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81. 发明授权

US09613184B2 Analyzing a washout period characteristic for psychiatric disorder therapy delivery 有权
公开(公告)号：US09613184B2
公开(公告)日：2017-04-04
申请号：US12426065
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , G06F19/00 , A61M5/142 , A61N1/08 , A61N1/36 , A61M5/172 , A61N1/372
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

82. 发明授权

US09072870B2 Sleep stage detection 有权
标题翻译：睡眠阶段检测
公开(公告)号：US09072870B2
公开(公告)日：2015-07-07
申请号：US12238105
申请日：2008-09-25
申请人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
发明人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
IPC分类号： A61N1/00 , A61N1/08 , A61M21/02 , A61B5/00 , A61B5/04 , A61B5/048 , A61M21/00 , G06F19/00
CPC分类号： A61B5/4812 , A61B5/0031 , A61B5/01 , A61B5/02055 , A61B5/024 , A61B5/04014 , A61B5/04015 , A61B5/0402 , A61B5/0478 , A61B5/048 , A61B5/1116 , A61B5/1118 , A61B5/4082 , A61B5/4839 , A61M5/1723 , A61M21/02 , A61M2005/1726 , A61M2021/0072 , A61M2205/3523 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/36078 , A61N1/36139 , G06F19/3481 , G16H40/63
摘要： Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
摘要翻译：可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化。可以基于睡眠阶段确定来选择或修改治疗程序。根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

83. 发明授权

US08594779B2 Seizure prediction 有权
标题翻译：缉获预测
公开(公告)号：US08594779B2
公开(公告)日：2013-11-26
申请号：US11799031
申请日：2007-04-30
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/053 , A61B5/024 , A61B5/0402 , A61B5/0478 , A61B5/0488 , A61B5/4094 , A61B5/4839 , A61B5/7203 , A61B5/7225 , A61B5/7228 , A61B5/7275 , A61N1/08 , A61N1/36025 , A61N1/36082 , G06F19/00
摘要： Seizure prediction systems and methods include measuring impedance and a potential within a brain of a patient to determine whether the brain is in a state indicative of a possibility of seizure. In some embodiments, at least one of the measured impedance or the measured potential may be used as a primary indication of the brain state indicative of a possibility of seizure. In one embodiment, if one of the measured impedance or the measured potential indicates a seizure, the other measurement (impedance or potential) may be used to validate whether the brain is in the state indicative of the possibility of seizure.
摘要翻译：缉获预测系统和方法包括测量患者的脑中的阻抗和潜力，以确定大脑是否处于指示癫痫发作可能性的状态。在一些实施例中，测量的阻抗或测量电位中的至少一个可以用作指示发作可能性的脑状态的主要指示。在一个实施例中，如果所测量的阻抗或测量的电位之一表示发作，则可以使用另一测量（阻抗或电位）来验证大脑是否处于表示发作可能性的状态。

84. 发明申请

US20130053722A1 Method and Apparatus for Detecting a Biomarker in the Presence of Electrical Stimulation 有权
标题翻译：在电刺激下检测生物标志物的方法和装置
公开(公告)号：US20130053722A1
公开(公告)日：2013-02-28
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.
摘要翻译：各种实施方案涉及在存在电刺激的情况下鉴定生物标志物。各种实施例涉及向患者提供电刺激并且在电刺激被传送的同时感测一个或多个信号，所述一个或多个信号包括指示生理活动的数据。各种实施例还包括确定电刺激的强度并且基于可变阈值来确定数据是否指示生物标志物的存在，所述可变阈值基于电刺激的强度而变化。各种实施方案涉及确定刺激强度和生物标记参数之间的关系以确定可变阈值的可变性。

85. 发明授权

US08265769B2 Chopper-stabilized instrumentation amplifier for wireless telemetry 有权
标题翻译：用于无线遥测的斩波稳定仪表放大器
公开(公告)号：US08265769B2
公开(公告)日：2012-09-11
申请号：US11700738
申请日：2007-01-31
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： H03F1/02
CPC分类号： H03F3/393 , A61B5/0031 , A61B5/7203 , A61B5/7228 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device. The amplifier may be used for physiological signal sensing, impedance sensing, telemetry or other test and measurement applications.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于低功率系统，例如可植入医疗设备。放大器可用于生理信号感测，阻抗检测，遥测或其他测试和测量应用。

