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81. 发明授权

US6139510A Super elastic alloy guidewire 失效
标题翻译：超弹性合金导丝
公开(公告)号：US6139510A
公开(公告)日：2000-10-31
申请号：US545672
申请日：1995-10-31
申请人： Thomas J. Palermo
发明人： Thomas J. Palermo
IPC分类号： A61L31/02 , A61L31/10 , A61B5/00
CPC分类号： A61M25/09 , A61L31/022 , A61L31/10 , A61L2400/16 , A61M2025/09133 , A61M2025/09141 , A61M2025/09175 , A61M25/09033
摘要： This invention is a surgical device. It is a guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire may be of a high elasticity metal alloy, preferably a Ni-Ti alloy, having specified physical parameters, and is especially useful for accessing peripheral or soft tissue targets. A special variation of the inventive guidewire includes the concept of coating the wire with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen. The "necked" guidewire tip also forms a specific variant of the invention.
摘要翻译： PCT No.PCT / US94 / 05219 Sec。 371日期1995年10月31日 102（e）1995年10月31日的PCT PCT 1994年5月11日提交本发明是一种外科装置。它是用于导管的导丝，用于进入患者身体的管腔系统中的目标部位。导丝可以是具有特定物理参数的高弹性金属合金，优选Ni-Ti合金，并且特别适用于接近外周或软组织靶。本发明的导丝的特殊变型包括用一种或多种润滑聚合物涂覆线的概念，以增强其在导管内和血管腔内部使用的适用性。 “颈缩”导丝尖还形成本发明的具体变型。

82. 发明授权

US6123714A System for detaching an occlusive device within a body using a solderless, electrolytically severable joint 失效
公开(公告)号：US6123714A
公开(公告)日：2000-09-26
申请号：US743494
申请日：1996-11-04
申请人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
发明人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
IPC分类号： A61F2/82 , A61B17/00 , A61B17/12 , A61F2/06 , A61F2/84 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61F2/95 , A61B2017/00017 , A61B2017/00292 , A61B2017/12063 , A61B2018/1495
摘要： A solderless sacrificial link between a detachable member which is placed at and is intended to remain at a desired site within the mammalian body and the core wire used to introduce the detachable member. The detachable member device may be one used to create emboli in the vascular system or may be of any other type deliverable into the human body and detached into an ionic aqueous environment, either for later removal or permanent placement.

83. 发明授权

US6090099A Multi-layer distal catheter section 失效
标题翻译：多层远端导管段
公开(公告)号：US6090099A
公开(公告)日：2000-07-18
申请号：US653602
申请日：1996-05-24
申请人： Gene Samson , Kim Nguyen
发明人： Gene Samson , Kim Nguyen
IPC分类号： A61B17/00 , A61M25/00
CPC分类号： A61M25/0045 , A61M25/005 , A61M25/0053
摘要： This is a distal-most section of a catheter suitable for treating a tissue target within the body, which target is accessible through the vascular system. Central to the invention is a multi-component or multi-layer catheter section used distally on an endovascular catheter. In particular, the inventive catheter section has at least one interior stiffener member and an exterior tubing member. Between the at least one interior stiffener member and the exterior tubing member is a metallic braid.
摘要翻译：这是适合于治疗身体内的组织靶的导管最远部分，该靶可通过血管系统进入。本发明的中心是在血管内导管上远端使用的多组分或多层导管部分。特别地，本发明的导管部分具有至少一个内部加强件和外部管件。在至少一个内部加强件和外部管件之间是金属编织物。

84. 外观设计

USD427680S Spiral vaso-occlusion coil 失效
公开(公告)号：USD427680S
公开(公告)日：2000-07-04
申请号：US109561
申请日：1999-08-18
申请人： Michael Mariant , Thomas J. Palermo
设计人： Michael Mariant , Thomas J. Palermo

85. 发明授权

US6077260A Assembly containing an electrolytically severable joint for endovascular embolic devices 失效
公开(公告)号：US6077260A
公开(公告)日：2000-06-20
申请号：US26373
申请日：1998-02-19
申请人： E. Thomas Wheelock , Erik T. Engelson , Harold F. Carrison
发明人： E. Thomas Wheelock , Erik T. Engelson , Harold F. Carrison
IPC分类号： A61B17/12 , A61B17/38 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12063
摘要： This invention is an apparatus for the formation of occlusions in spaces in the human body, occluding such as thrombi in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas. In particular, it deals with a one piece assembly having an improved electrolytically erodable link to an occlusive member and further having an incorporated return electrode in the assembly. The occlusion-forming member is introduced to and is intended to remain at the desired occlusion site. The invention also relates to the joint itself. The invention further includes a method for introduction and electrolytic separation of the device.

