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81. 发明申请

US20170021187A1 METHODS AND SYSTEMS FOR CONTROLLING MAGNETIC FIELDS AND MAGNETIC FIELD INDUCED CURRENT 审中-公开
标题翻译：用于控制磁场和磁场感应电流的方法和系统
公开(公告)号：US20170021187A1
公开(公告)日：2017-01-26
申请号：US15300979
申请日：2015-04-02
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： Liyi Elliott HONG , Fow-Sen CHOA
IPC分类号： A61N2/00 , A61N1/40 , A61N2/02
CPC分类号： A61N2/006 , A61N1/40 , A61N2/02
摘要： The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. During operation, at least some of the magnetic coils function as DC coil pairs configured to generate a DC magnetic field, while at least some DC coil of the other magnetic coils function as transient magnetic field generators to generate an induced current within a portion of the patient's body, such as in a region of the patient's brain. The system is configured such that the DC magnetic fields may be used to manipulate the transient magnetic fields, in turn allowing significantly improved control and focus of the induced current within a specifically desired volume of interest within a patient's body.
摘要翻译：本发明公开了用于控制磁场和磁场感应电流的方法和系统，更具体地，以非侵入性方式提供患者体内的刺激，例如深部脑刺激，并且具有比已经提供的更大的焦点和控制通过先前已知的方法和系统。根据实施例的某些方面，提供磁性线圈阵列并且围绕患者身体的一部分定位。在操作期间，至少一些磁性线圈用作被配置为产生DC磁场的DC线圈对，而其他磁性线圈的至少一些DC线圈用作瞬态磁场发生器，以在该部分内产生感应电流患者的身体，如患者大脑的区域。该系统被配置为使得DC磁场可以用于操纵瞬态磁场，反过来允许在患者身体内的特定期望的感兴趣体积内显着改善感应电流的控制和聚焦。

82. 发明申请

US20160348048A1 MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING 审中-公开
公开(公告)号：US20160348048A1
公开(公告)日：2016-12-01
申请号：US15167743
申请日：2016-05-27
申请人： University of Maryland Baltimore County
发明人： Govind RAO , Yordan KOSTOV , Leah TOLOSA , Hung LAM , Xudong GE , Douglas FREY , Virendra SINGH
IPC分类号： C12M1/00 , C12M1/36 , B01D15/38 , C12M1/34 , B01D15/36 , B01D15/32 , C07K1/36 , C12M1/40
CPC分类号： C12M21/14 , B01D15/327 , B01D15/361 , B01D15/3847 , C07K1/34 , C07K1/36 , C12M21/18 , C12M29/04 , C12M41/34 , C12M41/48 , C12M43/00 , C12M47/12
摘要： A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.

83. 发明授权

US09463496B2 Organic biofilm substrata as a microbial inoculum delivery vehicle for bioaugmentation of persistent organic pollutants in contaminated sediments and soils 有权
公开(公告)号：US09463496B2
公开(公告)日：2016-10-11
申请号：US14612887
申请日：2015-02-03
申请人： University of Maryland Baltimore County
发明人： Kevin R. Sowers , Birthe Kjellerup , Upal Ghosh
IPC分类号： C12N1/12 , A62D3/00 , A62D3/02 , B09C1/10 , C12N1/20 , B09C1/08 , A62D101/22
CPC分类号： B09C1/10 , A62D3/02 , A62D2101/22 , B09C1/08 , C12N1/20
摘要： A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1) inoculation of microorganisms to degrade POPs and 2) accumulation of POPs on the substrata, effective in maintaining bioavailable concentrations for sustaining microbial activity. Microorganisms capable of degrading or transforming POPs are actively associated with the substrata as a biofilm. Application of this delivery vehicle will enhance the microbial degradation of POPs, while simultaneously adsorbing hydrophobic POPs from the environment making them bioavailable for the microorganisms located in the formed biofilms and additionally lowering the aqueous concentration of POPs that have detrimental effects towards fish and mammals as they bioaccumulate through the food chain.

