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81. 发明授权

US06410286B1 Asparaginyl tRNA synthetase from Staphylococcus Aureus 失效
标题翻译：来自金黄色葡萄球菌的天冬酰胺酰基tRNA合成酶
公开(公告)号：US06410286B1
公开(公告)日：2002-06-25
申请号：US09018824
申请日：1998-02-04
申请人： John Edward Hodgson , Elizabeth Jane Lawlor
发明人： John Edward Hodgson , Elizabeth Jane Lawlor
IPC分类号： C12N900
CPC分类号： C12N9/93 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , C12Y601/01022
摘要： The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译：本发明提供了tRNA合成酶多肽和编码tRNA合成酶多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用tRNA合成酶多肽来保护免受感染，特别是细菌感染的方法。

82. 发明授权

US06348578B1 Apt 失效
标题翻译：易于
公开(公告)号：US06348578B1
公开(公告)日：2002-02-19
申请号：US09417511
申请日：1999-10-14
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Robert King Stodola , Magdalena Zalacain
IPC分类号： C07K100
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用适当多肽筛选抗菌化合物的方法。

83. 发明授权

US06348328B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06348328B1
公开(公告)日：2002-02-19
申请号：US08858207
申请日：1997-05-14
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard Oakley Nicholas , Robert King Stodola
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard Oakley Nicholas , Robert King Stodola
IPC分类号： C12P2102
CPC分类号： C07K14/3156 , C07K2319/00
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这些多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。

84. 发明授权

US06284489B1 Compounds 失效
标题翻译：化合物
公开(公告)号：US06284489B1
公开(公告)日：2001-09-04
申请号：US09347333
申请日：1999-07-02
申请人： Elizabeth Jane Lawlor , John Edward Hodgson
发明人： Elizabeth Jane Lawlor , John Edward Hodgson
IPC分类号： C12P2106
CPC分类号： C12N9/93 , A61K38/00 , A61K39/00
摘要： The invention provides tyrS polypeptides and DNA (RNA) encoding tyrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tyrS polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了tyrS多肽和编码tyrS多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用tyrS多肽筛选抗菌化合物的方法。

85. 发明授权

US06218159B1 Glutamyl-tRNA synthetase from Staphylococcus aureus 失效
标题翻译：来自金黄色葡萄球菌的谷氨酰-tRNA合成酶
公开(公告)号：US06218159B1
公开(公告)日：2001-04-17
申请号：US08913578
申请日：1997-09-16
申请人： John Edward Hodgson , Elizabeth Jane Lawlor
发明人： John Edward Hodgson , Elizabeth Jane Lawlor
IPC分类号： C12N900
CPC分类号： C12N9/93 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides glutamyl-tRNA synthetase polypeptides and DNA (RNA) encoding glutamyl-tRNA synthetase polypeptides from Staphylococcus aureus. The invention also provides methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides for protection against infection, particularly bacterial infections.
摘要翻译：本发明提供谷氨酰-tRNA合成酶多肽和编码来自金黄色葡萄球菌的谷氨酰-tRNA合成酶多肽的DNA（RNA）。本发明还提供了通过重组技术产生这种多肽的方法。还提供了利用这些多肽来保护免受感染，特别是细菌感染的方法。

86. 发明授权

US06165762A DNA encoding adenine phosphoribosyltransferase from Streptococcus pneumoniae 失效
标题翻译：从肺炎链球菌编码腺嘌呤磷酸核糖基转移酶的DNA
公开(公告)号：US06165762A
公开(公告)日：2000-12-26
申请号：US958668
申请日：1997-10-27
申请人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
发明人： Michael Arthur Lonetto , Richard Oakley Nicholas , James Raymond Brown , David Justin Charles Knowles , Michael Terence Black , John Edward Hodgson , Robert King Stodola , Magdalena Zalacain
IPC分类号： C12N15/09 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N9/12 , C12N9/78 , C12N9/80 , C12N15/00 , C12N15/54 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/46 , G01N33/50 , C07H21/04 , C12N1/20
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1077 , C12N9/1205 , C12N9/78 , C12N9/80 , C12Y207/01002 , Y10S530/825
摘要： The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了适应多肽和编码适应多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用适当多肽筛选抗菌化合物的方法。

87. 发明授权

US6136556A TCTS response regulator 失效
公开(公告)号：US6136556A
公开(公告)日：2000-10-24
申请号：US771321
申请日：1996-12-20
申请人： John Edward Hodgson , Nicola Gail Wallis
发明人： John Edward Hodgson , Nicola Gail Wallis
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/195 , C07K14/31 , C07K16/12 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/445 , C12D21/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/31 , A61K2039/51 , C07K2319/00
摘要： Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.

88. 发明授权

US6084086A TCSTS polynucleotides 失效
标题翻译： TCSTS多核苷酸
公开(公告)号：US6084086A
公开(公告)日：2000-07-04
申请号：US771110
申请日：1996-12-20
申请人： John Edward Hodgson , Nicola Gail Wallis
发明人： John Edward Hodgson , Nicola Gail Wallis
IPC分类号： G01N33/50 , A61K39/00 , A61K39/085 , C07K14/31 , C12N15/00 , C12N15/09 , C12R1/445 , G01N33/15 , G01N33/566 , G01N33/569 , C07H21/00 , C07H21/04 , C12P21/06
CPC分类号： C07K14/31 , A61K2039/51 , A61K39/00 , C07K2319/00 , Y10S435/883
摘要： Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.
摘要翻译：公开了新型的响应调节剂多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种多核苷酸和多肽治疗感染，特别是细菌感染的方法。还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染，特别是细菌感染的治疗剂的用途。还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。

89. 发明授权

US6077677A Fibronectin binding protein B compounds 失效
标题翻译：纤连蛋白结合蛋白B化合物
公开(公告)号：US6077677A
公开(公告)日：2000-06-20
申请号：US205049
申请日：1998-12-04
申请人： John Edward Hodgson , Martin Karl Russell Burnham
发明人： John Edward Hodgson , Martin Karl Russell Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/31 , G01N33/53
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.
摘要翻译：公开了新型纤连蛋白结合蛋白B多肽和编码这种新型纤连蛋白结合蛋白B的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种新型纤连蛋白结合蛋白B来治疗感染，特别是细菌感染的方法。还公开了抗这种新型纤连蛋白结合蛋白B的拮抗剂及其用作治疗感染特别是细菌感染的治疗剂。还公开了用于检测与宿主中新型纤连蛋白结合蛋白B核酸序列和多肽的存在相关的疾病的诊断测定。还公开了用于检测编码新型纤连蛋白结合蛋白B家族的多核苷酸并用于检测宿主中的多肽的诊断测定。

90. 发明授权

US5891667A SpoIIIe polynucleotides 失效
标题翻译： SpoIIIe多核苷酸
公开(公告)号：US5891667A
公开(公告)日：1999-04-06
申请号：US785431
申请日：1997-01-17
申请人： John Edward Hodgson , Alison Frances Chalker
发明人： John Edward Hodgson , Alison Frances Chalker
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/085 , A61K48/00 , A61P31/04 , A61P37/04 , C07K14/31 , C07K16/12 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/02 , C12P21/04 , C12Q1/68 , C12R1/445 , G01N33/15 , G01N33/569
CPC分类号： C07K14/31 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , Y10S530/82 , Y10S530/825
摘要： The invention provides spoIIIE polypeptides and DNA (RNA) encoding spIIIE polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译：本发明提供了spoIIIE多肽和编码spIIIE多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。还提供了利用spoIIIE多肽来保护免受感染，特别是细菌感染的方法。

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