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81. 发明授权

US07534336B2 Continuous flow particle concentrator 有权
标题翻译：连续流粒子集中器
公开(公告)号：US07534336B2
公开(公告)日：2009-05-19
申请号：US10838570
申请日：2004-05-04
申请人： Armin R. Volkel , Meng H. Lean , H Ben Hsieh , Jurgen H Daniel
发明人： Armin R. Volkel , Meng H. Lean , H Ben Hsieh , Jurgen H Daniel
IPC分类号： G01N27/453
CPC分类号： B03C5/028 , G01N2030/0035
摘要： An apparatus for extracting and concentrating bioagents within a continuously flowing fluid medium includes a flow channel fluid inlet, in which bioagents are concentrated from three dimensions to a two-dimensional transport layer in a preconcentration area. Traveling wave grids cause the preconcentrated bioagents to migrate to one side of the flow channel and then to an extraction port. Each of the traveling wave grids includes a substrate, a collection of closely spaced and parallel electrically conductive electrodes extending across said substrate, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids. Fluid exits through an outlet port.
摘要翻译：用于在连续流动的流体介质中提取和浓缩生物体的装置包括流动通道流体入口，其中生物体从三维集中到预浓缩区域中的二维输送层。旅行波谷使预浓缩的生物标签迁移到流动通道的一侧，然后迁移到提取口。每个行波波谷包括基板，跨越所述基板的紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。电压控制器提供多相电信号，用于收集行波网格的总线和电极。流体通过出口排出。

82. 发明授权

US07479625B2 Sensing photons from object in channels 有权
标题翻译：从通道中的物体感应光子
公开(公告)号：US07479625B2
公开(公告)日：2009-01-20
申请号：US12098584
申请日：2008-04-07
申请人： Peter Kiesel , Meng H. Lean , Oliver Schmidt , Armin R. Volkel , Noble M. Johnson
发明人： Peter Kiesel , Meng H. Lean , Oliver Schmidt , Armin R. Volkel , Noble M. Johnson
IPC分类号： G01J3/50
CPC分类号： G01N21/05 , G01N21/645 , G01N21/65 , G01N21/658 , G01N2021/0346 , G01N2021/1734 , G01N2021/6421 , G01N2021/6482
摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.
摘要翻译：流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。至少一个感测组件包括一组光电传感器阵列的单元。该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析组件，或从通道清除对象。

83. 发明授权

US07448287B2 Pipette with agitation feature 失效
标题翻译：移液器具有搅动功能
公开(公告)号：US07448287B2
公开(公告)日：2008-11-11
申请号：US11537700
申请日：2006-10-02
申请人： Jürgen H. Daniel , Meng H. Lean
发明人： Jürgen H. Daniel , Meng H. Lean
IPC分类号： G01N1/00
CPC分类号： B01F11/0077 , B01F11/0088 , B01F11/04 , B01L3/0217 , G01N2035/00534 , G01N2035/1058 , Y10T436/25
摘要： A system and method extracts/deposits fluid and includes a pipette having a pipette body portion and a pipette tip. A stirring/agitation mechanism including a fiber or a rod extends through the interior of the pipette tip, wherein a fiber end or rod end of the fiber or rod, extends out of a narrowed end of the pipette tip, and the fiber end or rod end is configured to stir or agitate the fluid.
摘要翻译：系统和方法提取/沉积流体并且包括具有移液管主体部分和移液管末端的移液管。包括纤维或棒的搅拌/搅拌机构延伸穿过移液管尖端的内部，其中纤维或杆的纤维端或杆端延伸出移液管尖端的狭窄端，纤维端或杆末端配置为搅拌或搅拌流体。

