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1. 发明授权

US06477426B1 System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors 有权
公开(公告)号：US06477426B1
公开(公告)日：2002-11-05
申请号：US09597234
申请日：2000-06-20
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： A system and method for safely heating cancerous and pre-cancerous conditions of the prostate, as well as benign and pre-benign lesions (any localized pathological change in the prostate tissue) by irradiation of the prostate tissue with coherent phased array or non-coherent energy is introduced. Microwave energy and prostate compression provide preferential heating of high-water content prostate carcinoma and benign cells in the prostate compared to the surrounding lower-water content normal prostate tissues and tissue surrounding the prostate. To coherently focus the energy, such as microwave energy, in the prostate, the patient's prostate can be compressed via a urethral and rectal balloon and either a single electric-field probe, inserted in the central portion of the prostate, or two noninvasive electric-field sensors on the urethral and rectal walls, can be used to measure a feedback signal to adjust the energy phase delivered to the applicators located in the urethra and in the rectum. The initial energy power delivered to the energy applicators is set to a desired value that is known to produce a desired increase in temperature in the prostate. Temperature feedback sensors are used to measure urethral and rectal wall temperatures during treatment to adjust the energy power delivered to the applicators to avoid overheating the urethral and rectal walls. The energy delivered to the applicators is monitored in real time during treatment, and the treatment is completed when a desired total energy dose has been administered. The system according to the invention can heat and destroy the prostate carcinoma and benign cells sufficiently in order to prevent prostate cancer and benign prostatic hyperplasia. The treatment is administered as a preventative for cancer and BPH, when a patient's PSA level is less than 4 and for BPH, when a patient's AUA Symptom Index scores less than 13.

2. 发明授权

US06470217B1 Method for heating ductal and glandular carcinomas and other breast lesions to perform thermal downsizing and a thermal lumpectomy 有权
公开(公告)号：US06470217B1
公开(公告)日：2002-10-22
申请号：US09548630
申请日：2000-04-13
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method for selectively heating cancerous conditions of the breast including invasive ductal carcinoma and invasive glandular lobular carcinoma, and pre-cancerous conditions of the breast including ductal carcinoma in-situ, lobular carcinoma in-situ, and intraductal hyperplasia, as well as benign lesions (any localized pathological change in the breast tissue) such as fibroadenomas and cysts by irradiation of the breast tissue with adaptive phased array focused microwave energy is introduced. Microwave energy provides preferential heating of high-water content breast tissues such as carcinomas, fibroadenomas, and cysts compared to the surrounding lower-water content normal breast tissues. To focus the microwave energy in the breast, the patient's breast can be compressed and a single electric-field probe, inserted in the central portion of the breast, or two noninvasive electric-field probes on opposite sides of the breast skin, can be used to measure a feedback signal to adjust the microwave phase delivered to waveguide applicators on opposite sides of the compressed breast tissue. The initial microwave power delivered to the microwave applicators is set to a desired value that is known to produce a desired increase in temperature in breast tumors. Temperature feedback sensors are used to measure skin temperatures during treatment to adjust the microwave power delivered to the waveguide applicators to avoid overheating the skin. The microwave energy delivered to the waveguide applicators is monitored in real time during treatment, and the treatment is completed when a desired total microwave energy dose has been administered. By heating and destroying the breast lesion sufficiently, lesions can be reduced in size and surrounding normal breast tissues are spared so that surgical mastectomy can be replaced with surgical lumpectomy or the lesions can be completely destroyed so that surgical mastectomy or lumpectomy is avoided.

