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1. 发明授权

US08207363B2 Thraustochytrids, fatty acid compositions, and methods of making and uses thereof 有权
标题翻译： Thraustochytrids，脂肪酸组合物及其制备方法和用途
公开(公告)号：US08207363B2
公开(公告)日：2012-06-26
申请号：US12407687
申请日：2009-03-19
申请人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
发明人： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC分类号： A23D9/00 , C11B1/00 , C12P7/64 , A61K31/202
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译：本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。

2. 发明授权

US08187845B2 Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors 有权
公开(公告)号：US08187845B2
公开(公告)日：2012-05-29
申请号：US11745531
申请日：2007-05-08
申请人： Richard B. Bailey , Don DiMasi , John M. Hansen , Peter J. Mirrasoul , Craig M. Ruecker , George T. Veeder, III , Tatsuo Kaneko , William R. Barclay
发明人： Richard B. Bailey , Don DiMasi , John M. Hansen , Peter J. Mirrasoul , Craig M. Ruecker , George T. Veeder, III , Tatsuo Kaneko , William R. Barclay
IPC分类号： C12P7/64 , C12N1/14
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.

3. 发明授权

US08133706B2 Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors 有权
标题翻译：通过发酵罐中真核微生物的非常高密度培养物增强含有多烯酸脂肪酸的脂质的产生
公开(公告)号：US08133706B2
公开(公告)日：2012-03-13
申请号：US11745526
申请日：2007-05-08
申请人： Richard B. Bailey , Don DiMasi , John M. Hansen , Peter J. Mirrasoul , Craig M. Ruecker , George T. Veeder, III , Tatsuo Kaneko , William R. Barclay
发明人： Richard B. Bailey , Don DiMasi , John M. Hansen , Peter J. Mirrasoul , Craig M. Ruecker , George T. Veeder, III , Tatsuo Kaneko , William R. Barclay
IPC分类号： C12P7/64 , C12N1/14
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
摘要翻译：本发明提供了一种生长真核微生物的方法，其能够产生脂质，特别是含有多烯脂肪酸的脂质。本发明还提供了一种生产真核微生物脂质的方法。

4. 发明申请

US20120021470A1 Chimeric PUFA Polyketide Synthase Systems and Uses Thereof 有权
标题翻译：嵌合PUFA聚酮合成酶系统及其用途
公开(公告)号：US20120021470A1
公开(公告)日：2012-01-26
申请号：US13170011
申请日：2011-06-27
申请人： Craig A. WEAVER , Ross Zirkle , Daniel H. Doherty , James G. Metz
发明人： Craig A. WEAVER , Ross Zirkle , Daniel H. Doherty , James G. Metz
IPC分类号： C12P7/64 , C12N1/21 , C12N1/15 , C12N1/11 , C12N1/00 , C12N1/19 , A01H5/00 , C12N1/13
CPC分类号： C12P7/6427 , C12N9/93 , C12N15/52 , C12N15/8247 , C12N15/8273 , C12P7/62 , C12P7/625 , C12P7/6472
摘要： Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
摘要翻译：公开了嵌合多不饱和脂肪酸（PUFA）聚酮化合物合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。

