专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US5965434A Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds 失效
标题翻译：两亲PH敏感化合物和用于递送生物活性化合物的递送系统
公开(公告)号：US5965434A
公开(公告)日：1999-10-12
申请号：US365841
申请日：1994-12-29
申请人： Jon A. Wolff , Vladimir Budker , Vladimir Gurevich
发明人： Jon A. Wolff , Vladimir Budker , Vladimir Gurevich
IPC分类号： A61K9/127 , C07C219/06 , C07C239/12 , C07C279/12 , C07D295/092 , C07D295/13 , C12N15/88 , C12N15/63
CPC分类号： C07D295/088 , A61K9/1272 , C07C219/06 , C07C239/12 , C07C279/12 , C07D295/13 , C12N15/88 , Y10T428/2984
摘要： The present invention provides amphipathic lipid compounds comprising a hydrophilic, catonic, pH-sensitive moiety, the positive charge of which moiety increases as pH decreases over the pH range of 8.0 to 4.5. Vesicular delivery systems comprising such amphipathic compounds and the use of those systems for delivering biologically active substances to cells are also provided.
摘要翻译：本发明提供包含亲水性，结合性，pH敏感性部分的两亲性脂质化合物，当pH在8.0至4.5的pH范围内pH降低时，其部分的正电荷增加。还提供了包含这种两亲化合物的囊泡递送系统和用于将生物活性物质递送到细胞的那些系统的用途。

82. 发明授权

US5635487A Amphipathic, micellar delivery systems for biologically active polyions 失效
标题翻译：用于生物活性多阴离子的两亲性胶束递送系统
公开(公告)号：US5635487A
公开(公告)日：1997-06-03
申请号：US368150
申请日：1994-12-29
申请人： Jon A. Wolff , Vladimir Budker , Vladimir Gurevich
发明人： Jon A. Wolff , Vladimir Budker , Vladimir Gurevich
IPC分类号： A61K9/107 , A61K9/127 , A61K48/00 , C07J31/00 , C07J41/00 , C07J43/00 , A61K31/415 , A61K31/66
CPC分类号： C07J41/0055 , A61K48/00 , A61K9/1075 , A61K9/1272 , C07J31/003 , C07J41/0066 , C07J43/003
摘要： The present invention provides a composition comprising a population of micelles wherein each micelle comprises at least one amphipathic compound layer that surrounds a non-aqueous core that contains a polyion. Also provided are a method of preparing such a composition and the uses of such compositions for delivering biologically active polyions to cells.
摘要翻译：本发明提供一种包含一组胶束的组合物，其中每个胶束包含至少一个两性化合物层，其包围含有聚阴离子的非水性核心。还提供了制备这种组合物的方法以及这种组合物用于将生物活性聚阴离子递送至细胞的用途。

83. 发明授权

US07262056B2 Enhancing intermolecular integration of nucleic acids using integrator complexes 有权
标题翻译：使用积分复合物增强核酸的分子间整合
公开(公告)号：US07262056B2
公开(公告)日：2007-08-28
申请号：US10291342
申请日：2002-11-08
申请人： Christine Wooddell , Hans Herweijer , Jon A. Wolff
发明人： Christine Wooddell , Hans Herweijer , Jon A. Wolff
IPC分类号： C12N15/00 , C12N15/74 , C12N15/861 , C12N15/66 , C12N1/20
CPC分类号： C12N9/22 , C12N15/907 , C12N2800/90 , C12N2840/20
摘要： We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents.
摘要翻译：我们公开了用于增强转座子介导的核酸分子整合到另一靶核酸分子中的组合物和方法。通过阳离子试剂增强了积分器复合物的整合。

