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81. 发明申请

US20090318941A1 Self-Expandable Endovascular Device For Aneurysm Occlusion 审中-公开
标题翻译：用于动脉瘤闭塞的自扩张血管内装置
公开(公告)号：US20090318941A1
公开(公告)日：2009-12-24
申请号：US12294210
申请日：2007-03-23
申请人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
发明人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
IPC分类号： A61B17/08 , A61M25/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/12181 , A61B90/39 , A61B2017/00526 , A61B2017/00867 , A61B2017/00893 , A61B2017/12095
摘要： The self-expandable endovascular apparatus for aneurysm occlusion of the invention comprises a deformable shape memory frame with at least a partial segment covering comprised of a matrix implant material. The device can be folded and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expands in place as it adopts its original shape on release from the device into an aneurysm. A method of treating an aneurysm, comprises the steps of: (a) providing the self-expandable endovascular apparatus inserted into a lumen of a delivery device comprising a proximal end and a distal end, the distal end having a distal tip; (b) advancing the distal tip of the delivery device into an opening in an aneurysm having an interior sac; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery device, whereby the apparatus expands into the sac and covers the opening.
摘要翻译：本发明的用于动脉瘤闭塞的自扩张型血管内装置包括具有由基质植入材料构成的至少部分段覆盖物的可变形形状记忆框架。该装置可以被折叠和/或拉伸以采用窄的轮廓以装载到同轴输送装置中，并且在从装置释放到动脉瘤中时采用其原始形状而扩展就位。一种治疗动脉瘤的方法，包括以下步骤：（a）提供插入到包括近端和远端的输送装置的内腔中的自扩张型血管内装置，所述远端具有远端; （b）将输送装置的远端前进到具有内囊的动脉瘤的开口中; （c）使设备通过内腔进入开口; 和（d）取出输送装置，从而使装置膨胀成囊并覆盖开口。

82. 再颁专利

USRE41029E1 Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 有权
标题翻译：动脉，静脉，动脉瘤，血管畸形和动静脉瘘中血栓形成的血管内电解可分离线和尖端
公开(公告)号：USRE41029E1
公开(公告)日：2009-12-01
申请号：US11377895
申请日：2006-03-15
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/04 , A61B17/12 , A61B18/14 , A61B18/12 , A61B17/00
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B18/1402 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/09175
摘要： An artery, vein, aneurysms vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.REEAXMINATION RESULTS The questions raised in reexamination request 90/007,231, filed Oct. 4, 2004 have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e), for ex parte reexaminations, or the reexamination certificate required by 35 U.S.C. 316 as provided in 37 CFR 1.99(e) for inter partes reexaminations.
摘要翻译：动脉，静脉，动脉瘤血管畸形或动脉瘘通过血管内插入铂丝和/或尖端进入血管腔而通过血管内闭塞而闭塞。血管腔填充有尖端以阻止血液流动或进入腔中的血液，使得腔中的血块凝块和形成闭塞。尖端可以是细长的和柔性的，使得其通过在其自身上折叠多次来包装空腔，或者可以通过尖端的丝状或模糊结构来包装空腔。然后将尖端机械地从线分离，或者通过电极将电极与线分离。之后取出线和微导管，留下尖端嵌入形成在血管腔内的血栓。通过在微导管上提供不透射线的近端标记物和线上的相应指示标记，更容易跟踪导线在微导管中的移动。通过将接地电极放置在微导管的远端并在微导管电极和尖端之间流动电流来促进血栓形成。审议结果2004年10月4日提交的复审请求90 / 007,231中提出的问题已被考虑，其结果反映在该重新颁发专利中，该专利构成了35U.S.C.所要求的复审证书。根据第37 CFR 1.570（e）条规定，单方面复审或35 U.S.C.所要求的复审证书。 316，如第37 CFR 1.99（e）条所述，用于跨部门复审。