3. 发明授权

US5540737A Minimally invasive monopole phased array hyperthermia applicators and method for treating breast carcinomas 失效
标题翻译：微创单极相控阵热疗仪及乳腺癌治疗方法
公开(公告)号：US5540737A
公开(公告)日：1996-07-30
申请号：US157928
申请日：1993-11-24
申请人： Alan J. Fenn
发明人： Alan J. Fenn
IPC分类号： A61N5/02 , A61N5/04 , A61N5/00
CPC分类号： A61N5/04 , A61N5/02
摘要： An RF hyperthermia applicator for inducing a temperature rise in a human female breast for treating carcinomas includes a waveguide applicator having an aperture and a phased-array of monopole electric field radiators coupled to a source of electric field energy for producing electric field radiation output from the waveguide through the aperture. Compression means is used for compressing a human breast to a predetermined thickness. The waveguide is positioned adjacent to the compression means such that the breast is positioned adjacent to the aperture and thereby receives electric field radiation from the waveguide. In another embodiment, at least two waveguide applicators are positioned on opposite sides of the compression means so that the compressed breast is positioned between the opposed apertures of the waveguides. An electric field probe is placed into a target within the breast to assist in focusing the electric field energy into the target.
摘要翻译：用于诱导人乳房乳房中温度升高以用于治疗癌症的RF热疗施加器包括具有孔径的波导施加器和耦合到电场能量源的单极电场辐射器的相控阵列，用于产生从波导通孔。压缩装置用于将人乳房压缩至预定厚度。波导定位成与压缩装置相邻，使得乳房定位成邻近孔径，从而接收来自波导的电场辐射。在另一个实施例中，至少两个波导管施加器位于压缩装置的相对侧上，使得压缩的乳房位于波导的相对的孔之间。将电场探针放置在乳房内的靶中，以帮助将电场能量聚焦到靶中。

4. 发明申请

US20200146740A1 Thermodilatation and Thermocompression to Facilitate Targeted Cluster Tissue Ablation and Immune Response 审中-公开
公开(公告)号：US20200146740A1
公开(公告)日：2020-05-14
申请号：US16186317
申请日：2018-11-09
申请人： William W. Jow , John Mon , Stuart E. Katz , Alan J. Fenn
发明人： William W. Jow , John Mon , Stuart E. Katz , Alan J. Fenn
IPC分类号： A61B18/04 , A61B18/02 , A61B18/18
摘要： Method for treatment of the body with localized energy application in combination with other treatments to facilitate cluster tissue ablation and increase immune response including a method of treatment of a localized treatment area of a body including injection, IV or otherwise to entrap and/saturate a localized treatment area to be used singularly or in combination with: a high electric conductive material comprising a saline solution, hypertonic saline solution, a solution with metallic compounds, metals, nanoparticles, gel, polymers, high-polarity molecules, peptides, liposomes to treat and cause preferential heating and effect secondary conductive heating from cluster sites to adjacent tissues using external or intracavitary energy applicators.

5. 发明授权

US06768925B2 Method for improved safety in externally focused microwave thermotherapy for treating breast cancer 有权
标题翻译：改善外部聚焦微波热疗法治疗乳腺癌的安全性的方法
公开(公告)号：US06768925B2
公开(公告)日：2004-07-27
申请号：US10195455
申请日：2002-07-16
申请人： Alan J. Fenn , John Mon , Dennis Smith
发明人： Alan J. Fenn , John Mon , Dennis Smith
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method and apparatus that increases safety when employing externally focused adaptive phased array microwave thermotherapy (hyperthermia) for breast cancer treatment include microwave absorbing pads and metallic shielding to prevent undesired or stray surface tissue heating and to cushion the breast from mechanical pressure during breast compression. The microwave absorbing pads are attached on the top of the microwave waveguide thermotherapy applicators and on top of the breast compression paddles. A metallic-shielding strip mounted across the top portion of the microwave applicator aperture acts to block microwave radiation from illuminating the base of the breast and chest wall area. The patient treatment table utilizes a metallic shield to shield the body from stray microwave radiation. Combined E-field and temperature sensors within a single catheter are used to require only a single minimally invasive skin entry point for E-field focusing and measurement of the tumor temperature. Breast compression is maintained for a period of time following microwave-induced heating to accumulate additional equivalent thermal dose. Treatments incorporating the safety improvements include thermotherapy for early-stage breast carcinomas, locally advanced breast cancer, ductal carcinoma in-situ, and benign breast lesions.
摘要翻译：使用外部聚焦的自适应相控阵微波热疗法（热疗）用于乳腺癌治疗的方法和装置包括微波吸收垫和金属屏蔽物，以防止不期望的或杂散的表面组织加热并且在乳房压缩期间使乳房缓冲乳房的机械压力。微波吸收垫连接在微波波导热疗器施加器的顶部并且在乳房压缩桨的顶部。安装在微波加工器孔的顶部的金属屏蔽条用于阻止微波辐射照射乳房和胸壁区域的基部。患者治疗台使用金属屏蔽来屏蔽身体免受杂散微波辐射。单个导管内的组合电场和温度传感器仅用于仅需要单个微创皮肤入口点进行电场聚焦和测量肿瘤温度。乳房压缩在微波诱导加热后保持一段时间，以累积额外的等效热剂量。结合安全改善的治疗包括早期乳腺癌的热疗，局部晚期乳腺癌，原位导管癌和良性乳腺病变。

