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81. 发明授权

US06939342B2 System and method for evaluating a secondary LASIK treatment 有权
标题翻译：用于评估二次LASIK治疗的系统和方法
公开(公告)号：US06939342B2
公开(公告)日：2005-09-06
申请号：US10318443
申请日：2002-12-12
申请人： Howard P. Markman
发明人： Howard P. Markman
IPC分类号： A61B3/10 , A61B3/107 , A61B19/00 , A61F9/01 , A61B18/18
CPC分类号： A61B3/107 , A61B3/1005 , A61B34/10 , A61F9/00806 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A method and system are disclosed for evaluating the safety of a prospective secondary LASIK treatment to correct a person's vision. The difficulties with making an accurate, direct measurement of corneal thickness of a cornea having a pre-existing keratectomy are overcome by using pre-LASIK topography and pachymetry measurements, and per- and post-LASIK wavefront measurements to determine post-LASIK corneal thickness, and thus the suitability and safety of a prospective secondary LASIK procedure. A system embodiment includes diagnostic and computing platforms for generating and analyzing data, and a device readable medium for storing and transferring an instruction to a laser ablation system.
摘要翻译：公开了一种用于评估预期的次级LASIK治疗以校正人的视力的安全性的方法和系统。通过使用前LASIK拓扑和深度测量法以及LASIK波前测量和后LASIK波前测量来克服具有预先存在的角膜切除术的角膜的角膜厚度的准确，直接测量的难度，以确定LASIK角膜后厚度，并因此预期的次级LASIK手术的适用性和安全性。系统实施例包括用于生成和分析数据的诊断和计算平台，以及用于存储和传送指令给激光烧蚀系统的设备可读介质。

82. 发明申请

US20050143717A1 Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating 审中-公开
$Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating$
标题翻译：使用粘贴涂层的上皮下或腔内角膜镶嵌治疗屈光不正的方法
公开(公告)号：US20050143717A1
公开(公告)日：2005-06-30
申请号：US10784169
申请日：2004-02-24
申请人： Gholam Peyman
发明人： Gholam Peyman
IPC分类号： A61B17/24 , A61B18/18 , A61F9/00 , A61F9/008 , A61F9/01 , A61F9/013 , A61B18/20
CPC分类号： A61F9/008 , A61F9/0017 , A61F9/00808 , A61F9/00812 , A61F9/00819 , A61F9/00836 , A61F9/013 , A61F2009/00872 , A61F2009/0088
摘要： A method of treatment of refractive errors of an eye, the eye including a central visual axis and a cornea with a first corneal layer overlying a second corneal layer, comprising the steps of separating a first surface of the first corneal layer from a second surface of the second corneal layer, thereby forming a flap and exposing the second surface, implanting on the second surface an inlay adapted to correct a refractive error of the eye, coating a surface of the inlay with a compound that promotes bonding with the cornea, and replacing the flap over the inlay.
摘要翻译：一种治疗眼睛屈光不正的方法，包括中心视轴的眼睛和覆盖第二角膜层的第一角膜层的角膜包括以下步骤：将第一角膜层的第一表面与第二角膜层的第二表面第二角膜层，从而形成皮瓣并暴露第二表面，在第二表面上植入适于校正眼睛的屈光不正的嵌体，用促进与角膜粘合的化合物涂覆嵌体的表面，并且替换翻盖在镶嵌上。

83. 发明申请

US20050099600A1 Apparatus and method for objective measurement and correction of optical systems using wavefront analysis 审中-公开
标题翻译：使用波前分析的光学系统的物镜测量和校正的装置和方法
公开(公告)号：US20050099600A1
公开(公告)日：2005-05-12
申请号：US11016978
申请日：2004-12-20
申请人： Rudolph Frey , James Burkhalter , Neil Zepkin , Edward Poppeliers , John Campin
发明人： Rudolph Frey , James Burkhalter , Neil Zepkin , Edward Poppeliers , John Campin
IPC分类号： A61B3/103 , A61B3/107 , A61B3/15 , A61F9/008 , A61F9/01 , A61B18/18 , A61B3/10 , A61M35/00
CPC分类号： A61F9/00806 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： A method for enhancing vision of an eye includes a laser delivery system having a laser beam for ablating corneal material from the cornea of the eye. Measurements are made to determine an optical path difference between a plane wave and a wavefront emanating from the retina of the eye for a location at a surface of the cornea. An optical correction is provided to the laser delivery system for the location based on the optical path difference and refractive indices of media through which the wavefront passes. The optical correction includes dividing the optical path difference by a difference between an index of refraction of corneal material and an index of refraction of air. The laser beam is directed to the location on the surface of the cornea and corneal material ablated at the location in response to the optical correction to cause the wavefront to approximate the shape of the plane wave at that location.
摘要翻译：用于增强眼睛视力的方法包括具有激光束的激光传送系统，用于从眼睛的角膜中消除角膜材料。进行测量以确定在角膜表面处的位置处从眼睛的视网膜发出的平面波和波前之间的光程差。基于波前通过的介质的光程差和折射率，向位置的激光传送系统提供光学校正。光学校正包括将光程差除以角膜材料的折射率与空气的折射率之差。激光束被引导到角膜表面上的位置，并且响应于光学校正在位置处消融角膜材料，以使波前近似该位置处的平面波的形状。

