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1. 发明授权

US09458488B2 Point of care sensor systems 有权
标题翻译：护理点传感器系统
公开(公告)号：US09458488B2
公开(公告)日：2016-10-04
申请号：US13844334
申请日：2013-03-15
申请人： Nanomix, Inc.
发明人： Bradley N. Johnson , Jui-Ming Yang , Kanchan A. Joshi , Ray R. Radtkey , Garrett Gruener , Sergei Skarupo
IPC分类号： G01N27/416 , C12Q1/00 , G01N33/543 , B01L3/00 , G01N33/49 , G01N35/10 , G01N27/27
CPC分类号： G01N33/5438 , B01L3/502715 , B01L3/502738 , B01L2200/04 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0883 , B01L2400/0487 , B01L2400/0633 , C12Q1/001 , G01N27/27 , G01N27/3272 , G01N27/3274 , G01N27/4163 , G01N33/492 , G01N35/1079 , G01N2035/1018 , G01N2035/1034
摘要： Provided are point of care sensor systems that include portable readers and disposable cartridges for receiving and analyzing samples. A cartridge may be equipped with one or more sensor channels, each containing one or more sensors. After providing a sample to a cartridge, the cartridge can be inserted into a reader, which can interact with the cartridge to perform on-cartridge sensing and receive signals indicating the presence and/or quantity of one or more targets in the sample. Examples of cartridges can include cardiac panels, sepsis panels and the like. In some embodiments, the same sensor hardware may be configured for multiple measurements of different targets conducted at different time frames. Also provided herein are novel on-cartridge solid and liquid reagent storage and delivery mechanisms.
摘要翻译：提供的护理传感器系统包括便携式读取器和用于接收和分析样品的一次性盒。墨盒可以配备有一个或多个传感器通道，每个传感器通道包含一个或多个传感器。在将样品提供到墨盒之后，墨盒可以插入到读取器中，读取器可以与墨盒相互作用以执行暗盒感测并接收指示样品中一个或多个目标的存在和/或数量的信号。药筒的实例可以包括心脏板，败血症面板等。在一些实施例中，相同的传感器硬件可以被配置用于在不同时间帧进行的不同目标的多个测量。本文还提供了新颖的固体和液体试剂储存和递送机制。

2. 发明申请

US20130075690A1 Ammonia Nanosensors, and Environmental Control System 审中-公开
标题翻译：氨氮传感器和环境控制系统
公开(公告)号：US20130075690A1
公开(公告)日：2013-03-28
申请号：US13442720
申请日：2012-04-09
申请人： Mikhail Briman , Craig Bryant , Ying-Lan Chang , Jean-Christophe P. Gabriel , Shripal C. Gandhi , Bradley N. Johnson , Willem-Jan Ouborg , John Loren Passmore , Kastooriranganathan Ramakrishnan , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Mikhail Briman , Craig Bryant , Ying-Lan Chang , Jean-Christophe P. Gabriel , Shripal C. Gandhi , Bradley N. Johnson , Willem-Jan Ouborg , John Loren Passmore , Kastooriranganathan Ramakrishnan , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： H01L29/06
CPC分类号： G01N33/0054 , B82Y15/00 , G01N27/127 , G01N27/129 , G01N27/4146 , G01N33/0062 , G01N2033/0068 , H01L29/0669 , Y10S977/957
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described.
摘要翻译：描述了纳米电子传感器的实施例，包括用于检测分析物这种氨的传感器。描述了采用纳米电子传感器的环境控制系统。描述了配置为使用纳米电子传感器的一次性标签的人员安全系统。描述了提供多个操作优点的传感器的动态采样和曝光的方法。

