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81. 发明授权

US5274233A Mass spectrometry method using supplemental AC voltage signals 失效
标题翻译：使用补充交流电压信号的质谱法
公开(公告)号：US5274233A
公开(公告)日：1993-12-28
申请号：US884455
申请日：1992-05-14
申请人： Paul E. Kelley
发明人： Paul E. Kelley
IPC分类号： H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/0081 , H01J49/0063 , H01J49/424 , H01J49/427 , H01J49/429
摘要： A mass spectrometry method in which one or more high power supplemental AC voltage signals and one or more low power supplemental AC voltage signals are applied to an ion trap. The frequency of each supplemental AC voltage is selected to match a resonance frequency of an ion having a desired mass-to-charge ratio. The low power supplemental voltage signals are applied for the purpose of dissociating specific ions (i.e., parent ions) within the trap, and the high power supplemental voltage signals are applied to resonate products of the dissociation process (i.e., daughter ions) so that they can be detected. In one class of embodiments, the high power voltage signals resonate daughter ions out from the trap for detection by an external detector. In another class of embodiments, each high power voltage signal resonates the daughter ions only to a degree sufficient for detection by an in-trap detector (which may comprise one or more of the electrodes which define the trapping field, or may be mounted integrally with such electrodes).
摘要翻译：一种质谱方法，其中将一个或多个高功率补充AC电压信号和一个或多个低功率补充AC电压信号施加到离子阱。选择每个补充AC电压的频率以匹配具有期望质荷比的离子的共振频率。施加低功率补充电压信号用于解离陷阱内的特定离子（即母体离子），并且施加高功率补充电压信号以共振解离过程（即，子离子）的产物，使得它们可以检测。在一类实施例中，高功率电压信号使子离子从陷阱中共振，由外部检测器检测。在另一类实施例中，每个高功率电压信号仅使子离子谐振到足以由陷阱检测器（其可以包括定义捕获场的一个或多个电极，或可以与这样的电极）。

82. 发明授权

US4736101A Method of operating ion trap detector in MS/MS mode 失效
标题翻译：在MS / MS模式下操作离子阱检测器的方法
公开(公告)号：US4736101A
公开(公告)日：1988-04-05
申请号：US84518
申请日：1987-08-11
申请人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
发明人： John E. P. Syka , John N. Louris , Paul E. Kelley , George C. Stafford , Walter E. Reynolds
IPC分类号： G01N27/62 , G21K1/087 , H01J49/42
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
摘要翻译：以MS / MS模式通过四极离子阱质谱仪对样品进行质量分析的简单而经济的方法包括以下步骤：在捕获结构内形成离子，改变RF和DC电压，使得离子与在所需范围内的质荷比将被捕获在陷阱结构内，并且通过碰撞将这些离子解离成碎片，并再次增加场强，使得所产生的片段将变得不稳定并顺序地离开陷阱体积以被检测。附加的AC场可以另外施加以提供各种扫描模式以及离子离解。

83. 发明授权

US4090075A Method and apparatus for mass analysis by multi-pole mass filters 失效
标题翻译：多极质量过滤器质量分析方法与装置
公开(公告)号：US4090075A
公开(公告)日：1978-05-16
申请号：US624746
申请日：1975-10-23
申请人： Uwe Hans Werner Brinkmann
发明人： Uwe Hans Werner Brinkmann
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/4215 , H01J49/004 , H01J49/429 , H01J49/48
摘要： An ionized substance to be analysed is applied to a quadrupole filter that establishes stable and unstable ion trajectories dependent upon the potential applied to the poles. Varying this potential determines which mass line spectrum will be transmitted to an analyser at the output of the filter.
摘要翻译：要分析的电离物质应用于四极滤波器，其根据施加到极的电位建立稳定和不稳定的离子轨迹。改变该电位决定哪个质谱线将被传输到滤波器输出端的分析仪。

84. 发明公开

US20240304434A1 MASS SPECTROMETRY VIA FREQUENCY TAGGING 审中-公开
公开(公告)号：US20240304434A1
公开(公告)日：2024-09-12
申请号：US18630314
申请日：2024-04-09
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder
IPC分类号： H01J49/42 , G01N33/68 , H01J49/02
CPC分类号： H01J49/4225 , G01N33/6848 , H01J49/025 , H01J49/429
摘要： The invention generally relates to mass spectrometry via frequency tagging.

85. 发明公开

US20240087874A1 METHOD FOR DRIVING LINEAR ION TRAP AND MASS SPECTROMETER 审中-公开
公开(公告)号：US20240087874A1
公开(公告)日：2024-03-14
申请号：US18348753
申请日：2023-07-07
申请人： SHIMADZU CORPORATION
发明人： Masaru NISHIGUCHI
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/423 , H01J49/4265 , H01J49/429
摘要： A method for driving a linear ion trap having rod electrodes arranged so as to surround a central axis includes: an ion-introducing step for introducing ions into an ion-capturing space surrounded by the rod electrodes, and for capturing the ions by a multipole RF electric field created within the ion-capturing space; and an ion-ejecting step for creating both a DC electric field for ion extraction extending from an external area outside the ion-capturing space into the ion-capturing space through a space between two predetermined rod electrodes neighboring each other around the central axis among the plurality of rod electrodes and the multipole RF electric field, and for sequentially ejecting ions according to their m/z from the ion-capturing space toward the external area through the space between the two predetermined rod electrodes by changing at least one of the multipole RF electric field and the DC electric field.

