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1. 发明申请

US20090257111A1 Tunable Optical Array Device Comprising Liquid Cells 失效
标题翻译：包含液体电池的可调谐光学阵列器件
公开(公告)号：US20090257111A1
公开(公告)日：2009-10-15
申请号：US12100032
申请日：2008-04-09
申请人： Jason Heikenfeld , Joachim Bradl
发明人： Jason Heikenfeld , Joachim Bradl
IPC分类号： G02F1/29 , B05D5/00
CPC分类号： G02B26/005 , G02B5/045 , G02B26/06 , G09G3/3433 , G09G3/3648 , G09G2300/0439 , G09G2300/0842 , G09G2320/028
摘要： A tunable optical component includes comprises a plurality of individual tunable liquid cells regularly arranged and integrated to at least one cell structure forming an array on the supporting substrate. A single liquid cell comprises several integrated cell walls, the cell walls projecting away from the supporting substrate and having a closed base area and an open cell surface at the cell wall edges. The liquid cell is filled with at least two liquids or fluids to provide at least one tunable interface area for varying the optical characteristic of the liquid cell.
摘要翻译：可调谐光学部件包括多个单独的可调谐液体单元，其规则地布置并集成到在支撑基板上形成阵列的至少一个单元结构。单个液体池包括几个集成的细胞壁，细胞壁远离支撑基底突出，并且在细胞壁边缘处具有封闭的基部区域和开放的细胞表面。液体池填充有至少两种液体或流体，以提供用于改变液体池的光学特性的至少一个可调谐界面区域。

2. 发明授权

US07898740B2 Tunable optical array device comprising liquid cells 失效
标题翻译：包括液体电池的可调谐光学阵列装置
公开(公告)号：US07898740B2
公开(公告)日：2011-03-01
申请号：US12100032
申请日：2008-04-09
申请人： Jason Heikenfeld , Joachim Bradl
发明人： Jason Heikenfeld , Joachim Bradl
IPC分类号： G02B1/06 , G02B3/12
CPC分类号： G02B26/005 , G02B5/045 , G02B26/06 , G09G3/3433 , G09G3/3648 , G09G2300/0439 , G09G2300/0842 , G09G2320/028
摘要： A tunable optical component includes comprises a plurality of individual tunable liquid cells regularly arranged and integrated to at least one cell structure forming an array on the supporting substrate. A single liquid cell comprises several integrated cell walls, the cell walls projecting away from the supporting substrate and having a closed base area and an open cell surface at the cell wall edges. The liquid cell is filled with at least two liquids or fluids to provide at least one tunable interface area for varying the optical characteristic of the liquid cell.
摘要翻译：可调谐光学部件包括多个单独的可调谐液体单元，其规则地布置并集成到在支撑基板上形成阵列的至少一个单元结构。单个液体池包括几个集成的细胞壁，细胞壁远离支撑基底突出，并且在细胞壁边缘处具有封闭的基部区域和开放的细胞表面。液体池填充有至少两种液体或流体，以提供用于改变液体池的光学特性的至少一个可调谐界面区域。

3. 发明授权

US07002717B1 Apparatus for beam deflection 有权
标题翻译：光束偏转装置
公开(公告)号：US07002717B1
公开(公告)日：2006-02-21
申请号：US09681014
申请日：2000-11-20
申请人： Rafael Storz , Johann Engelhardt , Holger Birk , Joachim Bradl
发明人： Rafael Storz , Johann Engelhardt , Holger Birk , Joachim Bradl
IPC分类号： G02B26/08
CPC分类号： G02B21/0048
摘要： The invention concerns an apparatus for beam deflection, in particular for scanning microscopy, a light beam being deflectable by a mirror arrangement that is alternatingly rotatable by a rotary drive. The apparatus for beam deflection makes possible maximum variability in terms of frequency range and maximally achievable oscillation frequency, and is thus usable in flexible and versatile fashion. It moreover allows almost any desired angular offset from the zero point position to be established, and is characterized in that the rotary drive comprises two mutually independent drive units which rotate the mirror arrangement, together or mutually independently, about a rotation axis.
摘要翻译：本发明涉及一种用于光束偏转的装置，特别是用于扫描显微镜的光束，可通过由旋转驱动器交替旋转的反射镜装置偏转。用于光束偏转的装置在频率范围和最大可实现的振荡频率方面可能是最大的可变性，因此可以灵活和多用途的方式使用。此外，它允许几乎任何期望的从零点位置的角度偏移被建立，并且其特征在于，旋转驱动器包括两个相互独立的驱动单元，其将反射镜装置围绕旋转轴线一起或相互独立地旋转。

