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81. 发明申请

US20100112572A1 COMPOSITIONS, METHODS, AND KITS FOR FABRICATING CODED MOLECULAR TAGS 审中-公开
标题翻译：用于制备编码分子标签的组合物，方法和工具
公开(公告)号：US20100112572A1
公开(公告)日：2010-05-06
申请号：US12507016
申请日：2009-07-21
申请人： Timothy M. Woudenberg , Dar Bahatt , Muhammad A. Sharaf , Timothy Z. Liu , Serguei Ermakov , Charles R. Connell , Jens J. Hyldig-Nielsen , Benjamin Schroeder , Paolo Vatta
发明人： Timothy M. Woudenberg , Dar Bahatt , Muhammad A. Sharaf , Timothy Z. Liu , Serguei Ermakov , Charles R. Connell , Jens J. Hyldig-Nielsen , Benjamin Schroeder , Paolo Vatta
IPC分类号： C12Q1/68
CPC分类号： G01N33/533 , C12Q1/6816 , G01N33/532 , G01N2035/00158 , C12Q2565/102 , C12Q2563/179
摘要： The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern.
摘要翻译：本文的教导通常涉及包含用于检测分析物的制造的编码分子标签的探针。该教导还涉及用于制造编码分子标签的组合物，方法和试剂盒，其包含有序图案中的多个或报告基团。

82. 发明申请

US20100069258A1 Hydrophilic Labels for Biomolecules 有权
标题翻译：亲水标签生物分子
公开(公告)号：US20100069258A1
公开(公告)日：2010-03-18
申请号：US12560957
申请日：2009-09-16
申请人： Charles K. Brush , Kaizhang He , Peter T. Czemey , Matthias Wenzel
发明人： Charles K. Brush , Kaizhang He , Peter T. Czemey , Matthias Wenzel
IPC分类号： C40B30/04 , C07D209/02 , C07K14/00 , C07K16/00 , C07H19/20 , C07H21/00 , C12N9/96 , C07K14/42 , C07K14/575 , G01N21/00 , C12Q1/00 , C12Q1/02 , G01N21/64 , C12Q1/68 , G01N27/26
CPC分类号： C09B23/083 , C09B23/06 , G01N33/532 , G01N33/533 , G01N33/582 , G01N33/583
摘要： Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labeling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diastereomeric cyanines with high hydrophilicity and other desirable properties.
摘要翻译：用于光学的化合物，组合物和方法，包括用于标记生物分子如蛋白质和脱氧核糖核酸的荧光光学测定用于其检测和定量。该化合物是具有高亲水性和其它所需性质的非对映体花青。

83. 发明申请

US20100036102A1 NOVEL CHELATING AGENTS AND HIGHLY LUMINESCENT AND STABLE CHELATES AND THEIR USE 有权
标题翻译：新型冷凝剂和高亮度和稳定的螯合物及其使用
公开(公告)号：US20100036102A1
公开(公告)日：2010-02-11
申请号：US12580990
申请日：2009-10-16
申请人： Jari HOVINEN , Veli-Matti Mukkala , Harri Hakala , Jari Peuralahti
发明人： Jari HOVINEN , Veli-Matti Mukkala , Harri Hakala , Jari Peuralahti
IPC分类号： C07F5/00 , C07K17/02 , C07K16/00 , C07H21/04 , C07H21/02
CPC分类号： C07D401/14 , C07D213/38 , C07F9/58 , C07F9/6512 , C07F9/6515 , C07F9/6524 , G01N33/532
摘要： This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
摘要翻译：本发明涉及一组新型螯合剂，新螯合物，用所述螯合物或螯合剂标记的生物分子以及与所述螯合物，螯合剂或标记生物分子缀合的固体支持物。特别地，本发明涉及用于寡核苷酸或寡肽的固相合成的新型螯合剂以及如此获得的寡核苷酸和寡肽。