84. 发明申请

US20040135969A1 Keratectomy data determining device and keratectomy data determining program 失效
标题翻译：角膜切除术数据确定装置和角膜切除术数据确定程序
公开(公告)号：US20040135969A1
公开(公告)日：2004-07-15
申请号：US10476246
申请日：2003-10-30
发明人： Masaaki Hanebuchi
IPC分类号： A61B003/10
CPC分类号： A61B3/103 , A61B3/1035 , A61B3/107 , A61F9/00806 , A61F2009/00872 , A61F2009/0088
摘要： The purpose of the present invention is to provide a corneal-ablation-data determining apparatus and a corneal-ablation-data determining program capable of controlling corneal ablation amount distribution and expanding ablation applicability. In the present invention, the corneal-ablation-data determining apparatus for use in keratorefractive surgery for ablating a corneal surface to correct a refractive error has input means for inputting measurement data on any one of wavefront aberration distribution and refractive power distribution of a patient's eye, decentering means for decentering a reference axis being a calculation reference for a corneal ablation amount, and calculation means for obtaining the corneal ablation amount based on the measurement data and data on eccentricity of the reference axis.
摘要翻译：本发明的目的是提供一种能够控制角膜消融量分布和扩大消融适用性的角膜消融数据确定装置和角膜消融数据确定程序。在本发明中，用于消融角膜表面以矫正屈光不正的角膜磨削术的角膜消融数据确定装置具有用于输入患者眼睛的波前像差分布和屈光度分布中的任何一个的测量数据的输入装置用于使参考轴偏心的偏心装置是用于角膜消融量的计算参考，以及用于基于测量数据和参考轴的偏心数据获得角膜消融量的计算装置。

85. 发明申请

US20040021874A1 Integrated scanning and ocular tomography system and method 失效
标题翻译：综合扫描和眼部断层扫描系统及方法
公开(公告)号：US20040021874A1
公开(公告)日：2004-02-05
申请号：US10601119
申请日：2003-06-19
申请人： VISX, INCORPORATED, A Delaware Corporation
发明人： John K. Shimmick
IPC分类号： G01B009/02
CPC分类号： A61F9/008 , A61B3/1005 , A61B2090/061 , A61F9/00804 , A61F9/00812 , A61F2009/00842 , A61F2009/00851 , A61F2009/00853 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897 , G01B9/02002 , G01B9/02007 , G01B9/02044 , G01B9/0209 , G01B9/02091 , G01B2290/25 , G01B2290/70
摘要： Systems and methods of the present invention measure at least one reflecting surface of an object disposed along an optical path. In some embodiments a measured optical interference signal for each of at least three wavelengths of reflected light may be used to determine a modulation of frequency components of a Fourier series. Frequency components of a Fourier series may be transformed to spatial components that describe intensities and positions of light reflected along an optical path. Systems and methods of the present invention permit rapid measuring and may monitor corneal thickness during surgery. The invention may do so by integrating an ablation device and a measurement apparatus into a single system. An integrated scanning and monitoring system may include an ablative light source producing an ablative beam and a measurement light source producing a measurement beam.
摘要翻译：本发明的系统和方法测量沿着光路布置的物体的至少一个反射表面。在一些实施例中，用于反射光的至少三个波长中的每一个的测量的光学干涉信号可以用于确定傅里叶级数的频率分量的调制。傅立叶级数的频率分量可以被变换为描述沿光路反射的光的强度和位置的空间分量。本发明的系统和方法允许快速测量并且可以在手术期间监测角膜厚度。本发明可以通过将消融装置和测量装置集成到单个系统中来实现。集成的扫描和监视系统可以包括产生烧蚀光束的消融光源和产生测量光束的测量光源。

