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1. 发明授权

US08796320B2 1,3,4-Oxadiazole-2-carboxamide compound 有权
标题翻译： 1,3,4-恶二唑-2-甲酰胺化合物
公开(公告)号：US08796320B2
公开(公告)日：2014-08-05
申请号：US13519707
申请日：2010-12-28
申请人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
发明人： Akira Asai , Kenji Matsuno , Naohisa Ogo , Osamu Takahashi , Yoshiaki Masuda , Ayumu Muroya , Yasuto Akiyama , Tadashi Ashizawa , Tadashi Okawara
IPC分类号： A61K31/4245 , C07D271/10 , C07D413/14
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
摘要翻译：提供具有STAT3抑制活性并可用作抗癌剂的1,3,4-恶二唑-2-甲酰胺化合物。提供由式（I）表示的1,3,4-恶二唑-2-甲酰胺化合物或其药学上可接受的盐（在该式中，Ar表示呋喃基等; R 1表示氢原子等; -X-Y表示二苯基等二芳基）。

2. 发明授权

US08324205B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US08324205B2
公开(公告)日：2012-12-04
申请号：US12471280
申请日：2009-05-22
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61K31/535 , A61K31/497
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

3. 发明授权

US07265486B2 Light emitting diode including a cover covering a light emitting diode element 失效
标题翻译：发光二极管包括覆盖发光二极管元件的盖
公开(公告)号：US07265486B2
公开(公告)日：2007-09-04
申请号：US10901222
申请日：2004-07-29
申请人： Toshinobu Yoko , Masahide Takahashi , Kenji Matsuno
发明人： Toshinobu Yoko , Masahide Takahashi , Kenji Matsuno
IPC分类号： H05B33/04 , H05B33/00
CPC分类号： C08L83/04 , C08G77/20 , C08G77/70 , H01L33/56 , H01L2224/45144 , H01L2224/48091 , H01L2224/48247 , H01L2224/48257 , H01L2924/00014 , H01L2924/00
摘要： In an LED (Light Emitting Diode) including a cover covering an LED element, the cover is formed using glass having a composition RnSiO2-n/2. The glass according to the present invention is low melting point glass with a softening temperature of −40° C. to 300° C., melts at lower temperatures compared to conventional glass, and can safely form the cover without damaging the LED element. Since glass has better moisture shield performance and resistance to light compared to epoxy resins, the cover is formed using glass, and consequently deterioration of the LED element and a phosphor caused by moisture is reduced, deterioration of the cover caused by light is reduced, and changes in color and luminous intensity are restrained.
摘要翻译：在包括覆盖LED元件的盖的LED（发光二极管）中，使用具有组成R n SiO 2 -n / 2/2的玻璃形成盖。根据本发明的玻璃是与常规玻璃相比软化温度为-40℃至300℃的低熔点玻璃，在较低温度下熔化，并且可以安全地形成该盖而不损坏该LED元件。由于与环氧树脂相比，玻璃具有更好的防潮性能和耐光性，所以使用玻璃形成盖，因此降低了LED元件和由水分引起的荧光体的劣化，降低了由光引起的盖的劣化，以及颜色和发光强度的变化受到限制。

4. 发明授权

US06982266B2 Quinazoline derivatives as kinase inhibitors 失效
标题翻译：喹唑啉衍生物作为激酶抑制剂
公开(公告)号：US06982266B2
公开(公告)日：2006-01-03
申请号：US10344736
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A01K31/675 , A01K31/517 , C07D43/02 , C07D239/72
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法，血管重构，癌症和肾小球硬化症。

5. 发明授权

US06956039B2 Nitrogenous heterocylic compounds 失效
标题翻译：含氮杂环化合物
公开(公告)号：US06956039B2
公开(公告)日：2005-10-18
申请号：US10344737
申请日：2001-08-17
申请人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
发明人： Anjali Pandey , Robert M. Scarborough , Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shinichi Ide , Eiji Tsukuda , Junko Sasaki , Shoji Oda
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D487/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