4. 发明授权

US06678089B1 Microscope 失效
标题翻译：显微镜
公开(公告)号：US06678089B1
公开(公告)日：2004-01-13
申请号：US09549026
申请日：2000-04-13
申请人： Johann Engelhardt , Joachim Bradl
发明人： Johann Engelhardt , Joachim Bradl
IPC分类号： G02B2100
CPC分类号： G02B21/0024
摘要： A microscope (1), preferably a confocal laser scanning microscope, having at least one light source, a detector, and two objectives (2), one of the objectives (2) being arranged on each of the two sides of the specimen plane (3) and the objectives (2) being directed toward one another and having a common focus; and at least one beam splitter (5) for distributing the illuminating light (6) to the objectives (2), and a beam recombiner (5) for combining the detected light (7) coming from the objectives (2), being provided in the illumination/detection beam path (4), is characterized, for selectable, subsequent implementation of ultrahigh-resolution microscope techniques, in that the objectives (2) and the beam splitter/beam recombiner (5) are grouped into a modular assembly (8); and the assembly (8) has an interface (9) for connection to the illumination/detection beam path (4) of the microscope (1).
摘要翻译：具有至少一个光源，检测器和两个物镜（2）的显微镜（1），优选共聚焦激光扫描显微镜，物镜（2）中的一个被布置在样品平面的两侧 3）和目标（2）相互指向并共同关注; 以及用于将照明光（6）分配到物镜（2）的至少一个分束器（5）和用于组合来自物镜（2）的检测光（7）的光束重组器（5），其设置在其特征在于，为了可选择地实现超高分辨率显微镜技术，其目的（2）和分束器/光束重组器（5）被分组成模块化组件（8））; 并且组件（8）具有用于连接到显微镜（1）的照明/检测光束路径（4）的接口（9）。

5. 发明授权

US06740868B1 Scanning microscope and a method of scanning a specimen 有权
标题翻译：扫描显微镜和扫描样品的方法
公开(公告)号：US06740868B1
公开(公告)日：2004-05-25
申请号：US09681019
申请日：2000-11-28
申请人： Werner Knebel , Joachim Bradl
发明人： Werner Knebel , Joachim Bradl
IPC分类号： H01J314
CPC分类号： G02B21/0076
摘要： A method and a scanning microscope for application of the method for optical-light scanning of a specimen; preferably in scanning microscopy, in particular in confocal laser scanning microscopy, the intensity of the light being regulated, is characterized, in order to optimize signal yield already during the actual data recording or measurement, in that regulation is accomplished as a function of the current focus position in the specimen region of the scanned, focused light beam.
摘要翻译：一种用于样本光学扫描方法的方法和扫描显微镜; 优选在扫描显微术中，特别是在共聚焦激光扫描显微术中，被调节的光的强度被表征，以便在实际的数据记录或测量期间优化信号的产量，该调节作为电流的函数来完成在被扫描的聚焦光束的样本区域中的对焦位置。

