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81. 发明申请

US20140037750A1 AUTOMATED METHODS AND SYSTEMS FOR PROVIDING PLATELET CONCENTRATES WITH REDUCED RESIDUAL PLASMA VOLUMES AND STORAGE MEDIA FOR SUCH PLATELET CONCENTRATES 有权
标题翻译：用于提供具有减少残留等离子体体积的平板浓度的自动化方法和系统以及用于这些等离子体浓度的储存介质
公开(公告)号：US20140037750A1
公开(公告)日：2014-02-06
申请号：US14110076
申请日：2012-04-06
申请人： Katherine Radwanski , Kyungyoon Min
发明人： Katherine Radwanski , Kyungyoon Min
IPC分类号： A61K35/14
CPC分类号： C12N5/0644 , A01N1/0226 , A61K35/19 , A61M1/0209 , A61M1/0272 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0427
摘要： Automated systems and methods for providing platelet concentrates and synthetic storage media with reduced residual plasma volumes are disclosed. The disclosed systems and methods reduce the residual volume of plasma in platelet concentrate to obtain a platelet product having a volume of plasma that is approximately 5% or less of the total platelet product volume. The disclosed systems and methods also reduce the residual volume of plasma in platelet concentrate to obtain a washed platelet product, wherein the volume of plasma in the washed platelet product is approximately 1% or less of the total washed platelet product volume. Storage media for platelets including less than approximately 10% plasma are also disclosed.
摘要翻译：公开了用于提供具有降低的残留血浆体积的血小板浓缩物和合成储存介质的自动化系统和方法。所公开的系统和方法减少血小板浓缩物中的血浆的剩余体积，以获得血小板体积大约为总血小板产品体积的约5％或更小的血小板产品。所公开的系统和方法还减少血小板浓缩物中的血浆的剩余体积以获得洗涤的血小板产物，其中洗涤的血小板产物中的血浆体积为总洗涤的血小板产物体积的约1％或更少。还公开了包含小于约10％血浆的血小板的储存介质。

82. 发明申请

US20140034230A1 FLUID FLOW CONDUITS AND APPARATUS AND METHODS FOR MAKING AND JOINING FLUID CONDUITS 有权
标题翻译：流体流量和流体流量的制作和接合方法
公开(公告)号：US20140034230A1
公开(公告)日：2014-02-06
申请号：US14110010
申请日：2012-12-12
申请人： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
发明人： Christopher Wegener , Kyungyoon Min , Mark Brierton , Benjamin Kusters , James Madsen , William H. Cork
IPC分类号： B29C65/36
CPC分类号： A61M39/143 , A61M39/14 , B29C65/022 , B29C65/2015 , B29C65/203 , B29C65/30 , B29C65/32 , B29C65/3444 , B29C65/3456 , B29C65/36 , B29C65/3644 , B29C65/3656 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C65/7841 , B29C66/0342 , B29C66/1142 , B29C66/3494 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/5346 , B29C66/5414 , B29C66/543 , B29C66/71 , B29C66/72321 , B29C66/73115 , B29C66/73141 , B29C66/857 , B29C66/91231 , B29C66/91421 , B29C66/91651 , B29C66/919 , B29C66/91933 , B29C66/949 , B29C66/954 , B29K2027/06 , B29K2023/12 , B29K2067/003
摘要： Fluid flow conduits (14a, 14b) and apparatus (40) and methods for joining the conduits (14a, 14b), preferably in a sterile manner, are disclosed. Each conduit (14, 14b) has a polymeric open end that is sealed by a sealing member (26a, 26b) that may include a heating element (28). The polymeric end material is melted, the sealing members (26a, 26b) are moved to expose the melted open ends of the conduits (14a, 14b) and the ends are brought together to form a fused or welded connection (12) between the conduits (14a, 14b).
摘要翻译：公开了优选以无菌方式连接导管（14a，14b）的流体流动导管（14a，14b）和装置（40）和方法。每个导管（14,14b）具有由可包括加热元件（28）的密封构件（26a，26b）密封的聚合物开口端。聚合物端部材料被熔化，密封件（26a，26b）被移动以露出导管（14a，14b）的熔化的开口端，并且端部被接合在一起，以在导管之间形成熔接或焊接的连接（12）（14a，14b）。

83. 发明申请

US20130334139A1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
公开(公告)号：US20130334139A1
公开(公告)日：2013-12-19
申请号：US14003294
申请日：2012-03-09
申请人： Bryan Blickhan , Kyungyoon Min , William H. Cork
发明人： Bryan Blickhan , Kyungyoon Min , William H. Cork
IPC分类号： A61M1/38
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