84. 发明授权

US06872519B1 In vitro process for selecting phage resistant to blood inactivation 失效
标题翻译：选择抗血液灭活的噬菌体的体外方法
公开(公告)号：US06872519B1
公开(公告)日：2005-03-29
申请号：US09559021
申请日：2000-04-27
申请人： Alexander V. Sokoloff , Jon A. Wolff
发明人： Alexander V. Sokoloff , Jon A. Wolff
IPC分类号： G01N33/543 , G01N33/68 , C12Q1/68 , A61K49/00 , C07H21/04 , C12N7/00 , C12Q1/70
CPC分类号： G01N33/6878 , G01N33/543
摘要： The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for the identification and selection of peptides and peptide associated factors with desired properties (e.g., targeting specificity, stability, etc.). The present invention further provides methods and compositions for the isolation and identification of peptide-specific antibodies. The present invention also includes methods and compositions employing nuclear localization signals for enhanced nuclear transport and expression of DNA.
摘要翻译：本发明涉及用于选择和使用表面暴露表位的组合物和方法。本发明包括用于鉴定和选择具有所需性质（例如，靶向特异性，稳定性等）的肽和肽相关因子的体内和体外噬菌体肽双重显示方法。本发明还提供了用于分离和鉴定肽特异性抗体的方法和组合物。本发明还包括使用核定位信号用于增强核转运和DNA表达的方法和组合物。

85. 发明授权

US06706694B1 Expression of exogenous polynucleotide sequences in a vertebrate 失效
标题翻译：外源多核苷酸序列在脊椎动物中的表达
公开(公告)号：US06706694B1
公开(公告)日：2004-03-16
申请号：US09588655
申请日：2000-06-06
申请人： Jon A. Wolff , David J. Duke , Philip L. Felgner
发明人： Jon A. Wolff , David J. Duke , Philip L. Felgner
IPC分类号： A61K4800
CPC分类号： B82Y5/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for the polypeptide into the interstitial space of the heart, whereby the naked polynucleotide is taken up into the interior of the cell and has a pharmacological effect on the vertebrate. In a preferred embodiment wherein the polynucleotide encodes polypeptide immunologically foreign to the vertebrate, the delivery method preferably comprises delivering an immunosuppressive agent to the vertebrate to limit immune responses directed to the polypeptide.
摘要翻译：本发明提供了一种用于在体内将药物多肽递送至脊椎动物心脏细胞内部的方法，其包括将包含药学上可接受的可注射载体的制剂和可操作地编码多肽的裸核苷酸引入到心脏，其中裸多核苷酸被吸收到细胞内部并且对脊椎动物具有药理作用。在其中多核苷酸编码对脊椎动物免疫外源的多肽的优选实施方案中，递送方法优选包括将免疫抑制剂递送至脊椎动物以限制针对多肽的免疫应答。

86. 发明授权

US06265387B1 Process of delivering naked DNA into a hepatocyte via bile duct 失效
标题翻译：通过胆管将裸DNA递送到肝细胞中的过程
公开(公告)号：US06265387B1
公开(公告)日：2001-07-24
申请号：US08975573
申请日：1997-11-21
申请人： Jon A. Wolff , Vladimir Budker , Stuart J. Knechtle
发明人： Jon A. Wolff , Vladimir Budker , Stuart J. Knechtle
IPC分类号： A61K3500
CPC分类号： A61K48/00 , A61K48/0008
摘要： A process for delivering a polynucleotide to a parenchymal cell in a mammal by injecting the polynucleotide into a blood vessel connected to the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell and functionally expressed to therapeutic levels.
摘要翻译：将多核苷酸通过将多核苷酸注射到与哺乳动物的组织或器官中的实质细胞连接的血管中将多核苷酸递送至实质细胞的方法，使得多核苷酸被转染到实质细胞中并在功能上表达为治疗水平。

87. 发明授权

US5762927A Thymus tolerance in primates 失效
标题翻译：灵长类动物胸腺容忍
公开(公告)号：US5762927A
公开(公告)日：1998-06-09
申请号：US827772
申请日：1997-04-11
申请人： Stuart J. Knechtle , Jue Wang , Jon A. Wolff , David M. Neville, Jr.
发明人： Stuart J. Knechtle , Jue Wang , Jon A. Wolff , David M. Neville, Jr.
IPC分类号： A61K35/14 , A61K38/16 , A61K39/395 , A61K47/48 , C07K14/34 , C07K16/28 , A61K35/12
CPC分类号： C07K16/2809 , A61K38/164 , A61K39/39541 , A61K47/48238 , A61K47/48484 , A61K47/48561 , C07K14/34 , C07K2319/00
摘要： Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.
摘要翻译：公开了一种抑制灵长类动物对移植器官的排斥反应的方法。将灵长类动物暴露于与抗CD3抗体连接的突变白喉毒素，从而大大消除宿主的外周血T细胞淋巴细胞群体。在同一时间或之后，暴露步骤一个施用于灵长类动物的胸腺供体淋巴细胞。随机移植器官。灵长类动物容忍移植器官。