83. 发明授权

US07288065B1 Access platform for internal mammary dissection 失效
标题翻译：内部乳腺切开手术平台
公开(公告)号：US07288065B1
公开(公告)日：2007-10-30
申请号：US09480828
申请日：2000-01-10
申请人： Charles S. Taylor , William N. Aldrich , Federico J. Benetti , Richard S. Ginn , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Ivan Sepetka , William F. Witt
发明人： Charles S. Taylor , William N. Aldrich , Federico J. Benetti , Richard S. Ginn , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Ivan Sepetka , William F. Witt
IPC分类号： A61B17/04 , A61B1/32 , A61M29/00
CPC分类号： A61B17/3423 , A61B17/0206 , A61B17/025 , A61B17/3476 , A61B90/50 , A61B2017/349
摘要： An access platform having a first and a second blade interconnected to a spreader member that laterally drives the blades apart or together and a sternal pad interconnected to a blade. The superior blade is preferably pivotally coupled to the spreader member such that it naturally rises as the blades are separated. Alternatively, a vertical displacement member is operably interconnected to a blade and the spreader member and is used to vertically displace the interconnected superior blade and, thus, increase a surgeon's working space and visual access for the dissection of an internal mammary artery. A tissue retractor is interconnected to the blades to draw the soft tissue around an incision away from the surgeon's working area.
摘要翻译：一种进入平台，具有互连到扩张器构件的第一和第二刀片，所述第二和第二刀片横向地驱动刀片彼此分开或一起，以及与刀片互连的胸骨垫。优选的叶片优选地枢转地联接到扩展器构件，使得其随着叶片分离而自然地上升。或者，垂直移位构件可操作地连接到叶片和吊架构件，并且用于垂直地移位互连的上叶片，并且因此增加外科医生的工作空间和用于解剖内部乳房动脉的视觉进入。组织牵缩器与刀片相互连接以将软组织围绕切口远离外科医生的工作区域。

84. 发明授权

US06743169B1 Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery 失效
公开(公告)号：US06743169B1
公开(公告)日：2004-06-01
申请号：US09975392
申请日：2001-10-10
申请人： Charles S. Taylor , William N. Aldrich , Thomas L. Baughman , Federico J. Benetti , Brian J. Bennett , Michael J. Billig , Thomas J. Fogarty , John J. Frantzen , Richard S. Ginn , Robert C. Glines , Harry L. Green , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Amr Salahieh , Ivan Sepetka , Benjamin Sherman , Christian Skieller , Valavanur A. Subramanian , Gary B. Weller , William F. Witt
发明人： Charles S. Taylor , William N. Aldrich , Thomas L. Baughman , Federico J. Benetti , Brian J. Bennett , Michael J. Billig , Thomas J. Fogarty , John J. Frantzen , Richard S. Ginn , Robert C. Glines , Harry L. Green , Dwight P. Morejohn , Brent Regan , Eugene E. Reis , Amr Salahieh , Ivan Sepetka , Benjamin Sherman , Christian Skieller , Valavanur A. Subramanian , Gary B. Weller , William F. Witt
IPC分类号： A61B132
CPC分类号： A61B17/3421 , A61B17/00234 , A61B17/02 , A61B17/0206 , A61B17/0218 , A61B17/0642 , A61B17/12 , A61B17/3423 , A61B17/8076 , A61B90/00 , A61B2017/00243 , A61B2017/00539 , A61B2017/00703 , A61B2017/00858 , A61B2017/00991 , A61B2017/0243 , A61B2017/0648 , A61B2017/1139 , A61B2017/2825 , A61B2017/2913 , A61B2017/2929 , A61B2017/306 , A61B2017/349
摘要： The invention is methods and devices which a surgeon may use to stabilize the beating heart during a surgical procedure on the heart. Pursuant to the invention, a stabilizing device is introduced through an opening in the chest and brought into contact with the beating heart. By contacting the heart with the device and by exerting a stabilizing force on the device, the motion of the heart caused by the contraction of the heart muscles is effectively eliminated such that the heart is stabilized and the site of the surgery moves only minimally if at all. Typically, in separate steps, the surgeon contacts the heart with the stabilizing means, assesses the degree of movement of the anastomosis site, and exerts a force on the stabilizing means such that the contraction of the beating heart causes orgy minimal excess motion at the surgery site. By fixing the position of the stabilizing means in a configuration where the motion of the beating heart is effectively eliminated, the surgeon is able to stabilize the beating heart for the duration of the procedure. The stabilizing means may be attached to a rigid support or may be attached to a semi-rigid support which is rendered motionless mechanically, chemically, or by human intervention. In certain preferred embodiments, the stabilizing means is affixed to a semi-rigid support which is caused to become rigid, by any of a variety of techniques, such that the position of the stabilizing means becomes fixed by the support, and the heart remains substantially motionless for the duration of the procedure.

