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1. 发明授权

US6096027A Bag enclosed stent loading apparatus 有权
标题翻译：袋式封闭式支架装载装置
公开(公告)号：US6096027A
公开(公告)日：2000-08-01
申请号：US310763
申请日：1999-05-12
申请人： Richard Layne
发明人： Richard Layne
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61B17/00
CPC分类号： A61F2/958 , A61F2/95 , A61F2002/9522
摘要： An apparatus for loading a stent onto or into a catheter. A flexible sterile sleeve is provided to encase the stent as it is pulled through a loading device. The loading device is a simple design utilizing a tapered passageway. The passageway has first diameter at a proximal end which tapers to a second diameter, forming a funnel. The passageway continues at the second diameter forming a tube. The sleeved stent is pulled through the loading device from the proximal end to the distal end, smoothly compressing the stent. Depending on the type of stent and catheter being used, the stent is either crimped onto the catheter as it is pulled through the funnel, or is loaded into a catheter positioned at the distal end of the loading device. The sleeve acts to minimize the frictional forces to which the stent is subjected and to eliminate the longitudinal force that the stent would be subjected to if pushed or pulled directly. The sleeve may be close-ended to provide an additional sterility barrier about the stent.
摘要翻译：用于将支架装载到导管上或其中的装置。提供柔性无菌套筒以在支架被拉动穿过装载装置时包围支架。装载装置是采用锥形通道的简单设计。该通道在近端处具有逐渐变细至第二直径的第一直径，形成漏斗。通道在第二直径处继续形成管。套管支架从近端拉到远端，平滑地压缩支架。根据使用的支架和导管的类型，支架在被拉动通过漏斗时被卷曲到导管上，或者被装载到位于装载装置远端的导管中。套筒用于使支架受到的摩擦力最小化，并且如果直接推动或拉动，则消除支架将受到的纵向力。套筒可以是近端的，以在支架周围提供额外的无菌屏障。

2. 发明授权

US6053943A Endoluminal graft with integral structural support and method for making same 失效
标题翻译：具有整体结构支持的腔内移植物及其制备方法
公开(公告)号：US6053943A
公开(公告)日：2000-04-25
申请号：US77533
申请日：1998-05-28
申请人： Tarun J. Edwin , Christopher E. Banas
发明人： Tarun J. Edwin , Christopher E. Banas
IPC分类号： A61F2/00 , A61F2/06 , B29C47/00 , B29C53/14 , B29C53/58 , B29C55/22 , A61F2/04
CPC分类号： A61F2/07 , B29C47/0019 , B29C47/0023 , B29C47/003 , B29C47/0033 , B29C55/22 , A61F2/0077 , A61F2/848 , A61F2/88 , A61F2002/072 , A61F2002/8483 , A61F2220/0016 , B29C47/00 , B29C53/14 , B29C53/58 , B29L2031/753
摘要： A structurally supported graft (10) having a support structure (26) with strain relief sections (30) contained with an internal surface, an external surface, or a wall thickness of a tubular graft member (12). The structurally supported graft (10) may include a beading element (24) which is co-extruded with the support structure (26) having strain relief sections (30) and spiraled about the tubular graft (10). The support structure (26) includes differing types of strain relief sections (30) which are capable of allowing for the longitudinal and radial expansion of the structurally supported graft (10), respectively. The strain relief sections (30) may also include unconnected ends which form outwardly protruding barbs (62) upon expansion of the structurally supported graft within a blood vessel or body lumen. The method for making the structurally supported graft includes selecting or preparing a support structure with strain relief sections, co-extruding the structural support with a beading element, forming a spiral about the tubular graft with the co-extruded structure, and securing the co-extruded structure to the tubular graft.
摘要翻译： PCT No.PCT / US95 / 16497 Sec。 371日期：1998年5月28日 102（e）日期1998年5月28日PCT提交1995年12月8日PCT公布。公开号WO97 / 21401 日期：1997年6月19日具有支撑结构（26）的结构支撑的移植物（10）具有应变消除部分（30），其包含管状移植部件（12）的内表面，外表面或壁厚。结构支撑的移植物（10）可以包括与具有应变消除部分（30）并且围绕管状移植物（10）螺旋化的支撑结构（26）共挤出的卷边元件（24）。支撑结构（26）包括不同类型的应变消除部分（30），其能够分别允许结构支撑的移植物（10）的纵向和径向膨胀。应变消除部分（30）还可以包括在结构上支撑的移植物在血管或体腔内膨胀时形成向外突出的倒钩（62）的未连接的端部。用于制造结构支撑的移植物的方法包括选择或制备具有应变消除部分的支撑结构，将结构支撑件用滚珠元件共挤出，用共挤出结构在管状移植物周围形成螺旋，挤压结构到管状移植物。

