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81. 发明申请

US20120101294A1 PROCESS FOR PRODUCING (FLUOROALKYLTHIO) ACETIC ACID ESTER 审中-公开
标题翻译：生产（氟烷基）乙酸酯的方法
公开(公告)号：US20120101294A1
公开(公告)日：2012-04-26
申请号：US13382121
申请日：2010-08-06
申请人： Masaji Hirota , Hiroyuki Miyazaki , Tadayoshi Itoh
发明人： Masaji Hirota , Hiroyuki Miyazaki , Tadayoshi Itoh
IPC分类号： C07C319/12 , C07C315/02
CPC分类号： C07C319/18 , C07C315/02 , C07C315/04 , C07C319/20 , C07C323/52 , C07C317/44
摘要： Disclosed is a process for producing a (fluoroalkylthio)acetic acid ester represented by the formula (3) wherein R, R1 and R2 have the same meanings as defined below, which comprises reacting a thioglycolic acid ester represented by the formula (1) wherein R represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and R1 represents an alkyl group having 1 to 4 carbon atoms, with fluoroolefin represented by the formula (2) wherein R2 represents a fluoroalkyl group having 1 to 5 carbon atoms, in the presence of a radical generator.
摘要翻译：公开了一种由式（3）表示的（氟烷基硫代）乙酸酯的制备方法，其中R 1，R 2和R 2具有如下定义的相同含义，该方法包括使式（1）表示的巯基乙酸酯与式表示氢原子或碳原子数1〜5的烷基，R1表示碳原子数1〜4的烷基，式（2）表示的氟代烯烃，其中，R2表示碳原子数1〜5的氟代烷基，在自由基发生器的存在下。

82. 发明申请

US20110207967A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 有权
标题翻译：维生素K2的制备方法
公开(公告)号：US20110207967A1
公开(公告)日：2011-08-25
申请号：US13119585
申请日：2009-09-24
申请人： Lars Skattebol , Inger Aukrust , Marcel Sandberg
发明人： Lars Skattebol , Inger Aukrust , Marcel Sandberg
IPC分类号： C07C45/00 , C07C315/04 , C07C319/12 , C07C317/18 , C07C43/215 , C07C45/59
CPC分类号： C07C46/02 , C07B2200/13 , C07C17/16 , C07C21/215 , C07C41/18 , C07C41/22 , C07C41/26 , C07C41/30 , C07C43/215 , C07C46/04 , C07C50/14 , C07C315/04 , C07C319/20 , C07C43/1782 , C07C43/23 , C07C43/225 , C07C21/19 , C07C317/18 , C07C323/16
摘要： Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
摘要翻译：使用Kumada，Suzuki和Biellmann化学的组合，各种甲萘醌可以快速合成并具有立体化学完整性，为制药市场提供了制备这些维生素K2组分的新方法。在一个实施方案中，定义了式（I）化合物的制备方法，包括其中（i）式（II）化合物与其中R为烷基的式（III）反应的步骤; LG是离职团体 m为0〜8的整数; n为0〜9的整数; X是氢，卤素，羟基或保护的羟基; 在铜，镍或钯催化剂的存在下。

83. 发明申请

US20110028746A1 METHOD FOR THE DECARBOXYLATIVE HYDROFORMYLATION OF ALPHA, BETA- UNSATURATED CARBOXYLIC ACIDS 审中-公开
标题翻译：阿尔法，非饱和羧酸的脱羧氢化方法
公开(公告)号：US20110028746A1
公开(公告)日：2011-02-03
申请号：US12934743
申请日：2009-03-25
申请人： Jens Rudolph , Joachim Schmidt-Leithoff , Rocco Paciello , Bernhard Breit , Thomas Smejkal
发明人： Jens Rudolph , Joachim Schmidt-Leithoff , Rocco Paciello , Bernhard Breit , Thomas Smejkal
IPC分类号： C07C45/49 , C07C319/12 , C07F7/08 , C07C51/14 , C07C269/06 , C07C67/36
CPC分类号： C07C45/50 , B01J31/2404 , B01J2231/321 , B01J2531/004 , C07C67/29 , C07C2601/14 , C07F7/1892 , C07C47/228 , C07C47/11 , C07C49/185 , C07C47/277 , C07C47/21 , C07C47/198 , C07C47/02 , C07C69/78
摘要： The present invention relates to a process for preparing aldehydes by reacting an α,β-unsaturated carboxylic acid or a salt thereof with carbon monoxide and hydrogen in the presence of a catalyst comprising at least one complex of a metal of transition group VIII of the Periodic Table of the Elements with at least one compound of the formula (I), where Pn is pnicogen; W is a divalent bridging group having from 1 to 8 bridge atoms between the flanking bonds; R1 is a functional group capable of forming at least one intermolecular, noncovalent bond with the —X(═O)OH group of the compound of the formula (I); R2, R3 are each in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl or together with the pnicogen atom and together with the groups Y2 and Y3 if present form an optionally fused and optionally substituted 5- to 8-membered heterocycle; a, b and c are each 0 or 1; and Y1,2,3 are each, independently of one another, O, S, NRa or SiRbRc, where Ra,b,c are each H or in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; and the use of the above-described catalyst for the decarboxylative hydroformylation of α,β-unsaturated carboxylic acids.
摘要翻译：本发明涉及一种通过使α-，β-不饱和羧酸或其盐与一氧化碳和氢气在催化剂存在下反应来制备醛的方法，所述催化剂包含至少一种式具有式（I）的至少一种化合物的元素周期表，其中Pn是pnicogen; W是在侧翼键之间具有1至8个桥原子的二价桥连基团; R1是能够与式（I）化合物的-X（= O）OH基团形成至少一个分子间，非共价键的官能团; R2，R3各自为任选取代的烷基，环烷基，杂环烷基，芳基或杂芳基，或与pnicogen原子一起并与Y2和Y3基团一起形成任选稠合的和任选取代的5-至8-元杂环; a，b和c各自为0或1; 其中R a，b，c各自为H，或者在每种情况下均为任选取代的烷基，环烷基，杂环烷基，芳基或杂芳基;其中R 1和R 2各自独立地为O，S，NR a或SiR b R c。以及使用上述催化剂进行α，β-不饱和羧酸的脱羧加氢甲酰化反应。

