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81. 发明申请

US20070249052A1 Cartilage Regeneration By Generation Of Chondrons Under High Concentrations Of Magnesium 审中-公开
标题翻译：软骨再生通过在高浓度镁下产生软骨细胞
公开(公告)号：US20070249052A1
公开(公告)日：2007-10-25
申请号：US10575232
申请日：2004-10-08
申请人： Frank Witte , Henning Windhagen , Volker Kaese , Frank Feyerabend
发明人： Frank Witte , Henning Windhagen , Volker Kaese , Frank Feyerabend
IPC分类号： C12N5/02
CPC分类号： A61L27/02 , A61L27/04 , A61L2430/06 , A61L2430/40 , C12N5/0655 , C12N2500/16 , C12N2500/32 , C12N2500/34 , C12N2500/42 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/23 , C12N2533/74 , C12N2533/76
摘要： The present invention relates to a method for the generation of chondrons and of cartilaginous tissue. In particular, the present invention relates to the ability of Mg ions to stimulate the growth and regeneration of chondrons, particularly of pseudo-chondrons as an intermediate in the regeneration and growth of cartilaginous tissue. Especially, Unphysiologically high extracellular concentrations of Mg are able to regenerate hyaline cartilage, elastic cartilage and/or fibrocartilage via the intermediate form of chondrons.
摘要翻译：本发明涉及产生软骨细胞和软骨组织的方法。特别地，本发明涉及Mg离子在软骨组织的再生和生长中刺激软骨细胞，特别是假软骨细胞的生长和再生的能力，作为中间体。特别地，非生物学上高的细胞外浓度的Mg能够通过中间形式的软骨再生透明软骨，弹性软骨和/或纤维软骨。

82. 发明授权

US07087431B2 Ex vivo generation of functional leukemia cells in a three-dimensional bioreactor 有权
标题翻译：在三维生物反应器中离体产生功能性白血病细胞
公开(公告)号：US07087431B2
公开(公告)日：2006-08-08
申请号：US09796830
申请日：2001-03-01
申请人： J. H. David Wu , Athanassios Mantalaris , Nicki Panoskaltsis
发明人： J. H. David Wu , Athanassios Mantalaris , Nicki Panoskaltsis
IPC分类号： C12N5/06
CPC分类号： G01N33/5011 , C12N5/0694 , C12N2501/22 , C12N2501/23 , C12N2501/39 , C12N2503/00 , C12N2531/00 , C12N2533/76 , C12N2533/78
摘要： The present invention provides cultured leukemia cells. The method comprises isolating mononuclear cells, which contain leukemia cells, culturing the leukemia cells in a chamber having a scaffolding covered or surrounded with culture medium, where the scaffolding allows for leukemia cells to have cell to cell contacts in three dimensions. The subject leukemia cells are useful for screening compounds which inhibit or stimulate leukemia cell function or formation.
摘要翻译：本发明提供培养的白血病细胞。该方法包括分离含有白血病细胞的单核细胞，在具有被培养基覆盖或围绕的支架的室中培养白血病细胞，其中支架允许白血病细胞在三维中具有细胞与细胞接触。受试者白血病细胞可用于筛选抑制或刺激白血病细胞功能或形成的化合物。

83. 发明申请

US20030144127A1 Manufacture of improved support matrices 失效
标题翻译：改进的支撑矩阵的制造
公开(公告)号：US20030144127A1
公开(公告)日：2003-07-31
申请号：US10168709
申请日：2002-09-09
发明人： Eva Berggren , Dag Lindstrom
IPC分类号： B01J019/00
CPC分类号： B01J20/285 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/28011 , B01J20/28016 , B01J20/28042 , B01J2219/00497 , B01J2220/52 , B01J2220/82 , C07B2200/11 , C07K1/042 , C07K1/16 , C08J3/28 , C12N5/0068 , C12N2533/76 , C12N2533/78
摘要： A method for the production of a cross-linked support matrix that in form of a bed will permit liquid flow velocities above 5 cm/h, preferably above 50 cm/h, to pass through the bed. The method is characterized in that it comprises the steps: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation. The use of a cross-linked support matrix produced by a method comprising the steps of: (a) providing a starting support matrix that has pendent unsaturated groups, and (b) subjecting said starting support matrix to electron beam or gamma-ray irradiation as a support matrix in liquid chromatography, cell culturing, step-wise solid phase synthesis of organic compounds, running catalytic reactions by the use of a solid phase bound catalyst.
摘要翻译：用于生产以床形式的交联载体基质的方法将允许高于5cm / h，优选地高于50cm / h的液体流速通过床。该方法的特征在于其包括以下步骤：（a）提供具有侧链不饱和基团的起始载体基质，和（b）使所述起始载体基质经受电子束或γ射线照射。使用通过包括以下步骤的方法产生的交联载体基质：（a）提供具有侧链不饱和基团的起始载体基质，和（b）使所述起始载体基质进行电子束或γ射线照射，液相色谱法中的支持基质，细胞培养，有机化合物的逐步固相合成，通过使用固相结合的催化剂进行催化反应。