3. 发明授权

US5512229A Process of uniformly expanding polymer film 失效
标题翻译：聚合物膜均匀膨胀的工艺
公开(公告)号：US5512229A
公开(公告)日：1996-04-30
申请号：US248606
申请日：1994-05-25
申请人： Charles F. Bosse , Rajagopal R. Kowligi
发明人： Charles F. Bosse , Rajagopal R. Kowligi
IPC分类号： B29C55/10 , B29C55/00 , B29C55/20
CPC分类号： B29C55/10 , B29K2027/18 , Y10S425/053 , Y10S428/91
摘要： An apparatus and process for expanding polymer films such as PTFE films includes gripping the unexpanded film about its periphery with a number of symmetrically disposed gripping members each equidistant from the center of the film. The gripping members are simultaneously rotated through an arc away from the center of the film, as by pivotally securing each gripping member to the end of an associated expansion arm and rotating the end of each expansion arm away from the center of the film while maintaining the gripping members equidistant from the center of the film. The expansion arms are uniformly rotated by a geared shaft powered by a drive mechanism that extends through the wall of an oven for coupling to an external motor. Also disclosed is an expanded PTFE film made in accordance with such process.
摘要翻译：用于膨胀诸如PTFE膜的聚合物膜的装置和方法包括用与膜的中心等距的多个对称设置的夹持构件夹持其周边的未膨胀膜。夹持构件同时通过远离膜的中心的弧旋转，如通过将每个夹持构件枢转地固定到相关联的膨胀臂的端部并将每个膨胀臂的端部远离膜的中心旋转，同时保持夹紧构件与电影中心等距。膨胀臂由驱动机构驱动的齿轮轴均匀地旋转，驱动机构延伸穿过炉的壁连接到外部电动机。还公开了根据这种方法制成的膨胀PTFE薄膜。

4. 发明授权

US5453235A Method of forming dual porosity FTFE tubes by extrusion of concentric preforms 失效
标题翻译：通过挤出同心预制件形成双孔PTFE管的方法
公开(公告)号：US5453235A
公开(公告)日：1995-09-26
申请号：US10974
申请日：1993-01-29
申请人： Robert W. Calcote , Rajagopal R. Kowligi , Stacy Wollner
发明人： Robert W. Calcote , Rajagopal R. Kowligi , Stacy Wollner
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , A61M25/00 , B29C47/00 , B29C47/06 , B29C47/54 , B29C55/00 , B29C55/22
CPC分类号： B29C47/54 , A61L27/16 , A61L27/56 , B29C47/0004 , B29C47/0023 , B29C47/065 , B29C47/26 , B29C55/30 , A61F2/06 , A61M2025/0062 , A61M25/0009 , B29C55/00 , B29K2027/18 , B29L2031/7534 , B29L2031/7542 , Y10T428/139 , Y10T428/1393 , Y10T428/249981 , Y10T428/31544
摘要： A dual porosity PTFE tube including an inner surface of expanded PTFE material having a first porosity and an outer surface of expanded PTFE material having a porosity different from that of the inner surface. The preferred method includes the step of forming inner and outer preformed tubular billets of PTFE resin particles mixed with a lubricant; the outer billet is adapted to closely fit around and concentric to the inner billet. Porosity of the inner and outer surfaces is varied by changing, in the respective billets, the lubrication level and/or the PTFE resin characteristic average particle size. The inner billet is placed inside the outer billet, and the two are extruded together, thereby melding the two billets. The extrudate is then longitudinally expanded and sintered. The inner surface of the resulting PTFE tube exhibits a different porosity than the outer surface of the tube; the porosities of the inner and outer surfaces are both within a range of about 0.10-200.mu..
摘要翻译：一种双孔PTFE管，其包括具有第一孔隙率的膨胀PTFE材料的内表面和具有不同于内表面的孔隙率的膨胀PTFE材料的外表面。优选的方法包括形成与润滑剂混合的PTFE树脂颗粒的内部和外部预制管状坯料的步骤; 外部坯料适于紧密地配合并且与内部坯料同心。通过在相应的坯料中改变润滑水平和/或PTFE树脂特征平均粒径来改变内表面和外表面的孔隙率。将内部坯料放置在外部坯料内部，将两个坯料挤压在一起，从而使两个坯料熔合。然后将挤出物纵向膨胀并烧结。所得PTFE管的内表面与管的外表面具有不同的孔隙率; 内表面和外表面的孔隙率都在约0.10-200μm的范围内。