84. 发明申请

US20130052188A1 SYSTEMS AND METHODS FOR OBTAINING IMMUNOGLOBULIN FROM BLOOD 审中-公开
标题翻译：从血液中获取免疫球蛋白的系统和方法
公开(公告)号：US20130052188A1
公开(公告)日：2013-02-28
申请号：US13618772
申请日：2012-09-14
申请人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
发明人： Kyungyoon Min , Larry Backes , Francisco M. Rausa, III , Shawn F. Bairstow , Sindhu Ramachandran , Sharon Pokropinski
IPC分类号： A61K39/395 , A61P25/28
CPC分类号： A61M1/3472 , A61M1/3486 , A61M1/38 , A61M2202/0419 , A61M2202/0057
摘要： The present disclosure relates generally to systems for obtaining a pharmaceutically acceptable immunoglobulin from blood of a donor comprising a first conduit configured to convey blood from the donor to a substrate, wherein said blood includes at least one first component and at least one second component, said first component of the blood including immunoglobulin, and wherein said substrate is adapted to bind immunoglobulin; and a second conduit configured to convey at least a portion of the second component of the blood from the first conduit to the donor.
摘要翻译：本公开一般涉及用于从供体的血液获得药学上可接受的免疫球蛋白的系统，其包括构建成将血液从供体输送到底物的第一导管，其中所述血液包括至少一种第一组分和至少一种第二组分，所述第一组分包括免疫球蛋白的血液的第一组分，并且其中所述底物适于结合免疫球蛋白; 以及第二导管，其构造成将血液的第二组分的至少一部分从第一导管输送到供体。

85. 发明申请

US20120204990A1 Sterile Docking Device, Medical Fluid Flow System With Sterile Docking Device and Method Of Using Same 有权
标题翻译：无菌对接装置，具有无菌对接装置的医用流体流动系统及其使用方法
公开(公告)号：US20120204990A1
公开(公告)日：2012-08-16
申请号：US13028372
申请日：2011-02-16
申请人： Kyungyoon Min , William H. Cork
发明人： Kyungyoon Min , William H. Cork
IPC分类号： F16L13/14 , F16J15/02
CPC分类号： A61M39/143 , F04C2270/0421 , F16L29/005 , F16L47/02 , F16L2201/44
摘要： Method and apparatus are disclosed for forming a sealed communication between conduits or conduit subassemblies, each of which has a wall with an exterior surface, and at least one of the walls includes an electrically conductive portion. The exterior surfaces may be brought into a facing relationship, and each conductive portion is heated sufficiently to sterilize the exterior surfaces of the walls by generating electrical current in the conductive portion, such as by application of a voltage or by induction. An aperture is then provided, as by an aperture-forming member, through the facing walls to provide communication between the conduits or conduit subassemblies.
摘要翻译：公开了用于在导管或导管子组件之间形成密封连接的方法和装置，每个管子组件具有带有外表面的壁，并且至少一个壁包括导电部分。外表面可以处于面对的关系，并且每个导电部分被充分加热以通过在导电部分中产生电流来消除（例如通过施加电压或通过感应）的电流。然后，通过孔形成构件，通过面向壁提供孔，以在导管或导管组件之间提供连通。

86. 发明授权

US08211049B2 Blood processing system for single or double access draw and return 有权
标题翻译：血液处理系统可单程或双程进行抽取和归还
公开(公告)号：US08211049B2
公开(公告)日：2012-07-03
申请号：US12392193
申请日：2009-02-25
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： A61M37/00 , A61M1/00
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/3616 , A61M1/3627
摘要： A blood processing system is disclosed which is adapted for single or double access draw and return. The blood processing system includes a blood processor for separating blood (or blood components) into one or more components or other components. In one embodiment the blood processor includes an inlet for receiving blood from blood source and an outlet for returning at least one blood component to the source. The processing system includes a first flow path in communication with the inlet, a second flow path in communication with the outlet, a third flow path in communication with a second flow path at two spaced apart locations, a reservoir communicates with the third flow path between the two spaced apart locations, and a flow communication site associated with the second flow path downstream of the spaced apart locations which communication site is adapted to permit communication with the first flow path.
摘要翻译：公开了一种血液处理系统，其适用于单次或双次存取和返回。血液处理系统包括用于将血液（或血液成分）分离成一个或多个组分或其它组分的血液处理器。在一个实施例中，血液处理器包括用于从血液源接收血液的入口和用于将至少一个血液成分返回到源的出口。处理系统包括与入口连通的第一流动路径，与出口连通的第二流动路径，在两个间隔开的位置处与第二流动路径连通的第三流动路径，储存器与第二流动路径在第二流动路径之间连通，两个间隔开的位置，以及与间隔开的位置下游的第二流动路径相关联的流动通信站点，该通信站点适于允许与第一流动路径的通信。