84. 发明申请

US20100029495A1 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US20100029495A1
公开(公告)日：2010-02-04
申请号：US12066584
申请日：2006-09-11
申请人： Juergen Schaefer
发明人： Juergen Schaefer
IPC分类号： C40B30/04 , C40B40/00 , C40B40/08 , C40B40/10 , C40B30/10
CPC分类号： G01N33/532 , C12Q2563/167 , G01N33/6851 , Y10T436/24
摘要： Provided is a set of mass labels, each mass label in the set comprising a mass marker moiety attached via a cleavable linker to a mass normalisation moiety, each mass label in the set having a common mass; wherein the set comprises a plurality of groups of mass labels, the mass of the mass marker moiety being the same for mass labels within a group, the mass of the mass marker moiety being different between groups; the mass marker moiety is capable of fragmentation into two or three fragments; and the mass of at least one fragment of the mass marker moiety differs between mass labels within a group.
摘要翻译：提供了一组质量标签，该组中的每个质量标签包含通过可切割连接体连接至质量标准化部分的质量标记部分，该组中的每个质量标签具有共同质量; 其中所述组包含多组质量标签，所述质量标记物部分的质量对于组内的质量标签是相同的，质量标记物部分的质量在组之间是不同的; 质量标记物部分能够分裂成两个或三个片段; 并且质量标记物部分的至少一个片段的质量在组内的质量标签之间不同。

85. 发明申请

US20090311806A1 GOLD-BINDING PROTEIN AND USE THEREOF 有权
公开(公告)号：US20090311806A1
公开(公告)日：2009-12-17
申请号：US12473203
申请日：2009-05-27
申请人： Hidenori Shiotsuka , Takeshi Imamura , Izumi Kumagai
发明人： Hidenori Shiotsuka , Takeshi Imamura , Izumi Kumagai
IPC分类号： G01N33/553
CPC分类号： G01N33/532 , C07K16/44 , C07K2317/21 , C07K2317/56 , C07K2317/622 , C07K2317/92
摘要： A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or a complex protein containing such a protein can be used for the detection of a target substance.

86. 发明申请

US20090258435A1 BIOTIN-RECEPTOR REAGENTS FOR SENSITIVITY MODULATION IN ASSAYS 审中-公开
标题翻译：用于测定灵敏度调节的生物受体试剂
公开(公告)号：US20090258435A1
公开(公告)日：2009-10-15
申请号：US12103245
申请日：2008-04-15
申请人： Sandra A. Lewisch , Pratap Singh , Viral Desai , Karen L. Krakowski , James E. Duffy
发明人： Sandra A. Lewisch , Pratap Singh , Viral Desai , Karen L. Krakowski , James E. Duffy
IPC分类号： G01N33/566 , G01N33/536
CPC分类号： G01N33/532 , G01N33/54393 , G01N33/566
摘要： Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophilicity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody to obtain an optimum assay sensitivity and/or dynamic range. In some embodiments the method comprises preparing two or more conjugates by selecting a set of parameters for each conjugate wherein the set of parameters is different for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要翻译：公开了设计用于分析物检测以获得最佳测定灵敏度和/或动态范围的测定中的抗体试剂的方法。抗体试剂是通过间隔基团与分析物的抗体连接的小分子的缀合物。该方法包括在共轭物的制备中控制包括间隔基团的疏水性或亲水性，间隔基团的长度，与抗体连接的小分子的分子数目和小分子到抗体以获得最佳测定灵敏度和/或动态范围。在一些实施方案中，该方法包括通过为每个缀合物选择一组参数来制备两种或多种缀合物，其中该组参数对于每个缀合物是不同的，使用每个缀合物进行分析物的测定，并选择用于测定缀合物提供最佳测定灵敏度和/或动态范围。

87. 发明授权

US07595198B2 Photocleavable isotope-coded affinity tags 失效
标题翻译：可透光同位素编码的亲和标签
公开(公告)号：US07595198B2
公开(公告)日：2009-09-29
申请号：US11582294
申请日：2006-10-17
申请人： Jerzy Olejnik , Kenneth J. Rothschild
发明人： Jerzy Olejnik , Kenneth J. Rothschild
IPC分类号： C07D495/04 , C07K1/00 , G01N33/68
CPC分类号： G01N33/532 , C07D495/04 , C07K1/1077 , C07K1/13 , C07K1/14 , C07K1/16 , C07K1/22 , G01N2458/15 , Y10T436/24
摘要： This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in vivo and in vitro sources. Agents comprise a detectable group bound to a photoreactive group. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed. The invention also relates to targets isolated with these conjugates which may be useful as pharmaceutical agents or compositions that can be administered to humans and other mammals.
摘要翻译：本发明涉及可用于从体内和体外来源的生物样品的复杂混合物如蛋白质和蛋白质片段检测和分离靶组分的试剂和缀合物。试剂包含与光反应性基团结合的可检测基团。缀合物包括通过共价界限偶联到底物的试剂，其可以通过施用电磁辐射被选择性地切割。目标可以用可检测分子标记的物质可以很容易地识别，并与物质的异源混合物分离。缀合物暴露于放射线以功能形式释放靶，完全不变。使用可光致发光的分子前体作为共轭物，标记可以并入大分子中，分离出新生大分子，并将标记完全除去。本发明还涉及用这些缀合物分离的靶，其可用作可以施用于人和其它哺乳动物的药剂或组合物。