86. 发明公开

US20240038524A1 MASS SPECTROMETER AND MASS SPECTROMETRY METHOD 审中-公开
公开(公告)号：US20240038524A1
公开(公告)日：2024-02-01
申请号：US18213974
申请日：2023-06-26
申请人： HITACHI, LTD.
发明人： Masuyuki SUGIYAMA , Shun KUMANO , Akihiro NOJIMA
IPC分类号： H01J49/42 , H01J49/06 , H01J49/00
CPC分类号： H01J49/4225 , H01J49/065 , H01J49/429 , H01J49/0031
摘要： The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.

87. 发明申请

US20180342382A1 SYSTEMS AND METHODS FOR CONDUCTING NEUTRAL LOSS SCANS IN A SINGLE ION TRAP 审中-公开
公开(公告)号：US20180342382A1
公开(公告)日：2018-11-29
申请号：US15985188
申请日：2018-05-21
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0036 , H01J49/0081 , H01J49/422 , H01J49/429
摘要： The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.

88. 发明授权

US10056244B1 Tuning multipole RF amplitude for ions not present in calibrant 有权
公开(公告)号：US10056244B1
公开(公告)日：2018-08-21
申请号：US15662811
申请日：2017-07-28
申请人： Thermo Finnigan LLC
发明人： Scott T. Quarmby , Joshua T. Maze , Nathaniel L. Sanders
IPC分类号： H01J3/14 , H01J49/42 , H01J49/04 , H01J49/36 , H01J49/10 , H01J49/02
CPC分类号： H01J49/429 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/04 , H01J49/062 , H01J49/10 , H01J49/36 , H01J49/4225 , H01J49/426
摘要： A mass spectrometry apparatus includes an ion source configured to generate ions; an ion guide configured to guide ions from the ion source towards a detector; the ion detector configured to detect ions; and a mass spectrometry controller. The mass spectrometry controller is configured to generate a tune curve for the ion guide; determine an observed low mass cutoff for the ion guide from the tune curve; calculate an effective r0 for the ion guide based on the observed low mass cutoff; determine an RF voltage based on the effective r0 and the RF frequency; apply the RF voltage to the ion guide; and perform a mass analysis of ions in a sample.

89. 发明授权

US09984864B2 Spatial zoom mode for accumulative trapped ion mobility spectrometry 有权
公开(公告)号：US09984864B2
公开(公告)日：2018-05-29
申请号：US15341250
申请日：2016-11-02
申请人： Bruker Daltonik GmbH
发明人： Oliver Räther , Melvin Andrew Park
IPC分类号： H01J49/42
CPC分类号： H01J49/429 , G01N27/622 , H01J49/421
摘要： The invention relates to the operation of ion mobility spectrometers based on gases pushing the ions over electrical field barriers, preferably in combination with mass spectrometers, and relates to trapped ion mobility spectrometers (“TIMS”). The invention proposes to accumulate and to scan the ions of a selected range of mobilities by using a long and flat electric field ramp created by additional voltages. By a voltage supplied at the beginning of the flat ramp, the lowest mobility of the mobility range of ions to be collected can be selected. By the difference of the voltages at the beginning and the end, the width of the mobility range is determined. The spatial zoom advantageously can collect considerable more ions of interest than a temporal zoom without severe losses by space charge effects, and more ions can be detected in the mass-mobility map.

90. 发明授权

US09685312B2 Removal of ions from survey scans using variable window band-pass filtering to improve intrascan dynamic range 有权
公开(公告)号：US09685312B2
公开(公告)日：2017-06-20
申请号：US14887215
申请日：2015-10-19
申请人： DH Technologies Development PTE. LTD.
发明人： Stephen A. Tate , Nic G. Bloomfield
IPC分类号： H01J49/06 , H01J49/00 , H01J49/42
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/429
摘要： Systems and methods are used to band-pass filter ions from a mass range. A full spectrum is received for a full scan of a mass range using a tandem mass spectrometer. A mass selection window of the full spectrum is selected and a set of tuning parameter values is selected. The tandem mass spectrometer is instructed to perform a scan of the mass selection window using the set of tuning parameter values. A spectrum is received for the scan from the tandem mass spectrometer. A band-pass filtered spectrum is created for the mass range that includes values from the spectrum for the mass selection window of the mass range. Systems and methods are also used to band-pass filter ions from two or more mass selection windows across the mass range and to filter out ions from a mass selection window between two band-pass mass selection windows.

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