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81. 发明授权

US6078834A Device and method for detection and treatment of syncope 失效
标题翻译：用于检测和治疗晕厥的装置和方法
公开(公告)号：US6078834A
公开(公告)日：2000-06-20
申请号：US257566
申请日：1999-02-25
申请人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
发明人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
IPC分类号： A61M5/172 , A61N1/365 , A61M5/142
CPC分类号： A61M5/1723 , A61N1/365 , A61N1/36571 , A61N1/36592
摘要： The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.
摘要翻译：本文公开的本发明涉及用于检测和治疗晕厥的可植入医疗装置，其包括用于基于与晕厥发作相关的生理活动来确定晕厥的存在的算法，以及用于输注药物的装置。药物输注治疗可以与起搏一起使用或与起搏组合使用。该装置检测和使用的生理活动选自心率，心率变异性，QT间期，PR间期，压力，血流，迷走神经活动，温度，pH和AV传导时间的变化，呼吸频率，位置，运动及其组合。可用于本发明的药物包括能够同时进行心内膜施用和治疗晕厥的药物组合物，例如包含β-受体阻滞剂的组合物。

82. 发明授权

US5722963A Coronary sinus catheter 失效
公开(公告)号：US5722963A
公开(公告)日：1998-03-03
申请号：US625908
申请日：1996-04-01
申请人： Keith G. Lurie , David G. Benditt , Jeffrey J. Shultz , John David Ockuly , John J. Fleischhacker
发明人： Keith G. Lurie , David G. Benditt , Jeffrey J. Shultz , John David Ockuly , John J. Fleischhacker
IPC分类号： A61M25/00
CPC分类号： A61N1/056 , A61M25/0041 , A61M25/0054 , A61M2025/0081
摘要： A catheter for insertion in the ostium of the coronary sinus in the right atrium comprised of a main reinforced portion, an intermediate zone portion and a soft tip portion wherein a portion of the catheter is curved in a double curve, wherein the first curve is a first longitudinal curve, wherein the second curve is a second longitudinal curve, wherein the second longitudinal curve is curved in approximately the same direction as the first longitudinal curve and wherein the first and second longitudinal curves are generally coplanar.

83. 发明授权

US5692498A CPR device having valve for increasing the duration and magnitude of negative intrathoracic pressures 失效
标题翻译： CPR装置具有用于增加阴性胸内压力的持续时间和量值的瓣膜
公开(公告)号：US5692498A
公开(公告)日：1997-12-02
申请号：US403009
申请日：1995-03-10
申请人： Keith G. Lurie , Michael Sweeney , Barbara Gold
发明人： Keith G. Lurie , Michael Sweeney , Barbara Gold
IPC分类号： A61M16/00 , A61H31/00 , A61M16/04 , A61M16/20 , A62B9/02 , A62B7/00
CPC分类号： A61H31/005 , A61H31/00 , A61H31/006 , A61H31/007 , A61M16/0084 , A61M16/04 , A61M16/1065 , A61M16/107 , A61M16/20 , A61M16/208 , A61H2031/001 , A61H2201/1238 , A61M16/0078 , A61M16/06
摘要： According to the invention, methods and devices for increasing cardiopulmonary circulation induced by chest compression and decompression when performing cardiopulmonary resuscitation are provided. Cardiopulmonary circulation is increased according to the invention by impeding airflow into a patient's lungs to enhance the extent and duration of negative intrathoracic pressure during decompression of the patient's chest. Enhanced extent and duration of negative of intrathoracic pressure thus promotes venous blood flow into the heart and lungs from the peripheral venous vasculature. In one embodiment, impeding the airflow into the patient's lungs is accomplished by placing a ventilation tube in the patient's airway. The ventilation tube contains either a flow restrictive orifice disposed within or connected in series with a lumen of the ventilation tube, or a pressure-responsive valve within a lumen of the tube to impede the inflow of air. In a preferred embodiment, the patient's mouth and nose are covered with a facial mask which can impede airflow into the patient's airway. Also provided is an improved endotracheal tube to allow air to be impeded from flowing to the patient's lungs during decompression. Another apparatus according to the invention provides for an improved air-delivery system comprising a compressible structure which has been modified to allow for the impedance of the flow of gases to the patient's lungs. Also, the compressible structure is interfaced with the patient, preferably by attaching a facial mask or an endotracheal to the structure.
摘要翻译：根据本发明，提供了在进行心肺复苏时增加由胸部压缩和减压引起的心肺循环的方法和装置。根据本发明，通过阻止患者肺部的气流来增加病人胸部减压期间的负胸腔内压力的程度和持续时间，从而增加心肺循环。胸腔内压增加的程度和持续时间增加，从而促进静脉血液从外周静脉血管进入心脏和肺。在一个实施例中，通过将通气管放置在患者的气道中来实现阻止进入患者肺部的气流。通气管包括设置在通气管的内腔内或与通气管的内腔串联连接的限流孔，或者管内腔内的压力响应阀，以阻止空气的流入。在优选实施例中，患者的嘴和鼻子被面罩遮盖，该面罩可阻碍进入患者气道的气流。还提供了改进的气管内管，以在减压期间阻止空气流向患者的肺。根据本发明的另一种装置提供了一种改进的空气输送系统，其包括可压缩结构，该可压缩结构已被修改以允许气体流向患者肺的阻抗。此外，可压缩结构优选地通过将面罩或气管内附接到结构而与患者接合。

