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81. 发明授权

US5698406A Disposable device in diagnostic assays 失效
标题翻译：诊断测定中的一次性装置
公开(公告)号：US5698406A
公开(公告)日：1997-12-16
申请号：US414331
申请日：1995-03-30
申请人： Cheryl A. Cathey , Henry L. Schwartz , Tom Saul , Jeffrey D. Langford
发明人： Cheryl A. Cathey , Henry L. Schwartz , Tom Saul , Jeffrey D. Langford
IPC分类号： G01N33/48 , B01F13/00 , B01F13/08 , B01L3/00 , C12M1/34 , C12Q1/00 , G01N33/52 , G01N33/543 , G01N35/00 , G01N33/53 , G01N33/558
CPC分类号： B01L3/50273 , B01F13/0059 , B01F13/0818 , B01L3/5027 , B01L3/502746 , G01N33/54366 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , B01L3/502738 , G01N2035/00267 , Y10S435/81 , Y10S435/973 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： A disposable diagnostic device and method of its use are provided. The device comprises a housing containing first and second flow paths orthogonal to each other. The first flow path commences at a sample addition port and continues through a transport channel which feeds sample to an incubation area by means of capillary flow. The incubation area comprises a signal producing system and is underneath an optically-clear window. The first flow path terminates in a top waste reservoir which receives sample and wash fluid. The second flow path begins on one side of the incubation area at an inlet port over a side reagent reservoir. Liquid flows along the second flow path from the side reagent reservoir across the incubation area into the side waste reservoir. The incubation area may comprise agitation means for homogenous dispersion of reagent into liquid. Various reagents of a signal producing system may be contained within the device and the necessary liquids added automatically by appropriate instrumentation, so as to have the assay carried out automatically, without technician involvement, providing an accurate and sensitive determination.
摘要翻译：提供了一次性诊断装置及其使用方法。该装置包括容纳彼此正交的第一和第二流动路径的壳体。第一流路在样品加入口处开始并继续通过运送通道，其通过毛细管流将样品送入孵育区。孵化区包括信号产生系统，并在光学透明的窗口下方。第一流路终止于接收样品和洗涤流体的顶部废物储存器中。第二流路在侧试剂储存器的入口处从孵化区的一侧开始。液体沿着第二流动路径从侧面试剂储存器流过孵化区域流入侧面废物储存器。孵育区域可以包括用于将试剂均匀分散到液体中的搅拌装置。信号产生系统的各种试剂可以包含在装置内，并且通过适当的仪器自动加入必需的液体，以便在没有技术人员参与的情况下自动进行测定，提供精确和灵敏的测定。

82. 发明授权

US5547280A Magnetic stirrer with a sealed glass housing 失效
标题翻译：带有密封玻璃外壳的磁力搅拌器
公开(公告)号：US5547280A
公开(公告)日：1996-08-20
申请号：US394971
申请日：1995-02-27
申请人： Alfred Wanninger, deceased , by Peter Wanninger, heir
发明人： Alfred Wanninger, deceased , by Peter Wanninger, heir
IPC分类号： B01F13/08
CPC分类号： B01F13/0818
摘要： A magnetic stirrer (1) has a two-part housing (2), wherein the lower part (3) contains a drive motor (5) and its controlling, while the upper part (4) forms the mounting surface for a stirring container that holds the stirring magnet, and wherein the separating surface of the two parts (3) and (4) runs approximately horizontal when in the working position. The upper part (4) of this housing (2) is made of glass and the edge (8) of this upper part (4), when in its working position, is tightly pressed against an opposing surface (9) of the lower part (3), and is possibly even bonded thereto. The edge (8) can have a widening (10) that engages into a corresponding undercut (11) of the lower part (3). This provides a very simple and economical design for the magnetic stirrer (1), but one which is nevertheless also tightly sealed and impervious to aggressive vapors.
摘要翻译：磁力搅拌器（1）具有两部分壳体（2），其中下部（3）包含驱动马达（5）并进行控制，而上部（4）形成用于搅拌容器的安装表面，保持搅拌磁体，并且其中两个部分（3）和（4）的分离表面在工作位置时大致水平地延伸。该壳体（2）的上部（4）由玻璃制成，并且该上部（4）的边缘（8）在其工作位置被紧紧地压靠在下部的相对表面（9）（3），并且可能甚至结合到其上。边缘（8）可以具有接合到下部（3）的相应底切（11）中的加宽（10）。这为磁力搅拌器（1）提供了一种非常简单和经济的设计，但仍然密封并且不会侵蚀蒸气。