85. 发明授权

US06387108B1 Surgical instruments for making precise incisions in a cardiac vessel 有权
标题翻译：用于在心脏血管中进行精确切口的手术器械
公开(公告)号：US06387108B1
公开(公告)日：2002-05-14
申请号：US09541851
申请日：2000-04-03
申请人： Charles S. Taylor , John J. Frantzen , Ivan Sepetka
发明人： Charles S. Taylor , John J. Frantzen , Ivan Sepetka
IPC分类号： A61B1732
CPC分类号： A61B17/32 , A61B17/320016 , A61B2017/00243 , A61B2017/00703 , A61B2017/00778 , A61B2017/2925 , A61B2017/320052
摘要： The invention is surgical instruments which facilitate substantially linear incisions, especially through the wall of vessels, such as arteries, which have been specifically designed for coronary artery bypass graft procedures (CABG) on the beating heart. The instruments of the invention are particularly useful to create the incision in the artery to which the bypass graft is sewed, typically the left anterior descending artery (LAD). The instruments of the invention allow incisions to be rapidly made, precisely measured, and cleanly formed so that a bypass graft can be rapidly sewn in place. In one embodiment, the invention is comprised of a hand-held instrument with a curved cutting edge formed on the interior edge of a curved or arcuitous segment located near the end of the instrument. The tip of the instrument has a point of penetrating the vessel wall. The point may have several alternate shapes to facilitate penetration of the vessel wall while maximizing the trauma to the surrounding tissue. Another embodiment is comprised of a hand-held instrument with moveable member such that the incision is created by engaging a cutting blade against a stop with the tissue being cut therebetween. This instrument is also constructed to facilitate a rapid linear incisions in a vessel while minimizing the possibility for damage to the surrounding tissue. In another embodiment, the instrument features a motion-cancelling member which compensates for the movement of the target surface to be incised. This embodiment has a cutting blade which is manipulated form handle which is isolated from the movement of the tissue containing or proximate to the target of the incision. The instruments facilitate the invasive cardiac procedures by creating linear incisions quickly without undue trauma to surrounding tissue and without excess loss of blood.
摘要翻译：本发明是促进基本上线性切口的手术器械，特别是通过在搏动心脏上专门设计用于冠状动脉旁路移植手术（CABG）的血管如动脉壁。本发明的器械特别可用于在旁路移植物缝合的动脉中形成切口，通常为左前降支动脉（LAD）。本发明的仪器允许快速地进行切割，精确地测量和清洁地形成切口，使得旁路移植物能够快速地缝合到位。在一个实施例中，本发明包括具有弯曲切割边缘的手持式仪器，其形成在位于靠近仪器端部的弯曲或直立部分的内边缘上。仪器的尖端具有穿透血管壁的点。该点可以具有几种替代形状，以促进血管壁的穿透，同时使周围组织的创伤最大化。另一个实施例包括具有可移动构件的手持式仪器，使得通过将切割刀片接合在止动件上而在其间切割的组织而产生切口。该仪器还构造成便于在容器中快速线性切口，同时最小化对周围组织的损伤的可能性。在另一个实施例中，仪器具有补偿待切割的目标表面的移动的运动消除构件。该实施例具有切割刀片，该切割刀片从手柄被操纵，所述切割刀片与包含或接近切口的靶标的组织的运动隔离。这些仪器通过快速创建线性切口来促进侵入性心脏手术，而不会对周围组织造成不必要的创伤，而不会导致血液过多的流失。