86. 发明申请

US20110125078A1 OPTICAL STIMULATION THERAPY 审中-公开
标题翻译：光刺激治疗
公开(公告)号：US20110125078A1
公开(公告)日：2011-05-26
申请号：US12951852
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
IPC分类号： A61M37/00 , A61N5/06
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
摘要翻译：用于递送光学刺激的方法包括用对波长范围内的光敏感的光敏通道蛋白转染靶组织，通过光学刺激装置将波长范围内的光传送到目标组织，基本上同时将光传递到靶组织，感测生物电信号，基于生物电信号确定患者治疗状态，以及基于感测到的患者治疗状态来调整到目标组织的光的传送。

87. 发明申请

US20110068861A1 CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER 有权
公开(公告)号：US20110068861A1
公开(公告)日：2011-03-24
申请号：US12959135
申请日：2010-12-02
申请人： Timothy J. Denison
发明人： Timothy J. Denison
IPC分类号： H03F3/38
CPC分类号： H03F3/38 , A61B5/04 , A61B5/053 , A61B5/7203 , A61B5/7217 , A61B5/7225 , A61B5/7228 , A61B5/7242
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

88. 发明申请

US20100280335A1 PATIENT STATE DETECTION BASED ON SUPERVISED MACHINE LEARNING BASED ALGORITHM 审中-公开
标题翻译：基于监督机器学习算法的患者状态检测
公开(公告)号：US20100280335A1
公开(公告)日：2010-11-04
申请号：US12694044
申请日：2010-01-26
申请人： David L. Carlson , Timothy J. Denison , Ali H. Shoeb , David E. Linde
发明人： David L. Carlson , Timothy J. Denison , Ali H. Shoeb , David E. Linde
IPC分类号： A61B5/00 , A61B5/11
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N20/00 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译：用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

89. 发明申请

US20100256710A1 HYBRID RECTIFICATION FOR RECHARGING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于补充可植入医疗器械的混合整流器
公开(公告)号：US20100256710A1
公开(公告)日：2010-10-07
申请号：US12418291
申请日：2009-04-03
申请人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
发明人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
IPC分类号： A61N1/02 , H02J7/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J50/10
摘要： A charging system is disclosed. In one embodiment, the system includes a charging unit having a primary coil, and an implantable medical device comprising a secondary coil to receive charge from the primary coil. The implantable medical device further includes a half-wave voltage-doubling rectifier coupled to the secondary coil, a full-wave rectifier coupled to the secondary coil, and a rechargeable power source. Control logic is provided to periodically configure the rechargeable power source to receive charge from a selected one of the voltage-doubling circuit and the full-wave rectifier in a manner that increases rate at which charge is transferred from the secondary coil to the rechargeable power source. The control logic may configure the rechargeable power source to receive charge based on one or more monitored conditions which may include, for example, an indication of a current, a voltage, a coupling coefficient, back-scatter, and temperature.
摘要翻译：公开了一种充电系统。在一个实施例中，系统包括具有初级线圈的充电单元和包括用于接收来自初级线圈的电荷的次级线圈的可植入医疗装置。可植入医疗装置还包括耦合到次级线圈的半波倍压整流器，耦合到次级线圈的全波整流器和可再充电电源。提供控制逻辑以周期性地配置可再充电电源，以便以增加电荷从次级线圈传递到可再充电电源的速率的方式从所选倍压电路和全波整流器中接收电荷。控制逻辑可以配置可再充电电源以基于一个或多个监视的条件来接收电荷，这些状态可以包括例如电流，电压，耦合系数，反向散射和温度的指示。

90. 发明授权

US07714757B2 Chopper-stabilized analog-to-digital converter 有权
标题翻译：斩波稳定的模数转换器
公开(公告)号：US07714757B2
公开(公告)日：2010-05-11
申请号：US11861939
申请日：2007-09-26
申请人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
发明人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
IPC分类号： H03M3/00
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

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