83. 发明授权

US5340449A Apparatus for electroelution 失效
标题翻译：电洗脱设备
公开(公告)号：US5340449A
公开(公告)日：1994-08-23
申请号：US965862
申请日：1992-10-23
申请人： Ashok K. Shukla
发明人： Ashok K. Shukla
IPC分类号： B01D57/02 , B01D61/28 , B01D61/42 , B01F13/08 , C12N15/10 , G01N1/34 , G01N27/447
CPC分类号： B01D61/422 , B01D57/02 , B01D61/28 , B01D61/425 , B01F13/0818 , C12N15/101 , G01N27/4473 , G01N2001/4016
摘要： This invention involves the elution of macromolecules such as proteins, deoxyribonucleic acid(DNA), ribonucleic acid(RNA) from solid phase matrix such as polyacrylamide, agarose and membranes such as polyvinyl difluoride (PVDF) in an electric field. The elution chamber shown in FIG. 1 consists of two separate screws 9, 9a and attachable chamber 1. The screw well 8 holds the gel matrix containing the macromolecules and is separated by the bottom chamber 1 with a membrane 5 with a nominal molecular weight cutoff higher than the macromolecule. On the other hand, the macromolecule is retained in the well 1 by introducing another membrane 6 having a molecular weight cutoff lower than the molecular weight of the macromolecule. Alternatively, macromolecules separated on membrane, e.g. PVDF, are held in a Teflon or plastic membrane holder 11. This holder can fit inside well 8 in screw 9. In addition, chamber 1 contains a well 7. The macromolecules migrate through the electrophoretic field and are concentrated in well 7. Since the volume of the well 7 is predetermined (10 ul--one ml or more), results in concentration of the macromolecules. Next, the chamber 1 is unscrewed from the top screw 8 and closed with a screw without a hole 13, and the entire device is submerged into a dialysis buffer. Following dialysis for a given time, the fluid above the bottom screw 9a itself and the membrane beneath it are removed. The sample is taken out from hole 7. If further concentration of the sample is required, then following removal of the fluid above the screw 9a, the entire device is transferred to a vacuum desiccator and concentrated to any desired volume.
摘要翻译：本发明涉及在电场中从固相基质如聚丙烯酰胺，琼脂糖和膜如聚二氟乙烯（PVDF）等洗脱大分子如蛋白质，脱氧核糖核酸（DNA），核糖核酸（RNA）。图1所示的洗脱室。 1由两个单独的螺钉9,9a和可连接室1组成。螺旋孔8保持含有大分子的凝胶基质，并由底部室1与膜5隔离，其中标称分子量截止值高于大分子。另一方面，通过引入分子量低于高分子分子量的另一膜6，将大分子保留在孔1中。或者，在膜上分离的大分子，例如 PVDF被保持在特氟隆或塑料膜保持器11中。该保持器可以装配在螺钉9中的孔8内。另外，腔室1包含孔7.大分子迁移通过电泳场并且集中在井7.由于孔7的体积是预定的（10ul-1ml或更大），导致大分子的浓度。接下来，将腔室1从顶部螺钉8拧下，并用不带孔13的螺丝封闭，并将整个装置浸入透析缓冲液中。在给定时间透析后，去除底部螺丝9a本身上方的流体和其下面的膜。样品从孔7中取出。如果需要进一步浓缩样品，则在除去螺杆9a上方的流体之后，将整个装置转移至真空干燥器并浓缩至任何所需体积。

