专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US07857957B2 Integrated portable biological detection system 失效
标题翻译：综合便携式生物检测系统
公开(公告)号：US07857957B2
公开(公告)日：2010-12-28
申请号：US11702417
申请日：2007-02-05
申请人： Jing Cheng , Lei Wu , Michael J. Heller , Edward L. Sheldon , Jonathan M. Diver , James P. O'Connell , Dan Smolko , Shila Jalali , David Willoughby
发明人： Jing Cheng , Lei Wu , Michael J. Heller , Edward L. Sheldon , Jonathan M. Diver , James P. O'Connell , Dan Smolko , Shila Jalali , David Willoughby
IPC分类号： G01N27/447 , C12N1/06
CPC分类号： C12Q1/24 , B01L3/502 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2400/0424 , B01L2400/0487 , G01N21/6428
摘要： We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imaging. We have also released DNA and RNA from the isolated cells electronically and detected specific marker sequences by DNA amplification followed by electronic hybridization to immobilized capture probes. Efforts towards the construction of a “laboratory-on-a-chip” system are presented which involves the selection of DNA probes, dyes, reagents and prototyping of the fully integrated portable instrument.
摘要翻译：我们通过介电电泳在微细电子芯片中进行细胞和癌细胞与外周血液分离。通过用荧光染料染色细胞核，然后激光诱导荧光成像来检查分离的细胞。我们还通过电子方式从分离的细胞中释放DNA和RNA，并通过DNA扩增检测特异性标记序列，然后与固定的捕获探针进行电子杂交。提出了建立“芯片实验室”系统的努力，其中包括选择DNA探针，染料，试剂和完全集成的便携式仪器的原型。

82. 发明申请

US20100307150A1 ELECTROTHERMAL MICROACTUATOR FOR LARGE VERTICAL DISPLACEMENT WITHOUT TILT OR LATERAL SHIFT 有权
标题翻译：无倾斜或横向移位的大直角位移电热微处理器
公开(公告)号：US20100307150A1
公开(公告)日：2010-12-09
申请号：US12743499
申请日：2008-12-15
申请人： Lei Wu , Huikai Xie
发明人： Lei Wu , Huikai Xie
IPC分类号： F03G7/06
CPC分类号： B81B3/0024 , B81B2201/032 , B81B2201/047 , B81B2203/053
摘要： A microactuator for displacing a platform vertically with respect to a substrate includes a first rigid frame, a first flexible bimorph beam connecting the first frame to the substrate, a second rigid frame, a second flexible bimorph beam connecting the second frame to the first frame, and a third flexible bimorph beam connecting a platform to the second frame. Activation of the first, second, and third flexible bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A microactuator assembly includes a substrate, a plurality of first rigid frames, a plurality of first flexible bimorph beams, a plurality of second rigid frames, a plurality of second flexible bimorph beams, a platform, and a plurality of third flexible bimorph beams. Activation of the first, second, and third bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A further embodiment with four identical such microactuators oriented at four sides of the platform, can achieve 1D or 2D angular scanning of the mirror plate by the activation of 1 or 2 adjacent microactuators.
摘要翻译：用于使平台相对于衬底垂直移位的微致动器包括第一刚性框架，将第一框架连接到衬底的第一柔性双压电晶片梁，第二刚性框架，将第二框架连接到第一框架的第二柔性双压电晶片梁，以及将平台连接到第二框架的第三柔性双压电晶片。第一，第二和第三柔性双晶片束的激活允许平台相对于衬底的垂直位移，具有可忽略的横向偏移。微致动器组件包括基板，多个第一刚性框架，多个第一柔性双压电晶片梁，多个第二刚性框架，多个第二柔性双压电晶片梁，平台和多个第三柔性双压电晶片。第一，第二和第三双晶片束的激活允许平台相对于衬底的垂直位移，具有可忽略的横向偏移。具有四个相同的这样的微致动器的另一实施例在平台的四个侧面定向，可以通过激活1或2个相邻微致动器来实现镜板的1D或2D角扫描。

83. 发明授权

US07776543B2 Microdevice containing photorecognizable coding patterns and methods of using and producing the same 有权
公开(公告)号：US07776543B2
公开(公告)日：2010-08-17
申请号：US09924428
申请日：2001-08-07
申请人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
发明人： Lei Wu , Xiaobo Wang , Guoliang Tao , Junquan Xu , Jing Cheng , Mingxiang Huang , Baoquan Sun , Wei Shao , Litian Liu , Depu Chen , David M. Rothwarf , Weiping Yang
IPC分类号： G01N33/53
摘要： This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on the substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof.

