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1. 发明授权

US08374702B2 Drug delivery 有权
标题翻译：药物递送
公开(公告)号：US08374702B2
公开(公告)日：2013-02-12
申请号：US13523336
申请日：2012-06-14
申请人： John Mon , Alan J. Fenn
发明人： John Mon , Alan J. Fenn
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：一种使用热疗法在身体导管附近处理组织的方法和装置（100），同时防止由于水肿导致的身体导管的障碍，包括将药物包封在热敏载体（例如脂质体）内部的区域内的待处理组织。由能量发射源（110）产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分。此外，由能量发射源（110）产生的热激活热敏载体以激活封装药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

2. 发明授权

US08224455B2 Drug delivery 有权
标题翻译：药物递送
公开(公告)号：US08224455B2
公开(公告)日：2012-07-17
申请号：US12902858
申请日：2010-10-12
申请人： John Mon , Alan J. Fenn
发明人： John Mon , Alan J. Fenn
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：使用热疗治疗身体导管附近的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，包括在组织区域内注射包封在热敏载体（例如脂质体）内的药物，被处理。由能量发射源产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分的时间。此外，由能量发射源产生的热激活热敏载体以激活包封的药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

3. 发明申请

US20110034976A1 DRUG DELIVERY 有权
标题翻译：药物递送
公开(公告)号：US20110034976A1
公开(公告)日：2011-02-10
申请号：US12902858
申请日：2010-10-12
申请人： JOHN Mon , Alan J. Fenn
发明人： JOHN Mon , Alan J. Fenn
IPC分类号： A61F7/12
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：使用热疗治疗身体导管附近的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，包括在组织区域内注射包封在热敏载体（例如脂质体）内的药物，被处理。由能量发射源产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分的时间。此外，由能量发射源产生的热激活热敏载体以激活包封的药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

4. 发明申请

US20100298913A1 DEVICE AND METHOD FOR TREATMENT OF TISSUE ADJACENT A BODILY CONDUIT BY THERMOCOMPRESSION 有权
标题翻译：用热处理方法治疗组织相邻体液的装置和方法
公开(公告)号：US20100298913A1
公开(公告)日：2010-11-25
申请号：US12849458
申请日：2010-08-03
申请人： John MON , Dennis SMITH
发明人： John MON , Dennis SMITH
IPC分类号： A61F7/00
CPC分类号： A61B18/1815 , A61B18/18
摘要： A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.
摘要翻译：使用热疗治疗身体导管附近的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，采用温热流体的循环来维持身体导管壁的温度并压缩待治疗的组织以增加辐照热的有效性。将包含能量发射源的导管插入身体导管中并定位在待治疗组织的区域中，使得能量发射源将能量辐射到待治疗组织。加热至超过30℃的流体循环进入导管并通过导管，使其靠近导管的身体导管的温暖壁。循环的流体使气囊膨胀至压力以压缩待治疗的组织。超过30℃的温热流体的组合在身体导管附近循环以保持其壁中的温暖并且待处理的组织的压缩使得能够形成在导管和压缩气囊被移除之后保留的天然支架。

5. 发明申请

US20070077230A1 Method for the pre-conditioning/fixation and treatment of diseases with heat activation/release with thermo-activated drugs and gene products 有权
标题翻译：用热激活药物和基因产物进行热激活/释放的疾病的预处理/固定和治疗的方法
公开(公告)号：US20070077230A1
公开(公告)日：2007-04-05
申请号：US11527688
申请日：2006-09-27
申请人： John Mon
发明人： John Mon
IPC分类号： A61N1/39 , A61K48/00 , A61K31/704 , A61K9/127
CPC分类号： A61B18/1477 , A61B18/18 , A61B2018/143 , A61B2218/002 , A61K41/0052 , A61N7/02
摘要： A method of treating cancer by introducing heat into cancerous tissue and delivering a liposome containing an active agent or a thermo-activated drug, gene or virus to said tissue. The heat delivered is sufficient to release the active agent or activate the thermo-activated drug, gene or virus. The cancer can be esophageal cancer. The liposome containing an active agent or a thermo-activated drug, gene or virus can be a thermosensitive liposome. The active agent can be an anti-neoplastic agent, for example doxorubicin.
摘要翻译：通过将热量引入癌组织并将含有活性剂或热活化药物，基因或病毒的脂质体递送到所述组织来治疗癌症的方法。输送的热量足以释放活性剂或活化热活化药物，基因或病毒。癌症可以是食管癌。含有活性剂或热活化药物，基因或病毒的脂质体可以是热敏脂质体。活性剂可以是抗肿瘤剂，例如多柔比星。

6. 发明授权

US06807446B2 Monopole phased array thermotherapy applicator for deep tumor therapy 有权
公开(公告)号：US06807446B2
公开(公告)日：2004-10-19
申请号：US10233012
申请日：2002-09-03
申请人： Alan J. Fenn , John Mon , Dennis Smith
发明人： Alan J. Fenn , John Mon , Dennis Smith
IPC分类号： A61N502
CPC分类号： A61N1/403
摘要： A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements each for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiating element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.

