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81. 发明申请

US20070076510A1 Method of Reducing Disturbs in Non-Volatile Memory 有权
标题翻译：减少非易失性存储器中的干扰的方法
公开(公告)号：US20070076510A1
公开(公告)日：2007-04-05
申请号：US11538521
申请日：2006-10-04
申请人： John Mangan , Daniel Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker Quader
发明人： John Mangan , Daniel Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker Quader
IPC分类号： G11C8/00
CPC分类号： G11C7/12 , G11C16/12 , G11C16/3427 , G11C29/02 , G11C29/021 , G11C29/028 , G11C29/50012 , G11C2029/1204
摘要： In a non-volatile memory, the displacement current generated in non-selected word lines that results when the voltage levels on an array's bit lines are changed can result in disturbs. Techniques for reducing these currents are presented. In a first aspect, the number of cells being simultaneously programmed on a word line is reduced. In a non-volatile memory where an array of memory cells is composed of a number of units, and the units are combined into planes that share common word lines, the simultaneous programming of units within the same plane is avoided. Multiple units may be programmed in parallel, but these are arranged to be in separate planes. This is done by selecting the number of units to be programmed in parallel and their order such that all the units programmed together are from distinct planes, by comparing the units to be programmed to see if any are from the same plane, or a combination of these. In a second, complementary aspect, the rate at which the voltage levels on the bit lines are changed is adjustable. By monitoring the frequency of disturbs, or based upon the device's application, the rate at which the bit line drivers change the bit line voltage can be adjusted. This can be implemented by setting the rate externally, or by the controller based upon device performance and the amount of data error being generated.
摘要翻译：在非易失性存储器中，在阵列位线上的电压电平改变时产生的未选择字线中产生的位移电流可能导致干扰。提出了减少这些电流的技术。在第一方面，减少了在字线上同时编程的单元的数量。在非易失性存储器中，存储器单元阵列由多个单元组成，并且单元被组合成共享公共字线的平面，避免同一平面内的单元的同时编程。多个单元可以并行编程，但是它们被布置成处于分开的平面中。这是通过选择并行编程的单元数量及其顺序，使得所有编程在一起的单元都来自不同的平面，通过比较要编程的单元以查看是否来自同一平面，或者组合这些。在第二个互补方面，位线上的电压电平改变的速率是可调节的。通过监视干扰的频率，或者基于设备的应用，可以调整位线驱动器改变位线电压的速率。这可以通过外部设置速率或由控制器基于设备性能和产生的数据错误量来实现。

82. 发明授权

US07145804B2 Method of reducing disturbs in non-volatile memory 有权
公开(公告)号：US07145804B2
公开(公告)日：2006-12-05
申请号：US11238911
申请日：2005-09-28
申请人： Daniel C. Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker N. Quader
发明人： Daniel C. Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker N. Quader
IPC分类号： G11C11/34
CPC分类号： G11C7/12 , G11C16/12 , G11C16/3427 , G11C29/02 , G11C29/021 , G11C29/028 , G11C29/50012 , G11C2029/1204
摘要： In a non-volatile memory, the displacement current generated in non-selected word lines that results when the voltage levels on an array's bit lines are changed can result in disturbs. Techniques for reducing these currents are presented. In a first aspect, the number of cells being simultaneously programmed on a word line is reduced. In a non-volatile memory where an array of memory cells is composed of a number of units, and the units are combined into planes that share common word lines, the simultaneous programming of units within the same plane is avoided. Multiple units may be programmed in parallel, but these are arranged to be in separate planes. This is done by selecting the number of units to be programmed in parallel and their order such that all the units programmed together are from distinct planes, by comparing the units to be programmed to see if any are from the same plane, or a combination of these. In a second, complementary aspect, the rate at which the voltage levels on the bit lines are changed is adjustable. By monitoring the frequency of disturbs, or based upon the device's application, the rate at which the bit line drivers change the bit line voltage can be adjusted. This can be implemented by setting the rate externally, or by the controller based upon device performance and the amount of data error being generated.