86. 发明授权

US06685319B2 Enhanced wavefront ablation system 有权
标题翻译：增强波前消融系统
公开(公告)号：US06685319B2
公开(公告)日：2004-02-03
申请号：US09960163
申请日：2001-09-20
申请人： Jason Watson , John K. Shimmick
发明人： Jason Watson , John K. Shimmick
IPC分类号： A61B300
CPC分类号： A61B3/04 , A61B3/112 , A61F9/00806 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088
摘要： Systems and methods verify and/or correct optical errors of an eye. A plan is generated for a corrective procedure of the eye from a measured optical error, and a verification lens is formed based on the measured optical error to verify the procedure plan. Alignment of an aperture (with a size selected to correspond to the size of the pupil) with the eye while measuring optical properties of the eye through the verification lens improves verification accuracy, as does mounting of the verification lens and aperture to the patient with a trial frame.
摘要翻译：系统和方法验证和/或校正眼睛的光学错误。从测量的光学误差产生用于眼睛的校正过程的计划，并且基于测量的光学误差形成验证透镜，以验证程序计划。通过验证透镜测量眼睛的光学性质，孔眼（具有选定为对应于瞳孔大小的尺寸）与眼睛的对准提高了验证精度，以及将验证透镜和孔径安装到患者身上试用框架。

87. 发明申请

US20030220629A1 Cornea contact system for laser surgery 有权
标题翻译：角膜激光手术接触系统
公开(公告)号：US20030220629A1
公开(公告)日：2003-11-27
申请号：US10155810
申请日：2002-05-24
发明人： Josef Bille , Klaus Baumeister , Frieder Loesel
IPC分类号： A61B018/20
CPC分类号： A61F9/009 , A61F9/00825 , A61F2009/00872 , A61F2009/0088
摘要： A system for accurately guiding a laser focal point along a predetermined path within the stroma of a cornea includes a contact lens for conforming the anterior surface of the cornea to a radius of curvature, Rlens, that is approximately 8.3 mm. Conforming the cornea to the lens causes minimal discomfort to the patient and does not upset the three-dimensional architecture of the corneal lamellae. As the focal point is advanced along a path within the cornea, the laser source is selectively translated parallel to the optical axis of the cornea to control the depth of the laser focal point. The movement includes three components: a first component, z1 that is dependent upon the shape of the contact lens, a second component, z2 that compensates for refraction at the surfaces of the contact lens, and a third component, z3, that compensates for refraction caused by the anatomical configuration of the cornea.
摘要翻译：用于沿着角膜的基质内的预定路径准确地引导激光焦点的系统包括用于使角膜前表面与曲率半径（Rens）约为8.3mm的接触镜。将角膜与镜片配合会对患者造成最小的不适，并且不会破坏角膜片的三维结构。当焦点沿着角膜内的路径前进时，激光源被选择性地平行于角膜的光轴平移以控制激光焦点的深度。该运动包括三个部件：取决于隐形眼镜的形状的第一部件z1，补偿隐形眼镜表面的折射的第二部件z2以及补偿折射的第三部件z3 由角膜的解剖结构引起。

