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1. 发明授权

US06448032B1 Human melanocyte stimulating hormone receptor polypeptide and DNA 失效
标题翻译：人类黑素细胞激素受体多肽和DNA
公开(公告)号：US06448032B1
公开(公告)日：2002-09-10
申请号：US08387805
申请日：1995-02-21
申请人： Jarl Wikberg , Vijay Chhajlani
发明人： Jarl Wikberg , Vijay Chhajlani
IPC分类号： C07K1472
CPC分类号： C07K16/2869 , A61K38/00 , C07K14/72 , C07K2317/34 , C07K2319/00
摘要： Novel DNA fragments encoding novel polypeptides having properties of melanotropic hormone receptors, especially DNA molecules encoding melanocyte stimulating hormone receptors (MSH receptors), as well as polypeptides which are MSH receptors, are disclosed. The use and engineering of melanotropic hormone receptor DNA and polypeptides for production of monoclonal antibodies for diagnostic and therapeutic purposes, as well as the engineering of drugs, cell lines, vectors, and DNA for therapeutic and diagnostic purposes are also disclosed.
摘要翻译：公开了编码具有黑素激素受体特性，编码黑素细胞刺激激素受体（MSH受体）的DNA分子以及作为MSH受体的多肽的性质的新型多肽的新型DNA片段。还公开了用于诊断和治疗目的的用于产生单克隆抗体的黑素激素受体DNA和多肽的用途和工程，以及用于治疗和诊断目的的药物，细胞系，载体和DNA的工程。

2. 发明授权

US06338951B1 G-protein parathyroid hormone receptor HLTDG74 失效
公开(公告)号：US06338951B1
公开(公告)日：2002-01-15
申请号：US09236468
申请日：1999-01-25
申请人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人： Daniel Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号： C07K1472
CPC分类号： C07K14/723 , A61K48/00 , C12N2799/026
摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

3. 发明授权

US06372711B1 Methods for assaying human FSH using human FSH receptor 失效
标题翻译：使用人类FSH受体测定人类FSH的方法
公开(公告)号：US06372711B1
公开(公告)日：2002-04-16
申请号：US08474986
申请日：1995-06-07
申请人： Christie Ann Kelton , Shirley Vui Yen Cheng , Noreen Patrice Nugent , Rene Lynn Schweickhardt
发明人： Christie Ann Kelton , Shirley Vui Yen Cheng , Noreen Patrice Nugent , Rene Lynn Schweickhardt
IPC分类号： C07K1472
CPC分类号： C07K14/723 , A61K38/00 , Y10S514/841 , Y10S514/843
摘要： The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present invention also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating patients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.
摘要翻译：本发明包括基本上纯化的FSH受体或其结合FSH的片段或突变体，编码所述受体，片段或突变体的DNA，包含所述DNA的表达载体，用所述表达载体转染的细胞，以及产生所述受体的片段，片段或通过培养所述转染的细胞来突变。本发明还包括包含所述受体，片段或突变体的药物组合物，以及治疗患有这些组合物的患者降低内源性FSH生物活性的方法。还公开了使用本发明的受体，片段或突变体的人FSH的改进测定。

4. 发明授权

US06348574B1 Seven transmembrane receptors 失效
标题翻译：七个跨膜受体
公开(公告)号：US06348574B1
公开(公告)日：2002-02-19
申请号：US09088337
申请日：1998-06-01
申请人： Ronald Godiska , Patrick W. Gray , Vicki Louise Schweickart
发明人： Ronald Godiska , Patrick W. Gray , Vicki Louise Schweickart
IPC分类号： C07K1472
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/505 , C07K16/28 , C07K2319/00
摘要： DNA sequences encoding seven novel seven transmembrane receptors and variants thereof are disclosed as well as materials and methods for production of the same by recombinant techniques. Antibody substances specific for each of the seven transmembrane receptors are disclosed as useful for the modulation of the ligand/receptor binding reactions of the receptors.
摘要翻译：公开了编码七种新型七个跨膜受体及其变体的DNA序列以及通过重组技术制备其的材料和方法。公开了对七种跨膜受体中的每一种特异性的抗体物质，用于调节受体的配体/受体结合反应。