83. 发明申请

US20050287540A1 Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences 审中-公开
标题翻译：从克隆的核苷酸序列产生减毒的负链RNA病毒疫苗
公开(公告)号：US20050287540A1
公开(公告)日：2005-12-29
申请号：US10916827
申请日：2004-08-11
申请人： Brian Murphy , Peter Collins , Anna Durbin , Mario Skiadopoulos
发明人： Brian Murphy , Peter Collins , Anna Durbin , Mario Skiadopoulos
IPC分类号： A61K39/12 , A61K39/155 , C12N7/04 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/544 , C12N7/00 , C12N2760/18534 , C12N2760/18561 , C12N2760/18634
摘要： Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid positions(s) corresponding to a site of an attenuating mutation in a heretologous, mutant negative stranded RNA virus. A similar attenuating mutation as identified in the heterologous negative stranded RNA virus is thus incorporated at a corresponding site within the recombinant virus to confer an attenuated phenotype on the recombinant virus. The attenuating mutation incorporated in the recombinant virus may be identical or conservative in relation to the attenuating mutation identified in the heterologous, mutant virus. By the transfer of mutations into recombinant negative stranded RNA viruses in this matter, candidate vaccine viruses are engineered to elicit a desired immune response against a subject virus in a host susceptible to infection thereby.
摘要翻译：减毒，从编码病毒的一个或多个分离的多核苷酸分子产生适合疫苗使用的重组负链RNA病毒。修饰受试病毒的重组基因组或反基因组，以在对应于本体异质突变体负链RNA病毒中的减毒突变位点的一个或多个氨基酸位置上编码病毒重组蛋白内的突变。因此，在异源负链RNA病毒中鉴定的类似的减毒突变被并入重组病毒中的相应位点，以在重组病毒上赋予减毒表型。结合在重组病毒中的减毒突变可以与异源突变病毒中鉴定的减毒突变相同或保守。通过将突变转移到重组负链RNA病毒中，候选疫苗病毒被工程化以在由此感染的宿主中引发针对受试者病毒的所需免疫应答。

84. 发明申请

US20050273782A1 Thread synchronization methods and apparatus for managed run-time environments 失效
标题翻译：管理运行时环境的线程同步方法和设备
公开(公告)号：US20050273782A1
公开(公告)日：2005-12-08
申请号：US10860692
申请日：2004-06-03
申请人： Tatiana Shpeisman , Ali-Reza Adl-Tabatabai , Brian Murphy
发明人： Tatiana Shpeisman , Ali-Reza Adl-Tabatabai , Brian Murphy
IPC分类号： G06F9/46
CPC分类号： G06F9/52 , Y10S707/99938
摘要： Thread synchronization methods and apparatus for managed run-time environments are disclosed. An example method disclosed herein comprises determining a set of locking operations to perform on a lock corresponding to an object, performing an initial locking operation comprising at least one of a balanced synchronization of the lock and an optimistically balanced synchronization of the lock if the initial locking operation is not unbalanced, and, if the initial locking operation is active and comprises the optimistically balanced synchronization, further comprising modifying a state of a pending optimistically balanced release corresponding to the optimistically balanced synchronization if a subsequent locking operation is unbalanced.
摘要翻译：公开了用于管理的运行时环境的线程同步方法和装置。本文公开的示例性方法包括确定一组锁定操作以对对应于对象的锁执行，执行包括锁的平衡同步和锁的乐观平衡同步中的至少一个的初始锁定操作，如果初始锁定并且如果初始锁定操作是活动的并且包括乐观平衡的同步，则还包括如果随后的锁定操作不平衡，则修改对应于乐观平衡同步的未决乐观平衡释放的状态。

85. 发明申请

US20050223799A1 System and method for motion capture and analysis 审中-公开
标题翻译：运动捕捉和分析的系统和方法
公开(公告)号：US20050223799A1
公开(公告)日：2005-10-13
申请号：US10815237
申请日：2004-03-31
申请人： Brian Murphy
发明人： Brian Murphy
IPC分类号： A61B5/11 , A63B69/00 , G01P3/56
CPC分类号： A63B24/0003 , A61B5/1124 , A61B5/1127 , A63B69/00 , A63B2024/0012 , A63B2220/806
摘要： A system and method for capturing and analyzing motion. According to embodiments of the present invention, the system and method may include defining a standard motion; receiving a first signal from a first sensor, the first signal being representative of a motion under analysis; receiving a second signal from a second sensor, the second signal being representative of the motion under analysis; synchronizing the first signal to the second signal; and comparing the motion under analysis represented by the synchronized first signal and second signal to the standard motion. The system may include video cameras and position sensors and may be include a computer. The computer may be networked.
摘要翻译：一种用于捕获和分析运动的系统和方法。根据本发明的实施例，系统和方法可以包括定义标准运动; 从第一传感器接收第一信号，所述第一信号代表被分析的运动; 从第二传感器接收第二信号，所述第二信号代表所分析的运动; 使第一信号与第二信号同步; 以及将由同步的第一信号和第二信号表示的分析下的运动与标准运动进行比较。该系统可以包括摄像机和位置传感器，并且可以包括计算机。计算机可能联网。