88. 发明申请

US20090215032A1 ANALYTE DETECTION USING BARCODED POLYMERS 失效
标题翻译：使用BARCODED聚合物进行分析检测
公开(公告)号：US20090215032A1
公开(公告)日：2009-08-27
申请号：US11364856
申请日：2006-02-27
申请人： Eric Jon White , Rudolf Gilmanshin
发明人： Eric Jon White , Rudolf Gilmanshin
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N15/10 , C12N15/66 , C12Q1/6813 , G01N33/532 , G01N33/542 , G01N33/569 , C12Q2537/143 , C12Q2525/197 , C12Q2525/205 , C12Q2525/203 , C12Q2537/119
摘要： The invention relates to methods and systems for identifying, quantitating and/or analyzing analytes from samples. The analytes may be organic or inorganic in nature and include but are not limited to pathogens such as viruses.
摘要翻译：本发明涉及用于从样品中鉴定，定量和/或分析分析物的方法和系统。分析物本质上可以是有机或无机的，包括但不限于病原体如病毒。

89. 发明申请

US20090176279A1 Bioreactive agents 审中-公开
标题翻译：生物反应剂
公开(公告)号：US20090176279A1
公开(公告)日：2009-07-09
申请号：US12380886
申请日：2009-03-04
申请人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
发明人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
IPC分类号： C12P19/34 , C07H21/00
CPC分类号： C12Q1/6876 , A61K38/00 , A61K41/0042 , C07C205/45 , C07C205/57 , C07D207/404 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/6823 , G01N33/5306 , G01N33/532 , G01N33/58 , C12Q2523/319
摘要： This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed. The invention also relates to targets isolated with these conjugates which may be useful as pharmaceutical agents or compositions that can be administered to humans and other mammals. Useful compositions include biological agents such as nucleic acids, proteins, lipids and cytokines. Conjugates can also be used to monitor the pathway and half-life of pharmaceutical composition in vivo and for diagnostic, therapeutic and prophylactic purposes. The invention also relates to kits comprised of agents and conjugates that can be used for the detection of diseases, disorders and nearly any individual substance in a complex background of substances.
摘要翻译：本发明涉及可用于从复杂混合物检测和分离靶组分的试剂和缀合物，例如来自生物样品的核酸，来自体液的细胞和来自翻译反应的新生蛋白。试剂包含与光反应性部分结合的可检测部分。缀合物包括通过共价界限偶联到底物的试剂，其可以通过施用电磁辐射被选择性地切割。目标可以用可检测分子标记的物质可以很容易地识别，并与物质的异源混合物分离。缀合物暴露于放射线以功能形式释放靶，完全不变。使用可光致发光的分子前体作为共轭物，标记可以并入大分子中，分离出新生大分子，并将标记完全除去。本发明还涉及用这些缀合物分离的靶，其可用作可以施用于人和其它哺乳动物的药剂或组合物。有用的组合物包括生物制剂如核酸，蛋白质，脂质和细胞因子。缀合物也可用于监测药物组合物在体内和诊断，治疗和预防目的中的途径和半衰期。本发明还涉及可用于检测疾病，病症和物质复杂背景中的几乎任何单一物质的试剂和缀合物的试剂盒。

90. 发明申请

US20080287342A1 Compositions Comprising Modified Collagen and Uses Therefor 有权
标题翻译：包含改性胶原蛋白的组合物及其用途
公开(公告)号：US20080287342A1
公开(公告)日：2008-11-20
申请号：US11791425
申请日：2005-11-23
申请人： Michael Yu , Jennifer H. Elisseeff , Allen Y. Wang , Hyeseung J. Lee , Xiao Mo
发明人： Michael Yu , Jennifer H. Elisseeff , Allen Y. Wang , Hyeseung J. Lee , Xiao Mo
IPC分类号： A61K38/02 , C07K14/78 , C07K14/00 , C07K7/08 , C12N5/06 , A61P7/02 , C07K7/06 , C12Q1/02
CPC分类号： C07K14/78 , A61K38/10 , A61K38/16 , A61K47/60 , G01N33/532 , G01N33/587 , G01N2333/78
摘要： The invention provides modified collagen and related therapeutic and diagnostic methods.
摘要翻译：本发明提供了改进的胶原蛋白和相关的治疗和诊断方法。

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