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1. 发明授权

US09889168B2 Respiratory syncytial virus with a genomic deficiency complemented in trans 有权
公开(公告)号：US09889168B2
公开(公告)日：2018-02-13
申请号：US14815131
申请日：2015-07-31
申请人： De Staat der Nederlanden, vert, door de minister van VWS
发明人： Willem Luytjes , Myra Noorely Widjojoatmodjo
IPC分类号： A61K39/155 , A61K35/76 , C07K14/005 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： A61K35/76 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18532 , C12N2760/18534 , C12N2760/18552 , C12N2760/18561 , C12N2760/18562
摘要： The invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion. The invention also relates to methods for producing the pneumoviral virions and for using the virions in the treatment or prevention of pneumoviral infection and disease. A preferred pneumoviral virion is a virion of Respiratory Syncytial Virus in which preferably the gene for the G attachment protein is inactivated and complemented in trans.

2. 发明申请

US20150329833A1 RESPIRATORY SYNCYTIAL VIRUS WITH A GENOMIC DEFICIENCY COMPLEMENTED IN TRANS 审中-公开
标题翻译：具有传染性疾病的基因缺陷的呼吸道感染性病毒
公开(公告)号：US20150329833A1
公开(公告)日：2015-11-19
申请号：US14815131
申请日：2015-07-31
申请人： De Staat der Nederlanden, vert. door de minister van VWS
发明人： Willem LUYTJES , Myra Noorely WIDJOJOATMODJO
IPC分类号： C12N7/00 , A61K35/76
CPC分类号： A61K35/76 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18532 , C12N2760/18534 , C12N2760/18552 , C12N2760/18561 , C12N2760/18562
摘要： The invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion. The invention also relates to methods for producing the pneumoviral virions and for using the virions in the treatment or prevention of pneumoviral infection and disease. A preferred pneumoviral virion is a virion of Respiratory Syncytial Virus in which preferably the gene for the G attachment protein is inactivated and complemented in trans.
摘要翻译：本发明涉及包含在编码对肺病毒感染性必需的蛋白质的基因中具有突变的病毒基因组的肺病毒病毒，由此突变引起仅从病毒基因组产生的病毒缺乏感染性，并且由此病毒粒子包含蛋白质的形式和数量是病毒体的感染性所需的量。本发明还涉及用于产生肺病毒病毒颗粒和使用病毒粒子治疗或预防肺病毒感染和疾病的方法。优选的肺病毒颗粒是呼吸道合胞病毒的病毒粒子，其中G附着蛋白的基因优选被灭活并以反式互补。

3. 发明授权

US09107939B2 Respiratory syncytial virus with a genomic deficiency complemented in trans 有权
标题翻译：具有基因组缺陷的呼吸道合胞病毒在反式互补
公开(公告)号：US09107939B2
公开(公告)日：2015-08-18
申请号：US10583800
申请日：2004-12-24
申请人： Willem Luytjes , Myra Noorely Widjojoatmodjo
发明人： Willem Luytjes , Myra Noorely Widjojoatmodjo
IPC分类号： A61K39/155 , A61K35/76 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K35/76 , A61K39/12 , A61K39/155 , A61K2039/5252 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18532 , C12N2760/18534 , C12N2760/18552 , C12N2760/18561 , C12N2760/18562
摘要： The invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for infectivity of the pneumovirus, whereby the mutation causes a virus produced from only the viral genome to lack infectivity, and whereby the virion comprises the protein in a form and in an amount that is required for infectivity of the virion. The invention also relates to methods for producing the pneumoviral virions and for using the virions in the treatment or prevention of pneumoviral infection and disease. A preferred pneumoviral virion is a virion of Respiratory Syncytial Virus in which preferably the gene for the G attachment protein is inactivated and complemented in trans.
摘要翻译：本发明涉及包含在编码对肺病毒感染性必需的蛋白质的基因中具有突变的病毒基因组的肺病毒病毒，由此突变引起仅从病毒基因组产生的病毒缺乏感染性，并且由此病毒粒子包含蛋白质的形式和数量是病毒体的感染性所需的量。本发明还涉及用于产生肺病毒病毒颗粒和使用病毒粒子治疗或预防肺病毒感染和疾病的方法。优选的肺病毒颗粒是呼吸道合胞病毒的病毒粒子，其中G附着蛋白的基因优选被灭活并以反式互补。