86. 发明申请

US20050147622A1 Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 失效
标题翻译：表达免疫调节分子的重组呼吸道合胞病毒的生产
公开(公告)号：US20050147622A1
公开(公告)日：2005-07-07
申请号：US10754895
申请日：2004-01-08
申请人： Peter Collins , Alexander Bukreyev , Brian Murphy , Stephen Whitehead
发明人： Peter Collins , Alexander Bukreyev , Brian Murphy , Stephen Whitehead
IPC分类号： A61K39/00 , A61K48/00 , C07K14/135 , C07K14/54 , C12N7/04 , C12N15/86 , A61K39/12 , A61K39/155 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , C07K14/54 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译：提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。本发明中使用的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白介素5（IL-5），白介素6（IL6）或白细胞介素18（IL-18），肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。

87. 发明申请

US20050146933A1 Method of reducing disturbs in non-volatile memory 失效
公开(公告)号：US20050146933A1
公开(公告)日：2005-07-07
申请号：US11054084
申请日：2005-02-08
申请人： Daniel Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker Quader
发明人： Daniel Guterman , George Samachisa , Brian Murphy , Chi-Ming Wang , Khandker Quader
IPC分类号： G11C16/02 , G11C16/12 , G11C16/04
CPC分类号： G11C7/12 , G11C16/12 , G11C16/3427 , G11C29/02 , G11C29/021 , G11C29/028 , G11C29/50012 , G11C2029/1204
摘要： In a non-volatile memory, the displacement current generated in non-selected word lines that results when the voltage levels on an array's bit lines are changed can result in disturbs. Techniques for reducing these currents are presented. In a first aspect, the number of cells being simultaneously programmed on a word line is reduced. In a non-volatile memory where an array of memory cells is composed of a number of units, and the units are combined into planes that share common word lines, the simultaneous programming of units within the same plane is avoided. Multiple units may be programmed in parallel, but these are arranged to be in separate planes. This is done by selecting the number of units to be programmed in parallel and their order such that all the units programmed together are from distinct planes, by comparing the units to be programmed to see if any are from the same plane, or a combination of these. In a second, complementary aspect, the rate at which the voltage levels on the bit lines are changed is adjustable. By monitoring the frequency of disturbs, or based upon the device's application, the rate at which the bit line drivers change the bit line voltage can be adjusted. This can be implemented by setting the rate externally, or by the controller based upon device performance and the amount of data error being generated.

88. 发明申请

US20050100886A1 Construction of West Nile virus and dengue virus chimeras for use in a live virus vaccine to prevent disease caused by West Nile virus 有权
标题翻译：建立西尼罗病毒和登革热病毒嵌合体，用于活病毒疫苗，以预防西尼罗病毒引起的疾病
公开(公告)号：US20050100886A1
公开(公告)日：2005-05-12
申请号：US10871775
申请日：2004-06-18
申请人： Alexander Pletnev , Joseph Putnak , Robert Chanock , Brian Murphy , Stephen Whitehead , Joseph Blaney
发明人： Alexander Pletnev , Joseph Putnak , Robert Chanock , Brian Murphy , Stephen Whitehead , Joseph Blaney
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/12 , A61K39/295 , A61P31/12 , C07K14/18 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24162 , C12Q1/6888 , Y02A50/386 , Y02A50/394
摘要： The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.
摘要翻译：本发明涉及建立在用于产生免疫原性，活的，减毒的西尼罗病毒疫苗的登革病毒骨架上的减毒，免疫原性的西尼罗病毒嵌合体。

