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1. 发明授权

US06316247B1 System and method for refining liposuctioned adipose tissue 失效
标题翻译：脂肪抽吸脂肪组织的系统和方法
公开(公告)号：US06316247B1
公开(公告)日：2001-11-13
申请号：US09333532
申请日：1999-06-15
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Frank R. Walters
IPC分类号： C07G1700
CPC分类号： A61L27/3604 , A61L27/3683
摘要： A device and method for producing refined adipose tissue for use in autologous adipose transplantation or research wherein a sterile environment is maintained. More particularly, a system for refining tissue comprising a first flexible container, a second flexible container having a plurality of pores providing for fluid communication between the interior of the first flexible container and the interior of the first enveloping flexible container, a first port that provides communication between the exterior environment and the interior of the first flexible container and thereby provides a means for introducing fluids into the interior of the first flexible container and allowing waste effluent to exit the first container, a second flexible container, a second port for inserting tissue into the second container and expressing refined tissue out of the container, and a means for controlling the opening and closing of the first and second ports. The method comprises introducing a tissue sample into the system and subjecting it to a washing phase wherein the tissue is agitated, the waste effluent is allowed to exit the system through the first port, and the refined tissue is expressed out the second port for further refinement or transplantation.
摘要翻译：用于生产用于自体脂肪移植或研究的精制脂肪组织的装置和方法，其中保持无菌环境。更具体地，涉及一种用于精制组织的系统，包括第一柔性容器，具有多个孔的第二柔性容器，所述第二柔性容器提供用于在第一柔性容器的内部与第一包封柔性容器的内部之间的流体连通;第一端口，外部环境和第一柔性容器的内部之间的连通，从而提供用于将流体引入第一柔性容器的内部并允许废物流出物离开第一容器，第二柔性容器，用于插入组织的第二端口进入第二容器并从容器中表达精制的组织，以及用于控制第一和第二端口的打开和关闭的装置。该方法包括将组织样品引入系统并使其进行洗涤阶段，其中组织被搅动，允许废物流出物通过第一端口离开系统，并且精制组织被表达出第二端口用于进一步细化或移植。

2. 发明申请

US20150191698A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20150191698A1
公开(公告)日：2015-07-09
申请号：US14659308
申请日：2015-03-16
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明提供脂肪来源的干细胞和晶格。一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

3. 发明申请

US20100173411A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20100173411A1
公开(公告)日：2010-07-08
申请号：US12653940
申请日：2009-12-18
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/0775 , C12N5/10
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明提供脂肪来源的干细胞和晶格。一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

4. 发明申请

US20150376572A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20150376572A1
公开(公告)日：2015-12-31
申请号：US14581956
申请日：2014-12-23
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/077 , C12N9/12
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

5. 发明申请

US20130224858A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20130224858A1
公开(公告)日：2013-08-29
申请号：US13852463
申请日：2013-03-28
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/07
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

6. 发明申请

US20130217118A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20130217118A1
公开(公告)日：2013-08-22
申请号：US13712546
申请日：2012-12-12
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk
IPC分类号： C12N5/071
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

7. 发明申请

US20120208274A1 ADIPOSE-DERIVED STEM CELLS AND LATTICES 审中-公开
公开(公告)号：US20120208274A1
公开(公告)日：2012-08-16
申请号：US13408840
申请日：2012-02-29
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/0775
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

8. 发明申请

US20110318833A1 ADIPOSE-DERIVED STEM CELLS AND LATICCES 审中-公开
公开(公告)号：US20110318833A1
公开(公告)日：2011-12-29
申请号：US13226338
申请日：2011-09-06
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/06 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明提供脂肪来源的干细胞和晶格。一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

9. 发明申请

US20110027879A1 Adipose-derived stem cells and lattices 审中-公开
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US20110027879A1
公开(公告)日：2011-02-03
申请号：US12657722
申请日：2010-01-26
申请人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
发明人： Adam J. Katz , Ramon Llull , J. William Futrell , Marc H. Hedrick , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu , Patricia Zuk , Peter H. Ashjian
IPC分类号： C12N5/0775
CPC分类号： C12N5/0653 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N9/1276 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90 , C12Y207/07049
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

10. 发明授权

US07470537B2 Adipose-derived stem cells and lattices 有权
标题翻译：脂肪来源的干细胞和晶格
公开(公告)号：US07470537B2
公开(公告)日：2008-12-30
申请号：US10740315
申请日：2003-12-17
申请人： Marc H. Hedrick , Adam J. Katz , Ramón Llull , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
发明人： Marc H. Hedrick , Adam J. Katz , Ramón Llull , J. William Futrell , Prosper Benhaim , Hermann Peter Lorenz , Min Zhu
IPC分类号： C12N5/00
CPC分类号： C12N5/0667 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译：本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。另一方面，本发明提供了基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。

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