5. 发明授权

US08012354B2 Extraction and winterization of lipids from oilseed and microbial sources 有权
标题翻译：从油籽和微生物来源提取和冬化脂质
公开(公告)号：US08012354B2
公开(公告)日：2011-09-06
申请号：US12757383
申请日：2010-04-09
申请人： Daniel G. Dueppen , Samuel G. Zeller , Sandra I. Diltz , Robert H. Driver
发明人： Daniel G. Dueppen , Samuel G. Zeller , Sandra I. Diltz , Robert H. Driver
IPC分类号： B01D11/00 , C11B1/10
CPC分类号： C11B1/00 , A23V2002/00 , C11B1/10 , C11B3/006 , C11B7/0025 , A23V2250/1942
摘要： A process for purifying a lipid composition having predominantly neutral lipid components having at least one long chain polyunsaturated fatty acid is disclosed. The process employs contacting the lipid composition with a polar solvent, such as acetone, wherein the solvent is selected such that contaminants are less soluble in the solvent than is the long chain polyunsaturated fatty acid. The process is typically conducted at cooler temperatures, including about 0° C. Upon precipitation of the contaminants from the lipid composition, a separation is conducted to remove the precipitated material from the lipid composition. The long chain polyunsaturated fatty acids can include ARA, DPA, EPA, and/or DHA. The process of the present invention effectively winterizes lipid compositions, thereby reducing the tendency of such compositions to become hazy.
摘要翻译：公开了一种纯化具有主要具有至少一种长链多不饱和脂肪酸的中性脂质组分的脂质组合物的方法。该方法使脂质组合物与极性溶剂如丙酮接触，其中选择溶剂使污染物比溶于长链多不饱和脂肪酸的溶解性较少。该方法通常在较冷的温度（包括约0℃）下进行。当从脂质组合物沉淀污染物时，进行分离以从脂质组合物中除去沉淀的物质。长链多不饱和脂肪酸可以包括ARA，DPA，EPA和/或DHA。本发明的方法有效地使脂质组合物变凉，从而降低这些组合物变得模糊的倾向。

6. 发明授权

US08008061B2 Trophic conversion of obligate phototrophic algae through metabolic engineering 失效
标题翻译：通过代谢工程营养转化专性光营养藻类
公开(公告)号：US08008061B2
公开(公告)日：2011-08-30
申请号：US11842898
申请日：2007-08-21
申请人： Kirk Emil Apt , F. C. Thomas Allnutt , David J. Kyle , James Casy Lippmeier
发明人： Kirk Emil Apt , F. C. Thomas Allnutt , David J. Kyle , James Casy Lippmeier
IPC分类号： C12N1/12
CPC分类号： C12N15/8209 , C12N1/12 , C12N15/65 , C12N15/79 , C12N15/8207 , Y10S435/946
摘要： Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization. Finally, this work also represents critical progress toward large-scale commercial exploitation of obligate phototrophic algae through the use of microbial fermentation technology, eliminating significant limitations resulting from light-dependent growth.
摘要翻译：大多数微藻是专性光自养体，其生长严格依赖于光合作用衍生能量的产生。在这项研究中，显示微藻Phaeodaclylurn三角褐豆可以通过引入编码葡萄糖转运蛋白的基因进行工程化以导入葡萄糖并在黑暗中生长。人和小球藻凯斯勒葡萄糖转运蛋白都促进了三角褐指藻的葡萄糖摄取，使得细胞代谢外源有机碳，并且独立于光。这是通过代谢工程首次成功地营养专一性自养型营养转化，并且表明通过引入单一基因可以从根本上改变细胞营养的方法。由于用葡萄糖转运基因转化的菌株能够非光合作用生长，因此可以通过突变体的产生和表征来开发光合作用的分析。最后，这项工作也是通过使用微生物发酵技术大规模商业开发专利性光营养藻类的重要进展，消除了光依赖性生长造成的重大限制。

7. 发明申请

US20110200644A1 DHA Ester Emulsions 审中-公开
标题翻译： DHA酯乳剂
公开(公告)号：US20110200644A1
公开(公告)日：2011-08-18
申请号：US13031172
申请日：2011-02-18
申请人： Jung LEE , Bernard A. MIKRUT , Xuejun TANG
发明人： Jung LEE , Bernard A. MIKRUT , Xuejun TANG
IPC分类号： A61K9/107 , A61K31/232 , A61P19/02 , A61P1/16
CPC分类号： A61K31/232 , A61K9/0019 , A61K9/107
摘要： The present invention is directed to an emulsion comprising an emulsifier, an isotonic agent and a docosahexaenoic acid ethyl ester (DHA-EE) wherein the emulsion is substantially free of eicosapentaenoic acid (EPA) and is suitable for parenteral administration.
摘要翻译：本发明涉及包含乳化剂，等渗剂和二十二碳六烯酸乙酯（DHA-EE）的乳液，其中所述乳液基本上不含二十碳五烯酸（EPA），并且适用于肠胃外给药。