84. 发明申请

US20090209029A1 HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS 审中-公开
标题翻译：高密度离子传输测量生物技术设备和方法
公开(公告)号：US20090209029A1
公开(公告)日：2009-08-20
申请号：US12233565
申请日：2008-09-18
申请人： Antonio Guia , George Walker , Mingxian Huang , Abdelleh Menikh , Lei Wu , Sithiphong Khachonesin , Julian Yuan , Jia Xu
发明人： Antonio Guia , George Walker , Mingxian Huang , Abdelleh Menikh , Lei Wu , Sithiphong Khachonesin , Julian Yuan , Jia Xu
IPC分类号： C12M1/34
CPC分类号： G01N33/48728 , B01L3/502761 , B01L3/502792 , B01L3/5085 , B01L3/5088 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/12 , B01L2300/0819 , B01L2300/0887 , B01L2300/12 , B01L2300/161 , B01L2400/049 , B03C5/026 , B65B31/00 , C12Q2565/629 , C23C16/452 , F16J15/021 , G01N15/1031 , G01N31/22 , G01N35/00029 , G01N2035/00158 , G01N2333/705 , H01J2237/3142
摘要： The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips.
摘要翻译：本发明包括用于测量细胞离子通道的生物芯片和使用和制造方法。本发明的生物芯片具有增强的密封能力，其部分通过化学改性生物芯片表面或基底的表面或通过暴露于电离气体而提供。本发明还包括用于生物芯片的新型盒。

85. 发明授权

US07576649B2 Anti-theft alarm system for portable computer 失效
标题翻译：便携式电脑防盗报警系统
公开(公告)号：US07576649B2
公开(公告)日：2009-08-18
申请号：US11309535
申请日：2006-08-18
申请人： Lei Wu
发明人： Lei Wu
IPC分类号： G08B13/14
CPC分类号： G08B13/1436 , G06F21/88
摘要： An anti-theft alarm system for a portable computer, the anti-theft alarm system includes a controller, a button for delivering an anti-theft enabling signal to the controller, and a motion sensor enabled when the controller receives the anti-theft enabling signal and providing a detection signal indicating unauthorized movement of the portable computer, the controller providing an alarm control signal to an audio portion when it receives the detection signal, the audio portion producing an audible sound for a theft deterrence effect when it receives the alarm control signal.
摘要翻译：一种用于便携式计算机的防盗报警系统，防盗报警系统包括控制器，用于向控制器传送防盗使能信号的按钮以及当控制器接收到防盗使能信号时使能的运动传感器并且提供指示便携式计算机的未授权移动的检测信号，所述控制器在接收到所述检测信号时向所述音频部分提供报警控制信号，所述音频部分在接收到所述报警控制信号时产生用于防盗措施的可听见的声音。

