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1. 发明授权

US07176299B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US07176299B2
公开(公告)日：2007-02-13
申请号：US11166905
申请日：2005-06-23
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
IPC分类号： C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译：本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。

2. 发明授权

US5858709A Fibronectin binding protein B compounds 失效
公开(公告)号：US5858709A
公开(公告)日：1999-01-12
申请号：US732791
申请日：1996-10-15
申请人： John Edward Hodgson , Martin Karl Russell Burnham
发明人： John Edward Hodgson , Martin Karl Russell Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/31 , C12P21/06 , C07H21/02 , C07H21/04
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.

3. 发明授权

US6077677A Fibronectin binding protein B compounds 失效
标题翻译：纤连蛋白结合蛋白B化合物
公开(公告)号：US6077677A
公开(公告)日：2000-06-20
申请号：US205049
申请日：1998-12-04
申请人： John Edward Hodgson , Martin Karl Russell Burnham
发明人： John Edward Hodgson , Martin Karl Russell Burnham
IPC分类号： A61K38/00 , A61K39/00 , C07K14/31 , G01N33/53
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.
摘要翻译：公开了新型纤连蛋白结合蛋白B多肽和编码这种新型纤连蛋白结合蛋白B的DNA（RNA）和通过重组技术产生此类多肽的方法。还公开了利用这种新型纤连蛋白结合蛋白B来治疗感染，特别是细菌感染的方法。还公开了抗这种新型纤连蛋白结合蛋白B的拮抗剂及其用作治疗感染特别是细菌感染的治疗剂。还公开了用于检测与宿主中新型纤连蛋白结合蛋白B核酸序列和多肽的存在相关的疾病的诊断测定。还公开了用于检测编码新型纤连蛋白结合蛋白B家族的多核苷酸并用于检测宿主中的多肽的诊断测定。

4. 发明授权

US5891672A Polynucleotides encoding GTP cyclohydrolase II (ribA) 失效
标题翻译：编码GTP环化水解酶II（ribA）的多核苷酸
公开(公告)号：US5891672A
公开(公告)日：1999-04-06
申请号：US977554
申请日：1997-11-25
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H21/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/78 , C12N9/86 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/445 , C07H21/00 , C12N15/63
CPC分类号： C12Y305/04025 , C12N9/78 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribA多肽筛选抗菌化合物的方法。

5. 发明授权

US06171598B2 GTP cyclohydrolase II (RIBA) 失效
标题翻译： GTP环化水解酶II（RIBA）
公开(公告)号：US06171598B2
公开(公告)日：2001-01-09
申请号：US09225967
申请日：1999-01-06
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： A61K3850
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribA多肽筛选抗菌化合物的方法。

6. 发明授权

US5801234A Polynucleotide encoding saliva binding protein 失效
标题翻译：多核苷酸编码唾液结合蛋白
公开(公告)号：US5801234A
公开(公告)日：1998-09-01
申请号：US896371
申请日：1997-07-18
申请人： John Edward Hodgson , Martin Karl Russell Burnham
发明人： John Edward Hodgson , Martin Karl Russell Burnham
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/21 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , C07H21/04
CPC分类号： C07K14/31 , A61K39/00 , A61K48/00
摘要： Saliva binding protein polypeptides and DNA (RNA) of Staphylococcus aureus encoding such saliva binding protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such saliva binding protein for the treatment of infection, particularly bacterial infections. Antagonists against such saliva binding protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of saliva binding protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding saliva binding protein family and for detecting the polypeptide in host.
摘要翻译：公开了唾液结合蛋白多肽和编码这种唾液结合蛋白的金黄色葡萄球菌的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种唾液结合蛋白来治疗感染，特别是细菌感染的方法。还公开了抗这种唾液结合蛋白的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。还公开了用于检测与宿主中唾液结合蛋白核酸序列和多肽的存在相关的疾病的诊断测定法。还公开了用于检测编码唾液结合蛋白家族的多核苷酸并用于检测宿主中的多肽的诊断测定。

7. 发明授权

US06299880B1 Cell surface protein compounds 失效
标题翻译：细胞表面蛋白质化合物
公开(公告)号：US06299880B1
公开(公告)日：2001-10-09
申请号：US09366575
申请日：1999-08-04
申请人： John Edward Hodgson , Martin Karl Russell Burnham
发明人： John Edward Hodgson , Martin Karl Russell Burnham
IPC分类号： A61K3902
CPC分类号： C07K14/31 , A61K39/00 , A61K48/00
摘要： Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.
摘要翻译：公开了新型细胞表面蛋白多肽和编码这种新型细胞表面蛋白质的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种新型细胞表面蛋白质治疗感染，特别是细菌感染的方法。还公开了抗这种新型细胞表面蛋白的拮抗剂及其作为治疗感染特别是细菌感染的治疗剂的用途。还公开了用于检测与宿主中新型细胞表面蛋白核酸序列和多肽的存在相关的疾病的诊断测定。还公开了用于检测编码细胞表面蛋白家族的多核苷酸并用于检测宿主中的多肽的诊断测定。

8. 发明授权

US06280971B1 Polynucleotides encoding GTP cyclohydrolase II (RIBA) 失效
标题翻译：编码GTP环化水解酶II（RIBA）的多核苷酸
公开(公告)号：US06280971B1
公开(公告)日：2001-08-28
申请号：US09227806
申请日：1999-01-11
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
IPC分类号： C12N1231
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribA多肽筛选抗菌化合物的方法。

9. 发明授权

US06448036B1 ribB 失效
公开(公告)号：US06448036B1
公开(公告)日：2002-09-10
申请号：US08977866
申请日：1997-11-25
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： C07H2104
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C12N9/78 , C12Y205/01009 , C12Y305/04025
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribB多肽筛选抗菌化合物的方法。

10. 发明授权

US06280735B1 ribG 失效
公开(公告)号：US06280735B1
公开(公告)日：2001-08-28
申请号：US09369700
申请日：1999-08-06
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： A61K3902
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ribG多肽筛选抗菌化合物的方法。

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