88. 发明授权

US5650148A Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system 失效
标题翻译：遗传修饰细胞移植治疗中枢神经系统缺陷，疾病或损害的方法
公开(公告)号：US5650148A
公开(公告)日：1997-07-22
申请号：US209609
申请日：1994-03-10
申请人： Fred H. Gage , Theodore Friedmann , Michael B. Rosenberg , Jon A. Wolff , Malcolm Schinstine , Michael D. Kawaja , Jasodhara Ray
发明人： Fred H. Gage , Theodore Friedmann , Michael B. Rosenberg , Jon A. Wolff , Malcolm Schinstine , Michael D. Kawaja , Jasodhara Ray
IPC分类号： A61K38/18 , A61K38/44 , A61K48/00 , C12N9/10 , A61K31/00 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1029 , A61K35/33 , A61K38/13 , A61K38/1808 , A61K38/1825 , A61K38/185 , A61K38/44 , C12N9/1077 , C12Y114/16002 , C12Y203/01006 , A61K38/00 , A61K48/00 , Y10S435/948
摘要： Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
摘要翻译：公开了通过基因转移遗传修饰供体细胞用于接枝入中枢神经系统以治疗有缺陷的，患病或损伤的细胞的方法。修饰的供体细胞产生影响CNS细胞恢复或改善功能的功能性分子。描述了用于进行基因转移和接枝的方法和载体。

89. 发明授权

US5580859A Delivery of exogenous DNA sequences in a mammal 失效
标题翻译：在哺乳动物中外源DNA序列的递送
公开(公告)号：US5580859A
公开(公告)日：1996-12-03
申请号：US215405
申请日：1994-03-18
申请人： Philip L. Felgner , Jon A. Wolff , Gary H. Rhodes , Robert W. Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon A. Wolff , Gary H. Rhodes , Robert W. Malone , Dennis A. Carson
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , A01N43/04 , A61K31/70 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K48/00 , A61K9/1272 , C07K14/61 , C12N15/87 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12Y113/12007 , C12N2740/16122
摘要： Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from association with transfection-facilitating proteins, viral particles, liposomal formulations, charged lipids and calcium phosphate precipitating agents.
摘要翻译：包含DNA和RNA分子的多核苷酸序列可以例如通过注射直接施用于组织如肌肉，并以蛋白质，多肽或多肽表达。多核苷酸可以包含在脂质体内，或多核苷酸可以与转染促进蛋白质，病毒颗粒，脂质体制剂，带电脂质和磷酸钙沉淀剂无关。

90. 发明授权

US5762926A Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system 失效
标题翻译：遗传修饰细胞移植治疗中枢神经系统缺陷，疾病或损害的方法
公开(公告)号：US5762926A
公开(公告)日：1998-06-09
申请号：US464397
申请日：1995-06-05
申请人： Fred H. Gage , Malcolm Schinstine , Jasodhara Ray , Theodore Friedmann , Michael D. Kawaja , Michael B. Rosenberg , Jon A. Wolff
发明人： Fred H. Gage , Malcolm Schinstine , Jasodhara Ray , Theodore Friedmann , Michael D. Kawaja , Michael B. Rosenberg , Jon A. Wolff
IPC分类号： A61K38/18 , A61K38/44 , A61K48/00 , C12N9/10 , C12N5/00 , C12N15/09 , C12N15/79
CPC分类号： C12N9/1029 , A61K35/33 , A61K38/13 , A61K38/1808 , A61K38/1825 , A61K38/185 , A61K38/44 , C12N9/1077 , C12Y114/16002 , C12Y203/01006 , A61K38/00 , A61K48/00 , Y10S435/948
摘要： Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
摘要翻译：公开了通过基因转移遗传修饰供体细胞用于接枝入中枢神经系统以治疗有缺陷的，患病或损伤的细胞的方法。修饰的供体细胞产生影响CNS细胞恢复或改善功能的功能性分子。描述了用于进行基因转移和接枝的方法和载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式