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1. 发明申请

US20130189276A1 METHOD INHIBITING CELL PROLIFERATION INDUCED BY ALTERNATIVELY SPLICED TISSUE FACTOR 有权
标题翻译：方法抑制由替代组织因子诱导的细胞增殖
公开(公告)号：US20130189276A1
公开(公告)日：2013-07-25
申请号：US13747405
申请日：2013-01-22
申请人： THE UNIVERSITY OF CINCINNATI
发明人： Vladimir Bogdanov , Henri Versteeg
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/02
CPC分类号： A61K39/39558 , A61K31/7088 , A61K38/02 , A61K2039/505 , C07K16/36 , C07K2317/76
摘要： Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration sufficient to attenuate asTF induced proliferation. In an embodiment, the proliferating cell is a cancer cell such as a breast cancer cell. The inhibitor of asTF may be an anti-asTF antibody, such as a monoclonal antibody or an antibody fragment, a small molecule, a peptide, nucleic acid, and combinations thereof.
摘要翻译：本发明的实施方案涉及抑制由asTF诱导的细胞增殖的方法，其包括将增殖细胞以足以减弱asTF诱导的增殖的浓度暴露于asTF抑制剂。在一个实施方案中，增殖细胞是癌细胞如乳腺癌细胞。 asTF的抑制剂可以是抗-TF抗体，例如单克隆抗体或抗体片段，小分子，肽，核酸及其组合。

2. 发明授权

US08202692B2 Expression profile of thyroid cancer 有权
标题翻译：甲状腺癌的表达谱
公开(公告)号：US08202692B2
公开(公告)日：2012-06-19
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供与甲状腺癌相关的基因表达谱。使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。此外，这些基因为癌症药物筛选和治疗应用提供了靶标。

3. 发明申请

US20120053125A1 PHOSPHATASE INHIBITOR PROTEIN-1 AS A REGULATOR OF CARDIAC FUNCTION 有权
标题翻译：磷酸酶抑制剂蛋白-1作为心脏功能的调节剂
公开(公告)号：US20120053125A1
公开(公告)日：2012-03-01
申请号：US13196450
申请日：2011-08-02
申请人： EVANGELIA KRANIAS , PATRICIA RODRIGUEZ , BRYAN MITTON
发明人： EVANGELIA KRANIAS , PATRICIA RODRIGUEZ , BRYAN MITTON
IPC分类号： A61K38/17 , A61K31/7088 , A61K31/711 , A61P9/00 , C07H21/04 , G01N33/566 , A61P9/04 , C07K14/47 , C07K16/18
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (I-1). In particular, the I-1 mutant forms comprise altered phosphorylation sites of PKC-α. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and heart failure, which employ the novel nucleic acids and polypeptides. Vectors comprising the novel nucleic acids, Antibodies to the novel proteins, and diagnostic and screening methods associated therewith, are also provided.
摘要翻译：本发明涉及编码新型突变型抑制蛋白-1（I-1）的新型核酸。特别地，I-1突变体形式包含PKC-α的改变的磷酸化位点。此外，本发明涉及调节心脏收缩力和功能以及使用新型核酸和多肽的治疗心脏肌病和心力衰竭的方法。还提供了包含新型核酸，新型蛋白质的抗体以及与其相关的诊断和筛选方法的载体。

4. 发明授权

US08118916B2 High capacity materials for capture of metal vapors from gas streams 有权
标题翻译：用于从气流捕获金属蒸气的高容量材料
公开(公告)号：US08118916B2
公开(公告)日：2012-02-21
申请号：US11550927
申请日：2006-10-19
申请人： Neville R. deGouvea-Pinto , Malyuba Abu-Daabes
发明人： Neville R. deGouvea-Pinto , Malyuba Abu-Daabes
IPC分类号： B01D53/14
CPC分类号： B01D53/64 , B01D53/82 , B01D2257/602 , B82Y30/00 , B82Y40/00
摘要： Metal ions are adsorbed or absorbed by a combination of a binding ligand and an ionic liquid effective to dissolve the metal complex. The ligand is preferably bound to a solid surface which is coated with the ionic liquid. This method is particularly suitable for adsorbing gaseous mercury, lead, zinc and cadmium.
摘要翻译：金属离子被结合配体和有效溶解金属络合物的离子液体的组合吸附或吸收。配体优选与被离子液体涂覆的固体表面结合。该方法特别适用于吸附气态汞，铅，锌，镉。