84. 发明授权

US4911556A Turbulent stirring unit 失效
标题翻译：湍流搅拌机
公开(公告)号：US4911556A
公开(公告)日：1990-03-27
申请号：US324676
申请日：1989-03-17
申请人： Franklin Lim , William H. Bingham , Richard D. Moss
发明人： Franklin Lim , William H. Bingham , Richard D. Moss
IPC分类号： B01F11/00 , B01F13/08
CPC分类号： B01F11/0082 , B01F13/0818
摘要： Efficient mixing is promoted in a turbulent stirring unit by providing an agitator with flexible finger-like appendages and by varying the rate of rotation of a rotating magnetic field such that the fingers execute an undulatory motion, disrupting laminar flow and tending to collapse the liquid vortex. Motor control for controlling the fluctuation of the rotating magnetic field may provided by simple and economical electronic or electromechanical means. The control unit may be separately configured to control a number of other pieces of equipment, either in common or independently. The controller also may be integrated into stirrers, vortexers or shaker tables or externally provided to control existing units.
摘要翻译：通过提供具有柔性指状附属物的搅拌器和通过改变旋转磁场的旋转速率使得手指执行波动运动，扰乱层流并倾向于使液体涡流折叠来在湍流搅拌单元中促进高效混合。用于控制旋转磁场波动的电动机控制可以通过简单和经济的电子或机电装置来提供。控制单元可以被单独地配置成控制多个设备的共同或独立的数量。控制器还可以集成到搅拌器，涡旋器或振动台中，或者外部设置以控制现有的单元。

85. 发明授权

US4808348A Microgravity carbonator 失效
标题翻译：微重碳酸器
公开(公告)号：US4808348A
公开(公告)日：1989-02-28
申请号：US49569
申请日：1987-05-14
申请人： Arthur G. Rudick , Kenneth G. Smazik , Leonard F. Antao
发明人： Arthur G. Rudick , Kenneth G. Smazik , Leonard F. Antao
IPC分类号： A23L2/54 , B01F3/04 , B01F7/04 , B01F13/08
CPC分类号： B01F3/04808 , B01F13/0818 , Y10S261/07
摘要： A carbonator system consisting of a holding tank divided into an upper and lower chamber may be used on earth or in the microgravity conditions of outer space. A first embodiment involves first introducing water and then carbon dioxide into the lower chamber of the holding tank. Pressure is then exerted on a moveable piston in this tank to cause the piston to reduce the volume of the lower chamber housing the carbon dioxide and water. This action plus the action of an agitator, drives the carbon dioxide into solution. An alternative embodiment is disclosed wherein carbon dioxide is first introduced into the lower chamber of the holding tank. Water is next introduced into this lower chamber such that it is completely filled with both water and carbon dioxide. While the water is being introduced, an agitator is used to aid mixing of this water and carbon dioxide to form carbonated water. The agitator may consist of a bar contained within the lower chamber of the holding tank. Circumferentially surrounding the holding tank, a series of electro-magnetic coils are provided. These coils influence the agitator bar via magnetic force to cause rotation of this bar about a longitudinal axis of the holding tank. This agitator may also be reciprocated along this longitudinal axis. A control system is also provided for operating the carbonator. This control system includes a microcontroller, piston position sensors, controllers for various valves and controls for the agitator.
摘要翻译：由分为上下室的容纳罐组成的碳酸化器系统可以在地球上或在外层空间的微重力条件下使用。第一实施例涉及首先将水，然后将二氧化碳引入到容纳槽的下腔室中。然后将压力施加在该罐中的可移动活塞上，以使活塞减小容纳二氧化碳和水的下腔室的体积。这个动作加上搅拌器的作用，驱使二氧化碳溶解。公开了一种替代实施例，其中首先将二氧化碳引入到容纳槽的下腔室中。然后将水引入该下室，使得其完全充满水和二氧化碳。当引入水时，使用搅拌器来帮助混合该水和二氧化碳以形成碳酸水。搅拌器可以由容纳在容纳槽的下腔室内的杆组成。周向围绕储罐，提供一系列电磁线圈。这些线圈通过磁力影响搅拌棒，从而使该棒围绕容纳槽的纵向轴线旋转。该搅拌器也可以沿该纵向轴线往复运动。还提供了用于操作碳酸化器的控制系统。该控制系统包括微控制器，活塞位置传感器，用于各种阀门的控制器和用于搅拌器的控制器。