88. 发明申请

US20030208190A1 Methods and instruments for refractive ophthalmic surgery 审中-公开
$Methods and instruments for refractive ophthalmic surgery$
标题翻译：折射眼科手术的方法和手段
公开(公告)号：US20030208190A1
公开(公告)日：2003-11-06
申请号：US10332891
申请日：2003-01-14
发明人： Cynthia Roberts , William J Dupps JR. , Noriko Katsube
IPC分类号： A61B018/20
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00806 , A61F2009/00857 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Biomechanical responses of the eye are used to improve photorefractive procedures. LASIK or PRK treatments, for example, can be improved by taking pre-operative measurement and predicting the corneas's biodynamic response to the ablative treatment. Predicitve use is mad of the biodynamic response of the cornea due to laser or mechanical keratectomy, that is, creating a corneal flap characterisitc of LASIK. Comparison of pre-flap and post-flap, (pre-ablation) data of the cornea such as corneal thickness, flap thickness, corneal topography and wavefront, for example, can provide predictive information applicable to modifying an ablation alorithm before the laser is engaged, either for a current operation or the development of a model. Modeling, by finite element analysis or other mathematical techniques, can also be used to predict post-operative outcomes based on a pre-operative (no flap cut or other surgical intervention) data for the cornea that is input for an accurate eye model that, in consideration of biodynamic response via the model, provides predictive information for optimizing the sucess of the refractive surgery and ultimately patient satisfaction.
摘要翻译：使用眼睛的生物力学反应来改善光折射程序。例如，可以通过术前测量和预测角膜对烧蚀治疗的生物动力学反应来改善LASIK或PRK治疗。由于激光或机械角膜切除术，即使产生LASIK的角膜瓣特征，预测使用的是生物动力学反应的角膜。例如，角膜厚度，瓣膜厚度，角膜形貌和波前等角膜的前瓣和后瓣（预消融）数据的比较可以提供适用于在激光接合之前修改消融算法的预测信息，用于当前操作或开发模型。通过有限元分析或其他数学技术的建模也可以用于基于为准确的眼睛模型输入的角膜的术前（无瓣膜切除或其他手术干预）数据来预测术后结果，考虑到通过该模型的生物动力学反应，提供用于优化屈光手术成功和最终患者满意度的预测信息。

89. 发明授权

US06610051B2 Device and method for performing refractive surgery 有权
$Device and method for performing refractive surgery$
标题翻译：用于进行屈光手术的装置和方法
公开(公告)号：US06610051B2
公开(公告)日：2003-08-26
申请号：US09976177
申请日：2001-10-12
申请人： Josef Bille
发明人： Josef Bille
IPC分类号： A61F02007
CPC分类号： A61F9/013 , A61F9/00829 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： A device and method for altering the refractive properties of the cornea by photodisrupting stromal lamellae involves focusing a laser beam within the stroma. To effectuate tissue alteration with minimal laser energies, the focal point of the laser beam is maintained inside the stromal lamella, rather than on an interface between layers of lamellae. To maintain the focal point inside the lamella, the bubbles that result from the photodisruption are measured using a wavefront detector. When a large bubble is observed, indicating photodisruption on an interface between layers of lamellae, the depth of the focal point, measured from the anterior surface, is adjusted to thereby resume photodisruption inside a lamella. A wavefront detector can be used to track the progress of the photodisruption procedure, providing information that can be used to update the amounts and locations of stromal tissue that must be removed to obtain the desired refractive correction.
摘要翻译：用于通过光致破坏基质薄片来改变角膜的折射特性的装置和方法包括将激光束聚焦在基质内。为了以最小的激光能量来实现组织改变，激光束的焦点保持在基质层内，而不是在层的层之间的界面上。为了保持薄片内的焦点，使用波前检测器测量由光破坏产生的气泡。当观察到大气泡时，指示薄片层之间的界面上的光破坏，调节从前表面测量的焦点的深度，从而恢复薄片内的光致破坏。波前检测器可用于跟踪光致中断过程的进展，提供可用于更新必须去除以获得期望的屈光矫正的基质组织的量和位置的信息。

90. 发明授权

US06592574B1 Hydration and topography tissue measurements for laser sculpting 有权
标题翻译：激光雕刻的水合和地形组织测量
公开(公告)号：US06592574B1
公开(公告)日：2003-07-15
申请号：US09626732
申请日：2000-07-27
申请人： John Karl Shimmick , Charles R. Munnerlyn , George Caudle , Terrance N. Clapham
发明人： John Karl Shimmick , Charles R. Munnerlyn , George Caudle , Terrance N. Clapham
IPC分类号： A61B1818
CPC分类号： A61B3/107 , A61F9/00804 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： Improved systems, devices, and methods measure and/or change the shape of a tissue surface, particularly for use in laser eye surgery. Fluorescence of the tissue may occur at and immediately underlying the tissue surface. The excitation energy can be readily absorbed by the tissue within a small tissue depth, and may be provided from the same source used for photodecomposition of the tissue. Changes in the fluorescence spectrum of a tissue correlate with changes in the tissue's hydration.
摘要翻译：改进的系统，装置和方法测量和/或改变组织表面的形状，特别是用于激光眼睛手术中。组织的荧光可发生在组织表面的正下方。激发能量可以容易地被组织内的组织深度吸收，并且可以由用于组织光分解的相同来源提供。组织荧光光谱的变化与组织水合的变化相关。

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