84. 发明申请

US20080204709A1 BIOSENSOR USING MICRODISK LASER 失效
标题翻译：生物传感器使用MICRODISK激光
公开(公告)号：US20080204709A1
公开(公告)日：2008-08-28
申请号：US12118056
申请日：2008-05-09
申请人： Peter KIESEL , Noble M. Johnson , Meng H. Lean , H. Ben Hsieh , Michael A. Kneissl
发明人： Peter KIESEL , Noble M. Johnson , Meng H. Lean , H. Ben Hsieh , Michael A. Kneissl
IPC分类号： G01N1/00
CPC分类号： B82Y20/00 , G01N33/54373 , H01S5/041 , H01S5/0607 , H01S5/1075 , H01S5/34333 , H01S5/4025
摘要： A compact sensor for detecting the presence of biological or chemical species includes a microdisk laser and a wavelength shift detector. The microdisk laser is coated with a biological or chemical recognition element, which binds preferentially with a target analyte. Because the recognition element and the target analyte adhere to the sidewall surface of the microdisk laser, they increase the effective diameter of the laser, which shifts the output wavelength by a detectable amount. The presence of a wavelength shift indicates the presence of the target analyte, and the magnitude of the wavelength shift corresponds to the mass load of the target analyte on the sidewall surface of the microdisk laser.
摘要翻译：用于检测生物或化学物质存在的紧凑型传感器包括微盘激光器和波长偏移检测器。微型体激光器涂覆有与目标分析物优先结合的生物或化学识别元件。因为识别元件和目标分析物粘附到微盘激光器的侧壁表面，所以它们增加了激光器的有效直径，这将输出波长移动了可检测的量。波长偏移的存在表示目标分析物的存在，并且波长漂移的大小对应于微盘激光器的侧壁表面上的目标分析物的质量负载。

85. 发明申请

US20080128331A1 Particle separation and concentration system 有权
标题翻译：颗粒分离和浓缩系统
公开(公告)号：US20080128331A1
公开(公告)日：2008-06-05
申请号：US11606460
申请日：2006-11-30
申请人： Meng H. Lean , Jeonggi Seo , Ashutosh Kole , Norine E. Chang , Scott Jong Ho Limb
发明人： Meng H. Lean , Jeonggi Seo , Ashutosh Kole , Norine E. Chang , Scott Jong Ho Limb
IPC分类号： B03B5/00
CPC分类号： B01D21/265 , B01D2221/10 , B01D2311/04 , B01D2311/16 , B01D2321/2025 , B03B5/32 , B04C1/00 , G01N15/0255 , G01N15/04 , B01D2311/2676
摘要： This invention is based on size and mass separation of suspended particles, including biological matter, which are made to flow in a spiral channel. On the spiral sections, the inward directed transverse pressure field from fluid shear competes with the outward directed centrifugal force to allow for separation of particles. At high velocity, centrifugal force dominates and particles move outward. At low velocities, transverse pressure dominates and the particles move inward. The magnitudes of the two opposing forces depend on flow velocity, particle size, radius of curvature of the spiral section, channel dimensions, and viscosity of the fluid. At the end of the spiral channel, a parallel array of outlets collects separated particles. For any particle size, the required channel dimension is determined by estimating the transit time to reach the side-wall. This time is a function of flow velocity, channel width, viscosity, and radius of curvature. Larger particles may reach the channel wall earlier than the smaller particles which need more time to reach the side wall. Thus a spiral channel may be envisioned by placing multiple outlets along the channel. This technique is inherently scalable over a large size range from sub-millimeter down to 1 μm.
摘要翻译：本发明基于使得在螺旋通道中流动的悬浮颗粒（包括生物物质）的尺寸和质量分离。在螺旋段上，来自流体剪切的向内定向的横向压力场与向外的定向离心力相竞争，以允许颗粒分离。在高速度下，离心力主导，颗粒向外移动。在低速度下，横向压力占主导，颗粒向内移动。两个相对力的大小取决于流速，粒径，螺旋截面的曲率半径，通道尺寸和流体的粘度。在螺旋通道的末端，平行排列的出口收集分离的颗粒。对于任何颗粒尺寸，所需的通道尺寸通过估计到达侧壁的通行时间来确定。这个时间是流速，通道宽度，粘度和曲率半径的函数。较大的颗粒可能比需要更多时间到达侧壁的较小颗粒更早地到达通道壁。因此，可以通过沿着通道设置多个出口来设想螺旋通道。这种技术在从亚毫米下降到1毫米的大尺寸范围内固有地可扩展。