84. 发明授权

US5618665A Enzymatic fluorometric assay for adenylate cyclase 失效
标题翻译：腺苷酸环化酶的酶学荧光测定法
公开(公告)号：US5618665A
公开(公告)日：1997-04-08
申请号：US184040
申请日：1994-01-21
申请人： Keith G. Lurie , Phi Wiegn , Atsushi Sugiyama
发明人： Keith G. Lurie , Phi Wiegn , Atsushi Sugiyama
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/34 , C12Q1/40 , C12Q1/44 , C12Q1/48 , C12Q1/527
CPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/34 , C12Q1/40 , C12Q1/44 , C12Q1/48 , C12Q1/527 , G01N2333/988 , Y10S435/963
摘要： A method for measuring the amount of adenylate cyclase without the use of radioactive reagents is provided. The method comprises combining a sample of physiological material containing an amount of cAMP with (a) a mixture of enzymes effective to eliminate any other endogenous adenine nucleotides which may be present in the sample; and (b) an amount of alkaline phosphatase effective to eliminate any glucose-6-phosphate present in the sample. The cAMP present in said sample is then converted to AMP and the amount of AMP measured, which may then be correlated to the amount of cAMP and AC present in the sample.
摘要翻译：提供了不使用放射性试剂测量腺苷酸环化酶的量的方法。该方法包括将含有一定量的cAMP的生理材料样品与（a）有效消除可能存在于样品中的任何其它内源腺嘌呤核苷酸的酶的混合物组合; 和（b）有效消除样品中存在的任何葡萄糖-6-磷酸的碱性磷酸酶的量。然后将存在于所述样品中的cAMP转化成AMP，测量AMP量，然后与样品中存在的cAMP和AC的量相关。

85. 发明授权

US5549581A Coronary sinus catheter 失效
公开(公告)号：US5549581A
公开(公告)日：1996-08-27
申请号：US371849
申请日：1995-01-12
申请人： Keith G. Lurie , David G. Benditt , Jeffrey J. Shultz , John D. Ockuly , John J. Fleischhacker
发明人： Keith G. Lurie , David G. Benditt , Jeffrey J. Shultz , John D. Ockuly , John J. Fleischhacker
IPC分类号： A61M25/00
CPC分类号： A61N1/056 , A61M25/0041 , A61M25/0054 , A61M2025/0081
摘要： A catheter for insertion in the ostium of the coronary sinus in the right atrium comprised of a main reinforced portion, an intermediate zone portion and a soft tip portion wherein a portion of the catheter is curved in a double curve, wherein the first curve is a first longitudinal curve, wherein the second curve is a second longitudinal curve, wherein the second longitudinal curve is curved in approximately the same direction as the first longitudinal curve and wherein the first and second longitudinal curves are generally coplanar.

86. 发明授权

US11857488B2 Systems and methods for head up cardiopulmonary resuscitation 有权
公开(公告)号：US11857488B2
公开(公告)日：2024-01-02
申请号：US18161761
申请日：2023-01-30
申请人： Keith G. Lurie
发明人： Keith G. Lurie , Kanchana Sanjaya Gunesekera Karunaratne , Joseph Manno , John P. Grimm
IPC分类号： A61H31/00 , A61G13/12
CPC分类号： A61H31/007 , A61G13/122 , A61G13/129 , A61G13/1215 , A61G13/1225 , A61G13/1255 , A61G13/1285 , A61H31/004 , A61H31/005 , A61H31/006 , A61H31/008 , A61H2031/001 , A61H2201/0103 , A61H2201/0192 , A61H2201/1619 , A61H2201/1623 , A61H2201/1676 , A61H2201/5007 , A61H2201/5097 , A61H2230/208 , A61H2230/305
摘要： A method for performing cardiopulmonary resuscitation (CPR) includes elevating the heart of an individual to a first height relative to a lower body of the individual. The lower body may be in a substantially horizontal plane. The method may also include elevating the head of the individual to a second height relative to the lower body of the individual. The second height may be greater than the first height. The method may further include performing one or more of a type of CPR or a type of intrathoracic pressure regulation while elevating the heart and the head. The first height and the second height may be determined based on one or both of the type of CPR or the type of intrathoracic pressure regulation.