5. 发明授权

US5246452A Vascular graft with removable sheath 失效
标题翻译：具有可移除鞘的血管移植物
公开(公告)号：US5246452A
公开(公告)日：1993-09-21
申请号：US867332
申请日：1992-04-13
申请人： Joseph B. Sinnott
发明人： Joseph B. Sinnott
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61F2/06 , A61F2250/0024
摘要： A porous graft is provided with a non-porous coating or sheath which does not adhere to the graft. After the graft is implanted into the patient, circulation is restored through the graft. The sheath is left in place temporarily while blood works its way through the wall of the porous graft to the non-porous sheath, where it is prevented from leaking. Clots form in the graft, sealing it. After a few minutes, the sheath is removed. The graft or the inside surface of the sheath can be pre-treated with a coagulant to accelerate clotting. The sheath is applied to the graft as a coating, e.g. by dipping or spraying, or as a separate sleeve, e.g. heat-shrinkable tubing. The sheath can be removed by cutting. Preferably, the sheath incorporates a string, strip, or ribbon of material which is attached to the sheath. For removal, the string is pulled, tearing the sheath which is removed with the string.
摘要翻译：多孔移植物具有不粘附到移植物上的无孔涂层或护套。将移植物植入患者后，通过移植物恢复循环。血液临时留在原处，而血液通过多孔移植物的壁穿过无孔护套，防止其渗漏。在移植物中形成栓塞，密封。几分钟后，将护套取出。护套的移植物或内表面可以用凝结剂预处理以加速凝血。将鞘作为涂层施用于移植物，例如。通过浸渍或喷涂，或作为单独的套筒，例如，热缩管。护套可以通过切割去除。优选地，护套包括连接到护套的绳，条或材料带。为了取出，拉出绳子，撕开用绳子去除的护套。

6. 发明申请

US20010039446A1 ENCAPSULATED INTRALUMINAL STENT-GRAFT AND METHODS OF MAKING SAME 失效
标题翻译：包埋的内皮支架及其制造方法
公开(公告)号：US20010039446A1
公开(公告)日：2001-11-08
申请号：US08833797
申请日：1997-04-09
申请人： IMPRA, Inc., a subsidiary of C.R. Bard, Inc.
发明人： TARUN J. EDWIN , BRENDAN J. MCCRAE , CHRISTOPHER E. BANAS
IPC分类号： A61F002/06
CPC分类号： A61F2/82 , A61F2/06 , A61F2/07 , A61F2/90 , A61F2002/072 , A61L27/507 , A61L31/048 , A61L31/10 , A61L2400/16 , B29C55/005 , B29C55/22 , B29K2027/18 , Y10S623/901 , C08L27/18
摘要： Shape memory alloy and elastically self-expanding endoluminal stents which are at least partially encapsulated in a substantially monolithic expanded polytetrafluoroethylene (nullePTFEnull) covering. An endoluminal stent, which has a reduced diametric dimension for endoluminal delivery and a larger in vivo final diametric diameter, is encapsulated in an ePTFE covering which circumferentially covers both the luminal and abluminal walls along at least a portion of the longitudinal extent of the endoluminal stent. The shape memory endoluminal stent is fabricated from a shape memory alloy which exhibits either shape memory or pseudoelastic properties or from an elastic material having an inherent spring tension.
摘要翻译：形状记忆合金和弹性自膨胀腔内支架，其至少部分地包封在基本上整齐的膨胀聚四氟乙烯（“ePTFE”）中。内窥镜支架具有减小的内腔输送的直径尺寸和较大的体内最终直径直径，被封装在ePTFE覆盖物中，沿着沿内腔支架的纵向范围的至少一部分圆周地覆盖管腔和囊腔壁。形状记忆腔内支架由形状记忆合金制成，其形状记忆或假弹性性质或具有固有弹簧张力的弹性材料。

