磷脂酶C抑制剂的步骤。还提供了在需要这种治疗的个体中抑制转移的方法，包括向所述个体施用药理学有效剂量的磷脂酶C抑制剂的步骤。还提供了包含肿瘤侵袭和转移的磷脂酶C抑制剂和药学上可接受的载体和药物组合物的药物组合物，其包含肿瘤侵袭和转移的磷脂酶C抑制剂，抗肿瘤剂和药学上可接受的载体。

10. 发明授权

US5120332A Gas resonance device 失效
标题翻译：气体共振装置
公开(公告)号：US5120332A
公开(公告)日：1992-06-09
申请号：US435122
申请日：1989-11-13
申请人： Alan Wells
发明人： Alan Wells
IPC分类号： B01D53/04 , F02G1/043 , F02G3/00 , F23C15/00 , F25B9/14
CPC分类号： F23C15/00 , B01D53/0423 , B01D53/047 , F02G1/0435 , F02G3/00 , F25B9/145 , B01D2253/102 , B01D2253/108 , B01D2256/12 , B01D2257/102 , B01D2257/104 , B01D2259/65 , F02G2243/52
摘要： A gas resonance device (101) comprises a pulsed combustor (102) located in the middle of a substantially spherical resonance chamber (103). Such a thermally driven gas resonance device has the advantage that the wall friction losses are eliminated altogether. A thermally driven gas resonance device (1, 101) may be combined with a pressure swing gas separator (16, 108), the oscillating gas in the gas resonance device (1, 101) being used to provide the pressure changes required to drive the pressure swing gas separator. Alternatively a thermally driven gas resonance device (1, 101) is combined with a heat pump (19, 120) with the oscillating gas in the gas resonance device (1, 101) being used to provide the power to operate the heat pump. The thermally driven gas resonance device (1, 101) may also drive an electrical generator (121, 122) to provide a combined heat and power device.
摘要翻译：气体共振装置（101）包括位于大致球形共振室（103）中间的脉冲燃烧室（102）。这种热驱动气体共振装置具有完全消除壁摩擦损失的优点。热驱动气体共振装置（1,101）可以与变压气体分离器（16,108）组合，气体共振装置（1,101）中的振荡气体用于提供驱动气体共振装置变压气体分离器。或者，热驱动气体共振装置（1,101）与热泵（19,120）组合，气体共振装置（1,101）中的振荡气体用于提供操作热泵的功率。热驱动气体共振装置（1,101）还可以驱动发电机（121,122）以提供组合的热和功率装置。

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