86. 发明授权

US06375668B1 Devices and methods for treating vascular malformations 有权
标题翻译：用于治疗血管畸形的装置和方法
公开(公告)号：US06375668B1
公开(公告)日：2002-04-23
申请号：US09324359
申请日：1999-06-02
申请人： Hanson S. Gifford , Ivan Sepetka , Mark E. Deem , Martin S. Dieck
发明人： Hanson S. Gifford , Ivan Sepetka , Mark E. Deem , Martin S. Dieck
IPC分类号： A61M2900
CPC分类号： A61B18/1492 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12118 , A61B17/12136 , A61B17/1214 , A61B17/12145 , A61B17/12168 , A61B17/12172 , A61B17/12177 , A61B17/12186 , A61B2017/00867 , A61B2017/1205 , A61B2017/12068 , A61B2017/12081 , A61B2017/12095 , A61B2018/00214 , A61B2018/00416 , A61B2018/1495 , A61M25/0068 , A61M25/007 , A61M25/0074 , A61M25/0082 , A61M25/1002 , A61M29/00 , A61M29/02 , A61M2025/1084 , A61M2205/36
摘要： A system for treating a vascular malformation has an expandable device and a heating device for heating and shrinking the malformation. The expandable device may have deformable elements which plastically deform in the expanded position. The balloon may be self-expanding, balloon expanded or expanded with an actuating rod. A fluid, such as saline, may be introduced during heating when using RF heating. A sealant may also be introduced into the expandable device to further seal the aneurysm.
摘要翻译：用于治疗血管畸形的系统具有用于加热和收缩畸形的可扩张装置和加热装置。可扩张装置可以具有在扩展位置塑性变形的可变形元件。气球可以是自膨胀的，气球膨胀的或用致动杆膨胀的。使用RF加热时，可以在加热过程中引入流体，如盐水。还可以将密封剂引入到可扩张装置中以进一步密封动脉瘤。

87. 发明授权

US06355030B1 Instruments and methods employing thermal energy for the repair and replacement of cardiac valves 有权
标题翻译：使用热能修复和更换心脏瓣膜的仪器和方法
公开(公告)号：US06355030B1
公开(公告)日：2002-03-12
申请号：US09161079
申请日：1998-09-25
申请人： William N. Aldrich , Michael V. Morejohn , Richard A. Helkowski , Ivan Sepetka
发明人： William N. Aldrich , Michael V. Morejohn , Richard A. Helkowski , Ivan Sepetka
IPC分类号： A61B1804
CPC分类号： A61B18/08 , A61B90/30 , A61B2017/00084 , A61B2017/00243 , A61B2018/046 , A61F2/2412 , A61F2/2427 , A61F2/2445 , A61F2/2463 , A61F2250/0059
摘要： The present invention is methods and devices for improving valve function in a heart. Particularly a device of the present invention comprises a an elongate member having a distal end and a proximal end, a thermal heating member fixed to the distal end of the elongate member, wherein the thermal heating member includes at least one thermal heating element adapted to supply thermal energy to a heart valve structure, and an energy source in communication with the thermal heating element. In use, a thermal heating device of the present invention is inserted into working space proximate the valve to be treated and is used to selectively contract the collagen fibers of the valve structure treated so as to improve the performance and functioning of the valve. Devices are disclosed suitable for use with a variety of access procedures on both beating and non-beating hearts, including: a minimally invasive surgical procedure, a sternotomy, a thoracotomy, an endovascular procedure, and endoscopic procedure, or a percutaneous procedure. Methods and devices are disclosed which are suitable for treatment of a chordae, leaflet, or annulus, as well as devices and methods for the replacement of heart valve with prosthetic valves.
摘要翻译：本发明是用于改善心脏中的瓣膜功能的方法和装置。特别地，本发明的装置包括具有远端和近端的细长构件，固定到细长构件的远端的热加热构件，其中热加热构件包括至少一个适于供应的热加热元件与心脏瓣膜结构的热能，以及与热加热元件连通的能量源。在使用中，将本发明的热加热装置插入靠近待处理的阀的工作空间中，并用于选择性地收缩被处理的阀结构的胶原纤维，以改善阀的性能和功能。公开的装置被公开适用于跳动和非跳动心脏上的各种进入程序，包括：微创外科手术，胸骨切开术，开胸手术，血管内手术和内窥镜手术或经皮手术。公开了适用于治疗腱索，小叶或环的方法和装置，以及用人造瓣膜置换心脏瓣膜的装置和方法。