7. 发明授权

US5935667A Dual porosity PTFE tubes 失效
标题翻译：双孔PTFE管
公开(公告)号：US5935667A
公开(公告)日：1999-08-10
申请号：US872093
申请日：1997-06-10
申请人： Robert Calcote , Rajagopal R. Kowligi , Stacy Wollner
发明人： Robert Calcote , Rajagopal R. Kowligi , Stacy Wollner
IPC分类号： A61F2/06 , A61L27/16 , A61L27/56 , A61M25/00 , B29C47/00 , B29C47/06 , B29C47/54 , B29C55/00 , B29D23/00
CPC分类号： B29C47/54 , A61L27/16 , A61L27/56 , B29C47/0004 , B29C47/0023 , B29C47/065 , B29C47/26 , B29C55/30 , A61F2/06 , A61M2025/0062 , A61M25/0009 , B29C55/00 , B29K2027/18 , B29L2031/7534 , B29L2031/7542 , Y10T428/139 , Y10T428/1393 , Y10T428/249981 , Y10T428/31544
摘要： A dual porosity PTFE tube including an inner surface of expanded PTFE material having a first porosity and an outer surface of expanded PTFE material having a porosity different from that of the inner surface. The preferred method includes the step of forming inner and outer preformed tubular billets of PTFE resin particles mixed with a lubricant; the outer billet is adapted to closely fit around and concentric to the inner billet. Porosity of the inner and outer surfaces is varied by changing, in the respective billets, the lubrication level and/or the PTFE resin characteristic average particle size. The inner billet is placed inside the outer billet, and the two are extruded together, thereby melding the two billets. The extrudate is then longitudinally expanded and sintered. The inner surface of the resulting PTFE tube exhibits a different porosity than the outer surface of the tube; the porosities of the inner and outer surfaces are both within a range of about 0.10-200 .mu..
摘要翻译：一种双孔PTFE管，其包括具有第一孔隙率的膨胀PTFE材料的内表面和具有不同于内表面的孔隙率的膨胀PTFE材料的外表面。优选的方法包括形成与润滑剂混合的PTFE树脂颗粒的内部和外部预制管状坯料的步骤; 外部坯料适于紧密地配合并且与内部坯料同心。通过在相应的坯料中改变润滑水平和/或PTFE树脂特征平均粒径来改变内表面和外表面的孔隙率。将内部坯料放置在外部坯料内部，将两个坯料挤压在一起，从而使两个坯料熔合。然后将挤出物纵向膨胀并烧结。所得PTFE管的内表面与管的外表面具有不同的孔隙率; 内表面和外表面的孔隙率都在约0.10-200μm的范围内。

8. 发明授权

US5749880A Endoluminal encapsulated stent and methods of manufacture and endoluminal delivery 失效
公开(公告)号：US5749880A
公开(公告)日：1998-05-12
申请号：US508033
申请日：1995-07-27
申请人： Christopher E. Banas , Tarun J. Edwin
发明人： Christopher E. Banas , Tarun J. Edwin
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/072
摘要： An radially expandable stent-graft and method of making the same, including at least one a stent member encapsulated between at least two longitudinally expanded polytetrafluoroethylene (ePTFE) coverings. The at least one stent member has openings through wall surfaces of the stent to permit radial expansion. The at least two longitudinally expanded ePTFE coverings are circumferentially applied over the at least one stent member in their unsintered state, and sintered during application of a circumferential pressure to bond the ePTFE around and through the wall surfaces of the stent. The sintered ePTFE forms a substantially continuous, monolithic and integral encapsulation of the at least one stent. Upon radial expansion of the stent-graft, the stent and the ePTFE node-fibril microstructure radially deform. Radial deformation of the ePTFE encapsulation results in nodal elongation in the axis of radial expansion. After radial expansion of the stent-graft, a substantial bonded area remains intact and maintains the encapsulation of the stent in vivo.