8. 发明申请

US20110195449A1 Recombinant Thraustochytrids that Grow on Sucrose, and Compositions, Methods of Making, and Uses Thereof 审中-公开
标题翻译：在蔗糖上生长的重组Thraustochytrids及其组合物，制备方法及其用途
公开(公告)号：US20110195449A1
公开(公告)日：2011-08-11
申请号：US12980322
申请日：2010-12-28
申请人： James Casey Lippmeier , Kirk Emil Apt , Jon Milton Hansen
发明人： James Casey Lippmeier , Kirk Emil Apt , Jon Milton Hansen
IPC分类号： C12P1/00 , C12N15/63 , C12N1/13
CPC分类号： C12N15/79 , A23K20/10 , A23K50/80 , A23L2/52 , A23L33/10 , A23V2002/00 , C12N1/10 , C12N1/12 , C12N9/2405 , C12P7/6463 , C12P7/649 , C12Y302/01026 , C12Y302/01048 , Y02E50/13
摘要： The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.
摘要翻译：本发明涉及在蔗糖上生长的重组thraustochytrid和包含重组thraustochytrids的细胞培养物，以及使用重组thraustochytrids生产细胞培养物，生物质，微生物油，组合物和生物燃料的方法。

9. 发明申请

US20110167508A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 审中-公开
标题翻译：多不饱和脂多糖合成酶系统及其用途
公开(公告)号：US20110167508A1
公开(公告)日：2011-07-07
申请号：US12904738
申请日：2010-10-14
申请人： JAMES G. METZ , CRAIG A. WEAVER , WILLIAM R. BARCLAY , JAMES H. FLATT
发明人： JAMES G. METZ , CRAIG A. WEAVER , WILLIAM R. BARCLAY , JAMES H. FLATT
IPC分类号： A01K67/027 , C07H21/00 , C12N15/63 , C12N1/00 , A01H5/00 , C12P1/00 , A01H1/06 , C12P7/64 , C12N9/96
CPC分类号： C12N15/52 , A23D7/001 , A23L33/115 , A23L33/135 , C07K14/28 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明一般涉及多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物分离到分离的核酸分子和编码这种PUFA PKS系统的生物活性结构域的重组核酸分子，所述基因修饰的生物体包含PUFA PKS 系统，制备和使用这些系统用于生产感兴趣的生物活性分子的方法，以及用于鉴定具有这种PUFA PKS系统的新的细菌和非细菌微生物的新方法。

10. 发明授权

US07960524B2 PUFA polyketide synthase systems and uses thereof 有权
标题翻译： PUFA聚酮化合物系统及其用途
公开(公告)号：US07960524B2
公开(公告)日：2011-06-14
申请号：US11689596
申请日：2007-03-22
申请人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
发明人： James G. Metz , James H. Flatt , Jerry M. Kuner , William R. Barclay
IPC分类号： C07H21/02 , C12N1/12 , C12N15/87 , C12P7/64 , A01H9/00
CPC分类号： C12N15/52 , C07K14/28 , C07K14/405 , C12N15/8247 , C12N15/8273 , C12P7/625 , C12P7/6427 , C12P7/6472
摘要： The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
摘要翻译：本发明通常涉及从分离自非细菌生物体或衍生自非细菌生物体的多不饱和脂肪酸（PUFA）聚酮化合物合酶（PKS）系统，其同源物，分离的核酸分子和编码这种PUFA PKS的生物活性结构域的重组核酸分子系统，涉及包含PUFA PKS系统的转基因生物，制备和使用此类体系用于生产感兴趣的生物活性分子的方法，以及鉴定具有这种PUFA PKS系统的新细菌和非细菌微生物的新方法。

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