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1. 发明授权

US07572937B2 Process for preparing amino acids using amidocarbonylation reaction 有权
标题翻译：使用酰胺基羰基化反应制备氨基酸的方法
公开(公告)号：US07572937B2
公开(公告)日：2009-08-11
申请号：US11570319
申请日：2005-05-14
申请人： Martin Hateley , Thomas Hauhlner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
发明人： Martin Hateley , Thomas Hauhlner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
IPC分类号： C07C319/12 , C07C227/20
CPC分类号： C07C231/12 , C07C227/20 , C07C319/20 , C07C323/59 , C07C323/58
摘要： The present invention relates to a sequence for the preparation of amino acids, for example alpha amino acids, in particular methionine, by making use of an amidocarbonylation reaction and reuse of the catalyst.
摘要翻译：本发明涉及通过使用酰胺基羰基化反应和再利用催化剂来制备氨基酸，例如α氨基酸，特别是甲硫氨酸的序列。

2. 发明授权

US07439390B2 Process for preparing amino acids using the amidocarbonylation reaction 有权
标题翻译：使用酰胺基羰基化反应制备氨基酸的方法
公开(公告)号：US07439390B2
公开(公告)日：2008-10-21
申请号：US11569319
申请日：2005-05-14
申请人： Martin Hateley , Thomas Häussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
发明人： Martin Hateley , Thomas Häussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
IPC分类号： C07C321/00 , C07C51/00 , B01J20/34
CPC分类号： B01J31/20 , B01J2531/845 , C07C227/20 , C07C319/20 , C07C323/58 , C07C323/59
摘要： The present invention relates to a sequence for the preparation of amino acids, for example alpha-amino acids, in particular methionine, by making use of an amidocarbonylation reaction in the presence of a cobalt carbonyl catalyst and separating the catalyst in the form of a Co(N-amino acid)2 compound.
摘要翻译：本发明涉及用于制备氨基酸的序列，例如α-氨基酸，特别是甲硫氨酸，通过在羰基钴催化剂存在下使用酰胺基羰基化反应，并以Co的形式分离催化剂（N-氨基酸）2 N 2化合物。

3. 发明申请

US20080009649A1 Process for Preparing Amino Acids Using the Amidocarbonylation Reaction 有权
标题翻译：使用酰胺基羰基化反应制备氨基酸的方法
公开(公告)号：US20080009649A1
公开(公告)日：2008-01-10
申请号：US11569319
申请日：2005-05-14
申请人： Martin Hateley , Thomas Haussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
发明人： Martin Hateley , Thomas Haussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
IPC分类号： C07C51/12 , C07C227/12 , C07C51/14 , C07C51/10
CPC分类号： B01J31/20 , B01J2531/845 , C07C227/20 , C07C319/20 , C07C323/58 , C07C323/59
摘要： The present invention relates to a sequence for the preparation of amino acids, for example alpha-amino acids, in particular methionine, by making use of an amidocarbonylation reaction in the presence of a cobalt carbonyl catalyst and separating the catalyst in the form of a Co(N-amino acid)2 compound.
摘要翻译：本发明涉及用于制备氨基酸的序列，例如α-氨基酸，特别是甲硫氨酸，通过在羰基钴催化剂存在下使用酰胺基羰基化反应，并以Co的形式分离催化剂（N-氨基酸）2 N 2化合物。

4. 发明申请

US20070244339A1 Process for Preparing Amino Acids Using Amidocarbonylation Reaction 有权
标题翻译：使用酰氨基羰基化反应制备氨基酸的方法
公开(公告)号：US20070244339A1
公开(公告)日：2007-10-18
申请号：US11570319
申请日：2005-05-14
申请人： Martin Hateley , Thomas Haussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
发明人： Martin Hateley , Thomas Haussner , Christoph Weckbecker , Klaus Huthmacher , Dieter Buss
IPC分类号： C07C51/10
CPC分类号： C07C231/12 , C07C227/20 , C07C319/20 , C07C323/59 , C07C323/58
摘要： The present invention relates to a sequence for the preparation of amino acids, for example alpha-amino acids, in particular methionine, by making use of an amidocarbonylation reaction and reuse of the catalyst.
摘要翻译：本发明涉及通过使用酰胺基羰基化反应和再利用催化剂来制备氨基酸，例如α-氨基酸，特别是甲硫氨酸的序列。