6. 发明授权

US07342717B1 Wave field microscope with detection point spread function 失效
标题翻译：波场显微镜具有检测点扩散功能
公开(公告)号：US07342717B1
公开(公告)日：2008-03-11
申请号：US09462435
申请日：1998-07-09
申请人： Michael Hausmann , Christoph Cremer , Joachim Bradl , Bernhard Schneider
发明人： Michael Hausmann , Christoph Cremer , Joachim Bradl , Bernhard Schneider
IPC分类号： G02B21/00
CPC分类号： G02B21/04 , C12Q1/6869 , G01N21/278 , G01N21/6458 , G01N2021/6441 , G02B21/06 , G02B21/16 , C12Q2565/601 , C12Q2563/107
摘要： The present invention relates to two new wave field microscopes, type I and type II, which are distinguished by the fact that they each have an illumination and excitation system, which include at least one real and one virtual illumination source, and at least one objective lens (in the case of type II), i.e., two objective lenses (in the case of type I), with the illumination sources and objective lenses being so positioned with respect to one another that they are suited for generating one-, two-, and three-dimensional standing wave fields in the object space. The calibration method in accordance with the present invention is adapted to this wave field microscopy and permits geometric distance measurements between fluorochrome-labeled object structures, whose distance can be less than the width at half maximum intensity of the effective point spread function. The invention relates moreover to a method of wave-field microscopic DNA sequencing.
摘要翻译：本发明涉及两种新型的I型和II型波场显微镜，其特征在于它们各自具有照明和激励系统，其包括至少一个实际和一个虚拟照明源，以及至少一个目标透镜（在II型的情况下），即两个物镜（在I型的情况下），其中照明源和物镜相对于彼此定位，使得它们适于产生一个，，以及对象空间中的三维驻波场。根据本发明的校准方法适用于这种波场显微镜，并且允许距离可以小于有效点扩散函数的半最大强度下的宽度的荧光染料标记物体结构之间的几何距离测量。本发明还涉及一种波场显微DNA测序方法。

7. 发明授权

US07031055B2 Microscope 失效
标题翻译：显微镜
公开(公告)号：US07031055B2
公开(公告)日：2006-04-18
申请号：US10717524
申请日：2003-11-21
申请人： Johann Engelhardt , Joachim Bradl
发明人： Johann Engelhardt , Joachim Bradl
IPC分类号： G02B21/06
CPC分类号： G02B21/0024
摘要： A microscope (1), preferably a confocal laser scanning microscope, having at least one light source, a detector, and two objectives (2), one of the objectives (2) being arranged on each of the two sides of the specimen plane (3) and the objectives (2) being directed toward one another and having a common focus; and at least one beam splitter (5) for distributing the illuminating light (6) to the objectives (2), and a beam recombiner (5) for combining the detected light (7) coming from the objectives (2), being provided in the illumination/detection beam path (4), is characterized, for selectable, subsequent implementation of ultrahigh-resolution microscope techniques, in that the objectives (2) and the beam splitter/beam recombiner (5) are grouped into a modular assembly (8); and the assembly (8) has an interface (9) for connection to the illumination/detection beam path (4) of the microscope (1).
摘要翻译：具有至少一个光源，检测器和两个物镜（2）的显微镜（1），优选共聚焦激光扫描显微镜，物镜（2）中的一个被布置在样品平面的两侧 3）和目标（2）相互指向并共同关注; 以及用于将照明光（6）分配到物镜（2）的至少一个分束器（5）和用于组合来自物镜（2）的检测光（7）的光束重组器（5），其设置在其特征在于，为了可选择地实现超高分辨率显微镜技术，其目的（2）和分束器/光束重组器（5）被分组成模块化组件（8））; 并且组件（8）具有用于连接到显微镜（1）的照明/检测光束路径（4）的接口（9）。