5. 发明授权

US08012374B2 Slow-release inhibitor for corrosion control of metals 有权
标题翻译：用于金属腐蚀控制的缓释抑制剂
公开(公告)号：US08012374B2
公开(公告)日：2011-09-06
申请号：US10981017
申请日：2004-11-04
申请人： William J. van Ooij , Hrishikesh Manian , Lin Yang , Hai Yang
发明人： William J. van Ooij , Hrishikesh Manian , Lin Yang , Hai Yang
IPC分类号： C23F11/00 , C23F11/18 , B32B5/00
CPC分类号： C23F11/149 , C09D5/002 , C09D5/082 , C23F11/08 , C23F11/185 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The present invention provides for a slow-release inhibitor that is applied to a metal surface, such as by way of a paint or primer coating, for corrosion control of the metal. An exemplary embodiment of the slow-release corrosion inhibitor includes a water-soluble particle, or pigment, and an organic polymeric film that encapsulates the particle. This water-soluble particle may be either organic or inorganic and, preferably, is non-carcinogenic and non-toxic. An additional water-soluble particle having an encapsulating, organic polymeric film further may be provided along with a water-soluble, organic compound to form the corrosion inhibitor. The polymeric film(s) are of a desired hydrophobicity and permeability to permit, upon interaction of the particle(s) with water, controlled diffusion of particle ions therethrough.
摘要翻译：本发明提供了一种缓释抑制剂，其被应用于金属表面，例如通过涂料或底漆涂层，用于金属的腐蚀控制。缓释缓蚀剂抑制剂的一个示例性实施方案包括水溶性颗粒或颜料，以及包封颗粒的有机聚合物膜。该水溶性颗粒可以是有机的或无机的，优选是非致癌的和无毒的。还可以与水溶性有机化合物一起提供另外具有包封的有机聚合物膜的水溶性颗粒以形成腐蚀抑制剂。聚合物膜具有所需的疏水性和渗透性，以便在颗粒与水相互作用时允许颗粒离子通过其控制扩散。

6. 发明申请

US20110183329A1 PROTEIN PHOSPHATASE-1 INHIBITOR-1 POLYMORPHISM AND METHODS OF USE 审中-公开
标题翻译：蛋白磷酸化酶-1抑制剂-1多态性及其使用方法
公开(公告)号：US20110183329A1
公开(公告)日：2011-07-28
申请号：US12911634
申请日：2010-10-25
申请人： Anand Pathak , Evangelia Kranias , Guoli Chen
发明人： Anand Pathak , Evangelia Kranias , Guoli Chen
IPC分类号： C12Q1/68 , C12N5/10 , C12N15/85 , C07K14/47 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N2800/325 , G01N2800/52
摘要： A method for diagnosing the presence of a G147D polymorphism of human phosphatase-1 inhibitor-1 protein is provided, wherein the method involves determining the presence of the polymorphism in a biological sample from a human subject by means which detect the presence of the polymorphism, wherein the presence of the polymorphism is indicative of a predisposition to impaired functioning of the β-adrenergic signaling pathway.
摘要翻译：提供了一种用于诊断人磷酸酶-1抑制剂-1蛋白的G147D多态性的存在的方法，其中所述方法包括通过检测多态性的存在的方式确定来自人受试者的生物样品中多态性的存在，其中所述多态性的存在指示所述β-肾上腺素能信号传导途径功能受损的倾向。

7. 发明授权

US07898740B2 Tunable optical array device comprising liquid cells 失效
标题翻译：包括液体电池的可调谐光学阵列装置
公开(公告)号：US07898740B2
公开(公告)日：2011-03-01
申请号：US12100032
申请日：2008-04-09
申请人： Jason Heikenfeld , Joachim Bradl
发明人： Jason Heikenfeld , Joachim Bradl
IPC分类号： G02B1/06 , G02B3/12
CPC分类号： G02B26/005 , G02B5/045 , G02B26/06 , G09G3/3433 , G09G3/3648 , G09G2300/0439 , G09G2300/0842 , G09G2320/028
摘要： A tunable optical component includes comprises a plurality of individual tunable liquid cells regularly arranged and integrated to at least one cell structure forming an array on the supporting substrate. A single liquid cell comprises several integrated cell walls, the cell walls projecting away from the supporting substrate and having a closed base area and an open cell surface at the cell wall edges. The liquid cell is filled with at least two liquids or fluids to provide at least one tunable interface area for varying the optical characteristic of the liquid cell.
摘要翻译：可调谐光学部件包括多个单独的可调谐液体单元，其规则地布置并集成到在支撑基板上形成阵列的至少一个单元结构。单个液体池包括几个集成的细胞壁，细胞壁远离支撑基底突出，并且在细胞壁边缘处具有封闭的基部区域和开放的细胞表面。液体池填充有至少两种液体或流体，以提供用于改变液体池的光学特性的至少一个可调谐界面区域。