5. 发明授权

US06797827B2 Process for the preparation of alpha-amino acids by hydrolysis of hydantoins at elevated pressure and elevated temperature 有权
标题翻译：通过在升高的压力和升高的温度下水解乙内酰脲来制备α-氨基酸的方法
公开(公告)号：US06797827B2
公开(公告)日：2004-09-28
申请号：US10630094
申请日：2003-07-30
申请人： Martin Körfer , Dieter Buss , Horst Weigel , Christoph Weckbecker , Hans Joachim Hasselbach , Klaus Huthmacher
发明人： Martin Körfer , Dieter Buss , Horst Weigel , Christoph Weckbecker , Hans Joachim Hasselbach , Klaus Huthmacher
IPC分类号： C07D23386
CPC分类号： C07C319/20 , C07C227/24 , C07C323/58 , C07C229/08 , C07C229/36
摘要： A process for the preparation of &agr;-amino acids by hydrolysis of hydantoins in the presence of water and at least one metallic oxide under conditions such that all the starting materials are completely dissolved in the water as a result of high pressure and high temperature and only one further phase is present in the reactor in addition to the metallic oxide phase.
摘要翻译：一种在水和至少一种金属氧化物的存在下水解乙内酰脲来制备α-氨基酸的方法，使得所有起始物质由于高压和高温而完全溶解在水中，只有在除了金属氧化物相之外，在反应器中还存在一个相。

6. 发明申请

US20100210871A1 Reactive Extraction of Free Organic Acids from the Ammonium Salts Thereof 审中-公开
标题翻译：从其铵盐中反应提取游离有机酸
公开(公告)号：US20100210871A1
公开(公告)日：2010-08-19
申请号：US12706512
申请日：2010-02-16
申请人： Christoph Kobler , Dieter Buss , Axel Ronneburg , Christoph Weckbecker
发明人： Christoph Kobler , Dieter Buss , Axel Ronneburg , Christoph Weckbecker
IPC分类号： C07F9/535 , C07C61/00 , C07C59/01 , C07C59/10 , C07C53/126 , C07C309/25
CPC分类号： C07F9/3834 , C07C51/02 , C07C51/48 , C07C303/22 , C07C319/20 , C07C2602/42 , C07C59/01 , C07C59/08 , C07C53/126 , C07C323/52 , C07C309/27
摘要： The invention relates to a process for converting ammonium salts of organic acids to the particular free organic acid, wherein an aqueous solution of the ammonium salt is contacted with an organic extractant and the salt is dissociated at temperatures and pressures at which the aqueous solution and the extractant are in the liquid state, and a stripping medium or entraining gas is introduced in order to remove NH3 from the aqueous solution and transfer at least a portion of the free organic acid formed to the organic extractant. The invention described here thus provides an improved process for releasing an organic acid, preferably a carboxylic, sulphonic or phosphonic acid, especially an alpha-hydroxycarboxylic acid or beta-hydroxycarboxylic acid, from the ammonium salt thereof by release and removal of ammonia and simultaneous extraction of the acid released with a suitable extractant from the aqueous phase. This process corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonium salt solution thereof can be improved significantly by the use of a stripping medium or entraining gas, for example nitrogen, air, steam or inert gases, for example argon. The ammonia released is removed from the aqueous solution by the continuous gas stream and can be fed back into a production process. The free acid can be obtained from the extractant by a process such as distillation, rectification, crystallization, re-extraction, chromatography, adsorption, or by a membrane process.
摘要翻译：本发明涉及将有机酸的铵盐转化为特定的游离有机酸的方法，其中铵盐的水溶液与有机萃取剂接触，并且盐在水溶液和萃取剂处于液体状态，并且引入汽提介质或夹带气体以从水溶液中除去NH 3并将至少一部分形成的游离有机酸转移到有机萃取剂中。因此，这里描述的发明提供了一种通过释放和除去氨并同时提取从其铵盐中释放有机酸，优选羧酸，磺酸或膦酸，特别是α-羟基羧酸或β-羟基羧酸的改进方法的酸从水相中用合适的萃取剂释放。该过程对应于反应萃取。通过使用汽提介质或夹带气体，例如氮气，空气，蒸气或惰性气体，例如氩气，可以显着地改善有机酸从其铵盐水溶液中的反应萃取。释放的氨通过连续气流从水溶液中除去，并可以反馈到生产过程中。游离酸可以通过蒸馏，精馏，结晶，再萃取，色谱法，吸附法或膜法等方法从萃取剂得到。

7. 发明申请

US20150197489A1 METHOD FOR THE PRODUCTION OF D,L-METHIONINE 审中-公开
标题翻译：生产D，L-甲硫氨酸的方法
公开(公告)号：US20150197489A1
公开(公告)日：2015-07-16
申请号：US14671435
申请日：2015-03-27
申请人： Dieter Buss , Martin Steurenthaler , Michael R. Rinner , Stephan Kretz , Hans Joachim Hasselbach , Caspar-Heinrich Finkeldei , Martin Koerfer , Pablo Zacchi
发明人： Dieter Buss , Martin Steurenthaler , Michael R. Rinner , Stephan Kretz , Hans Joachim Hasselbach , Caspar-Heinrich Finkeldei , Martin Koerfer , Pablo Zacchi
IPC分类号： C07C319/20
CPC分类号： C07C319/20 , C07C323/60 , C07C323/58 , C07C323/52
摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercapto-propionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.
摘要翻译：提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈是通过在多基团反应器的主反应区中作为催化剂的碱作为催化剂使3-甲基巯基丙醛与氰化氢反应得到的。残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