8. 发明授权

US06614525B1 Laser scanning microscope with single wavelength excitation 有权
标题翻译：激光扫描显微镜，单波长激发
公开(公告)号：US06614525B1
公开(公告)日：2003-09-02
申请号：US09718948
申请日：2000-11-20
申请人： Johann Engelhardt , Joachim Bradl
发明人： Johann Engelhardt , Joachim Bradl
IPC分类号： G01J330
CPC分类号： G02B21/0032 , G02B21/0064
摘要： A laser scanning microscope, preferably a confocal laser scanning microscope, having a laser light source for illuminating a specimen and a detector for detecting the light returning from the specimen, the specimen or parts thereof. The specimen is marked with markers that can be excited to emit. For the specific detection of preferably biological specimen structures, with high localization accuracy for the specimen structures, the laser light source emits exciting light substantially at one wavelength. Different markers emit light of different wavelengths, when irradiated with exciting light of substantially the same wavelength. The detector is embodied as a multi-band detector for the simultaneous detection of light at several wavelengths. A corresponding method for the detection of preferably biological specimens or specimen structures by laser scanning microscopy is described.
摘要翻译：激光扫描显微镜，优选共焦激光扫描显微镜，具有用于照射样本的激光光源和用于检测从样本返回的光的检测器，其样本或其部分。标本上标有可被激发发射的标记。对于优选生物样本结构的具体检测，对于样本结构具有高定位精度，激光光源基本上发射一个波长的激发光。当用基本上相同波长的激发光照射时，不同的标记发射不同波长的光。检测器被实现为用于同时检测几个波长的光的多波段检测器。描述了通过激光扫描显微镜检测优选生物样品或样本结构的相应方法。

9. 发明授权

US06654165B2 Optical arrangement 有权
标题翻译：光学布置
公开(公告)号：US06654165B2
公开(公告)日：2003-11-25
申请号：US10342750
申请日：2003-01-15
申请人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
发明人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
IPC分类号： G02B2106
CPC分类号： G02B21/0076 , G02B21/0024
摘要： An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally selective element (4) to inject the excitation light (3) of at least one light source (2) in the microscope and to extract the excitation light (3) scattered and reflected on the object (10) or the excitation wavelength from the light (13) coming from the object (10) through the detection beam path (12) is characterized for variable configurations with the simplest construction in that excitation light (3, 9) of different wavelengths can be extracted by the spectrally selective element (4). Alternatively, an optical arrangement like this is characterized in that the spectrally selective element (4) can be adjusted to the excitation wavelength to be extracted.
摘要翻译：适合于荧光激发的光源的光路中的光学装置，优选地在共聚焦激光扫描显微镜的光束路径中，具有至少一个光谱选择性元件（4）以将至少一个激发光（3）注入光源（2），并且通过检测光束路径（12）提取从物体（10）的光（13）散射和反射的激发光（3）或来自物体（10）的激发波长）的特征在于具有最简单结构的可变配置，其中不同波长的激发光（3,9）可以由光谱选择元件（4）提取。或者，这样的光学布置的特征在于，可以将光谱选择元件（4）调节到要提取的激发波长。

10. 发明授权

US06510001B1 Optical arrangement with a spectrally selective element 有权
标题翻译：具有光谱选择性元件的光学布置
公开(公告)号：US06510001B1
公开(公告)日：2003-01-21
申请号：US09622489
申请日：2000-08-17
申请人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
发明人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
IPC分类号： G02B2106
CPC分类号： G02B21/0076 , G02B21/0024
摘要： An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally selective element (4) to inject the excitation light (3) of at least one light source (2) in the microscope and to extract the excitation light (3) scattered and reflected on the object or the excitation wavelength from the light (13) coming from the object (10) through the detection beam path(12) is characterized for variable configuration with the simplest construction in that excitation light (3, 9) of different wavelengths can be extracted by the spectrally selective element (4). Alternatively, an optical arrangement like this is characterized in that the spectrally selective element (4) can be adjusted to the excitation wavelength to be extracted.
摘要翻译：适合于荧光激发的光源的光路中的光学装置，优选地在共聚焦激光扫描显微镜的光束路径中，具有至少一个光谱选择性元件（4）以将至少一个激发光（3）注入显微镜中的光源（2）和从物体（10）穿过检测光路（12）散射并反射在物体上或激发波长上的激发光（3）被提取出来对于具有最简单结构的可变配置，其中不同波长的激发光（3,9）可以由光谱选择元件（4）提取。或者，这样的光学布置的特征在于，可以将光谱选择元件（4）调节到要提取的激发波长。

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