9. 发明授权

US5321109A Uniformly expanded PTFE film 失效
标题翻译：均匀膨胀PTFE膜
公开(公告)号：US5321109A
公开(公告)日：1994-06-14
申请号：US977562
申请日：1992-11-17
申请人： Charles F. Bosse , Rajagopal R. Kowligi
发明人： Charles F. Bosse , Rajagopal R. Kowligi
IPC分类号： B29C55/10 , C08F114/26
CPC分类号： B29C55/10 , B29K2027/18 , Y10S425/053 , Y10S428/91
摘要： A uniformly expanded PTFE film is provided by extruding a PTFE film and gripping the unexpanded film about its periphery with a number of symmetrically disposed gripping members each equidistant from the center of the film. The extruded PTFE film is heated to a temperature in the range of 200-300 degrees Centigrade before expanding the extruded PTFE film. The gripping members are simultaneously rotated through an arc away from the center of the film, as by pivotally securing each gripping member to the end of an associated expansion arm and rotating the end of each expansion arm away from the center of the film while maintaining the gripping members equidistant from the center of the film. The expansion arms are uniformly rotated by a geared shaft powered by a drive mechanism that extends through the wall of an oven for coupling to an external motor.
摘要翻译：通过挤出PTFE薄膜并通过围绕其周边等距离的多个对称设置的夹持构件围绕其周边夹持未膨胀薄膜来提供均匀膨胀的PTFE薄膜。挤出的PTFE膜在膨胀挤出的PTFE膜之前被加热至200-300摄氏度的温度。夹持构件同时通过远离膜的中心的弧旋转，如通过将每个夹持构件枢转地固定到相关联的膨胀臂的端部并将每个膨胀臂的端部远离膜的中心旋转，同时保持夹紧构件与电影中心等距。膨胀臂由驱动机构驱动的齿轮轴均匀地旋转，驱动机构延伸穿过炉的壁连接到外部电动机。

10. 发明授权

US4955899A Longitudinally compliant vascular graft 失效
标题翻译：纵向合并血管移植
公开(公告)号：US4955899A
公开(公告)日：1990-09-11
申请号：US358787
申请日：1989-05-26
申请人： Linda V. Della Corna , Robert C. Farnan , William M. Colone , Rajagopal R. Kowligi
发明人： Linda V. Della Corna , Robert C. Farnan , William M. Colone , Rajagopal R. Kowligi
IPC分类号： A01N1/02 , A61F2/06 , A61F2/16 , A61L27/16 , A61L27/34 , A61L27/50 , A61L27/56 , A61M25/16 , B29D23/00
CPC分类号： B29D23/001 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/507 , A61L27/56 , Y10S623/901
摘要： A longitudinally compliant PTFE graft is provided by compressing at least a portion of a porous PTFE tube along its longitudinal axis and coating at least the outer wall of the compressed portion of the PTFE tube with a biocompatible elastomer for allowing the compressed portion of the tube to be stretched along the longitudinal axis. The PTFE tube is compressed by pulling the tube over a cylindrical mandrel of like diameter and applying a compression force to the tube along its longitudinal axis. The compressed portion(s) is (are) secured against movement upon the mandrel, and a coating of liquified polyurethane or other biocompatible elastomer is then applied over at least the compressed portion(s) of the tube. The elastomeric coating may be applied by dip coating or spray coating techniques. After the elastomeric coating has dried, the completed graft is removed from the mandrel.
摘要翻译：通过沿其纵向轴线压缩多孔PTFE管的至少一部分并且用生物相容的弹性体涂覆PTFE管的压缩部分的至少外壁，以使管的压缩部分沿纵轴拉伸。通过将管拉在相同直径的圆柱形心轴上并沿其纵向轴线向管施加压缩力来压缩PTFE管。被压缩的部分被固定以防止心轴上的移动，并且然后将液化的聚氨酯或其它生物相容的弹性体的涂层施加在至少管的压缩部分上。弹性体涂层可以通过浸涂或喷涂技术施加。在弹性体涂层干燥之后，将完成的移植物从心轴上移除。

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