6. 发明申请

US20050158859A1 Manipulation of non-terminally differentiated cells using the Notch pathway 审中-公开
标题翻译：使用Notch途径操纵非终末分化细胞
公开(公告)号：US20050158859A1
公开(公告)日：2005-07-21
申请号：US10746237
申请日：2003-12-22
申请人： Spyridon Artavanis-Tsakonas , Mark Fortini , Kenji Matsuno
发明人： Spyridon Artavanis-Tsakonas , Mark Fortini , Kenji Matsuno
IPC分类号： A61K35/12 , A61K38/00 , C07K14/47 , C12N5/00 , C12N5/07 , A61K48/00 , C12N5/08 , C12N15/85
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , C12N5/0018 , C12N5/0601 , C12N2501/42
摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
摘要翻译：本发明涉及使用Notch功能的激动剂来扩增非终末分化的细胞（“前体细胞”）的方法，通过抑制细胞的分化而不抑制增殖（有丝分裂活性），使得扩增的非 - 得到终末分化的细胞。细胞优选是干细胞或祖细胞。这些扩展的细胞可用于细胞替代疗法以提供所需的细胞群体并有助于患病和/或损伤组织的再生。扩增的细胞群体也可以重组并用于基因治疗，或可用于提供与特定前体细胞或其后代细胞相关的功能。

7. 发明申请

US20050023540A1 Light emitting diode 失效
标题翻译：发光二极管
公开(公告)号：US20050023540A1
公开(公告)日：2005-02-03
申请号：US10901222
申请日：2004-07-29
申请人： Toshinobu Yoko , Masahide Takahashi , Kenji Matsuno
发明人： Toshinobu Yoko , Masahide Takahashi , Kenji Matsuno
IPC分类号： H01L33/50 , C08L83/04 , H01L27/15 , H01L33/56
CPC分类号： C08L83/04 , C08G77/20 , C08G77/70 , H01L33/56 , H01L2224/45144 , H01L2224/48091 , H01L2224/48247 , H01L2224/48257 , H01L2924/00014 , H01L2924/00
摘要： In an LED (Light Emitting Diode) including a cover covering an LED element, the cover is formed using glass having a composition RnSiO2−n/2. The glass according to the present invention is low melting point glass with a softening temperature of −40° C. to 300° C., melts at lower temperatures compared to conventional glass, and can safely form the cover without damaging the LED element. Since glass has better moisture shield performance and resistance to light compared to epoxy resins, the cover is formed using glass, and consequently deterioration of the LED element and a phosphor caused by moisture is reduced, deterioration of the cover caused by light is reduced, and changes in color and luminous intensity are restrained.
摘要翻译：在包括覆盖LED元件的盖的LED（发光二极管）中，使用具有RnSiO 2 -n / 2组成的玻璃形成该盖。根据本发明的玻璃是与常规玻璃相比软化温度为-40℃至300℃的低熔点玻璃，在较低温度下熔化，并且可以安全地形成该盖而不损坏该LED元件。由于与环氧树脂相比，玻璃具有更好的防潮性能和耐光性，所以使用玻璃形成盖，因此降低了LED元件和由水分引起的荧光体的劣化，降低了由光引起的盖的劣化，以及颜色和发光强度的变化受到限制。

8. 发明授权

US06472391B2 Nitrogen-containing heterocyclic compounds 有权
标题翻译：含氮杂环化合物
公开(公告)号：US06472391B2
公开(公告)日：2002-10-29
申请号：US09734918
申请日：2000-12-13
申请人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
发明人： Kenji Matsuno , Michio Ichimura , Yuji Nomoto , Shigeki Fujiwara , Shinichi Ide , Eiji Tsukuda , Junko Irie , Shoji Oda
IPC分类号： A61K3153
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： 1,2,3 Triazines according to formula (I): and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering.
摘要翻译：根据式（I）的1,2,3-三嗪及其药学上可接受的盐抑制血小板衍生生长因子受体的磷酸化，从而阻碍异常细胞生长和细胞游动。