87. 发明授权

US11857486B2 Systems and methods for head up cardiopulmonary resuscitation 有权
公开(公告)号：US11857486B2
公开(公告)日：2024-01-02
申请号：US18161784
申请日：2023-01-30
申请人： Keith G. Lurie
发明人： Keith G. Lurie , Kanchana Sanjaya Gunesekera Karunaratne , Joseph John Manno
IPC分类号： A61H31/00 , A61G13/12
CPC分类号： A61H31/004 , A61G13/122 , A61G13/129 , A61G13/1215 , A61G13/1225 , A61G13/1255 , A61G13/1285 , A61H31/005 , A61H31/006 , A61H31/007 , A61H31/008 , A61H2201/0192 , A61H2201/1609 , A61H2201/1619 , A61H2201/1623 , A61H2201/1676 , A61H2201/5007 , A61H2201/5071 , A61H2201/5097 , A61H2230/208 , A61H2230/255 , A61H2230/305
摘要： A method for performing cardiopulmonary resuscitation (CPR) includes elevating the heart of an individual to a first height relative to a lower body of the individual. The lower body may be in a substantially horizontal plane. The method may also include elevating the head of the individual to a second height relative to the lower body of the individual. The second height may be greater than the first height. The method may further include performing one or more of a type of CPR or a type of intrathoracic pressure regulation while elevating the heart and the head. The first height and the second height may be determined based on one or both of the type of CPR or the type of intrathoracic pressure regulation.

88. 发明申请

US20230085083A1 SYSTEMS AND METHODS FOR HEAD UP CARDIOPULMONARY RESUSCITATION 有权
公开(公告)号：US20230085083A1
公开(公告)日：2023-03-16
申请号：US17842607
申请日：2022-06-16
申请人： Keith G. Lurie
发明人： Keith G. Lurie , Kanchana Sanjaya Gunesekera Karunaratne , Joseph Manno , John P. Grimm
IPC分类号： A61H31/00 , A61G13/12
摘要： A method for performing cardiopulmonary resuscitation (CPR) includes elevating the heart of an individual to a first height relative to a lower body of the individual. The lower body may be in a substantially horizontal plane. The method may also include elevating the head of the individual to a second height relative to the lower body of the individual. The second height may be greater than the first height. The method may further include performing one or more of a type of CPR or a type of intrathoracic pressure regulation while elevating the heart and the head. The first height and the second height may be determined based on one or both of the type of CPR or the type of intrathoracic pressure regulation.

89. 发明授权

US11259988B2 Active compression decompression and upper body elevation system 有权
公开(公告)号：US11259988B2
公开(公告)日：2022-03-01
申请号：US15160492
申请日：2016-05-20
申请人： Keith G. Lurie
发明人： Keith G. Lurie , Kanchana Sanjaya Gunesekera Karunaratne , Joseph Manno , John P. Grimm
IPC分类号： A61H31/00 , A61G13/12 , A61G13/08
摘要： An elevation device used in the performance of cardiopulmonary resuscitation (CPR) and after resuscitation includes a base and an upper support operably coupled to the base. The upper support is configured to elevate an individual's upper back, shoulders and head. The elevation device also includes a chest compression device coupled with the base. The chest compression device is configured to compress the chest and to actively decompress the chest.

90. 发明授权

US11246794B2 Systems and methods for improved post-resuscitation recovery 有权
公开(公告)号：US11246794B2
公开(公告)日：2022-02-15
申请号：US16418902
申请日：2019-05-21
申请人： Keith G. Lurie
发明人： Keith G. Lurie
IPC分类号： A61H31/00 , A61G13/12 , A61G13/04
摘要： A method for performing cardiopulmonary resuscitation (CPR) includes elevating the head, heart and shoulders of an individual from a starting elevation angle to a final elevation angle greater than zero degrees relative to horizontal while performing CPR by repeatedly compressing the chest. The method includes elevating the brain within a time period selected to be slow enough to permit a sufficient amount of blood to flow to the brain throughout the elevation time period. The method also includes regulating the intrathoracic pressure of the individual while performing CPR. The performance of chest compressions is stopped and after stopping the performance of chest compressions, the head, heart, and shoulders are promptly from the final elevation angle within a timeframe selected to prevent significant drainage of blood from the brain until the head, heart and shoulders are lowered.

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