5. 发明授权

US06262234B1 Nuclear receptor polypeptide ZPPAR4 失效
标题翻译：核受体多肽ZPPAR4
公开(公告)号：US06262234B1
公开(公告)日：2001-07-17
申请号：US09106194
申请日：1998-06-26
申请人： James L. Holloway , Laura J. Jelinek , Diane M. Durnam , Hal Blumberg
发明人： James L. Holloway , Laura J. Jelinek , Diane M. Durnam , Hal Blumberg
IPC分类号： C07K1472
CPC分类号： C07K14/47
摘要： The present invention relates to ZPPAR4 polynucleotide molecules and ZPPAR4 polypeptide molecules. ZPPAR4 is a novel member of the nuclear receptor superfamily. The novel ZPPAR4 nuclear receptor can be used to examine ZPPAR4-related complex transcriptional networks and biological processes. The disclosed ZPPAR4 polynucleotides and polypeptides provide a means to identify the natural ligand for ZPPAR4, as well as agonists and antagonists thereof.
摘要翻译：本发明涉及ZPPAR4多核苷酸分子和ZPPAR4多肽分子。 ZPPAR4是核受体超家族的新成员。新型ZPPAR4核受体可用于检测ZPPAR4相关的复合体转录网络和生物过程。所公开的ZPPAR4多核苷酸和多肽提供了鉴定ZPPAR4的天然配体以及其激动剂和拮抗剂的方法。

6. 发明授权

US06255089B1 Constitutively activated serotonin receptors 失效
标题翻译：组成型激活的5-羟色胺受体
公开(公告)号：US06255089B1
公开(公告)日：2001-07-03
申请号：US09032742
申请日：1998-02-27
申请人： Milt Teitler , Katharine Herrick-Davis , Christina C. Egan
发明人： Milt Teitler , Katharine Herrick-Davis , Christina C. Egan
IPC分类号： C07K1472
CPC分类号： C07K14/70571 , A01K2217/05
摘要： Mutations have been discovered in mammalian G protein-coupled serotonin 5-HT2A and 5-HT2C receptors which render the mutated receptors constitutively active. An alignment methodology based on the highly conserved sixth transmembrane domain has been discovered for the monoamine receptors which accurately predicts the amino acid position in the third intracellular loop which, when mutated, produces constitutive activation of the receptor. Constitutive activation of the G protein-coupled serotonin receptors has been shown by the demonstration of an enhanced affinity and potency for serotonin, by increased basal activity of the second messenger system in the absence of agonist, and by reduction of the basal second messenger activity by inverse agonists.
摘要翻译：在哺乳动物G蛋白偶联的5-羟色胺5-HT2A和5-HT2C受体中已经发现突变，其使突变的受体组成型活性。已发现基于高度保守的第六跨膜结构域的比对方法用于单胺受体，其精确地预测第三细胞内环路中的氨基酸位置，其在突变时产生受体的组成型激活。已经证明通过增加在不存在激动剂的情况下增加第二信使系统的基础活性以及通过减少基础第二信使活性来增强5-羟色胺的亲和力和效力，从而证明了G蛋白偶联的5-羟色胺受体的组成型活化反向激动剂。

7. 发明授权

US06207799B1 Neuropeptide Y receptor Y5 and nucleic acid sequences 有权
标题翻译：神经肽Y受体Y5和核酸序列
公开(公告)号：US06207799B1
公开(公告)日：2001-03-27
申请号：US09235839
申请日：1999-01-22
申请人： Yinghe Hu , Michael L. McCaleb , Brian T. Bloomquist , Jaime R. Flores-Riveros , Linda J. Cornfield
发明人： Yinghe Hu , Michael L. McCaleb , Brian T. Bloomquist , Jaime R. Flores-Riveros , Linda J. Cornfield
IPC分类号： C07K1472
CPC分类号： G01N33/6893 , A01K2217/05 , A61K38/1709 , C07K14/70571 , G01N2800/303
摘要： The present invention provides novel NPY/PYY receptor proteins and the nucleic acid sequence encoding them. The invention is directed to the isolation, characterization, and pharmacological use of these receptors and nucleic acids. In particular, this invention provides human and rat NPY/PYY receptors (which we call the NPY Y5 receptor) and nucleic acids. Also provided are recombinant expression constructs useful for transfecting cells and expressing the protein in vitro and in vivo. The invention further provides methods for detecting expression levels of the protein as well as methods for screening for receptor antagonists and agonists to be used for the treatment of obesity or anorexia, respectively.
摘要翻译：本发明提供新的NPY / PYY受体蛋白质和编码它们的核酸序列。本发明涉及这些受体和核酸的分离，表征和药理学应用。特别地，本发明提供人和大鼠NPY / PYY受体（我们称之为NPY Y5受体）和核酸。还提供了可用于转染细胞并在体外和体内表达蛋白质的重组表达构建体。本发明还提供了用于检测蛋白质的表达水平的方法以及分别用于治疗肥胖症或厌食症的受体拮抗剂和激动剂的筛选方法。

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