87. 发明申请

US20100217174A1 BLOOD PROCESSING SYSTEM FOR SINGLE OR DOUBLE ACCESS DRAW AND RETURN 有权
标题翻译：用于单次或双重访问的血液加工系统
公开(公告)号：US20100217174A1
公开(公告)日：2010-08-26
申请号：US12392193
申请日：2009-02-25
申请人： Kyungyoon Min
发明人： Kyungyoon Min
IPC分类号： A61M1/14
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/3616 , A61M1/3627
摘要： A blood processing system is disclosed which is adapted for single or double access draw and return. The blood processing system includes a blood processor for separating blood (or blood components) into one or more components or other components. In one embodiment the blood processor includes an inlet for receiving blood from blood source and an outlet for returning at least one blood component to the source. The processing system includes a first flow path in communication with the inlet, a second flow path in communication with the outlet, a third flow path in communication with a second flow path at two spaced apart locations, a reservoir communicates with the third flow path between the two spaced apart locations, and a flow communication site associated with the second flow path downstream of the spaced apart locations which communication site is adapted to permit communication with the first flow path.
摘要翻译：公开了一种血液处理系统，其适用于单次或双次存取和返回。血液处理系统包括用于将血液（或血液成分）分离成一个或多个组分或其它组分的血液处理器。在一个实施例中，血液处理器包括用于从血液源接收血液的入口和用于将至少一个血液成分返回到源的出口。处理系统包括与入口连通的第一流动路径，与出口连通的第二流动路径，在两个间隔开的位置处与第二流动路径连通的第三流动路径，储存器与第二流动路径在第二流动路径之间连通，两个间隔开的位置，以及与间隔开的位置下游的第二流动路径相关联的流动通信站点，该通信站点适于允许与第一流动路径的通信。

88. 发明申请

US20100137826A1 PRE-ASSEMBLED MEDICAL FLUID FLOW SYSTEM AND METHOD OF MAKING SAME 有权
标题翻译：预组装的医用流体流动系统及其制备方法
公开(公告)号：US20100137826A1
公开(公告)日：2010-06-03
申请号：US12327072
申请日：2008-12-03
申请人： Walter Timothy Watts , Kyungyoon Min , Daniel Martin Karlovsky
发明人： Walter Timothy Watts , Kyungyoon Min , Daniel Martin Karlovsky
IPC分类号： A61M5/165 , A61L2/00
CPC分类号： A61M39/18 , A61M1/0218 , A61M5/165 , A61M2005/1657 , A61M2039/1061 , A61M2205/12 , A61M2205/7509 , A61M2205/7518
摘要： A pre-assembled medical fluid flow system and method of making same are disclosed. The system includes a first sterilized fluid flow system component, a second sterilized fluid flow system component and a flow path for providing fluid communication therebetween. The flow path includes an isolated portion. An openable closure isolates the isolated portion from the first sterilized fluid system component, and a microorganism filter is disposed between and isolates the isolated portion of the flow path and the second sterilized fluid flow system component. Therefore, fluid from the isolated portion of the flow path must flow through the microorganism filter to reach the second sterilized fluid flow system component.
摘要翻译：公开了预组装的医用流体流动系统及其制造方法。该系统包括第一无菌流体流动系统部件，第二灭菌流体流动系统部件和用于在其间提供流体连通的流动路径。流路包括隔离部分。可打开的封闭物将隔离部分与第一无菌流体系统部件隔离，并且将微生物过滤器设置在流路的隔离部分和第二无菌流体流动系统部件之间并将其隔离。因此，来自流动路径的隔离部分的流体必须流过微生物过滤器以到达第二无菌流体流动系统部件。

89. 发明申请

US20090218277A1 SEPARATION APPARATUS AND METHOD 有权
标题翻译：分离装置和方法
公开(公告)号：US20090218277A1
公开(公告)日：2009-09-03
申请号：US12399545
申请日：2009-03-06
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur , Julie Moriarty
IPC分类号： B01D17/038
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

90. 发明授权

US07297272B2 Separation apparatus and method 有权
标题翻译：分离装置及方法
公开(公告)号：US07297272B2
公开(公告)日：2007-11-20
申请号：US10827603
申请日：2004-04-19
申请人： Kyungyoon Min , Richard I. Brown , Alp Akonur
发明人： Kyungyoon Min , Richard I. Brown , Alp Akonur
IPC分类号： B04B3/00 , B04B1/06 , B04B1/12 , B04B7/10 , B01D21/26 , B01D45/12
CPC分类号： A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2205/128 , B04B5/0442 , B04B2005/045
摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.
摘要翻译：使用分离装置和方法来使用用于围绕轴线旋转的分离通道。这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。入口将流体输送到通道中。屏障位于内外侧壁部分的通道中间。第一流动路径在屏障的上游侧和下游侧之间连通。收集区域可以位于屏障的下游，用于与第一流动路径通信。通道的外侧壁部分可以位于其上游部分的径向外侧。屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

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