8. 发明申请

US20050192460A1 Process for preparing amino acid esters and their acid addition salts 失效
标题翻译：制备氨基酸酯及其酸加成盐的方法
公开(公告)号：US20050192460A1
公开(公告)日：2005-09-01
申请号：US11061420
申请日：2005-02-18
申请人： Matthias Pascaly , Dietrich Maass , Dieter Buss , Burghard Gruning , Gunter Latoschinski , Tim Popken , Christian Weitemeyer
发明人： Matthias Pascaly , Dietrich Maass , Dieter Buss , Burghard Gruning , Gunter Latoschinski , Tim Popken , Christian Weitemeyer
IPC分类号： C07B61/00 , C07C227/18 , C07C227/22 , C07C229/08 , C07C229/24 , C07K1/02 , C07C51/16
CPC分类号： C07C227/18 , C07C227/22 , Y02P20/544 , C07C229/08 , C07C229/24
摘要： The invention provides a process for preparing amino acid esters and/or their acid addition salts from monomeric or polymeric amino acids, peptides, proteins and alcohols, which comprises carrying out the reaction in supercritical alcohols, preferably at pressures and temperatures which are at least 5% above the critical parameters, the alcohols serving both as the solvent and as reactants.
摘要翻译：本发明提供从单体或聚合氨基酸，肽，蛋白质和醇制备氨基酸酯和/或其酸加成盐的方法，其包括在超临界醇中进行反应，优选在至少为5的压力和温度高于关键参数的％，醇既用作溶剂又用作反应物。

9. 发明申请

US20120215022A1 METHOD FOR THE PRODUCTION OF 2-HYDROXY-4-(METHYLTHIO)BUTYRONITRILE FROM 3-(METHYLTHIO)PROPANAL AND HYDROGEN CYANIDE 有权
标题翻译：从3-（甲基）丙醛和氢氰化物生产2-羟基-4-（甲基）苯并呋喃的方法
公开(公告)号：US20120215022A1
公开(公告)日：2012-08-23
申请号：US13402041
申请日：2012-02-22
申请人： Dieter Buss , Martin Steurenthaler , Michael R. Rinner , Stephan Kretz , Hans Joachim Hasselbach , Caspar-Heinrich Finkeldei , Martin Koerfer , Pablo Zacchi
发明人： Dieter Buss , Martin Steurenthaler , Michael R. Rinner , Stephan Kretz , Hans Joachim Hasselbach , Caspar-Heinrich Finkeldei , Martin Koerfer , Pablo Zacchi
IPC分类号： C07C51/08 , C07C253/00
CPC分类号： C07C319/20 , C07C323/60 , C07C323/58 , C07C323/52
摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.
摘要翻译：提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂和残留量的氰化氢气体。将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

10. 发明授权

US08809576B2 Method for producing a free acid from the salt thereof 有权
标题翻译：从其盐生产游离酸的方法
公开(公告)号：US08809576B2
公开(公告)日：2014-08-19
申请号：US13141456
申请日：2010-02-01
申请人： Alexander Schraven , Thomas Tacke , Thomas Haas , Christoph Kobler , Dieter Buss , Axel Ronneburg , Olivier Zehnacker
发明人： Alexander Schraven , Thomas Tacke , Thomas Haas , Christoph Kobler , Dieter Buss , Axel Ronneburg , Olivier Zehnacker
IPC分类号： C07F9/22
CPC分类号： C07C51/02 , C07C59/00 , C07C55/10 , C07C59/01 , C07C55/00 , C07C65/00 , C07C59/08 , C07C63/00
摘要： The invention relates to an improved method for releasing an organic acid, preferably a carbon, sulfone or phosphone acid, particularly an alpha or beta hydroxycarbon acid, from the ammonia salt thereof by releasing and removing ammoniac and simultaneous extraction of the released acid, having an amine as a suitable extraction means from the aqueous phase. This method corresponds to a reactive extraction. The reactive extraction of an organic acid from the aqueous ammonia salt solution thereof can be significantly improved by the use of a strip medium or carrier gas, such as nitrogen, air, water vapor or inert gases such as argon. The released ammoniac is removed from the aqueous solution by the continuous gas flow and can be resupplied into a production process. The free acid can be obtained by a method such as distillation, rectification, crystallization, reextraction, chromatography, adsorption or by a membrane method from the extraction means.
摘要翻译：本发明涉及通过释放和除去氨和同时提取释放的酸的有机酸，优选碳，砜或膦酸，特别是α或β羟基碳酸从其氨盐中释放的改进方法，其具有胺作为来自水相的合适的提取方法。该方法对应于反应萃取。通过使用带状介质或载气如氮气，空气，水蒸汽或惰性气体如氩气，可以显着地改善有机酸从其氨水溶液中的反应萃取。通过连续气流将释放的氨水从水溶液中除去，并且可以再供给到生产过程中。游离酸可以通过蒸馏，精馏，结晶，再萃取，色谱法，吸附法或从提取方法通过膜法等方法得到。

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