88. 发明授权

US06280455B1 Surgical instrument for facilitating the detachment of an artery and the like 失效
标题翻译：用于促进动脉等的分离的手术器械
公开(公告)号：US06280455B1
公开(公告)日：2001-08-28
申请号：US09243742
申请日：1999-02-03
申请人： Richard S. Ginn , Hani Shennib , Charles S. Taylor , Ivan Sepetka
发明人： Richard S. Ginn , Hani Shennib , Charles S. Taylor , Ivan Sepetka
IPC分类号： A61B1700
CPC分类号： A61B17/00008 , A61B17/00234 , A61B17/02 , A61B17/320016 , A61B2017/00867 , A61B2017/00969 , A61B2017/2905 , A61B2017/2927 , A61B2018/00916 , A61B2018/1253 , A61B2018/1407 , A61B2018/1435
摘要： A surgical instrument is configured to aid in performing a procedure of detaching an internal mammary artery (IMA) and the like, from the connecting tissues and side branch vessels which surround the artery in its native location, wherein the detaching procedure is preliminary to the performing of a coronary artery bypass grafting procedure and wherein the IMA is detached via a minimally invasive thoracotomy. To this end, an elongated slender rod includes a handle at its proximal end and an artery engaging loop, arc, fork configuration, or hook at its distal working end. Embodiments may incorporate electrosurgical capability or electrical insulation. A surgeon thus has means for harvesting an intact and undamaged graft vessel from its native location through a minimally invasive incision with enhanced speed, visibility, and freedom of motion.
摘要翻译：手术器械被配置为有助于执行从其周围的动脉周围的连接组织和侧分支血管分离内部乳腺动脉（IMA）等的步骤，其中分离程序是执行的初步的冠状动脉旁路移植手术，其中通过微创开胸术分离IMA。为此，细长杆在其近端包括手柄，在其远端工作端处包括动脉接合环，弧形，叉形结构或钩。实施例可以包括电外科能力或电绝缘。因此，外科医生具有通过具有增强的速度，可见性和运动自由的微创切口从其原始位置收集完整且未损坏的移植血管的手段。

89. 发明授权

US06254592B1 Variable stiffness coils 失效
标题翻译：可变刚度线圈
公开(公告)号：US06254592B1
公开(公告)日：2001-07-03
申请号：US09073116
申请日：1998-05-05
申请人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G.M. Ken , Nga T. Van
发明人： Gene Samson , Ivan Sepetka , U. Hiram Chee , Christopher G.M. Ken , Nga T. Van
IPC分类号： A61B1700
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12109 , A61B17/12145
摘要： An implantable vaso-occlusive device, constructed of a helically wound coil having a central section along its longitudinal axis which is somewhat stiffer than at least one of its end regions.
摘要翻译：一种可植入血管闭塞装置，其由螺旋缠绕的线圈构成，该线圈具有沿着其纵向轴线的中心部分，该中心部分比其端部区域中的至少一个稍微更硬。

90. 发明授权

US06238415B1 Implant delivery assembly with expandable coupling/decoupling mechanism 失效
标题翻译：具有可扩张联轴器/解耦机构的植入物输送组件
公开(公告)号：US06238415B1
公开(公告)日：2001-05-29
申请号：US09034606
申请日：1998-03-03
申请人： Ivan Sepetka , U. Hiram Chee
发明人： Ivan Sepetka , U. Hiram Chee
IPC分类号： A61B1708
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/12068 , A61B2017/12081
摘要： An occlusive implant delivery assembly includes a rapid response decoupling or detachment mechanism that does not effect significant migration of the implant during release. The assembly includes an occlusive implant device, such as an embolic coil, a pusher or device to carry the implant to the selected location, and an expandable coupling-decoupling mechanism for releasing the implant at the selected site. The mechanical construction provides rapid release times. In addition, the releasing mechanism generally operates without exerting any significant force on the implant, thereby avoiding any significant displacement of the implant during release.
摘要翻译：闭塞植入物递送组件包括在释放期间不影响植入物的显着迁移的快速反应解耦或分离机构。该组件包括闭塞植入装置，例如栓塞线圈，用于将植入物携带到所选择的位置的推动器或装置，以及用于在选定部位释放植入物的可扩展联接 - 解耦机构。机械结构提供快速释放时间。此外，释放机构通常在植入物上不施加任何显着的力的情况下操作，从而避免在释放期间植入物的任何显着位移。

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