84. 发明授权

US09453797B2 Metal enhanced fluorescence from metallic nanoburger structures 有权
标题翻译：金属增强荧光从金属纳米结构
公开(公告)号：US09453797B2
公开(公告)日：2016-09-27
申请号：US14276207
申请日：2014-05-13
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： Chris D. Geddes
IPC分类号： G01N33/543 , G01N33/553 , G01N21/55 , G01N21/64 , B82Y15/00 , G01N21/552
CPC分类号： G01N21/64 , B82Y15/00 , G01N21/554 , G01N21/6408 , G01N21/648 , G01N33/54346 , G01N33/54353 , G01N33/553 , Y10T428/256
摘要： The present invention provides for metallic nanostructures or nanoburgers comprising a dielectric layer positioned between metallic layers and their use in metal enhanced emissions systems to enhance emissions from fluorophores, including intrinsic and extrinsic; luminophores; bioluminescent species and/or chemiluminescent species. The multilayer nanoburgers exhibit several distinctive properties including significantly enhanced intensity of emissions, decreased lifetime and increased photostability by simply varying the thickness of the dielectric layer while maintaining a constant thickness of the two metallic layers on opposite sides of the dielectric layer.
摘要翻译：本发明提供金属纳米结构或纳米级包含位于金属层之间的介电层的纳米级结构，以及它们在金属增强排放系统中的用途，以增强来自荧光团的排放，包括内在和外在的; 发光体生物发光物质和/或化学发光物质。该多层纳米铁矿石具有几个显着的特性，包括通过简单地改变电介质层的厚度同时保持电介质层的相对侧上的两个金属层的恒定厚度，显着提高发射强度，降低寿命和提高光稳定性。

85. 发明申请

US20160257696A1 THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF 有权
标题翻译：作为抗感染剂的苯丙酮和吡咯烷酮类似物及其使用方法
公开(公告)号：US20160257696A1
公开(公告)日：2016-09-08
申请号：US14634940
申请日：2015-03-02
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： KATHERINE L. RADTKE , Kartik Tembhurnikar
IPC分类号： C07D495/04 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
摘要翻译：本发明提供了表现出癌细胞增殖抑制活性的卤代噻吩并吡咯并嘧啶化合物的设计和合成及其在癌症治疗中的应用。

86. 发明授权

US09434742B1 Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof 有权
标题翻译：噻吩并吡咯并嘧啶类似物作为抗癌剂及其使用方法
公开(公告)号：US09434742B1
公开(公告)日：2016-09-06
申请号：US14634940
申请日：2015-03-02
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： Katherine L. Radtke , Kartik Temburnikar
IPC分类号： A01N43/90 , A61K31/519 , C07D495/04 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
摘要翻译：本发明提供了表现出癌细胞增殖抑制活性的卤代噻吩并吡咯并嘧啶化合物的设计和合成及其在癌症治疗中的应用。

87. 发明申请

US20160202183A1 SPECTRAL SHIFTS AND MODIFICATIONS IN METAL-ENHANCED FLUORESCENCE, PHOSPHORESCENCE AND ALPHA-FLUORESCENCE 审中-公开
标题翻译：金属增强荧光，磷光和荧光光谱的变化和变化
公开(公告)号：US20160202183A1
公开(公告)日：2016-07-14
申请号：US14994513
申请日：2016-01-13
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： CHRIS D. GEDDES
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6428 , G01N33/50 , G01N33/553 , G01N2021/6439
摘要： The present invention provides for excitable molecules positioned near metallic structures, wherein the metallic structures have a particles size from about 1 nm to 1000 nm and wherein the excitable molecules have fluorescence, phosphorescence or alpha-fluorescence emissions that are altered due to positioning near the metal structures. The emission spectra are distorted on either the blue or red edges in a range from 1 to 10 nm thereby changing the color of emissions. Further, the width of the emission spectrum is modified either by narrowing or broadening depending on the material of the metallic structures and type of excitable molecule.
摘要翻译：本发明提供位于金属结构附近的可兴奋分子，其中金属结构具有约1nm至1000nm的粒度，并且其中可激发分子具有荧光，磷光或α-荧光发射，其由于位于金属附近而定位而改变结构。发射光谱在1至10nm的范围内的蓝色或红色边缘上失真，从而改变了发射的颜色。此外，发光光谱的宽度根据金属结构的材料和可兴奋分子的类型而变窄或变宽。

