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81. 发明申请

US20110213436A1 METHOD AND DEVICE FOR TREATING MYOCARDIAL ISCHEMIA 有权
标题翻译：用于治疗心肌梗塞的方法和装置
公开(公告)号：US20110213436A1
公开(公告)日：2011-09-01
申请号：US13103477
申请日：2011-05-09
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

82. 发明申请

US20110087301A1 IMPLANTABLE DEVICE WITH HEMODYNAMIC SUPPORT OR RESUSCITATION THERAPY 审中-公开
标题翻译：具有HEMODYNAMIC支持或恢复治疗的可植入装置
公开(公告)号：US20110087301A1
公开(公告)日：2011-04-14
申请号：US12892298
申请日：2010-09-28
申请人： Dan Li , Allan C. Shuros , Arjun Sharma , Stephen Ruble
发明人： Dan Li , Allan C. Shuros , Arjun Sharma , Stephen Ruble
IPC分类号： A61N1/365 , A61N1/36 , A61N1/39
CPC分类号： A61N1/3601 , A61N1/3621 , A61N1/36507 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/3956
摘要： An apparatus comprises an implantable sensor, a stimulation circuit, and a controller. The implantable sensor is configured to provide a sensor signal representative of hemodynamic function of a subject. The stimulation circuit is configured to provide electrical simulation energy to an implantable electrode. The controller is communicatively coupled to the stimulation circuit and the implantable sensor and includes a hemodynamic monitor module. The hemodynamic monitor module is configured to detect an episode of reduced hemodynamic capacity in a subject using the sensor signal. In response to the detected episode, the controller is configured to initiate delivery of the electrical stimulation energy to artificially induce at least one of deep ventilation or rapid ventilation in the subject. The hemodynamic monitor module is configured to obtain a measure of hemodynamic performance after delivery of the electrical stimulation energy.
摘要翻译：一种装置包括可植入传感器，刺激电路和控制器。可植入传感器被配置为提供代表受试者的血液动力学功能的传感器信号。刺激电路被配置为向可植入电极提供电气模拟能量。控制器通信地耦合到刺激电路和可植入传感器并且包括血液动力学监测器模块。血液动力学监测器模块被配置为使用传感器信号来检测受试者中降低的血流动力学容量的发作。响应于检测到的情节，控制器被配置为启动电刺激能量的传递以人为地诱导受试者中深层通气或快速通气中的至少一种。血液动力学监测器模块被配置为在递送电刺激能量之后获得血流动力学性能的量度。

83. 发明申请

US20110022127A1 BLOOD VOLUME REDISTRIBUTION THERAPY FOR HEART FAILURE 有权
标题翻译：血液重新分配治疗心脏失败的血液
公开(公告)号：US20110022127A1
公开(公告)日：2011-01-27
申请号：US12843444
申请日：2010-07-26
申请人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
发明人： Viktoria A. Averina , Jason J. Hamann , Stephen Ruble , Allan C. Shuros
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译：可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。

84. 发明申请

US20100217346A1 METHOD AND APPARATUS FOR GASTROINTESTINAL STIMULATION VIA THE LYMPHATIC SYSTEM 审中-公开
标题翻译：通过淋巴系统进行气道刺激的方法和装置
公开(公告)号：US20100217346A1
公开(公告)日：2010-08-26
申请号：US12775223
申请日：2010-05-06
申请人： Allan C. Shuros
发明人： Allan C. Shuros
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： An implantable gastrointestinal (GI) stimulation system includes an implantable medical device and at least one stimulus delivery device configured to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. In one embodiment, the implantable medical device includes a GI stimulation circuit to deliver electrical stimulation pulses to one or more target regions adjacent to a lymphatic vessel through the stimulus delivery device. In one embodiment, to control obesity, the electrical stimulation pulses are delivered to the organs and/or nerves of the GI tract to create a sensation of satiety and/or to expedite food movement through the GI tract.
摘要翻译：植入式胃肠（GI）刺激系统包括可植入医疗装置和至少一个刺激递送装置，其被配置为放置在患者的一个或多个淋巴管中，例如患者的胸导管和/或从胸导管分支的血管。在一个实施例中，可植入医疗装置包括GI刺激电路，以通过刺激输送装置将电刺激脉冲输送到与淋巴管相邻的一个或多个目标区域。在一个实施方案中，为了控制肥胖，将电刺激脉冲输送到胃肠道的器官和/或神经以产生饱腹感和/或加速通过胃肠道的食物运动。

