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1. 发明授权

US6078834A Device and method for detection and treatment of syncope 失效
标题翻译：用于检测和治疗晕厥的装置和方法
公开(公告)号：US6078834A
公开(公告)日：2000-06-20
申请号：US257566
申请日：1999-02-25
申请人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
发明人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
IPC分类号： A61M5/172 , A61N1/365 , A61M5/142
CPC分类号： A61M5/1723 , A61N1/365 , A61N1/36571 , A61N1/36592
摘要： The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.
摘要翻译：本文公开的本发明涉及用于检测和治疗晕厥的可植入医疗装置，其包括用于基于与晕厥发作相关的生理活动来确定晕厥的存在的算法，以及用于输注药物的装置。药物输注治疗可以与起搏一起使用或与起搏组合使用。该装置检测和使用的生理活动选自心率，心率变异性，QT间期，PR间期，压力，血流，迷走神经活动，温度，pH和AV传导时间的变化，呼吸频率，位置，运动及其组合。可用于本发明的药物包括能够同时进行心内膜施用和治疗晕厥的药物组合物，例如包含β-受体阻滞剂的组合物。

2. 发明授权

US5919210A Device and method for detection and treatment of syncope 失效
公开(公告)号：US5919210A
公开(公告)日：1999-07-06
申请号：US831608
申请日：1997-04-10
申请人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
发明人： Keith G. Lurie , David Benditt , Stanislao F. Obino , Paul J. Buscemi
IPC分类号： A61M5/172 , A61N1/365 , A61M5/142
CPC分类号： A61M5/1723 , A61N1/365 , A61N1/36571 , A61N1/36592
摘要： The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.

3. 发明授权

US5755761A Atrial pacing catheter and method having multiple electrodes in the right atrium and coronary sinus 失效
标题翻译：心房起搏导管和方法在右心房和冠状窦具有多个电极
公开(公告)号：US5755761A
公开(公告)日：1998-05-26
申请号：US638105
申请日：1996-04-26
申请人： Stanislao F. Obino
发明人： Stanislao F. Obino
IPC分类号： A61N1/05 , A61N1/372 , A61N1/368
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An atrial catheter for insertion into the coronary sinus carries free-floating sensing electrodes and one or more pacing electrodes in contact with the tissue of the coronary sinus.
摘要翻译：用于插入冠状窦的心房导管携带自由浮动感测电极和一个或多个与冠状窦组织接触的起搏电极。

4. 发明授权

US5800498A Catheter for implantable rhythm control device 失效
标题翻译：导管用于植入式节律控制装置
公开(公告)号：US5800498A
公开(公告)日：1998-09-01
申请号：US639131
申请日：1996-04-26
申请人： Stanislao F. Obino , Paul J. Buscemi
发明人： Stanislao F. Obino , Paul J. Buscemi
IPC分类号： A61N1/05 , A61N1/362
CPC分类号： A61N1/3622 , A61N1/0563
摘要： A catheter for use with an implantable drug dispensing arrhythmia control device, includes a lumen and valve for dispensing the drug, and multiple electrodes for sensing heart activity.
摘要翻译：用于可植入药物分配心律失常控制装置的导管包括用于分配药物的内腔和阀以及用于感测心脏活动的多个电极。

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