84. 发明申请

US20110009672A1 Substituted Phenylsulfur Trifluoride and Other Like Fluorinating Agents 有权
标题翻译：取代的苯基三氟化硫和其他类似的氟化剂
公开(公告)号：US20110009672A1
公开(公告)日：2011-01-13
申请号：US12886286
申请日：2010-09-20
申请人： Teruo Umemoto
发明人： Teruo Umemoto
IPC分类号： C07C323/09 , C07C319/12
CPC分类号： C07C17/18 , C07B39/00 , C07C17/093 , C07C17/16 , C07C17/361 , C07C45/65 , C07C51/60 , C07C319/14 , C07C319/20 , C07C323/19 , C07C381/00 , C07C2601/14 , C07C19/08 , C07C22/08 , C07C23/10 , C07C323/03 , C07C63/10 , C07C63/04
摘要： Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.
摘要翻译：公开了用作氟化剂的新型取代苯基三氟化硫。还公开了它们的制备方法和它们用于将一个或多个氟原子引入目标底物化合物中的方法。最后，提供用于制备取代的苯基三氟化硫的各种中间体化合物。

85. 发明申请

US20110008261A1 METHOD TO PRODUCE HYPERPOLARISED AMINO ACIDS AND AMINOSULPHONIC ACIDS 审中-公开
标题翻译：生产高分子氨基酸和氨基酸的方法
公开(公告)号：US20110008261A1
公开(公告)日：2011-01-13
申请号：US12864521
申请日：2009-02-03
申请人： Mathilde H. Lerche , Magnus Karlsson , Pernille R. Jensen
发明人： Mathilde H. Lerche , Magnus Karlsson , Pernille R. Jensen
IPC分类号： A61K49/06 , C12Q1/02 , C07C229/26 , C07C323/58 , C07D207/10 , C07C229/06 , C07C307/02 , C07C303/34 , C07C227/14 , C07C319/12 , G01R33/44
CPC分类号： A61K49/10 , G01N33/58
摘要： The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures thereof is used.
摘要翻译：本发明涉及用于生产超极化氨基酸和氨基磺酸的动态核极化（DNP）方法和用于该方法的组合物。作为样品，使用氨基酸的铵盐，氨基磺酸的铵盐，氨基酸的羧酸盐，氨基磺酸的磺酸盐或其混合物。

86. 发明授权

US07572937B2 Process for preparing amino acids using amidocarbonylation reaction 有权
标题翻译：使用酰胺基羰基化反应制备氨基酸的方法
公开(公告)号：US07572937B2
公开(公告)日：2009-08-11
申请号：US11570319
申请日：2005-05-14
申请人： Martin Hateley , Thomas Hauhlner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
发明人： Martin Hateley , Thomas Hauhlner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
IPC分类号： C07C319/12 , C07C227/20
CPC分类号： C07C231/12 , C07C227/20 , C07C319/20 , C07C323/59 , C07C323/58
摘要： The present invention relates to a sequence for the preparation of amino acids, for example alpha amino acids, in particular methionine, by making use of an amidocarbonylation reaction and reuse of the catalyst.
摘要翻译：本发明涉及通过使用酰胺基羰基化反应和再利用催化剂来制备氨基酸，例如α氨基酸，特别是甲硫氨酸的序列。