84. 发明申请

US20030119107A1 Bioprocess for the generation of cells from spheroid-forming cells 失效
标题翻译：用于从球形细胞产生细胞的生物过程
公开(公告)号：US20030119107A1
公开(公告)日：2003-06-26
申请号：US10189642
申请日：2002-07-03
发明人： Stephen Dang , Peter W. Zandstra
IPC分类号： C12P021/06
CPC分类号： C12N5/0603 , C12M23/08 , C12M23/10 , C12M25/01 , C12M27/02 , C12N5/0012 , C12N5/0606 , C12N2533/76
摘要： The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES) cell-derived tissues. To counter this, the invention provides a novel bioprocess where aggregation of spheroid forming cells, such as embryonic stem cells and spheroids, such as EBs is controlled, such as by encapsulation of within a matrix. As a result, EBs can be generated with high efficiency and cultured in high cell density, well-mixed systems. Well-mixed conditions facilitate measurement and control of the bulk media conditions and allow for the use of scalable bioreactor systems for clinical production of tissue. Therefore, the invention enables generation of ES cell-derived tissue on a clinical scale. The invention is also applicable to any spheroid-forming cells and other types of pluripotent cells.
摘要翻译：本发明人鉴定了胚胎干细胞和胚状体（EB）的聚集作为难以产生大量胚胎干细胞（ES）细胞衍生组织的原因。为了解决这个问题，本发明提供了一种新颖的生物过程，其中例如通过在基质内封装来控制球形细胞如胚胎干细胞和球体如EB的聚集。结果，可以高效率地生成EB，并在高细胞密度，良好混合的系统中培养。良好混合的条件有助于测量和控制大量介质条件，并允许使用可扩展的生物反应器系统来临时生产组织。因此，本发明能够在临床规模上产生ES细胞衍生的组织。本发明也适用于任何球形细胞和其他类型的多能细胞。

85. 再颁专利

USRE38027E1 Preparation of agarose coated, solid agarose-collagen beads containing secretory cells 有权
标题翻译：制备含有分泌细胞的琼脂糖包被的固体琼脂糖胶原珠
公开(公告)号：USRE38027E1
公开(公告)日：2003-03-11
申请号：US09345196
申请日：1999-06-30
申请人： Kanti Jain , Albert L. Rubin , Barry Smith
发明人： Kanti Jain , Albert L. Rubin , Barry Smith
IPC分类号： A61K3512
CPC分类号： A61K9/1652 , A61K9/1658 , A61K9/5036 , A61K35/39 , A61K38/00 , A61K2035/126 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/54 , C12N2533/76
摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.
摘要翻译：生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。

86. 发明授权

US5053332A Agarose beads, preferably incorporating biological materials 失效
标题翻译：琼脂糖珠，优选掺入生物材料
公开(公告)号：US5053332A
公开(公告)日：1991-10-01
申请号：US383520
申请日：1989-07-24
申请人： Richard B. Cook , Richard B. Provonchee , Samuel Nochumson
发明人： Richard B. Cook , Richard B. Provonchee , Samuel Nochumson
IPC分类号： C12N5/00 , C12N11/10
CPC分类号： C12N11/10 , C12N5/0068 , C12N2533/76
摘要： A method for forming agarose beads, which may incorporate biological material at least partially labile at above 40.degree. C., in which an aqueous agarose solution is formed into bead-size portions which are gelled by contacting the portions with a cooled atmosphere, gas, and/or smooth hydrophobic surface, and then collected.
摘要翻译：一种用于形成琼脂糖珠的方法，其可以包含在40℃以上至少部分不稳定的生物材料，其中将琼脂糖水溶液形成为通过使所述部分与冷却的气氛接触而凝胶化的珠粒部分，气体，和/或疏水疏松表面，然后收集。

