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1. 发明授权

US06680292B1 Pharmaceutical composition comprising ribavirin and growth factors and methods of use 失效
标题翻译：包含利巴韦林和生长因子的药物组合物及其使用方法
公开(公告)号：US06680292B1
公开(公告)日：2004-01-20
申请号：US09856100
申请日：2001-09-24
申请人： Roger C. Guillemin , Fred Harrison Gage , Jasodhara Ray
发明人： Roger C. Guillemin , Fred Harrison Gage , Jasodhara Ray
IPC分类号： A61K3170
CPC分类号： C07H19/056 , A61K38/185 , C07H5/06 , A61K2300/00
摘要： The present invention is directed to compositions comprising 1-(&bgr;-D-ribofuranosyl)-1H-1,2,4-triazole compounds and either endogenous or exogenous neurotrophic factors. Methods of using such compounds and compositions are also provided. In one aspect, the invention provides methods of using invention compositions and compounds to enhance neurite outgrowth, neuronal survival and neuronal proliferation in mammalian cells. In a preferred embodiment, a 1-(&bgr;-D-ribofuranosyl)1H-1,2,4-triazole compound is infused directly to a desired situs. In a more preferred embodiment the 1-(&bgr;-D-ribofuranosyl)-1,2,4-triazole compound is administered orally. In another aspect, the invention provides methods of treating a neurological disease in a mammal subject. In a further aspect, the invention provides methods of treating neuronal trauma in a mammal subject.
摘要翻译：本发明涉及包含1-（β-D-呋喃核糖基）-1H-1,2,4-三唑化合物和内源或外源神经营养因子的组合物。还提供了使用这些化合物和组合物的方法。一方面，本发明提供了使用本发明组合物和化合物来增强哺乳动物细胞中神经突生长，神经元存活和神经元增殖的方法。在优选的实施方案中，将1-（β-D-呋喃核糖基）1H-1,2,4-三唑化合物直接注入所需的位置。在更优选的实施方案中，口服施用1-（β-D-呋喃核糖基）-1,2,4-三唑化合物。另一方面，本发明提供了治疗哺乳动物受试者的神经疾病的方法。在另一方面，本发明提供了治疗哺乳动物受试者的神经元损伤的方法。

2. 发明授权

US5650148A Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system 失效
标题翻译：遗传修饰细胞移植治疗中枢神经系统缺陷，疾病或损害的方法
公开(公告)号：US5650148A
公开(公告)日：1997-07-22
申请号：US209609
申请日：1994-03-10
申请人： Fred H. Gage , Theodore Friedmann , Michael B. Rosenberg , Jon A. Wolff , Malcolm Schinstine , Michael D. Kawaja , Jasodhara Ray
发明人： Fred H. Gage , Theodore Friedmann , Michael B. Rosenberg , Jon A. Wolff , Malcolm Schinstine , Michael D. Kawaja , Jasodhara Ray
IPC分类号： A61K38/18 , A61K38/44 , A61K48/00 , C12N9/10 , A61K31/00 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1029 , A61K35/33 , A61K38/13 , A61K38/1808 , A61K38/1825 , A61K38/185 , A61K38/44 , C12N9/1077 , C12Y114/16002 , C12Y203/01006 , A61K38/00 , A61K48/00 , Y10S435/948
摘要： Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
摘要翻译：公开了通过基因转移遗传修饰供体细胞用于接枝入中枢神经系统以治疗有缺陷的，患病或损伤的细胞的方法。修饰的供体细胞产生影响CNS细胞恢复或改善功能的功能性分子。描述了用于进行基因转移和接枝的方法和载体。

3. 发明授权

US6013521A Method for production of neuroblasts 失效
公开(公告)号：US6013521A
公开(公告)日：2000-01-11
申请号：US65858
申请日：1998-04-24
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12N15/09 , A61K35/12 , A61K35/30 , A61K45/00 , A61K48/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N5/10 , C12P21/08 , C12Q1/02 , C12N5/00
CPC分类号： C12N5/0623 , C12M23/20 , C12N5/0618 , C12N5/0619 , A61K35/12 , A61K48/00 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