3. 发明申请

US20110154648A1 ELECTRONIC SENSING OF BIOLOGICAL AND CHEMICAL AGENTS USING FUNCTIONALIZED NANOSTRUCTURES 审中-公开
标题翻译：使用功能化纳米结构的生物和化学试剂的电子感测
公开(公告)号：US20110154648A1
公开(公告)日：2011-06-30
申请号：US13047593
申请日：2011-03-14
申请人： Jean Christophe Gabriel , George Gruner , Philip Collins , Basil Swanson , Fred Wudl
发明人： Jean Christophe Gabriel , George Gruner , Philip Collins , Basil Swanson , Fred Wudl
IPC分类号： H05K13/00 , B82Y99/00
CPC分类号： B82Y30/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582 , Y10T29/49002
摘要： This invention provides for an apparatus and a method for detecting the presence of pathogenic agents with sensors containing functionalized nanostructures integrated into circuits on silicon chips. The nanostructures are functionalized with molecular transducers that recognize and bind targeted analytes which are diagnostic of the pathogenic agent of interest. The molecular transducer includes a receptor portion, which binds the analyte, and an anchor portion that attaches to the nanostructure. Upon binding of the analyte, a change in molecular configuration represented by the newly formed receptor-analyte complex creates a force that is transmitted to the nanostructure via the anchor portion of the transducer. The effect of the force transmitted to the nanostructure is to alter its conductivity. The change in conductivity of the nanotube thus represents a signal that indicates the presence of the pathogenic agent of interest.
摘要翻译：本发明提供了一种用于检测病原体的存在的装置和方法，所述传感器包含集成在硅芯片上的电路中的功能化纳米结构。纳米结构用识别和结合目标分析物的分子换能器进行功能化，这些目标分析物是目标病原体的诊断。分子换能器包括结合分析物的受体部分和附着到纳米结构的锚定部分。在分析物结合后，由新形成的受体 - 分析物复合物表示的分子构型的变化产生通过换能器的锚定部分传递到纳米结构的力。传递到纳米结构的力的作用是改变其导电性。因此，纳米管的电导率的变化表示表示感兴趣的病原体的存在的信号。

4. 发明授权

US07956525B2 Flexible nanostructure electronic devices 有权
标题翻译：柔性纳米结构电子器件
公开(公告)号：US07956525B2
公开(公告)日：2011-06-07
申请号：US10846072
申请日：2004-05-14
申请人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Grüner
发明人： N. Peter Armitage , Keith Bradley , Jean-Christophe P. Gabriel , George Grüner
IPC分类号： H01J1/02
CPC分类号： H01B1/24 , B82Y10/00 , B82Y15/00 , H01L51/0048 , H01L51/0097 , H01L51/0595
摘要： A flexible electronic device is made up of nanostructures. Specifically, the device includes a flexible substrate, a film of nanostructures in contact with the flexible substrate, a first conducting element in contact with the film of nanostructures, and a second conducting element in contact with the film of nanostructures. The nanostructures may comprise nanotubes, such as carbon nanotubes disposed along the flexible substrate, such as an organic or polymer substrate. The first and second conductive elements may serve as electrical terminals, or as a source and drain. In addition, the electronic device may include a gate electrode that is in proximity to the nanotubes and not in electrical contact with the nanotubes. In this configuration, the device can operate as a transistor or a FET. The device may also be operated in a resistive mode as a chemical sensor (e.g., for sensing NH3).
摘要翻译：灵活的电子设备由纳米结构组成。具体地，该装置包括柔性基板，与柔性基板接触的纳米结构薄膜，与纳米结构薄膜接触的第一导电元件和与纳米结构薄膜接触的第二导电元件。纳米结构可以包括纳米管，例如沿着柔性基底设置的碳纳米管，例如有机或聚合物基底。第一和第二导电元件可以用作电端子，或用作源极和漏极。此外，电子器件可以包括位于纳米管附近并且不与纳米管电接触的栅电极。在这种配置中，器件可以作为晶体管或FET工作。该装置还可以作为化学传感器（例如，用于感测NH 3）以电阻模式操作。

5. 发明申请

US20100268106A1 BREATH CONDENSATE SAMPLER AND DETECTOR AND BREATH/BREATH CONDENSATE SAMPLER AND DETECTOR 有权
标题翻译：呼吸冷凝器和探测器和呼吸器/呼吸器冷凝器和检测器
公开(公告)号：US20100268106A1
公开(公告)日：2010-10-21
申请号：US12761290
申请日：2010-04-15
申请人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
发明人： Bradley N. Johnson , Kanchan Joshi , Ying-Lan Chang , Ray Radtkey
IPC分类号： A61B5/097
CPC分类号： A61B5/097 , A61B5/0803 , A61B5/082 , A61B5/14539 , B82Y30/00 , G01N33/497 , G01N2001/2282
摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
摘要翻译：本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。呼吸冷凝液中的分析物在到达传感器表面之前凝结，或者直接凝结在传感器表面上瞬间被检测到。因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。呼吸被收集并引导到一个或多个子系统。在每个子系统内，呼吸部分被冷凝或防止冷凝。该技术还允许实时连续监测，从而允许立即反馈医疗专业人员和附加硬件，如呼吸机，麻醉机，药物输注系统和心脏起搏器。