86. 发明授权

US4715217A Determining organic compounds using a membrane 失效
标题翻译：使用膜测定有机化合物
公开(公告)号：US4715217A
公开(公告)日：1987-12-29
申请号：US903535
申请日：1986-09-04
申请人： Brenton S. Coyne , Andrew J. Strandjord , Mark W. Spence , Reid S. Willis , Robert A. Bredeweg , Timothy S. Stevens
发明人： Brenton S. Coyne , Andrew J. Strandjord , Mark W. Spence , Reid S. Willis , Robert A. Bredeweg , Timothy S. Stevens
IPC分类号： B01D61/24 , G01N1/10 , G01N1/22 , G01N1/38 , G01N30/00 , G01N33/04 , G01N33/18 , G01N35/08 , B01D15/08
CPC分类号： B01D61/28 , B01D61/18 , B01D69/04 , B01D71/70 , B01F13/0818 , G01N1/10 , G01N2001/383 , G01N33/04 , G01N33/1826
摘要： The invention relates to a membrane assisted analytical chemical method for the determination of the concentration of an organic compound in an aqueous matrix. The membrane partitions the matrix from a receiving fluid. The organic compound permeates the membrane and passes into the receiving fluid which is then analyzed for the permeated compound by, for example, liquid or gas chromatography. The membrane is selected to prevent contamination of the receiving fluid from otherwise interferring components of the matrix. The concentration of the organic compound is above its solubility limit in water which would ordinarily prevent effective use of such a membrane assisted method. However, when the organic compound is emulsified with, for example, a surfactant, then a membrane assisted method is successful. The sensitivity of the method can be improved by using a thermal focusing/gas chromatography technique to concentrate the permeated organic compound from the receiving fluid and the membrane can be protected from physical damage by enclosing it in a perforate structure.
摘要翻译：本发明涉及用于测定含水基质中有机化合物浓度的膜辅助分析化学方法。膜从接收流体分隔基质。有机化合物渗透膜并进入接收流体，然后通过例如液体或气相色谱分析透过化合物。选择膜以防止接收流体污染基质的其他干扰成分。有机化合物的浓度高于其在水中的溶解度极限，这通常将妨碍有效使用这种膜辅助方法。然而，当有机化合物用例如表面活性剂乳化时，则膜辅助方法是成功的。通过使用热聚焦/气相色谱技术将渗透的有机化合物从接收流体中浓缩，可以提高该方法的灵敏度，并且可以通过将膜封闭在穿孔结构中来保护膜免受物理损伤。

87. 发明授权

US4676955A Instrument to measure catalytic reaction rates 失效
标题翻译：测量催化反应速率的仪器
公开(公告)号：US4676955A
公开(公告)日：1987-06-30
申请号：US559711
申请日：1983-12-09
申请人： Jozsef M. Berty
发明人： Jozsef M. Berty
IPC分类号： B01F13/08 , B01J8/02
CPC分类号： B01J8/02 , B01F13/0818 , B01J2208/00061 , B01J2208/0007 , B01J2208/00407 , B01J2208/00539 , B01J2208/00548
摘要： A shaftless instrument achieves mixing by a rotor floating on a solution in association with an external magnet or magnetic field. The magnet is driven by a motor located outside of but in close proximity to said instrument. In one embodiment, a feed inlet is located in the vicinity of the lower portion of said instrument and communicates with the bottom interior of said instrument in the vicinity of the rotor location. During operation, a fluid feed supports said rotor a small distance above the instrument bottom and enables it to rotates above the fluid feed location.
摘要翻译：无轴仪器通过与外部磁体或磁场相关联的浮动在溶液上的转子进行混合。磁体由位于所述仪器外部但靠近所述仪器的电机驱动。在一个实施例中，进料口位于所述仪器的下部附近，并与所述仪器的底部内部在转子位置附近连通。在操作期间，流体进料支撑所述转子在仪器底部上方一小段距离，并使其能够在流体供给位置上方旋转。