6. 发明授权

US08749441B2 Simultaneous transmit and receive antenna system 有权
标题翻译：同时发射和接收天线系统
公开(公告)号：US08749441B2
公开(公告)日：2014-06-10
申请号：US13282700
申请日：2011-10-27
申请人： Alan J. Fenn , Peter T. Hurst , Jeffrey S. Herd , Kenneth E. Kolodziej , Leonard I. Parad , Hans Steyskal
发明人： Alan J. Fenn , Peter T. Hurst , Jeffrey S. Herd , Kenneth E. Kolodziej , Leonard I. Parad , Hans Steyskal
IPC分类号： H01Q9/16
CPC分类号： H01Q1/525 , H01Q21/20 , H01Q21/28
摘要： Described is a simultaneous transmit and receive antenna system having a ring array of transmit antenna elements and a receive antenna element disposed on an axis that is perpendicular to and passing through the center of the ring array. Alternatively, the ring array includes receive elements and a transmit antenna element is disposed on the axis perpendicular to the ring array. Opposite antenna elements in the ring array differ in phase by 180° so that a radiation pattern null occurs at the antenna element at the center of the ring array. Also included are at least one ground plane and an electrically-conductive cylinder disposed on the perpendicular axis inside the ring array to provide a high degree of isolation between the transmit and receive antenna elements. The system may be configured for wireless communications, for example, according to WIFI IEEE standard 802.11 or WIMAX IEEE standard 802.16.
摘要翻译：描述了具有发射天线元件的环阵列和设置在垂直于并穿过环阵列的中心的轴上的接收天线元件的同时发射和接收天线系统。或者，环阵列包括接收元件，并且发射天线元件设置在垂直于环阵列的轴上。环形阵列中的相对的天线元件的相位相差180°，使得在环阵列的中心处的天线元件处发生辐射图案零点。还包括设置在环阵列内的垂直轴上的至少一个接地平面和导电圆柱体，以在发射天线元件和接收天线元件之间提供高度隔离。该系统可以被配置用于无线通信，例如，根据WIFI IEEE标准802.11或WIMAX IEEE标准802.16。

7. 发明申请

US20120253099A1 DRUG DELIVERY 有权
标题翻译：药物递送
公开(公告)号：US20120253099A1
公开(公告)日：2012-10-04
申请号：US13523336
申请日：2012-06-14
申请人： John MON , Alan J. FENN
发明人： John MON , Alan J. FENN
IPC分类号： A61M37/00
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：一种使用热疗法在身体导管附近处理组织的方法和装置（100），同时防止由于水肿导致的身体导管的障碍，包括将药物包封在热敏载体（例如脂质体）内部的区域内的待处理组织。由能量发射源（110）产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分。此外，由能量发射源（110）产生的热激活热敏载体以激活封装药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

8. 发明授权

US06725095B2 Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue 有权
标题翻译：男性和女性患者治疗和预防癌症的热疗方法和组织的化妆消融
公开(公告)号：US06725095B2
公开(公告)日：2004-04-20
申请号：US10270312
申请日：2002-10-15
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioning at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.
摘要翻译：用于治疗身体或器官的癌症或良性病症的方法使用能量选择性地照射身体组织。该方法包括以下步骤：监测邻近身体的皮肤表面的温度，将至少一个能量施加器定位在身体周围，将能量传递到至少一个能量施加器以选择性地用能量照射身体组织并且治疗癌症中的至少一种以及身体的良性状态，基于所监测的皮肤温度，调整在治疗期间被输送到至少一个能量施加器的功率水平，监测传送到至少一个能量施加器的能量，确定传递给所述至少一个能量施加器的总能量至少一个能量施加器，并且当所述至少一个能量施加器被递送到所述身体时，完成所述治疗。