6. 发明申请

US20100231242A1 ELECTRONIC SENSING OF BIOLOGICAL AND CHEMICAL AGENTS USING FUNCTIONALIZED NANOSTRUCTURES 审中-公开
标题翻译：使用功能化纳米结构的生物和化学试剂的电子感测
公开(公告)号：US20100231242A1
公开(公告)日：2010-09-16
申请号：US12634525
申请日：2009-12-09
申请人： Jean Christophe Gabriel , George Gruner , Philip Collins , Basil Swanson , Fred Wudl
发明人： Jean Christophe Gabriel , George Gruner , Philip Collins , Basil Swanson , Fred Wudl
IPC分类号： G01R27/08
CPC分类号： B82Y30/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582 , Y10T29/49002
摘要： This invention provides for an apparatus and a method for detecting the presence of pathogenic agents with sensors containing functionalized nanostructures integrated into circuits on silicon chips. The nanostructures are functionalized with molecular transducers that recognize and bind targeted analytes which are diagnostic of the pathogenic agent of interest. The molecular transducer includes a receptor portion, which binds the analyte, and an anchor portion that attaches to the nanostructure. Upon binding of the analyte, a change in molecular configuration represented by the newly formed receptor-analyte complex creates a force that is transmitted to the nanostructure via the anchor portion of the transducer. The effect of the force transmitted to the nanostructure is to alter its conductivity. The change in conductivity of the nanotube thus represents a signal that indicates the presence of the pathogenic agent of interest.
摘要翻译：本发明提供了一种用于检测病原体的存在的装置和方法，所述传感器包含集成在硅芯片上的电路中的功能化纳米结构。纳米结构用识别和结合目标分析物的分子换能器进行功能化，这些目标分析物是目标病原体的诊断。分子换能器包括结合分析物的受体部分和附着到纳米结构的锚定部分。在分析物结合后，由新形成的受体 - 分析物复合物表示的分子构型的变化产生通过换能器的锚定部分传递到纳米结构的力。传递到纳米结构的力的作用是改变其导电性。因此，纳米管的电导率的变化表示表示感兴趣的病原体的存在的信号。

7. 发明申请

US20100085067A1 ANESTHESIA MONITOR, CAPACITANCE NANOSENSORS AND DYNAMIC SENSOR SAMPLING METHOD 审中-公开
标题翻译：麻醉监护仪，电容式纳米传感器和动态传感器采样方法
公开(公告)号：US20100085067A1
公开(公告)日：2010-04-08
申请号：US12560316
申请日：2009-09-15
申请人： Jean-Christophe P. Gabriel , Vikram Joshi , John Loren Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
发明人： Jean-Christophe P. Gabriel , Vikram Joshi , John Loren Passmore , Sergei Skarupo , Alexander Star , Christian Valcke
IPC分类号： G01N33/497 , G01N27/22 , A61B5/08 , A61B5/05
CPC分类号： A61B5/0833 , A61B5/097 , A61B5/4821 , A61B5/6819 , A61B2562/0285 , B82Y30/00
摘要： Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such as anesthesia gases, CO2 and the like in human breath. An integrated monitor system and disposable sensor unit is described which permits a number of different anesthetic agents to be identified and monitored, as well as concurrent monitoring of other breath species, such as CO2. The sensor unit may be configured to be compact, light weight, and inexpensive. Wireless embodiments provide such enhancements as remote monitoring. A simulator system for modeling the contents and conditions of human inhalation and exhalation with a selected mixture of a treatment agent is also described, particularly suited to the testing of sensors to be used in airway sampling.
摘要翻译：描述了纳米电子传感器的实施例，包括用于在人呼吸中检测分析物例如麻醉气体，CO 2等的传感器。描述了一种集成监视器系统和一次性传感器单元，其允许识别和监视多个不同的麻醉剂，以及对其它呼吸物质（例如CO 2）的并发监测。传感器单元可以被配置为紧凑，重量轻并且便宜。无线实施例提供诸如远程监视的增强。还描述了一种用于用选定的处理剂混合物对人吸入和呼出的内容物和条件进行建模的模拟器系统，特别适合于用于气道取样的传感器的测试。