4. 发明授权

US5770414A Regulatable retrovirus system for genetic modification of cells 失效
标题翻译：可调节逆转录病毒系统，用于细胞遗传修饰
公开(公告)号：US5770414A
公开(公告)日：1998-06-23
申请号：US602203
申请日：1996-02-20
申请人： Fred H. Gage , Jasodhara Ray , Minoru Hoshimaru
发明人： Fred H. Gage , Jasodhara Ray , Minoru Hoshimaru
IPC分类号： C12N15/85 , C12N15/867 , C12N15/00
CPC分类号： C12N15/86 , C12N15/85 , C12N2740/13043 , C12N2830/006 , C12N2830/15 , C12N2830/60 , C12N2840/203
摘要： A novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequence useful for immortalization of adult neuronal progenitor cells is provided. Regulation of a heterologous Producer cell lines which produce high titers of the recombinant retrovirus are also provided.
摘要翻译：提供了一种新型可调节的逆转录病毒载体，其中v-myc致癌基因由四环素控制的反式激活因子和与用于成年神经元祖细胞永生化的tet操纵子融合的人巨细胞病毒最小启动子驱动。还提供了产生高滴度重组逆转录病毒的异源生产细胞系的调节。

5. 发明授权

US5766948A Method for production of neuroblasts 失效
公开(公告)号：US5766948A
公开(公告)日：1998-06-16
申请号：US147843
申请日：1993-11-03
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12N15/09 , A61K35/12 , A61K35/30 , A61K45/00 , A61K48/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N5/10 , C12P21/08 , C12Q1/02 , C12N5/00
CPC分类号： C12N5/0623 , C12M23/20 , C12N5/0618 , C12N5/0619 , A61K35/12 , A61K48/00 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

6. 发明授权

US07732201B2 Method for production of neuroblasts 失效
标题翻译：神经母细胞生产方法
公开(公告)号：US07732201B2
公开(公告)日：2010-06-08
申请号：US11592504
申请日：2006-11-03
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12M23/20 , C12N5/0618 , C12N5/0619 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
摘要翻译：提供了一种用于产生神经母细胞的方法和包含富集的成神经细胞群的细胞组合物。还公开了用于鉴定影响成神经细胞和用于治疗具有神经元障碍的受试者的组合物的方法，以及用于生产和维持神经母细胞的培养系统。

7. 发明授权

US06713247B1 Human CNS cell lines and methods of use therefor 失效
标题翻译：人类CNS细胞系及其使用方法
公开(公告)号：US06713247B1
公开(公告)日：2004-03-30
申请号：US08711628
申请日：1996-09-03
申请人： Dinah W. Y. Sah , Fred H. Gage , Jasodhara Ray
发明人： Dinah W. Y. Sah , Fred H. Gage , Jasodhara Ray
IPC分类号： C12N508
CPC分类号： C12N5/0623 , A61K48/00 , C12N2501/11 , C12N2501/13 , C12N2501/135
摘要： Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
摘要翻译：提供有条件永生化的人类CNS祖细胞系。这些可能是克隆的细胞系可用于产生神经元和/或星形胶质细胞。这样的细胞系和/或分化细胞可用于开发治疗剂以预防和治疗各种CNS相关疾病。此类细胞系和/或分化细胞也可用于测定和CNS细胞发育，死亡和异常的一般研究。

8. 发明授权

US06265175B1 Method for production of neuroblasts 失效
标题翻译：神经母细胞生产方法
公开(公告)号：US06265175B1
公开(公告)日：2001-07-24
申请号：US08884427
申请日：1997-06-27
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12Q102
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12M23/20 , C12N5/0618 , C12N5/0619 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblast and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
摘要翻译：提供了一种用于产生神经母细胞的方法和包含富集的成神经细胞群的细胞组合物。还公开了用于鉴定影响成神经细胞和用于治疗具有神经元病症的受试者的组合物的方法，以及用于产生和维持神经母细胞的培养系统。

9. 发明授权

US6045807A Method for production of neuroblasts 失效
公开(公告)号：US6045807A
公开(公告)日：2000-04-04
申请号：US95769
申请日：1998-06-10
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12N15/09 , A61K35/12 , A61K35/30 , A61K45/00 , A61K48/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N5/10 , C12P21/08 , C12Q1/02 , C12N5/08
CPC分类号： C12N5/0623 , C12M23/20 , C12N5/0618 , C12N5/0619 , A61K35/12 , A61K48/00 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

10. 发明授权

US6020197A Method for production of neuroblasts 失效
公开(公告)号：US6020197A
公开(公告)日：2000-02-01
申请号：US65883
申请日：1998-04-24
申请人： Fred H. Gage , Jasodhara Ray
发明人： Fred H. Gage , Jasodhara Ray
IPC分类号： C12N15/09 , A61K35/12 , A61K35/30 , A61K45/00 , A61K48/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N5/10 , C12P21/08 , C12Q1/02 , C12N5/00
CPC分类号： C12N5/0623 , C12M23/20 , C12N5/0618 , C12N5/0619 , A61K35/12 , A61K48/00 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2501/392 , C12N2502/08 , C12N2510/04 , C12N2533/32
摘要： A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.

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