专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明授权

US06569992B1 Protein HLQDR48 失效
标题翻译：蛋白HLQDR48
公开(公告)号：US06569992B1
公开(公告)日：2003-05-27
申请号：US09369247
申请日：1999-08-05
申请人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
发明人： David W. LaFleur , Steven M. Ruben , Craig A. Rosen , Paul A. Moore , Yanggu Shi , Hla Kyaw , Ying-Fei Wei
IPC分类号： A61K3800
CPC分类号： C12Q1/6883 , A61K35/13 , A61K38/00 , C07K14/47 , G01N33/6893 , Y02A50/465
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

82. 发明授权

US06566325B2 49 human secreted proteins 失效
公开(公告)号：US06566325B2
公开(公告)日：2003-05-20
申请号：US09904615
申请日：2001-07-16
申请人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
发明人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
IPC分类号： C07K1400
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

83. 发明授权

US06486301B1 Interleukin-20 失效
标题翻译：白细胞介素20
公开(公告)号：US06486301B1
公开(公告)日：2002-11-26
申请号：US09231788
申请日：1999-01-15
申请人： Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
发明人： Reinhard Ebner , Marianne Murphy , Steven M. Ruben , Jing-Shan Hu , D. Roxanne Duan , Kimberly A. Florence , Craig A. Rosen
IPC分类号： C07K14475
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为细胞因子多肽家族成员的新型IL-20蛋白。特别地，提供编码人IL-20蛋白的分离的核酸分子。还提供了IL-20多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定IL-20活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

84. 发明授权

US06416984B1 Human DNA mismatch repair proteins 失效
标题翻译：人类DNA错配修复蛋白
公开(公告)号：US06416984B1
公开(公告)日：2002-07-09
申请号：US08468024
申请日：1995-06-06
申请人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
发明人： William A. Haseltine , Steven M. Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , Craig A. Rosen
IPC分类号： C12N900
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.
摘要翻译：本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA），以及通过重组技术生产此类蛋白质的方法。人类DNA修复蛋白hMLH1已被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可用于治疗和诊断治疗遗传易感性癌症。

85. 发明授权

US06372456B1 Polynucleotides encoding chemokine &agr;-6 失效
标题翻译：编码趋化因子α-6的多核苷酸
公开(公告)号：US06372456B1
公开(公告)日：2002-04-16
申请号：US09177304
申请日：1998-10-23
申请人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
发明人： Ying-Fei Wei , Steven M. Ruben , Craig A. Rosen
IPC分类号： C12N1519
CPC分类号： C07K16/24 , A61K38/00 , C07K14/522
摘要： The present invention relates to a novel CK(&agr;-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-6 protein. CK&agr;-6 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-6 activity. Also provided are diagnostic methods for detecting CNS and immune system-related disorders and therapeutic methods for treating CNS and immune system-related disorders.
摘要翻译：本发明涉及一种新的CK（α-6蛋白，其是α趋化因子家族的成员，特别是编码人CKalpha-6蛋白的分离的核酸分子，也提供了CKalpha-6多肽本发明还涉及用于鉴定CKalpha-6活性的激动剂和拮抗剂的筛选方法，还提供了用于检测CNS和免疫系统相关疾病的诊断方法以及用于治疗CNS和免疫系统相关疾病。

86. 发明授权

US06338951B1 G-protein parathyroid hormone receptor HLTDG74 失效
公开(公告)号：US06338951B1
公开(公告)日：2002-01-15
申请号：US09236468
申请日：1999-01-25
申请人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1472
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

87. 发明授权

US5948890A Human G-protein receptor HPRAJ70 失效
公开(公告)号：US5948890A
公开(公告)日：1999-09-07
申请号：US53303
申请日：1998-04-01
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/705 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505
摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

88. 发明授权

US08410248B2 HWBAO62 polypeptides 有权
公开(公告)号：US08410248B2
公开(公告)日：2013-04-02
申请号：US12753401
申请日：2010-04-02
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K14/435 , C07K14/00
CPC分类号： C07K14/47 , C07K14/4702 , C07K16/18
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions (such as immune, cardiovascular, cancer, and other proliferative diseases, disorders, and/or conditions) related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

89. 发明授权

US08206708B2 Vascular endothelial growth factor 2 有权
标题翻译：血管内皮生长因子2
公开(公告)号：US08206708B2
公开(公告)日：2012-06-26
申请号：US13096144
申请日：2011-04-28
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

90. 发明申请

US20120046221A1 ALBUMIN FUSION PROTEINS 有权
标题翻译： ALBUMIN融合蛋白
公开(公告)号：US20120046221A1
公开(公告)日：2012-02-23
申请号：US13078708
申请日：2011-04-01
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Tuner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Tuner , Steven M. Ruben
IPC分类号： A61K38/38 , A61P7/12 , A61P3/04 , A61P3/10 , A61P5/50
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式