89. 发明申请

US20050100557A1 Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences 有权
标题翻译：从克隆的核苷酸序列产生减毒的嵌合呼吸道合胞病毒疫苗
公开(公告)号：US20050100557A1
公开(公告)日：2005-05-12
申请号：US10722000
申请日：2003-11-25
申请人： Peter Collins , Brian Murphy , Stephen Whitehead
发明人： Peter Collins , Brian Murphy , Stephen Whitehead
IPC分类号： A61K39/00 , C07K14/135 , C12N7/04 , A61K39/12 , A61K39/175
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C12N7/00 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561
摘要： Chimeric respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing one or more heterologous gene(s) or gene segment(s) from one RSV subgroup or strain into a recipient RSV backround of a different subgroup or strain. The resulting chimeric RSV virus or subviral particle is infectious and attenuated, preferably by introduction of selected mutations specifying attenuated phenotypes into a chimeric genome or antigenome to yield, for example, temperature sensitive (ts) and/or cold adapted (ca) vaccine strains. Alternatively, chimeric RSV and vaccine compositions thereof incorporate other mutations specifying desired structural and/or phenotypic characteristics in an infectious chimeric RSV. Such chimeric RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of one or more selected nucleotide sequence(s), gene(s), or gene segment(s) in a chimeric RSV clone. This provides a method for development of novel vaccines against diverse RSV strains by using a common attenuated backbone as a vector to express protective antigens of heterologous strains. The immune system of an individual is stimulated to induce protection against natural RSV infection, preferably in a multivalent manner to achieve protection against multiple RSV strains and/or subgroups.
摘要翻译：嵌合呼吸道合胞病毒（RSV）及其疫苗组合物通过将一个或多个异源基因或基因区段从一个RSV亚组或菌株引入不同亚组或菌株的受体RSV背景中而产生。所得到的嵌合RSV病毒或亚病毒颗粒是感染性和减毒性的，优选通过将指定减毒表型的选定突变引入到嵌合基因组或反基因组中以产生例如温度敏感（ts）和/或冷适应（ca）疫苗株。或者，嵌合RSV及其疫苗组合物掺入在感染性嵌合RSV中指定所需结构和/或表型特征的其它突变。这种嵌合RSV包含通过嵌合RSV克隆中的一个或多个选定的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。这提供了通过使用共同的减毒骨架作为表达异源株的保护性抗原的载体来开发针对不同RSV菌株的新型疫苗的方法。刺激个体的免疫系统以诱导针对天然RSV感染的保护，优选以多价方式实现针对多个RSV菌株和/或亚组的保护。

90. 发明授权

US06659796B1 Multi-function mounting/latch component for electrical connectors 失效
标题翻译：用于电气连接器的多功能安装/闩锁部件
公开(公告)号：US06659796B1
公开(公告)日：2003-12-09
申请号：US10177511
申请日：2002-06-21
申请人： Kent D. Waddell , Denise Brennan , Eugene Folan , John M. Horgan , Enda Kelly , Joseph McCarthy , Brian Murphy , John Wallace , Jay H. Neer , John Meaney
发明人： Kent D. Waddell , Denise Brennan , Eugene Folan , John M. Horgan , Enda Kelly , Joseph McCarthy , Brian Murphy , John Wallace , Jay H. Neer , John Meaney
IPC分类号： H01R1373
CPC分类号： H01R13/745 , H01R12/7047
摘要： An electrical connector assembly is provided for mounting to a first side of a panel and through an opening in the panel. A connector housing is adapted for mounting through the opening in the panel and carries a plurality of terminals. A multi-function mounting/latch component includes at least one mounting boss for mounting the connector housing on a circuit board. The multi-function component includes at least one mounting aperture for receiving a mounting post of the connector housing for mounting the connector housing at the first side of the panel and through the opening in the panel. The multi-function component includes at least one latch arm projecting through the opening to a second side of the panel. A locking plate is engageable with the latch arm at the second side of the panel to hold the connector in assembly through the panel. The latch arm includes a latching aperture to facilitate latching the connector assembly to a complementary mating connector at the second side of the panel.
摘要翻译：电连接器组件被提供用于安装到面板的第一侧并穿过面板中的开口。连接器壳体适于通过面板中的开口安装并且承载多个端子。多功能安装/闩锁部件包括至少一个用于将连接器壳体安装在电路板上的安装凸台。多功能部件包括至少一个用于接收连接器壳体的安装柱的安装孔，用于将连接器壳体安装在面板的第一侧并穿过面板中的开口。多功能部件包括至少一个通过该开口突出到该面板第二侧的闩锁臂。锁定板可在面板的第二侧处与闩锁臂接合，以将连接器固定通过面板组装。闩锁臂包括闩锁孔，以有助于将连接器组件锁定在面板的第二侧处的互补配合连接器。

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