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1. 发明申请

US20120213777A1 VASCULAR ENDOTHELIAL GROWTH FACTOR 2 审中-公开
标题翻译：血管内皮生长因子2
公开(公告)号：US20120213777A1
公开(公告)日：2012-08-23
申请号：US13460217
申请日：2012-04-30
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61P37/00 , A61P41/00 , A61P29/00 , A61P3/02 , A61P31/00 , A61P17/02
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

2. 发明授权

US07850963B2 Vascular endothelial growth factor 2 有权
标题翻译：血管内皮生长因子2
公开(公告)号：US07850963B2
公开(公告)日：2010-12-14
申请号：US11730696
申请日：2007-04-03
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth Wager
IPC分类号： A61K39/395 , A61K39/44 , A61K39/00 , C12P21/08 , C07K16/22 , C07K16/46 , C12N5/10 , C12N5/12
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

3. 发明申请

US20090226429A1 Antibodies That Immunospecifically Bind to TRAIL Receptors 审中-公开
标题翻译：免疫特异性结合TRAIL受体的抗体
公开(公告)号：US20090226429A1
公开(公告)日：2009-09-10
申请号：US12016372
申请日：2008-01-18
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , C12N5/06
CPC分类号： C07K16/2878 , A61K39/39558 , A61K2039/505 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

4. 发明授权

US06251617B1 Glycine transporter 失效
标题翻译：甘氨酸转运蛋白
公开(公告)号：US06251617B1
公开(公告)日：2001-06-26
申请号：US09396177
申请日：1999-09-14
申请人： Vivian R. Albert , Leslie R. Z. Kowalski
发明人： Vivian R. Albert , Leslie R. Z. Kowalski
IPC分类号： C07K100
CPC分类号： C07K14/47 , Y10S436/804
摘要： Provided are, among other things, nucleic acid sequences encoding the GlyT1d form of glycine transporter, vectors, methods of producing the transporter, and methods for identifying bioactive agents.
摘要翻译：提供了编码GlyT1d形式的甘氨酸转运蛋白的核酸序列，载体，产生转运蛋白的方法以及鉴定生物活性剂的方法。

5. 发明授权

US5919653A Nucleic acids encoding a human glycine transporter 失效
标题翻译：编码人甘氨酸转运蛋白的核酸
公开(公告)号：US5919653A
公开(公告)日：1999-07-06
申请号：US700013
申请日：1996-08-20
申请人： Vivian R. Albert , Leslie R. Z. Kowalski , Laurence A. Borden , Jeffrey F. McKelvy
发明人： Vivian R. Albert , Leslie R. Z. Kowalski , Laurence A. Borden , Jeffrey F. McKelvy
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P21/02 , A61P25/00 , A61P25/08 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47
摘要： The invention provides nucleic acids and proteins derived from the sequence of the human GlyT-2 transporter of the amino acid glycine.
摘要翻译：本发明提供了源自氨基酸甘氨酸的人GlyT-2转运蛋白序列的核酸和蛋白质。

6. 发明授权

US5824486A Glycine transporter-transfected cells and uses thereof 失效
标题翻译：甘氨酸转运蛋白转染细胞及其用途
公开(公告)号：US5824486A
公开(公告)日：1998-10-20
申请号：US655836
申请日：1996-05-31
申请人： Laurence A. Borden , Michael De Vivo , Midori Yokoyama , Vivian R. Albert
发明人： Laurence A. Borden , Michael De Vivo , Midori Yokoyama , Vivian R. Albert
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C12N5/10 , G01N33/567
CPC分类号： C07K14/47
摘要： The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having transfected therein a glycine transporter. The methods relate to the manipulation of such cells such that agents are identified that cause intake or outflow of glycine with respect to a given glycine transporter.
摘要翻译：本发明涉及用于鉴定调节甘氨酸在细胞内进出细胞，特别是在神经元和神经元相关细胞内或外的细胞转运的药物的材料和方法。这些材料包括其中转染有甘氨酸转运蛋白的非哺乳动物细胞。所述方法涉及这种细胞的操作，使得鉴定出相对于给定的甘氨酸转运蛋白导致甘氨酸摄取或流出的药剂。

7. 发明授权

US08206708B2 Vascular endothelial growth factor 2 有权
标题翻译：血管内皮生长因子2
公开(公告)号：US08206708B2
公开(公告)日：2012-06-26
申请号：US13096144
申请日：2011-04-28
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C07K16/18 , C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

8. 发明授权

US07348003B2 Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors 有权
标题翻译：使用免疫特异性结合TRAIL受体的抗体治疗癌症的方法
公开(公告)号：US07348003B2
公开(公告)日：2008-03-25
申请号：US10986047
申请日：2004-11-12
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12P21/08 , C07K16/00 , C07H21/04
CPC分类号： A61K39/395 , A61K31/00 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

9. 发明授权

US06900033B2 Methods and compositions for modulating ACE-2 activity 有权
标题翻译：调节ACE-2活性的方法和组合物
公开(公告)号：US06900033B2
公开(公告)日：2005-05-31
申请号：US10158825
申请日：2002-06-03
申请人： Tom J. Parry , Les Sekut , Craig A. Rosen , Vivian R. Albert , Indrajit Sanyal , Lili Huang , Charles R. Wescott
发明人： Tom J. Parry , Les Sekut , Craig A. Rosen , Vivian R. Albert , Indrajit Sanyal , Lili Huang , Charles R. Wescott
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/16 , C12N5/06 , C12N9/64 , C12P21/02
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： Binding polypeptides comprising specific amino acid sequences are disclosed that specifically bind ACE-2 protein or ACE-2-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting, isolating, or purifying ACE-2 protein or ACE-2-like polypeptides in solutions or mixtures, or biological samples. The invention also relates to nucleic acid molecules encoding these ACE-2 binding polypeptides, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention also relates to methods and compositions for detecting, diagnosing, prognosing, preventing, treating or ameliorating a disease or disorder associated with aberrant ACE-2 or ACE-2 receptor expression or inappropriate function of ACE-2 or ACE-2 receptor, comprising use of ACE-2 binding polypeptides or fragments or variants thereof, that specifically bind to ACE-2.
摘要翻译：公开了包含特异性氨基酸序列的结合多肽，其特异性结合ACE-2蛋白或ACE-2样多肽。结合多肽可用于本发明的方法中用于在溶液或混合物或生物样品中检测，分离或纯化ACE-2蛋白或ACE-2样多肽。本发明还涉及编码这些ACE-2结合多肽的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明还涉及用于检测，诊断，预后，预防，治疗或改善与异常ACE-2或ACE-2受体表达或ACE-2或ACE-2受体的不适当功能相关的疾病或病症的方法和组合物，包括使用特异性结合ACE-2的ACE-2结合多肽或其片段或变体。

10. 发明授权

US07550569B2 Antibodies that specifically bind to GMAD 失效
标题翻译：特异性结合GMAD的抗体
公开(公告)号：US07550569B2
公开(公告)日：2009-06-23
申请号：US10935290
申请日：2004-09-08
申请人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
发明人： Kevin P. Baker , Vivian R. Albert , Partha Chowdhury
IPC分类号： C12P21/08 , C07K16/00
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
摘要翻译：本发明涉及免疫特异性结合GMAD的抗体和相关分子。这样的抗体具有例如用于预防和治疗胰岛素和非胰岛素依赖型糖尿病（即I型和II型糖尿病）和其它相关疾病。本发明还涉及编码抗GMAD抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是糖尿病和其它相关病症的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合GMAD的相关分子。

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