86. 发明申请

US20080118985A1 OSMOTIC REACTION DETECTOR FOR DETECTING BIOLOGICAL AND NON-BIOLOGICAL REACTIONS 有权
标题翻译：用于检测生物和非生物反应的操作反应检测器
公开(公告)号：US20080118985A1
公开(公告)日：2008-05-22
申请号：US11946268
申请日：2007-11-28
申请人： Francisco E. Torres , Jonathan S. Daniels , Meng H. Lean
发明人： Francisco E. Torres , Jonathan S. Daniels , Meng H. Lean
IPC分类号： G01N33/20
CPC分类号： B01L3/505 , G01N13/04 , Y10S436/807
摘要： A method and apparatus for measuring the presence or absence of interaction between at least a first and second material of interest by measuring osmotic pressure changes in an osmotic cell. Changes in osmotic pressure are determined by measuring the amount of compression exhibited by a compressible, semi-permeable material positioned in the cell.
摘要翻译：一种用于通过测量渗透细胞中的渗透压变化来测量至少第一和第二物质之间存在或不存在相互作用的方法和装置。渗透压的变化通过测量位于细胞中的可压缩的半渗透材料显示的压缩量来确定。

87. 发明申请

US20080081004A1 FLUID STIRRING MECHANISM 有权
标题翻译：流体搅拌机构
公开(公告)号：US20080081004A1
公开(公告)日：2008-04-03
申请号：US11537679
申请日：2006-10-02
申请人： Jurgen H. Daniel , Meng H. Lean , Armin R. Volkel
发明人： Jurgen H. Daniel , Meng H. Lean , Armin R. Volkel
IPC分类号： B01L3/02
CPC分类号： B01F11/0077 , B01F11/0088 , B01F11/0091 , B01F13/0059 , B01L3/5027
摘要： A fluidic system and method includes a channel reservoir which holds 1.5 milliliters or less of fluid. The agitation mechanism, which is partially integrated with the channel or reservoir, includes a fiber or rod at least partially situated within the channel or reservoir, and which acts to move or vibrate to stir and/or agitate fluid within the channel or reservoir. The fluid is then extracted from an extraction area following the agitation or stirring operation.
摘要翻译：流体系统和方法包括容纳1.5毫升或更少流体的通道储存器。与通道或贮存器部分整合的搅拌机构包括至少部分地位于通道或贮存器内的纤维或杆，并且其作用为移动或振动以搅动和/或搅动通道或储存器内的流体。然后在搅拌或搅拌操作之后从提取区域中提取流体。

88. 发明授权

US07290336B2 Method of fabricating an array of multi-electroded piezoelectric transducers for piezoelectric diaphragm structures 失效
标题翻译：制造用于压电隔膜结构的多电极压电换能器阵列的方法
公开(公告)号：US07290336B2
公开(公告)日：2007-11-06
申请号：US11104887
申请日：2005-04-13
申请人： Steven A. Buhler , John S. Fitch , Meng H. Lean , Karl A. Littau
发明人： Steven A. Buhler , John S. Fitch , Meng H. Lean , Karl A. Littau
IPC分类号： B21D53/76 , B41J2/045 , G01D15/00
CPC分类号： B41J2/14233 , B41J2/14282 , B41J2/161 , B41J2/1614 , B41J2/1632 , H01L41/0973 , H01L41/257 , H01L41/313 , H01L41/314 , H01L41/331 , Y10T29/42 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49156 , Y10T29/4921 , Y10T29/49401
摘要： A circuit provides energy to a plurality of piezoelectric diaphragm structures formed in a two-dimensional array. Each piezoelectric diaphragm structure includes a piezoelectric element in operational contact with at least a first side electrode and a second side electrode. A switching system includes a first connection for a first power source, for application of power to the first side electrode and a second connection for a second power source, for application of power to the second side electrode. In a first state, power appropriate for performing a poling operation of the piezoelectric material is available for application to the first electrode, and the second electrode, and in a second state, power appropriate to activate the piezoelectric material to cause operational movement of the poled piezoelectric diaphragm structure is available for application to the first electrode and the second electrode.
摘要翻译：电路向以二维阵列形成的多个压电振膜结构提供能量。每个压电膜结构包括与至少第一侧电极和第二侧电极操作接触的压电元件。交换系统包括用于第一电源的第一连接，用于向第一侧电极施加电力和用于第二电源的第二连接，用于向第二侧电极施加电力。在第一状态下，适于执行压电材料的极化操作的电力可用于施加到第一电极和第二电极，并且在第二状态下，适于激活压电材料的动力引起极化的操作运动压电膜结构可应用于第一电极和第二电极。