8. 发明申请

US20090084678A1 NANOELECTRONIC ELECTROCHEMICAL TEST DEVICE 有权
标题翻译：纳米电子电化学测试装置
公开(公告)号：US20090084678A1
公开(公告)日：2009-04-02
申请号：US12146320
申请日：2008-06-25
申请人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
发明人： Kanchan A. Joshi , Ray Radtkey , Christian Valcke
IPC分类号： G01N27/416 , C12N11/14 , B82B1/00
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14535 , A61B5/1486 , A61B5/14865 , B82Y10/00 , B82Y15/00 , C12Q1/006 , G01N27/4145 , G01N27/4146 , H01L51/0049 , H01L51/0093 , H01L51/0545 , Y10S977/723
摘要： Nanoelectronic devices for the detection and quantification of biomolecules are Provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
摘要翻译：提供用于检测和定量生物分子的纳米电子器件。在某些实施例中，装置被配置为检测和测量血糖水平。还提供了制造用于检测生物分子的纳米电子器件的方法。

9. 发明申请

US20070178477A1 Nanotube sensor devices for DNA detection 审中-公开
标题翻译：用于DNA检测的纳米管传感器装置
公开(公告)号：US20070178477A1
公开(公告)日：2007-08-02
申请号：US11212026
申请日：2005-08-24
申请人： Charles Joiner , Jean-Christophe Gabriel , George Gruner , Alexander Star
发明人： Charles Joiner , Jean-Christophe Gabriel , George Gruner , Alexander Star
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6825 , G01N27/4145 , G01N27/4146 , C12Q2565/631 , C12Q2565/107
摘要： A nanotube device is configured as an electronic sensor for a target DNA sequence. A film of nanotubes is deposited over electrodes on a substrate. A solution of single-strand DNA is prepared so as to be complementary to a target DNA sequence. The DNA solution is deposited over the electrodes, dried, and removed from the substrate except in a region between the electrodes. The resulting structure includes strands of the desired DNA sequence in direct contact with nanotubes between opposing electrodes, to form a sensor that is electrically responsive to the presence of target DNA strands. Alternative assay embodiments are described which employ linker groups to attach ssDNA probes to the nanotube sensor device.
摘要翻译：纳米管装置配置为目标DNA序列的电子传感器。将纳米管膜沉积在基板上的电极上。制备单链DNA的溶液以与靶DNA序列互补。将DNA溶液沉积在电极上，干燥，除去电极之外的区域。所得结构包括与相对电极之间的纳米管直接接触的所需DNA序列的链，以形成对目标DNA链的存在电响应的传感器。描述了使用连接体将ssDNA探针连接到纳米管传感器装置的替代试验实施方案。

10. 发明申请

US20040040316A1 Operation of a hydrogen storage and supply system 失效
标题翻译：氢气储存和供应系统的运行
公开(公告)号：US20040040316A1
公开(公告)日：2004-03-04
申请号：US10302154
申请日：2002-11-22
申请人： Nanomix, Inc.
发明人： Keith Bradley , Jeff Wyatt
IPC分类号： F17C011/00 , F17C009/02
CPC分类号： F17C11/005 , Y02E60/321 , Y02P90/45
摘要： This invention provides for an apparatus and a method for operation of a cryogenic hydrogen storage system that contains a porous medium configured to adsorb hydrogen. The hydrogen storage and supply system includes a hydrogen source apparatus, a cryosorptive storage apparatus, and a fuel recycle loop. Methods and devices that allow for an energy efficient release of hydrogen from the cryosorptive apparatus are described. At the outset of a fuel release, the cryosorptive hydrogen storage apparatus contains cold, pressurized hydrogen. Release of hydrogen from the storage apparatus is a process that consumes heat, thereby drawing down both the temperature and pressure. Heat can be provided to the cryosorptive storage apparatus by various direct approaches, or through the influx of warm, recycled hydrogen. The hydrogen storage and release apparatus contains a recycle loop, which warms a portion of the effluxing hydrogen, and returns it to the storage apparatus, thereby maintaining pressure and temperature conditions that support continued hydrogen desorption from the storage medium.
摘要翻译：本发明提供了一种用于操作低温氢存储系统的装置和方法，所述低温储氢系统包含构造成吸附氢气的多孔介质。氢存储和供给系统包括氢源装置，冷冻存储装置和燃料循环回路。描述了允许从冷冻吸收装置中高效释放氢的方法和装置。在燃料释放开始时，低温吸氢储氢装置含有冷的加压氢气。从储存装置释放氢气是消耗热量，从而降低温度和压力的过程。可以通过各种直接方法或通过热的循环氢气的流入将热量提供给冷冻存储设备。氢储存和释放装置包含一个循环回路，其加热一部分流出的氢气，并将其返回到存储装置，从而保持支持从存储介质继续氢解吸的压力和温度条件。

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