86. 发明授权

US6033423A Multiple layered vaso-occlusive coils 失效
标题翻译：多层血管闭塞线圈
公开(公告)号：US6033423A
公开(公告)日：2000-03-07
申请号：US974275
申请日：1997-11-19
申请人： Christopher G. M. Ken , Erik T. Engelson
发明人： Christopher G. M. Ken , Erik T. Engelson
IPC分类号： A61F2/82 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译：这是一种植入式血管闭塞装置。它是具有多个初级绕组次级层的复杂的螺旋卷绕线圈。最终形状本质上通常是块状的，并且可以以解剖腔的近似形状使用。它可以以球体，卵球形或其他变形的球形的近似形状部署。该装置是由预先形成的线性血管闭塞构件制成的自形成形状。纤维可以引入到装置上并固定到预成形的线性构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。

87. 外观设计

USD421304S Spiral vaso-occlusion coil 失效
公开(公告)号：USD421304S
公开(公告)日：2000-02-29
申请号：US91691
申请日：1998-08-04
申请人： Michael Mariant , Thomas J. Palermo
设计人： Michael Mariant , Thomas J. Palermo

88. 发明授权

US6024754A Aneurysm closure method 失效
标题翻译：动脉瘤闭合方法
公开(公告)号：US6024754A
公开(公告)日：2000-02-15
申请号：US943039
申请日：1997-10-02
申请人： Erik T. Engelson
发明人： Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12186 , A61B17/12195 , A61B2017/005 , A61B2017/1205 , A61B2017/12063
摘要： This is a procedure for stabilizing or filling an aneurysm in the vasculature. The procedure involves the introduction into the aneurysm of a solid vaso-occlusive device such as a coil or braid and a polymeric composition which may be reformed or solidified in situ. The solid vaso-occlusive device is at least partially surrounded or enveloped by that polymeric composition. The polymeric composition is reformed via light, heat, R.F. or the like to form a rigid mass with the solid vaso-occlusive device. These steps may be carried out sequentially or the steps of introducing the vaso-occlusive device and reforming the polymeric composition may be carried out simultaneously. The procedure may be accomplished using intravascular catheters to access the desired site and to deliver the noted materials.
摘要翻译：这是用于稳定或填充脉管系统中的动脉瘤的程序。该方法包括引入固体血管闭塞装置如线圈或编织物的动脉瘤和可以原位重整或固化的聚合物组合物。固体血管闭塞装置至少部分地被该聚合物组合物包围或包围。聚合物组合物通过光，热，R.F. 以形成具有固体血管闭塞装置的刚性质量。可以依次进行这些步骤，或者可以同时进行引入血管闭塞装置和重整聚合物组合物的步骤。该程序可以使用血管内导管来实现，以进入所需的部位并输送所述材料。

89. 发明授权

US6004338A Stretch resistant vaso-occlusive coils 有权
标题翻译：抗拉伸血管闭塞线圈
公开(公告)号：US6004338A
公开(公告)日：1999-12-21
申请号：US132117
申请日：1998-08-11
申请人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
发明人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase . The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

90. 发明授权

US6001092A Complex coils having fibered centers 失效
标题翻译：具有纤维中心的复杂线圈
公开(公告)号：US6001092A
公开(公告)日：1999-12-14
申请号：US909679
申请日：1997-08-12
申请人： Gregory E. Mirigian , Nga Thi Van , Son M. Gia
发明人： Gregory E. Mirigian , Nga Thi Van , Son M. Gia
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12145 , A61B17/1215
摘要： A vasoocclusive device in the form of a coil for placement in the vasculature of an animal to form thrombus in a selected site such as an aneurysm or AVM. The device involves a primary coil form having thrombogenic fibers placed on the coil in a specified fashion. The coil will pass through the lumen of a vascular catheter in the primary coil form and evolve into a convoluted or complex secondary form when ejected from the catheter's distal end. The fibers are attached to the coil and cooperate with the coil so that upon ejection from the catheter, the convoluted coil forms a shape in which the central region or secondary coil form center that contains the majority of these fibers.
摘要翻译：一种用于放置在动物脉管系统中的线圈形式的血管闭塞装置，以在选定部位如动脉瘤或AVM中形成血栓。该装置涉及具有以特定方式放置在线圈上的血栓形成纤维的初级线圈形式。线圈将以原始线圈形式通过血管导管的内腔，并且当从导管的远端喷出时，其演变成卷积或复杂的次级形式。纤维连接到线圈并与线圈配合，使得当从导管喷射时，卷积的线圈形成中心区域或次级线圈形成中心的形状，其中包含大多数这些纤维。

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