85. 发明申请

US20100210923A1 DEPLOYABLE SENSOR PLATFORM ON THE LEAD SYSTEM OF AN IMPLANTABLE DEVICE 有权
标题翻译：可移植设备引导系统上的可配置传感器平台
公开(公告)号：US20100210923A1
公开(公告)日：2010-08-19
申请号：US12686050
申请日：2010-01-12
申请人： Dan Li , Allan C. Shuros , Andrea Acuna , Bruce A. Tockman
发明人： Dan Li , Allan C. Shuros , Andrea Acuna , Bruce A. Tockman
IPC分类号： A61B5/02 , A61N1/05 , A61B5/07 , A61B17/00
CPC分类号： A61N1/056 , A61B5/042 , A61B5/6846 , A61B5/6852 , A61M25/0082 , A61M25/01 , A61M25/0102 , A61M25/0662 , A61M2025/0681 , A61N1/37211 , A61N2001/0585
摘要： Systems and methods for deploying a sensor assembly onto a cardiac lead are disclosed. The sensor assembly can include a resilient cuff having one or more sensor modules for sensing physiological parameters within the body. The resilient cuff may have a substantially cylindrical shape having an inner diameter that is smaller than an outer diameter of the lead body onto which the cuff is deployed such that the cuff is retained on the lead body by frictional forces. The sensor assembly may be deployed in conjunction with a new lead to be implanted within a chamber of the patient's heart or a body vessel, or may be deployed onto an existing, implanted lead implanted within the patient's body.
摘要翻译：公开了将传感器组件部署到心脏引线上的系统和方法。传感器组件可以包括具有用于感测身体内的生理参数的一个或多个传感器模块的弹性袖带。弹性箍可以具有基本上圆柱形的形状，其内径小于引导体的外径，袖带在其上展开，使得袖带通过摩擦力保持在引线体上。传感器组件可以与将要植入患者心脏或身体容器的腔室内的新导线一起部署，或者可以部署到植入患者体内的现有植入的导线上。

86. 发明授权

US07774061B2 Implantable cardiac device with ischemia response capability 有权
标题翻译：具有缺血反应能力的植入式心脏装置
公开(公告)号：US07774061B2
公开(公告)日：2010-08-10
申请号：US11318257
申请日：2005-12-23
申请人： Yi Zhang , Aaron McCabe , Kevin J. Stalsberg , Kent Lee , Marina V. Brockway , Joseph M. Pastore , Allan C. Shuros
发明人： Yi Zhang , Aaron McCabe , Kevin J. Stalsberg , Kent Lee , Marina V. Brockway , Joseph M. Pastore , Allan C. Shuros
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61B5/1102 , A61B2562/0219 , A61N1/3621 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3925 , A61N1/3962
摘要： A cardiac device is described with the capability of detecting cardiac ischemia using multiple sensing modalities. The device may be configured to modify its behavior in delivering therapies to treat bradycardia or tachyarrhythmias in response to detection of cardiac ischemia.
摘要翻译：描述了具有使用多种感测方式检测心脏缺血的能力的心脏装置。该装置可以被配置为在递送疗法时修改其行为以响应于心脏缺血的检测来治疗心动过缓或快速性心律失常。

87. 发明申请

US20100056858A1 PACING SYSTEM FOR USE DURING CARDIAC CATHETERIZATION OR SURGERY 审中-公开
标题翻译：在心脏导管或手术期间使用的PACING系统
公开(公告)号：US20100056858A1
公开(公告)日：2010-03-04
申请号：US12547316
申请日：2009-08-25
申请人： Eric A. Mokelke , Allan C. Shuros
发明人： Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/36 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/3207 , A61B2017/0243 , A61B2017/22001 , A61B2017/308 , A61B2090/3784 , A61N1/056 , A61N1/08 , A61N1/3625 , G16H40/63
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.
摘要翻译：应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。

88. 发明申请

US20090306486A1 SENSING VECTOR CONFIGURATION IN ICD TO ASSIST ARRHYTHMIA DETECTION AND ANNOTATION 有权
标题翻译： ICD中的感应矢量配置，以帮助ARRHYTHMIA检测和报告
公开(公告)号：US20090306486A1
公开(公告)日：2009-12-10
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/046 , A61B5/02 , A61B5/0464
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译：一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，到心脏信号感测电路。所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

89. 发明申请

US20090299427A1 CORONARY VEIN DIMENSIONAL SENSOR AND FIXATION APPARATUS 有权
标题翻译：冠状血管尺寸传感器和固定装置
公开(公告)号：US20090299427A1
公开(公告)日：2009-12-03
申请号：US12431301
申请日：2009-04-28
申请人： Lili Liu , Allan C. Shuros
发明人： Lili Liu , Allan C. Shuros
IPC分类号： A61N1/362 , A61N1/05 , A61B5/02
CPC分类号： A61N1/057 , A61B5/02 , A61B5/02028 , A61B5/0215 , A61B5/1076 , A61B5/1107 , A61B5/686 , A61B2562/0261 , A61N1/3627 , A61N1/36578 , A61N2001/0585
摘要： A system and method for estimating a hemodynamic performance parameter value of a patient's heart. The system includes a pulse generator and a medical electrical lead implanted partially within a coronary vein of the heart. The lead includes at least one sensor located within the coronary vein configured to generate a signal indicative of at least one dimensional parameter of the coronary vein. Changes in the dimensional parameter during one or more cardiac cycles are measured. The hemodynamic performance parameter is estimated based on the change in the dimensional parameter of the coronary vein.
摘要翻译：一种用于估计患者心脏的血液动力学性能参数值的系统和方法。该系统包括部分地植入心脏冠状静脉内的脉冲发生器和医用电线。引线包括位于冠状静脉内的至少一个传感器，其构造成产生指示冠状静脉的至少一维参数的信号。测量一个或多个心动周期内尺寸参数的变化。基于冠状静脉尺寸参数的变化估计血流动力学性能参数。

90. 发明申请

US20090299420A1 METHOD AND APPARATUS FOR CRYOTHERAPY AND PACING PRECONDITIONING 审中-公开
标题翻译：方法和装置用于结冰和皮肤预处理
公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
IPC分类号： A61B18/02 , A61N1/362
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译：描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。

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