87. 发明授权

US07323602B2 Preparation process of some halogeno-substituted monosulfides and their hydroxy-monosulfide or isothiouronium bromide equivalents as intermediates 有权
标题翻译：一些卤代取代的一硫化物及其羟基一硫化物或异硫脲鎓溴化物当量作为中间体的制备方法
公开(公告)号：US07323602B2
公开(公告)日：2008-01-29
申请号：US10491738
申请日：2002-10-03
申请人： Kenneth Edwin Herbert Warren , Anne Margaret Lamont Kane
发明人： Kenneth Edwin Herbert Warren , Anne Margaret Lamont Kane
IPC分类号： C07C319/02 , C07C319/12 , C07C321/04 , C07C323/44 , C07C335/32 , C07C249/00
CPC分类号： C07C319/02 , C07C303/28 , C07C319/14 , C07C319/20 , C07C323/12 , C07C335/32 , C07C323/03 , C07C309/66
摘要： A process for preparing an intermediate compound of formula (II) where n is an integer of from 3 to 14; R1 is haloC1-10alkyl, C1-10alkyl, C2-10alkenyl, C2-10cycloalkyl, carboxyC1-10alkyl, C1-10alkoxycarbonylC1-10alkyl, aryl (such as phenyl), aryl(C1-10)alkyl (such as phenyl(C1-10)alkyl) or di(C1-6alkyl)amino; and R2 is a halo group; the process comprising halogenation of a compound of formula (III) where n and R1 are as defined above. Novel compounds are also described and claimed.
摘要翻译：一种制备其中n为3至14的整数的式（II）的中间体化合物的方法; R 1是卤代C 1-10烷基，C 1-10烷基，C 2-10链烯基，C 2-10环烷基，羧基C 1-10烷基，C 1-10烷氧基羰基C 1-10烷基，芳基（如苯基），芳基（C 1-10）烷基（如苯基（C 1-10）烷基）或二（C 1-6）烷基）烷基）氨基; R 2是卤代基; 该方法包括卤化式（III）的化合物，其中n和R 1如上定义。还描述和要求保护新的化合物。

88. 发明申请

US20060047169A1 Preparation of 2-hydroxy-4-methylthiobutyric acid 有权
标题翻译： 2-羟基-4-甲硫基丁酸的制备
公开(公告)号：US20060047169A1
公开(公告)日：2006-03-02
申请号：US11212023
申请日：2005-08-25
申请人： Alexander Moller , Hans-Albrecht Hasseberg , Harald Heinzel , Volker Hafner
发明人： Alexander Moller , Hans-Albrecht Hasseberg , Harald Heinzel , Volker Hafner
IPC分类号： C07C319/12
CPC分类号： C07C319/20 , C07C323/52
摘要： A process for the preparation of 2-hydroxy-4-methylthiobutyric acid.
摘要翻译：一种制备2-羟基-4-甲硫基丁酸的方法。

89. 发明申请

US20050012092A1 (4,5,9,10-Tetrahydro-pyren-2-yl)-carbamic acid 4-(2-methylsulfanyl-alkyl)-3,5-dinitro-benzyl ester, method of synthesizing thereof, and molecular electronic device using the same 有权
标题翻译：（4,5,9,10-四氢 - 芘-2-基） - 氨基甲酸4-（2-甲基硫烷基 - 烷基）-3,5-二硝基 - 苄酯，其合成方法和使用相同
公开(公告)号：US20050012092A1
公开(公告)日：2005-01-20
申请号：US10864065
申请日：2004-06-08
申请人： Hyoyoung Lee , Mun Jeong , Do Kim , Taehyoung Zyung
发明人： Hyoyoung Lee , Mun Jeong , Do Kim , Taehyoung Zyung
IPC分类号： C07C323/55 , C07C271/26 , C07C319/12 , C07C319/20 , C07C323/16 , C07C327/28 , H01L27/28 , H01L35/24 , H01L51/00 , H01L51/05 , H01L51/30 , H03K19/091
CPC分类号： C07C327/28 , B82Y10/00 , B82Y30/00 , C07C319/12 , C07C319/20 , C07C2603/50 , H01L27/28 , H01L27/285 , H01L51/0054 , H01L51/0575 , H01L51/0595 , C07C323/16
摘要： A new compound derivative that can be used to form a unit molecular film as a rectifier in a molecular electronic device, a new rectifying compound (4,5,9,10-tetrahydro-pyren-2-yl)-carbamic acid 4-(2-methylsulfanyl-alkyl)-3,5-dinitro-benzyl ester and its derivative (4,5,9,10-Tetrahydro-pyren-2-yl)-carbamic acid 4-(2-methylsulfanyl-alkyl)-3,5-dinitro-benzyl ester, and methods of synthesizing the compounds are provided.
摘要翻译：可用于在分子电子器件中形成单元分子膜作为整流器的新的化合物衍生物，新的整流化合物（4,5,9,10-四氢 - 芘-2-基） - 氨基甲酸4-（（4-甲基硫烷基 - 烷基）-3,5-二硝基苄基酯及其衍生物（4,5,9,10-四氢 - 芘-2-基） - 氨基甲酸4-（2-甲基硫烷基 - 烷基） 5-二硝基 - 苄基酯，以及合成这些化合物的方法。

90. 发明授权

US06002013A 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US06002013A
公开(公告)日：1999-12-14
申请号：US148276
申请日：1998-09-04
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82 , C07D285/14 , C07D277/62 , C07C255/07 , C07C321/08
CPC分类号： C07D285/14 , C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0, 1, 2 or 3;Z is CN, CO--A or CS--A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R.sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or NProcesses for the preparation of compounds of the formula I are described.
摘要翻译：式I化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要中间产物。在式I和III化合物中：X为卤素，n为0 ，1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。描述了公式I。

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