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    • 81. 发明申请
    • NOVEL MULTIFUNCTIONAL INITIATORS FOR ANIONIC POLYMERIZATION AND POLYMERS THEREFROM
    • 用于阴离子聚合的新型多功能发射体及其聚合物
    • US20090326176A1
    • 2009-12-31
    • US12344653
    • 2008-12-29
    • Yuan-Yong Yan
    • Yuan-Yong Yan
    • C08F4/48C07F1/02C08G73/00
    • C08F4/488B60C1/00C07C211/65C08C19/44C08F36/06C08G73/0213C08L9/06
    • The embodiments of the invention relate to a multifunctional lithiated amine-containing compound comprising at least two molecules of lithiated amine in a molecule of the compound. In one embodiment, the compound has a formula where x is an integer of 1 or more, Q is (a) an element selected from the group consisting of O, S, N, P and Si or (b) an alkylene group having from 1 to 20 methylene groups, and R1 and R2 are the same or different and are selected from the group consisting of alkyls, cycloalkyls and aralkyls containing from 1 to 20 carbon atoms. In another embodiment, the compound comprises cyclic lithio amines and has a formula: where x is 1 or more, R3, R4 and R5 are the same or different and represent alkylene groups containing from 3 to 20 carbon atoms.
    • 本发明的实施方案涉及在化合物的分子中包含至少两个锂化胺分子的多官能含锂化胺化合物。 在一个实施方案中,该化合物具有其中x为1或更大的整数的式,Q为(a)选自O,S,N,P和Si的元素或(b) 1至20个亚甲基,R 1和R 2相同或不同,并且选自含有1至20个碳原子的烷基,环烷基和芳烷基。 在另一个实施方案中,该化合物包含环状硫代胺并具有下式:其中x为1或更多,R 3,R 4和R 5相同或不同,并且表示含有3至20个碳原子的亚烷基。
    • 85. 发明申请
    • Biodegradable polyacetals
    • 可生物降解聚缩醛
    • US20040166089A1
    • 2004-08-26
    • US10375705
    • 2003-02-25
    • Lei YuSang VanShouping JiKenji Matsumoto
    • A61K031/785C08G063/48C08G063/91
    • C08G73/0213A61K47/59C08G65/002
    • A polymer comprising recurring units represented by formula (I): 1 wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of null(CH2)2null, null(CH2)2nullOnull(CH2)2null, null(CH2)2nullOnull(CH2)2nullOnull(CH2)2null, and null(CH2)3nullNHC(O)null(CH2)6nullC(O)NHnull(CH2)3null is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.
    • 一种包含由式(I)表示的重复单元的聚合物:其中X选自C(O)OR 1,C(O)SR 1,C(O)NR 1 R 2 >和VZ,其中R 1和R 2各自独立地选自氢,C 1至C 10烷基和C 6至C 10芳基,其中V是不稳定的连接基团,并且其中Z被选择 由聚(乙烯亚胺),聚(丙烯亚胺),聚(赖氨酸),PAMAM树枝状聚合物,八胺树枝状聚合物和十六胺树枝状聚合物组成的组中; 并且其中Y选自 - (CH 2)2 - , - (CH 2)2 -O-(CH 2)2 - , - (CH 2)2 -O - (CH 2)2 -O - (CH 2)2 - 和 - (CH 2)3 -NHC(O) - (CH 2)6 -C(O)NH-(CH 2)3 - 可用于核酸递送应用。 式(I)的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。 在优选的实施方案中,在式(I)的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。
    • 88. 发明授权
    • Zwitterionic polyamines and process for their production
    • 两性离子多胺及其生产工艺
    • US06673890B1
    • 2004-01-06
    • US10030989
    • 2002-01-16
    • Dieter BoeckhOliver BorzykMichael EhleRalf NöerenbergEugene P. GosselinkJeffrey S. DuPontRobert H. RohrbaughKenneth N. PriceRandall S. Deinhammer
    • Dieter BoeckhOliver BorzykMichael EhleRalf NöerenbergEugene P. GosselinkJeffrey S. DuPontRobert H. RohrbaughKenneth N. PriceRandall S. Deinhammer
    • C08G7302
    • C08G73/0213C08G73/02C08G73/0226C08G73/0273C11D3/3723
    • A zwitterionic polyamine comprising a linear or branched hydrophobic polyamine backbone having 2 to 10 tertiary amino nitrogen atoms and a spacer between two tertiary nitrogen atoms wherein the spacer is, for example selected from C8-C16-alkylene, C5-C15-cyloalkylene, wherein in formula (IV) R═C1- to C22-alkyl or C7-C22-aralkyl and n=3 to 6, at least one tertiary amine end group of the polyamine backbone contains two groups having formula (V) or (VI), wherein A means an ethylene oxide unit, a propylene oxide unit, a unit of butylene oxides and a tetrahydrofuran unit, n is a number of from 1 to 50, X is an anionic group such as —SO3M, with the proviso that in formula (VI) one X may also be hydrogen and M is hydrogen, alkai metal or ammonium, or contains one group of formula (V) or (VI) and one group selected from radicals consisting of formula (VII), C1- to C22-alkyl and C7-C22-aralkyl the meaning of A and n is the same as in formula (V) or (VI), said zwitterionic polyetherpolyamine having a molecular weight up to 9000 and optionally containing up to 100% of the nitrogen atoms quaternize, and a process for the production of zwitterionic polyamines by alkoxylating said polyamines, introducing anionic groups into the alkoxylated polyamines and optionally quaternizing them before or after the introduction of anionic groups. The zwitterionic polyamines are used in detergents.
    • 包含具有2至10个叔氨基氮原子的直链或支链疏水性多胺主链和两个叔氮原子之间的间隔基的两性离子多胺,其中间隔基例如选自C 8 -C 16亚烷基,C 5 -C 15亚环烷基,其中在 式(Ⅳ)R = C 1〜C 22 - 烷基或C 7 -C 22 - 芳烷基,n = 3〜6,多胺骨架的至少一个叔胺端基含有具有式(Ⅴ)或(VI)的两个基团,其中 A表示环氧乙烷单元,环氧丙烷单元,环氧丁烷单元和四氢呋喃单元,n为1至50的数,X为-SO 3 M等阴离子基团,条件是在式(VI )一个X也可以是氢,M是氢,烷基金属或铵,或含有一组式(Ⅴ)或(Ⅵ)和一组选自由式(Ⅶ),C 1至C 22 - 烷基和 C7-C22-芳烷基,A和n的含义与式(Ⅴ)或(Ⅵ)中相同,所述两性离子聚醚多胺 分子量高达9000,任选地含有多达100%的氮原子季铵化,以及通过将所述多胺烷氧化生产两性离子多胺的方法,将阴离子基团引入到烷氧基化多胺中,并且在引入之前或之后任选季铵化 的阴离子基团。 两性离子多胺用于洗涤剂中。