9. 发明授权

US06690976B2 Thermotherapy method for treatment and prevention of breast cancer and cancer in other organs 有权
标题翻译：治疗和预防其他器官乳腺癌和癌症的热疗方法
公开(公告)号：US06690976B2
公开(公告)日：2004-02-10
申请号：US10193110
申请日：2002-07-12
申请人： Alan J. Fenn , John Mon
发明人： Alan J. Fenn , John Mon
IPC分类号： A61F200
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of an organ includes the steps of inserting an E-field probe sensor to a depth in the organ tissue, monitoring temperatures of the skin surface adjacent the organ, positioning two or more energy applicators around the organ, setting the initial relative phase delivered to each energy applicator to focus the energy at the E-field probe positioned in the organ tissue, delivering energy to the applicators to selectively irradiate the organ tissue, adjusting the power level to be delivered to each applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the applicators, determining total energy delivered to the applicators and displaying the total energy in real time during the treatment, and completing the treatment when the desired total energy dose has been delivered by the energy applicators to the organ. Either focused or non-focused may be employed.
摘要翻译：用于治疗器官的癌症或良性病症的方法包括以下步骤：将E场探针传感器插入器官组织中的深度，监测与器官相邻的皮肤表面的温度，将两个或更多个能量施放器定位在器官周围，设置递送到每个能量施加器的初始相对相位以将能量聚焦在位于器官组织中的E场探针处，将能量传递到施用器以选择性地照射器官组织，在治疗期间调整要输送到每个施用器的功率水平基于所监测的皮肤温度，监测递送到施用器的能量，确定递送到施用器的总能量并且在治疗期间实时显示总能量，以及当期望的总能量剂量由能量传递时完成治疗施放器到器官。可以采用聚焦或非焦点。

10. 发明授权

US5944749A X-ray needle providing heating with microwave energy 失效
标题翻译： X射线针提供微波能量加热
公开(公告)号：US5944749A
公开(公告)日：1999-08-31
申请号：US978319
申请日：1997-11-25
申请人： Alan J. Fenn
发明人： Alan J. Fenn
IPC分类号： A61B18/18 , A61F2/00 , A61N5/04 , A61N5/10 , A61B17/39
CPC分类号： A61N5/1001 , A61B18/18 , A61B18/1815 , A61N5/045
摘要： Electrons moving in a first direction are concentrated (e.g. magnetically) in a beam within a first tube. A converter converts the electrons to x-rays for movement to a particular position (e.g. tumor) in a patient. A fluid (e.g. water) flowing past the converter through a second tube co-axial with the first tube cools the converter. Microwave energy passes in the first direction through a third tube co-axial with the first tube. The third tube is open at the end near the converter so that the microwave energy will pass to the particular position in the patient. A second fluid (e.g. air) passing through a fourth tube coaxial with the first tube cools the tissue in direct contact with the x-ray needle. The second, third and fourth tubes may respectively have diameters of approximately 2, 3 and 4 millimeters. The microwave energy may pass into the third tube from a fifth tube transverse to the third tube. The microwave energy impedance may be approximately 50 .OMEGA. at the fifth tube input and approximately 5 .OMEGA. at the third tube input. The fifth tube is constructed to match the 50 .OMEGA. and 5 .OMEGA. impedances. A first portion of the microwave energy introduced to the third tube flows in the first direction through the third tube coaxially with the electron beam. A second portion of the microwave energy flows in a direction opposite to the first direction, is reflected by a short circuit and then flows in the first direction in phase with the first energy portion.
摘要翻译：沿第一方向移动的电子在第一管内的光束中集中（例如磁性地）。 A转换器将电子转换成x射线以移动到患者中的特定位置（例如肿瘤）。通过与第一管同轴的第二管流过转换器的流体（例如水）冷却转换器。微波能量沿第一方向通过与第一管同轴的第三管。第三管在转换器附近的端部开放，使得微波能量将传递到患者中的特定位置。通过与第一管同轴的第四管的第二流体（例如空气）将组织直接接触x射线针。第二，第三和第四管可以分别具有大约2,3和4毫米的直径。微波能量可以从横向于第三管的第五管进入第三管。微波能量阻抗在第五管输入处可以为大约50欧姆，在第三管输入处为约5欧米伽。第五个管被构造成匹配50个OMEGA和5个OMEGA阻抗。引入第三管的微波能量的第一部分沿第一方向通过与电子束同轴的第三管流动。微波能量的第二部分沿与第一方向相反的方向流动，被短路反射，然后沿第一方向与第一能量部分同相流动。

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