7. 发明申请

US20120265137A1 CATHETER 审中-公开
标题翻译：导管
公开(公告)号：US20120265137A1
公开(公告)日：2012-10-18
申请号：US13523302
申请日：2012-06-14
申请人： John MON
发明人： John MON
IPC分类号： A61M5/44 , A61M25/10
CPC分类号： A61B18/18 , A61B18/04 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2018/00154 , A61B2018/0022 , A61B2018/00547 , A61B2018/044
摘要： An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.
摘要翻译：一种用于治疗需要热疗的身体内的组织的装置，包括插入身体导管中的导管，设置在导管内的能量发射源，围绕能量发射源的压缩气囊，其中压缩气囊具有膨胀直径，大于处于松弛状态的身体管道，并且球囊的外表面涂覆有基因修饰剂和药物或药物之一，以及用于激活能量发射源以辐射能量以加热药物包被的压缩的装置气球和组织，由此加热的药物包被的压缩气囊将基因修饰剂和药物或药物中的一种有效地递送到患病组织的靶区域。此外，公开了使用上述装置来治疗患病组织的方法。

8. 发明申请

US20120253099A1 DRUG DELIVERY 有权
标题翻译：药物递送
公开(公告)号：US20120253099A1
公开(公告)日：2012-10-04
申请号：US13523336
申请日：2012-06-14
申请人： John MON , Alan J. FENN
发明人： John MON , Alan J. FENN
IPC分类号： A61M37/00
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00023 , A61B2018/00214 , A61B2018/00285 , A61B2018/00547 , A61B2018/046 , A61K9/0004 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61N5/045 , A61N7/022 , Y10S436/829 , Y10S514/866 , Y10T428/2984
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.
摘要翻译：一种使用热疗法在身体导管附近处理组织的方法和装置（100），同时防止由于水肿导致的身体导管的障碍，包括将药物包封在热敏载体（例如脂质体）内部的区域内的待处理组织。由能量发射源（110）产生的热将身体导管周围的组织的一部分加热至约43℃的温度足以破坏组织的加热部分。此外，由能量发射源（110）产生的热激活热敏载体以激活封装药物的释放，并且药物靶向待加热的组织。能量发射源的聚焦能量与作用在目标区域上的压缩有助于将药物输送到目标区域，使得天然支架具有长期功效。

9. 发明申请

US20110028886A1 Catheter 有权
标题翻译：导管
公开(公告)号：US20110028886A1
公开(公告)日：2011-02-03
申请号：US12902636
申请日：2010-10-12
申请人： JOHN MON
发明人： JOHN MON
IPC分类号： A61M25/10 , A61F7/12 , A61N7/02 , A61N5/06 , A61N5/067
CPC分类号： A61B18/18 , A61B18/04 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2018/044
摘要： An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.
摘要翻译：一种用于治疗需要热疗的身体内的组织的装置，包括插入身体导管中的导管，设置在导管内的能量发射源，围绕能量发射源的压缩气囊，其中压缩气囊具有膨胀直径，大于处于松弛状态的身体管道，并且球囊的外表面涂覆有基因修饰剂和药物或药物之一，以及用于激活能量发射源以辐射能量以加热药物包被的压缩的装置气球和组织，由此加热的药物包被的压缩气囊将基因修饰剂和药物或药物中的一种有效地递送到患病组织的靶区域。此外，公开了使用上述装置来治疗患病组织的方法。

10. 发明授权

US07837720B2 Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon 有权
标题翻译：用于用基因或药物包被的压缩气囊处理邻近身体导管的组织的装置
公开(公告)号：US07837720B2
公开(公告)日：2010-11-23
申请号：US10436500
申请日：2003-05-13
申请人： John Mon
发明人： John Mon
IPC分类号： A61B7/00
CPC分类号： A61B18/18 , A61B18/04 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2018/044
摘要： An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.
摘要翻译：一种用于治疗需要热疗的身体内的组织的装置，包括插入身体导管中的导管，设置在导管内的能量发射源，围绕能量发射源的压缩气囊，其中压缩气囊具有膨胀直径，大于处于松弛状态的身体管道，并且球囊的外表面涂覆有基因修饰剂和药物或药物之一，以及用于激活能量发射源以辐射能量以加热药物包被的压缩的装置气球和组织，由此加热的药物包被的压缩气囊将基因修饰剂和药物或药物中的一种有效地递送到患病组织的靶区域。此外，公开了使用上述装置来治疗患病组织的方法。

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