88. 发明申请

US20150214821A1 Active Control System for a Variable Electromotive-Force Generator with Applications to Wind Turbines, Ships, and Hybrid Vehicles 有权
标题翻译：用于风力发电机，船舶和混合动力车辆的可变电动势发电机的主动控制系统
公开(公告)号：US20150214821A1
公开(公告)日：2015-07-30
申请号：US14534112
申请日：2014-11-05
申请人： University of Maryland,Baltimore County
发明人： Weidong ZHU , Navid GOUDARZI , Xuefeng WANG
IPC分类号： H02K21/02 , F03D9/00 , B60L15/20 , H02P9/00
CPC分类号： H02K21/024 , B60L15/2009 , B60L2220/50 , B60L2240/421 , B60L2240/423 , B60L2270/145 , F03D7/0272 , H02K7/1838 , H02K21/24 , H02K2201/03 , H02K2213/09 , H02P9/00 , Y02E10/723 , Y02T10/641 , Y02T10/645 , Y02T10/7275
摘要： This invention relates to an active control system for a variable electromotive-force generator (VEG) for use in wind turbines, ships, hybrid vehicles, and related applications.
摘要翻译：本发明涉及用于风力涡轮机，船舶，混合动力车辆和相关应用的可变电动势发生器（VEG）的主动控制系统。

89. 发明申请

US20140287224A1 METAL ENHANCED FLUORESCENCE FROM METALLIC NANOBURGER STRUCTURES 审中-公开
标题翻译：金属纳米棒结构的金属增强荧光
公开(公告)号：US20140287224A1
公开(公告)日：2014-09-25
申请号：US14276207
申请日：2014-05-13
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： CHRIS D. GEDDES
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , B82Y15/00 , G01N21/554 , G01N21/6408 , G01N21/648 , G01N33/54346 , G01N33/54353 , G01N33/553 , Y10T428/256
摘要： The present invention provides for metallic nanostructures or nanoburgers comprising a dielectric layer positioned between metallic layers and their use in metal enhanced emissions systems to enhance emissions from fluorophores, including intrinsic and extrinsic; luminophores; bioluminescent species and/or chemiluminescent species. The multilayer nanoburgers exhibit several distinctive properties including significantly enhanced intensity of emissions, decreased lifetime and increased photostability by simply varying the thickness of the dielectric layer while maintaining a constant thickness of the two metallic layers on opposite sides of the dielectric layer.
摘要翻译：本发明提供金属纳米结构或纳米级包含位于金属层之间的介电层的纳米级结构，以及它们在金属增强排放系统中的用途，以增强来自荧光团的排放，包括内在和外在的; 发光体生物发光物质和/或化学发光物质。该多层纳米铁矿石具有几个显着的特性，包括通过简单地改变电介质层的厚度同时保持电介质层的相对侧上的两个金属层的恒定厚度，显着提高发射强度，降低寿命和提高光稳定性。

90. 发明公开

US20230416851A1 RAPID DIAGNOSTIC ELECTROCHEMICAL BIOSENSING TARGETED WITH ANTISENSE OLIGONUCLEOTIDES 审中-公开
公开(公告)号：US20230416851A1
公开(公告)日：2023-12-28
申请号：US18247474
申请日：2021-10-05
申请人： University of Maryland, Baltimore , University of Maryland, Baltimore County
发明人： Dipanjan PAN , Maha Mohammad Shehadeh ALAFEEF , Ketan DIGHE , Parikshit MOITRA
IPC分类号： C12Q1/70 , C12Q1/6825 , B01L3/00
CPC分类号： C12Q1/701 , C12Q1/6825 , B01L3/502715 , B01L2300/0663 , B01L2200/16
摘要： The present disclosure relates to electrochemical biosensing systems and methods that can be adapted to accurately and rapidly detect a target gene in clinical samples, using anti-sense oligonucleotides for selective detection of biological pathogens.

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