4. 发明申请

US20110045023A1 Recombinant RSV Virus Expression Systems And Vaccines 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US20110045023A1
公开(公告)日：2011-02-24
申请号：US12855885
申请日：2010-08-13
申请人： HONG JIN , RODERICK TANG , SHENGQIANG LI , MARTIN BRYANT , DAVID KIRKWOOD CLARKE , PETER PALESE
发明人： HONG JIN , RODERICK TANG , SHENGQIANG LI , MARTIN BRYANT , DAVID KIRKWOOD CLARKE , PETER PALESE
IPC分类号： A61K39/155 , C12N7/04 , C07H21/04 , A61K35/76 , A61K31/7088 , A61P37/04 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

5. 发明申请

US20090017517A1 Preparation of Negative-Stranded RNA Viruses by Electroporation 审中-公开
标题翻译：通过电穿孔制备负链RNA病毒
公开(公告)号：US20090017517A1
公开(公告)日：2009-01-15
申请号：US12171842
申请日：2008-07-11
申请人： Jeanne Schickli , Jasmine Kaur , Roderick Tang
发明人： Jeanne Schickli , Jasmine Kaur , Roderick Tang
IPC分类号： C12N13/00
CPC分类号： C12N7/00 , C12N2760/18361 , C12N2760/18561
摘要： The present invention encompasses methods of preparing non-segmented negative-stranded RNA viruses from cells utilizing electroporation.
摘要翻译：本发明包括使用电穿孔从细胞制备非分段负链RNA病毒的方法。

6. 发明授权

US07465574B2 Recombinant RSV virus expression systems and vaccines 失效
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US07465574B2
公开(公告)日：2008-12-16
申请号：US11078900
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： C12N7/00 , C12N7/02 , C12N7/04 , C07H21/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译：本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。

7. 发明申请

US20080279892A1 Recombinant RSV Virus Expression Systems And Vaccines 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US20080279892A1
公开(公告)日：2008-11-13
申请号：US11690957
申请日：2007-03-26
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K35/76 , C12N7/01
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

8. 发明申请

US20060057158A1 Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines 失效
标题翻译：减毒，人 - 牛嵌合呼吸道合胞病毒疫苗的生产
公开(公告)号：US20060057158A1
公开(公告)日：2006-03-16
申请号：US11097946
申请日：2005-03-31
申请人： Ursula Buchholz , Peter Collins , Brian Murphy , Stephen Whitehead , Christine Krempl
发明人： Ursula Buchholz , Peter Collins , Brian Murphy , Stephen Whitehead , Christine Krempl
IPC分类号： A61K39/12 , C07H21/04 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/544 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/203
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译：嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段不同的RSV菌株。本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反义基因组。感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

9. 发明申请

US20060018927A1 Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes 有权
公开(公告)号：US20060018927A1
公开(公告)日：2006-01-26
申请号：US11054343
申请日：2005-02-08
申请人： Christine Krempl , Peter Collins , Brian Murphy , Ursula Buchholz , Stephen Whitehead
发明人： Christine Krempl , Peter Collins , Brian Murphy , Ursula Buchholz , Stephen Whitehead
IPC分类号： A61K39/155 , C12Q1/70 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2760/18622
摘要： Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.

10. 发明申请

US20050158340A1 Recombinant RSV virus expression systems and vaccines 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：US20050158340A1
公开(公告)日：2005-07-21
申请号：US11079002
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
IPC分类号： A61K39/00 , C07K14/11 , C07K14/135 , C12N7/04 , C12N15/86 , C12Q1/70 , C07H21/02 , C12N7/00 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译：本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。

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