86. 发明申请

US20080057505A1 METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：US20080057505A1
公开(公告)日：2008-03-06
申请号：US11777962
申请日：2007-07-13
申请人： Ping Lin , Andrea Ghetti , Wenge Shi , Mengjia Tang , Gioulnar Harvie , Huimin Tao , Guoliang Tao , Lei Wu , David Cerny , Jia Xu
发明人： Ping Lin , Andrea Ghetti , Wenge Shi , Mengjia Tang , Gioulnar Harvie , Huimin Tao , Guoliang Tao , Lei Wu , David Cerny , Jia Xu
IPC分类号： G01N33/574 , C12Q1/02 , C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/54346 , G01N33/56966 , G01N33/574 , G01N2333/70525 , G01N2333/70589 , G01N2800/52
摘要： The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a downstream process such as identifies, characterizes or even grown in culture or used in other ways. The invention also include a method of determining the aggressiveness of the tumor or of the number or proportion of cancer cells in the enriched sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample containing at least one of each of red blood cells and white blood cells, resulting in the enrichment of rare target cells including circulating tumor cells (CTC), stromal cells, mesenchymal cells, endothelial cells, fetal cells, stem cells, non-hematopoietic cells etc from a blood sample. The method is based upon combination of immuno-microparticles (antibody coated microparticles) and density-based separation. The final enriched target cells can be subjected to a variety of analysis and manipulations, such as flowcytometry, PCR, immunofluorescence, immunocytochemistry, image analysis, enzymatic assays, gene expression profiling analysis, efficacy tests of therapeutics, culturing of enriched rare cells, and therapeutic use of enriched rare cells. In addition, depleted plasma protein and white blood cells can be optionally recovered, and subjected to other analysis such as inflammation studies, gene expression profiling, etc.

87. 发明申请

US20080047832A1 Integrated portable biological detection system 失效
标题翻译：综合便携式生物检测系统
公开(公告)号：US20080047832A1
公开(公告)日：2008-02-28
申请号：US11702417
申请日：2007-02-05
申请人： Jing Cheng , Lei Wu , Michael Heller , Edward Sheldon , Jonathan Diver , James O'Connell , Dan Smolko , Shila Jalali , David Willoughby
发明人： Jing Cheng , Lei Wu , Michael Heller , Edward Sheldon , Jonathan Diver , James O'Connell , Dan Smolko , Shila Jalali , David Willoughby
IPC分类号： C12M1/42
CPC分类号： C12Q1/24 , B01L3/502 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2400/0424 , B01L2400/0487 , G01N21/6428
摘要： We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the nuclei with fluorescent dye followed by laser induced fluorescence imaging. We have also released DNA and RNA from the isolated cells electronically and detected specific marker sequences by DNA amplification followed by electronic hybridization to immobilized capture probes. Efforts towards the construction of a “laboratory-on-a-chip” system are presented which involves the selection of DNA probes, dyes, reagents and prototyping of the fully integrated portable instrument.
摘要翻译：我们通过介电电泳在微细电子芯片中进行细胞和癌细胞与外周血液分离。通过用荧光染料染色细胞核，然后激光诱导荧光成像来检查分离的细胞。我们还通过电子方式从分离的细胞中释放DNA和RNA，并通过DNA扩增检测特异性标记序列，然后与固定的捕获探针进行电子杂交。提出了建立“芯片实验室”系统的努力，其中包括选择DNA探针，染料，试剂和完全集成的便携式仪器的原型。

88. 发明申请

US20080025589A1 Image measuring apparatus and method, and image measuring system for glomerular filtration rate 有权
标题翻译：图像测量装置和方法，以及用于肾小球滤过率的图像测量系统
公开(公告)号：US20080025589A1
公开(公告)日：2008-01-31
申请号：US11636475
申请日：2006-12-11
申请人： Hongfeng Ma , Qiang Di , Lei Wu , Honglei Fu , Longwei Mei , Liang Tian , Songmin Quan , Jun Zhang , Yan Kang
发明人： Hongfeng Ma , Qiang Di , Lei Wu , Honglei Fu , Longwei Mei , Liang Tian , Songmin Quan , Jun Zhang , Yan Kang
IPC分类号： G06K9/00
CPC分类号： G06K9/34 , A61B6/50 , G06K2209/05 , G06T7/0012 , G06T7/11 , G06T2207/10081 , G06T2207/30084
摘要： The present invention discloses an abdominal CT image measuring apparatus and method. The abdominal CT image measuring apparatus includes: an interface unit; a part recognizing unit and a characteristic data computing unit. The present invention can determine the specific region of the part under test with a little amount of computation, by registration and subtraction operation on the two-phase scan images. This is easy to be carried out in computers, thus the computing speed of the characteristic data can be guaranteed and the efficiency can be improved. By the recognizing of the kidney regions and the abdominal aorta region in the present invention, the glomerular filtration rates obtained by applying the key concept of the present invention to the image measuring of glomerular filtration rate can meet the clinical application requirements in both precision and speed.
摘要翻译：本发明公开了一种腹部CT图像测量装置及方法。腹部CT图像测量装置包括：接口单元; 部件识别单元和特征数据计算单元。本发明可以通过对两相扫描图像进行配准和减法操作，通过少量的计算来确定待测零件的特定区域。这在计算机中很容易实现，因此可以保证特征数据的计算速度并提高效率。通过本发明的肾脏区域和腹主动脉区域的识别，通过将本发明的关键概念应用于肾小球滤过率的图像测定而获得的肾小球滤过率可以满足临床应用的精度和速度要求。