9. 发明授权

US06423716B1 Nitrogenous heterocyclic compounds 有权
标题翻译：含氮杂环化合物
公开(公告)号：US06423716B1
公开(公告)日：2002-07-23
申请号：US09647490
申请日：2000-09-29
申请人： Kenji Matsuno , Yuji Nomoto , Michio Ichimura , Shin-ichi Ide , Shoji Oda
发明人： Kenji Matsuno , Yuji Nomoto , Michio Ichimura , Shin-ichi Ide , Shoji Oda
IPC分类号： A61K3150
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR1R2 (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and R2 represents a hydrogen atom, etc. ), OR4, or SR5; V represents an oxygen atom, a sulfur atom, N—R6, or CR7R8, at least one of X, Y and Z represents a nitrogen atom, and the others are the same or different, and each represents a nitrogen atom or C—RA; and D1, D2, D3 and D4 each independently represent C—RB, a nitrogen atom, an oxygen atom, a sulfur atom, etc., optional adjoining two among D1 to D4 are combined to represent a nitrogen atom, N—R2A, an oxygen atom, a sulfur atom, etc., or optional adjoining two selected from D1 to D4 represent C—RB″ (wherein two RB″s are combined to represent substituted or unsubstituted alicyclic alkene, substituted or unsubstituted pyrrole, substituted or unsubstituted pyrazole, etc.; or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及由式（I）表示的含氮杂环化合物：其中W表示1,4-哌嗪二基等; U表示NR1R2（其中R1表示氢原子，取代或未取代的烷基等; R2表示氢原子等），OR4或SR5; V表示氧原子，硫原子，N-R6或CR7R8，X，Y和Z中的至少一个表示氮原子，其它相同或不同，表示氮原子或C-RA ; D1，D2，D3和D4各自独立地表示C-RB，氮原子，氧原子，硫原子等，D1〜D4中任意相邻的2个相互组合，表示氮原子，N-R2A，氧原子，硫原子等，或选自D1〜D4中任意相邻的2个表示C-RB“（其中两个RB'组合以代表取代或未取代的脂环族烯烃，取代或未取代的吡咯，取代或未取代的吡唑等;或其药学上可接受的盐。

10. 发明授权

US5906286A Heat-resistant pressure-resistant and self standing container and method of producing thereof 失效
标题翻译：耐热耐压自立式容器及其制造方法
公开(公告)号：US5906286A
公开(公告)日：1999-05-25
申请号：US622415
申请日：1996-03-27
申请人： Kenji Matsuno , Nobuyuki Kato , Hiroo Ikegami , Setsuko Nakamaki , Kimio Takeuchi , Hotaka Fukabori , Yoshitsugu Maruhashi , Hideo Kurashima
发明人： Kenji Matsuno , Nobuyuki Kato , Hiroo Ikegami , Setsuko Nakamaki , Kimio Takeuchi , Hotaka Fukabori , Yoshitsugu Maruhashi , Hideo Kurashima
IPC分类号： B29C35/08 , B29C49/06 , B29C49/08 , B29C49/12 , B29C49/18 , B29C49/64 , B29C49/66 , B29C61/02 , B29K105/00 , B29L22/00 , B65D1/02 , B65D1/42 , B65D23/00
CPC分类号： B65D1/0284 , B29C49/12 , B29C49/18 , B29C49/649 , B65D1/0207 , B29B2911/14693 , B29B2911/147 , B29B2911/14713 , B29B2911/14906 , B29B2911/14933 , B29C2035/0822 , B29C2049/1219 , B29C49/06 , B29C49/66 , B29C61/02 , B29K2995/004 , B29L2031/7158 , Y10S264/906
摘要： A container is obtained by biaxially stretch-blow-molding a resin. Except the mouth-and-neck portion, vicinities thereof and the center of the bottom portion, the container as a whole is reduced in thickness under a highly drawing condition without being accompanied by whitening, and a portion constituting the bottom valley portions has an yielding load of not smaller than 25 kg/cm at 70.degree. C. The container exhibits excellent heat resistance, pressure resistance, shock resistance as well as self-standing ability.
摘要翻译：通过对树脂进行双轴拉伸吹塑来获得容器。除了口颈部，其附近和底部的中心之外，容器整体在高拉伸条件下厚度减小，而不伴随着白化，构成底部谷部的部分具有屈服 70℃时的载荷不小于25kg / cm。容器表现出优异的耐热性，耐压性，抗冲击性和自立能力。

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