88. 发明授权

US4498785A Floating magnetic stirrer for culture medium 失效
标题翻译：用于培养基的浮动磁力搅拌器
公开(公告)号：US4498785A
公开(公告)日：1985-02-12
申请号：US432128
申请日：1982-09-30
申请人： Norman A. de Bruyne
发明人： Norman A. de Bruyne
IPC分类号： B01F13/08 , C12M1/02 , C12M3/02
CPC分类号： C12M23/08 , B01F13/0818 , C12M23/50 , C12M23/56 , C12M27/02
摘要： A stirrer for stirring liquid in a flask comprises a magnetically attractable member formed by or supported by a buoyancy chamber, the stirrer having less density than the liquid to be stirred; the stirrer may include an impeller. A method of stirring a liquid comprising introducing liquid and a buoyant, magnetically attractable stirrer into a vessel, and causing a rotating magnetic field to rotate the stirrer.
摘要翻译：用于在烧瓶中搅拌液体的搅拌器包括由浮力室形成或由浮力室支撑的磁吸引构件，该搅拌器的密度小于待搅拌液体的密度; 搅拌器可以包括叶轮。一种搅拌液体的方法，包括将液体和浮力的磁吸引搅拌器引入容器中，并引起旋转磁场使搅拌器旋转。

89. 发明授权

US4214874A Combination and method for mixing the contents of a blood collection tube and thereafter removing the mixing element 失效
标题翻译：用于混合采血管的内容物并随后除去混合元件的组合和方法
公开(公告)号：US4214874A
公开(公告)日：1980-07-29
申请号：US10234
申请日：1979-02-08
申请人： Fred K. White
发明人： Fred K. White
IPC分类号： A61B5/15 , B01F11/00 , B01F13/08 , B01L3/14 , G01N33/16
CPC分类号： B01L3/5082 , A61B5/150022 , A61B5/150343 , A61B5/150587 , A61B5/150717 , A61B5/150755 , B01F11/0082 , B01F13/0818 , Y10S220/19 , Y10T436/25
摘要： Combination and method for mixing a blood sample and an anticoagulant within a collection tube and for then capturing, removing and discarding the mixing element without danger of direct contact between the blood sample and the technician. The full combination includes a blood collection tube, at least one resilient end cap for the tube having a cavity which extends well beyond that tube when the cap is in place, a magnetic element slidable within the tube and receivable in the cap, and a magnet for shifting the magnetic element. After being directed into the cap following a mixing operation, the blood-covered magnetic element may be held within the cavity by finger pressure on the cap and discarded along with the cap.
摘要翻译：用于在采集管内混合血液样品和抗凝血剂，然后捕获，去除和丢弃混合元件的组合和方法，而不会在血液样本和技术人员之间直接接触的危险。完整的组合包括采血管，用于管的至少一个弹性端盖，其具有当盖位于适当位置时远远超过该管延伸的空腔，可在管内滑动并可接收在盖中的磁性元件，以及磁体用于移动磁性元件。在混合操作之后被引导到盖中之后，血液覆盖的磁性元件可以通过手指压在盖子上而保持在腔内，并与盖一起被丢弃。

90. 发明授权

US4054270A Micro mixing apparatus and method 失效
标题翻译：微混合装置及方法
公开(公告)号：US4054270A
公开(公告)日：1977-10-18
申请号：US671752
申请日：1976-03-30
申请人： Robert E. Gugger , Samuel M. Mozersky
发明人： Robert E. Gugger , Samuel M. Mozersky
IPC分类号： B01F13/00 , B01F13/08
CPC分类号： B01F13/0059 , B01F13/0818
摘要： An apparatus having a tubular shaped mixing chamber in which is enclosed a coated bar magnet for thoroughly mixing multiple streams of continuously flowing individual solutions. Movement of the coated bar magnet is restricted to yawing, pitching, and rolling by designed space limitations. The bar magnet is activated by placing the chamber over or in close proximity to a magnetic stirrer.
摘要翻译：一种具有管状混合室的装置，其中封装有涂覆的棒状磁体，用于充分混合多个连续流动的单独溶液流。涂层棒磁体的运动受限于设计空间限制的偏航，俯仰和滚动。通过将腔室放置在磁力搅拌器上或紧邻磁力搅拌器来激活棒状磁体。

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