89. 发明授权

US07262016B2 Microdevices having a preferential axis of magnetization and uses thereof 有权
标题翻译：具有优先磁化轴的微器件及其用途
公开(公告)号：US07262016B2
公开(公告)日：2007-08-28
申请号：US11230411
申请日：2005-09-20
申请人： Mingxian Huang , Lei Wu , Xiaobo Wang , Junquan Xu , Guo Liang Tao , David M. Rothwarf
发明人： Mingxian Huang , Lei Wu , Xiaobo Wang , Junquan Xu , Guo Liang Tao , David M. Rothwarf
IPC分类号： C12Q1/68
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译：本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。特别地，本发明提供一种微型装置，该微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。还提供了用于使用微器件分离，检测和操作部分和合成文库的系统和方法。

90. 发明授权

US07166443B2 Methods, compositions, and automated systems for separating rare cells from fluid samples 有权
标题翻译：用于从流体样品中分离稀有细胞的方法，组合物和自动化系统
公开(公告)号：US07166443B2
公开(公告)日：2007-01-23
申请号：US10701684
申请日：2003-11-04
申请人： George Walker , Junquan Xu , Douglas Yamanishi , Paul Hujsak , Lei Wu , Mingxian Huang , Guoliang Tao , Sara Snyder , Charina Yap
发明人： George Walker , Junquan Xu , Douglas Yamanishi , Paul Hujsak , Lei Wu , Mingxian Huang , Guoliang Tao , Sara Snyder , Charina Yap
IPC分类号： C12Q1/04
CPC分类号： B01L3/502761 , A61M1/36 , A61M1/3618 , A61M1/362 , A61M1/3679 , B01D57/02 , B01D61/18 , B01D67/0034 , B01D67/0062 , B01D71/02 , B01D71/027 , B01D71/04 , B01D2325/021 , B01D2325/04 , B01L3/502 , B01L3/502753 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2400/0409 , B01L2400/0457 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01N1/40 , G01N15/0272 , G01N15/05 , G01N2001/4016 , G01N2015/0073 , G01N2015/0288 , G01N2015/0294 , G01N2015/0681
摘要： The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from a complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells from patient samples, can aid in diagnosis, prognosis, and development of therapeutic modalities for patients. The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples. Preferred fluid samples are blood, effusion, or urine samples, and rare cells that can be enriched from such sample include nucleated red blood cells and cancer cells.
摘要翻译：本发明认识到许多病症的诊断和预后可以取决于来自复杂流体样品的稀有细胞的富集。特别地，母体样品（例如母体血液样品）富集胎儿细胞可以大大有助于检测胎儿异常或各种遗传病症。此外，本发明认识到，来自患者样品的稀有恶性细胞的富集可以帮助患者的治疗方式的诊断，预后和发展。本发明包括用于过滤液体样品的微制造过滤器和使用本发明的微加工过滤器来富集稀有细胞液体样品的方法。本发明还包括从血液样品中选择性沉降红细胞（RBC）的方案和使用选择性RBC沉降溶液富集流体样品稀有细胞的方法。本发明的另一方面是一种用于处理流体样品的自动化系统，该系统包括：至少一个包括微加工过滤器的过滤室; 用于引导流体流过自动化系统的至少一个过滤室的自动装置，以及用于收集富集的稀有细胞的装置。本发明还包括使用自动化系统从流体样品中分离稀有细胞的方法。优选的流体样品是血液，渗出物或尿液样品，并且可以从这种样品中富集的稀有细胞包括成核红细胞和癌细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式