8. 发明授权

US07361191B2 Heart wall actuation device for the natural heart 失效
标题翻译：心墙致动装置为天然心脏
公开(公告)号：US07361191B2
公开(公告)日：2008-04-22
申请号：US10618986
申请日：2003-07-14
申请人： David Boyd Melvin
发明人： David Boyd Melvin
IPC分类号： A61M1/10
CPC分类号： A61M1/122 , A61F2/02 , A61F2/2481 , A61M1/1008 , A61M1/1046 , A61M1/1055 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： An actuation system for assisting the operation of the natural heart comprises a framework for interfacing with a natural heart, through the wall of the heart, which includes an internal framework element configured to be positioned within the interior volume of a heart and an external framework element configured to be positioned proximate an exterior surface of the heart. The internal framework is flexibly suspended with respect to the external frame. An actuator system is coupled to the framework and configured to engage an exterior surface of the heart. The actuator system comprises an actuator band extending along a portion of a heart wall exterior surface. The actuator band is selectively movable between an actuated state and a relaxed state and is operable, when in the actuated state, to assume a predetermined shape and thereby indent a portion of the heart wall to effect a reduction in the volume of the heart. A drive apparatus is coupled to the actuator band and is operable for selectively moving the actuator band between the relaxed and actuated states to achieve the desired assistance of the natural heart.
摘要翻译：用于辅助自然心脏的操作的致动系统包括用于通过心脏壁与自然心脏接口的框架，其包括构造成定位在心脏的内部体积内的内部框架元件和外部框架元件被配置为定位在心脏的外表面附近。内部框架相对于外框灵活地悬挂。致动器系统联接到框架并且构造成接合心脏的外表面。致动器系统包括沿着心壁外表面的一部分延伸的致动器带。致动器带可以在致动状态和松弛状态之间选择性地移动，并且当处于致动状态时，可以使其呈现预定形状，从而缩小心脏壁的一部分以实现心脏体积的减小。驱动装置联接到致动器带，并且可操作用于在致动状态之间选择性地移动致动器带，以实现自然心脏的期望协助。

9. 发明申请

US20070221484A1 Liquid Logic Structures for Electronic Device Applications 有权
标题翻译：液体逻辑结构的电子设备应用
公开(公告)号：US20070221484A1
公开(公告)日：2007-09-27
申请号：US11569412
申请日：2005-05-20
申请人： Andrew Steckl , Jason Heikenfeld
发明人： Andrew Steckl , Jason Heikenfeld
IPC分类号： H01H29/06
CPC分类号： H01H59/0009 , H01H2029/008
摘要： Electronic devices (10, 30, 50) utilizing electrically-controlled liquid components to accomplish device switching. Electric fields are used in a device structure to manipulate the position and/or geometrical shape of a conductive fluid or liquid (60, 24) using electrowetting. This manipulation regulates the flow of current between electrodes of the device structure, such as the source and drain regions (16, 20) of a transistor construction, by bridging a non-conductive channel (15) separating the electrodes (16, 20) so that the electrodes (16, 20) are electrically coupled.
摘要翻译：电子设备（10,30,50）利用电控液体组件完成设备切换。电场用于器件结构中以使用电润湿来操纵导电流体或液体（60,24）的位置和/或几何形状。这种操作通过桥接分离电极（16,20）的非导电通道（15）来调节器件结构的电极之间的电流（例如晶体管结构的源极和漏极区域（16,20））的流动，从而电极（16,20）电耦合。

10. 发明申请

US20050232817A1 Functional on-chip pressure generator using solid chemical propellant 审中-公开
标题翻译：使用固体化学推进剂的功能片上压力发生器
公开(公告)号：US20050232817A1
公开(公告)日：2005-10-20
申请号：US10946818
申请日：2004-09-22
申请人： Chong Ahn , Chein-Chong Hong , Suresh Murugesan , Sanghyo Kim , Gregory Beaucage
发明人： Chong Ahn , Chein-Chong Hong , Suresh Murugesan , Sanghyo Kim , Gregory Beaucage
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2300/0816 , B01L2400/0442 , B01L2400/046
摘要： A functional on-chip pressure source using a solid propellant chemical material is disclosed which, upon heating to a critical temperature, liberates a precise amount of gas which, when liberated within an enclosed cavity coupled to a liquid in a microfluidic channel, raises the pressure and causes precise displacement of the liquid. The functional on-chip pressure source may be easily integrated with a disposable biochip, may be fabricated using low-cost, high volume manufacturing techniques, uses very low power, and may provide a dynamically variable output pressure across a broad spectrum of pressures. Embodiments of the present invention address significant challenges in the development of disposable microfluidic biochips including providing a reliable solution for pumping liquids in a microfluidic system and immediately applying the solution to a variety of microfluidic biochip applications.
摘要翻译：公开了使用固体推进剂化学材料的功能性片上压力源，其在加热至临界温度时释放精确量的气体，当在与微流体通道中的液体耦合的封闭空腔内释放时，气体升高压力并导致液体的精确位移。功能片上压力源可以容易地与一次性生物芯片集成，可以使用低成本，高容量制造技术制造，使用非常低的功率，并且可以在宽范围的压力下提供动态可变的输出压力。本发明的实施例解决了一次性微流体生物芯片开发中的重大挑战，包括提供用于在微流体系统中泵送液体的可靠解决方案，并立即将该解决方案应用于各种微流体生物芯片应用。

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