87. 发明授权

US12078633B2 Method for predicting and monitoring clinical response to immunomodulatory therapy 有权
公开(公告)号：US12078633B2
公开(公告)日：2024-09-03
申请号：US17501784
申请日：2021-10-14
申请人： BIOHOPE Scientific Solutions for Human Health S.L.
发明人： Javier Dotor De Las Herrerías , Marianna Di Scala , Verónica Sánchez , Isabel Portero Sánchez
IPC分类号： G01N33/50 , C07K16/28 , G01N33/574 , C12N5/078
CPC分类号： G01N33/5047 , C07K16/2818 , G01N33/57492 , C12N5/0634 , C12N2533/54 , C12N2533/76 , G01N33/5091 , G01N2800/245 , G01N2800/52
摘要： The present invention provides a method to quantitatively measure the response of a patient to an immune-modulator drug that will aid clinicians in the determination of the optimal combination/posology of immunosuppressant/immune-modulator drugs. In addition, this method will open the possibility for clinicians to make the necessary adjustments in immunosuppressive therapy, as a way to avoid organ rejection to actually take place. Furthermore, this method will significantly reduce side effects of immunosuppressant drugs, optimizing therapeutic scheme and dosages, enabling the determination of the most effective immunosuppression regimen at the lower dosages for each patient individually and monitoring of treatment efficiency along time, thus opening the door to treatment personalization.

88. 发明授权

US12010963B2 Medium and culture method for blueberry tissue culture 有权
公开(公告)号：US12010963B2
公开(公告)日：2024-06-18
申请号：US17720652
申请日：2022-04-14
申请人： SHANDONG DAFENGYUAN AGRICULTURE CO., LTD.
发明人： Yangyan Zhou , Weijian Sun , Wenxiu Chen , Aowei Mo , Peng Guo , Penghao Xu
IPC分类号： A01H6/36 , A01G22/05 , A01G24/15 , A01G24/22 , A01H4/00 , A01H5/08 , C12N5/00 , C12N5/04
CPC分类号： A01H4/002 , A01G22/05 , A01G24/15 , A01G24/22 , A01H4/001 , A01H5/08 , A01H6/368 , C12N5/0025 , C12N5/04 , C12N2500/05 , C12N2500/32 , C12N2500/34 , C12N2500/35 , C12N2500/38 , C12N2500/60 , C12N2501/30 , C12N2533/76
摘要： The invention provides a callus induction medium for blueberry tissue culture, taking woody plant medium (WPM) as a basic medium, and including: 0.5-5.0 mg/L forchlorfenuron (CPPU) and 0.1-0.4 mg/L 2-isopentenyladenine (2-ip). The present invention also provides a callus culture method for blueberry, including inoculating the blueberry explant into the above callus induction medium to conduct induction culture in order to form blueberry callus. The present invention also discloses the medium combination and culture method to culture the above blueberry callus to blueberry tissue culture plant. For the above medium and culture method, the differentiation effect is good, efficiency is high, one can conduct continuous differentiation, and the effect is better on multiple varieties.

89. 发明公开

US20230383260A1 Multi-Layer Film Comprising Nutrient Material for Cell Culture, Method for Preparing Same, and Use of Same 审中-公开
公开(公告)号：US20230383260A1
公开(公告)日：2023-11-30
申请号：US18031415
申请日：2021-10-12
申请人： CJ CHEILJEDANG CORPORATION
发明人： Hyeong Rae Lee , Seung Yeon Lee , Seung Jin Baek , Jin Kee Hong , So Hyeon Park
IPC分类号： C12N5/077 , A23L13/00
CPC分类号： C12N5/0658 , A23L13/00 , C12N2533/72 , C12N2533/78 , C12N2533/76 , C12N2537/10
摘要： The present application relates to a multi-layer film comprising a nutrient material for cell culture, a method for preparing same, and the use of same. The multi-layer film of the present application can be utilized for cell culture for preparing cultured meat.

90. 发明授权

US11767514B2 Three-dimensional printed organs, devices, and matrices 有权
公开(公告)号：US11767514B2
公开(公告)日：2023-09-26
申请号：US16669453
申请日：2019-10-30
申请人： Prellis Biologies, Inc.
发明人： Melanie P. Matheu , Kathryn J. Parkinson , Emma R. Moulton
IPC分类号： C12N5/07 , C12N5/00 , C12N5/071 , C12M3/04 , C12N5/077 , C12N5/0775 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C07K16/10 , C07K16/00
CPC分类号： C12N5/0671 , C07K16/00 , C07K16/1081 , C12M3/04 , C12N5/0018 , C12N5/0062 , C12N5/064 , C12N5/0635 , C12N5/0637 , C12N5/0638 , C12N5/0667 , C12N5/0669 , C12N5/0691 , C12N5/0697 , C12N5/0698 , C07K2317/21 , C07K2317/76 , C12N2502/09 , C12N2502/094 , C12N2502/1114 , C12N2502/1121 , C12N2502/1323 , C12N2502/45 , C12N2506/1384 , C12N2506/28 , C12N2510/02 , C12N2513/00 , C12N2527/00 , C12N2533/30 , C12N2533/54 , C12N2533/74 , C12N2533/76 , C12N2533/80 , C12N2539/10
摘要： Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices.

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