89. 发明授权

US06969160B2 Ballistic aerosol marking apparatus 有权
公开(公告)号：US06969160B2
公开(公告)日：2005-11-29
申请号：US10628844
申请日：2003-07-28
申请人： Meng H. Lean , John J. Ricciardelli , Michael J. Savino , Osman T. Polatkan , Fred R. Stolfi , Eric Lindale
发明人： Meng H. Lean , John J. Ricciardelli , Michael J. Savino , Osman T. Polatkan , Fred R. Stolfi , Eric Lindale
IPC分类号： B41J2/015 , B41J2/215
CPC分类号： B41J2/04
摘要： A toner gating apparatus for supplying toner through an aperture to a gas channel having a propellant stream. The toner gating apparatus has a traveling wave grid having electrodes. A first gating electrode is located proximate a first side of the aperture. A second gating electrode is located proximate a second side of the aperture. A third gating electrode is located in the gas channel. A first voltage source having a first phase is connected to both the first gating electrode and a first electrode of the travelling wave grid. A second voltage source having a second phase is connected to both the second gating electrode and a second electrode of the travelling wave grid. A third voltage source having a third phase is connected to both the third gating electrode and a third electrode of the travelling wave grid.

90. 发明授权

US06511149B1 Ballistic aerosol marking apparatus for marking a substrate 有权
标题翻译：用于标记基材的弹道气溶胶标记装置
公开(公告)号：US06511149B1
公开(公告)日：2003-01-28
申请号：US09163893
申请日：1998-09-30
申请人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
发明人： Eric Peeters , Jaan Noolandi , Raj B. Apte , Philip D. Floyd , Jonathan A. Small , Gregory J. Kovacs , Meng H. Lean , Armin R. Volkel , Steven B. Bolte , An-Chang Shi , Frederick J. Endicott , Gregory B. Anderson , Dan A. Hays , Joel A. Kubby , Warren B. Jackson
IPC分类号： B41J215
CPC分类号： B41J2/01 , B41J2/14 , B41J2/211 , B41J2202/02
摘要： A marking apparatus is disclosed in which a propellant stream is passed through a channel and directed toward a substrate. Marking material, such as ink, toner, etc., is controllably introduced into the propellant stream and imparted with sufficient kinetic energy thereby to be made incident upon a substrate. At sufficient velocity, and with appropriate marking material, the marking material may be kinetically fused to the substrate. A multiplicity of channels for directing the propellant and marking material allow for high throughput, high resolution marking. Multiple marking materials may be introduced into the channel and mixed therein prior to being made incident on the substrate, or mixed or superimposed on the substrate without registration. One example is a single-pass, full-color printer.
摘要翻译：公开了一种标记装置，其中推进剂流通过通道并指向基板。诸如油墨，调色剂等的标记材料被可控地引入推进剂流中并且赋予足够的动能从而被入射到基底上。在足够的速度下，并且使用适当的标记材料，标记材料可以与基底动力学融合。用于引导推进剂和标记材料的多个通道允许高通量，高分辨率标记。可以将多个标记材料引入通道中并在其入射到基板之前混合，或者混合或叠加在基板上而不进行配准。一个例子是单程全彩色打印机。

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