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1. 发明授权

US5833705A Stretch resistant vaso-occlusive coils 失效
标题翻译：抗拉伸血管闭塞线圈
公开(公告)号：US5833705A
公开(公告)日：1998-11-10
申请号：US717285
申请日：1996-09-20
申请人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
发明人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase. The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

2. 发明授权

US6033423A Multiple layered vaso-occlusive coils 失效
标题翻译：多层血管闭塞线圈
公开(公告)号：US6033423A
公开(公告)日：2000-03-07
申请号：US974275
申请日：1997-11-19
申请人： Christopher G. M. Ken , Erik T. Engelson
发明人： Christopher G. M. Ken , Erik T. Engelson
IPC分类号： A61F2/82 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译：这是一种植入式血管闭塞装置。它是具有多个初级绕组次级层的复杂的螺旋卷绕线圈。最终形状本质上通常是块状的，并且可以以解剖腔的近似形状使用。它可以以球体，卵球形或其他变形的球形的近似形状部署。该装置是由预先形成的线性血管闭塞构件制成的自形成形状。纤维可以引入到装置上并固定到预成形的线性构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。

3. 发明授权

US6004338A Stretch resistant vaso-occlusive coils 有权
标题翻译：抗拉伸血管闭塞线圈
公开(公告)号：US6004338A
公开(公告)日：1999-12-21
申请号：US132117
申请日：1998-08-11
申请人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
发明人： Christopher G. M. Ken , Son M. Gia , Erik T. Engelson
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/84 , A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00867 , A61B2017/12063 , A61B2090/3937 , A61F2002/30093 , A61F2210/0019
摘要： This is an implantable vaso-occlusive device. It is typically a vaso-occlusive coil comprised of a primary helically wound coil which may then be wound into a secondary shape. Central to the invention is the use of a stretch-resisting member fixedly attached within at least a portion of the primary coil. The stretch-resisting member may be formed into coil tips at the ends of the coil by melting the polymeric fibers or alloys or by attaching the fibers with a glue. This stretch-resisting member is for the primary purpose of preventing stretching of the coil during movement of that coil, e.g., by retrieval or repositioning after deployment. The device typically has a self-forming secondary shape made from a pre-formed primary linear helically wound coil, although it need not have the secondary form. External fibers may be attached to the device and affixed to the pre-formed linear member to increase . The vaso-occlusive member may be also be covered with a fibrous braid. The device is typically introduced into the body through a catheter. The device is passed axially through the catheter sheath and assumes its secondary form upon exiting the catheter.
摘要翻译：这是一种植入式血管闭塞装置。通常是由初级螺旋缠绕线圈组成的血管闭塞线圈，然后可以将其卷绕成次级形状。本发明的中心是使用固定地附接在初级线圈的至少一部分中的拉伸抵抗构件。拉伸阻力构件可以通过熔化聚合物纤维或合金或通过用胶粘附纤维而在线圈的端部形成线圈尖端。该抗拉伸构件的主要目的是防止在线圈移动过程中线圈的拉伸，例如通过在展开后的取回或重新定位。该装置通常具有由预先形成的初级线性螺旋缠绕线圈制成的自成形次级形状，尽管它不需要具有二次形式。外部纤维可以附接到装置并固定到预先形成的线性构件上以增加。血管闭塞性构件也可以用纤维编织物覆盖。该装置通常通过导管引入身体。该装置轴向穿过导管护套，并在离开导管时呈现其次级形式。

4. 发明授权

US5749891A Multiple layered vaso-occlusive coils 失效
公开(公告)号：US5749891A
公开(公告)日：1998-05-12
申请号：US779378
申请日：1997-01-07
申请人： Christopher G. M. Ken , Erik T. Engelson
发明人： Christopher G. M. Ken , Erik T. Engelson
IPC分类号： A61F2/82 , A61B17/12 , A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/00526
摘要： This is an implantable vaso-occlusive device. It is a complex, helically wound coil having multiple secondary layers of primary windings. The final shape is often chunky in nature and may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, or other distorted spherical shape. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.

5. 发明授权

US06824553B1 High performance braided catheter 失效
标题翻译：高性能编织导管
公开(公告)号：US06824553B1
公开(公告)日：2004-11-30
申请号：US09648378
申请日：2000-08-25
申请人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
发明人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
IPC分类号： A61M2900
CPC分类号： A61M25/005 , A61M25/0053 , A61M25/0054 , A61M2025/0081
摘要： This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
摘要翻译：这是导管组件和导管组件的一部分。该导管组件可用于进入体内的组织靶，通常是通过血管系统可接近的靶。本发明的中心是使用位于导管主体内的编织金属加强构件，通常为超弹性合金带，以形成具有特别薄壁，受控刚度，高抗扭结性的导管，以及从扭结情况完全恢复体内。编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。由于在刚性部分中存在刚性聚合物管或金属管或合成材料，所以导管组件的近端部分通常比较远的部分更坚硬。

6. 发明授权

US06409721B1 Process for forming an occlusion in a body cavity 失效
标题翻译：在体腔中形成闭塞的方法
公开(公告)号：US06409721B1
公开(公告)日：2002-06-25
申请号：US09523540
申请日：2000-03-10
申请人： E. Thomas Wheelock , Erik T. Engelson , Harold F. Carrison
发明人： E. Thomas Wheelock , Erik T. Engelson , Harold F. Carrison
IPC分类号： A61B1814
CPC分类号： A61B17/12022 , A61B17/1214 , A61B2017/12063
摘要： This invention is an apparatus for the formation of occlusions in spaces in the human body, occluding such as thrombi in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas. In particular, it deals with a one piece assembly having an improved electrolytically erodable link to an occlusive member and further having an incorporated return electrode in the assembly. The occlusion-forming member is introduced to and is intended to remain at the desired occlusion site. The invention also relates to the joint itself. The invention further includes a method for introduction and electrolytic separation of the device.
摘要翻译：本发明是一种用于在人体空间中形成闭塞的装置，阻塞动脉，静脉，动脉瘤，血管畸形和动静脉瘘等血栓。特别地，它涉及具有改进的电解腐蚀性连接到闭塞构件的一体式组件，并且在组件中还具有并入的返回电极。将闭塞形成构件引入并且旨在保留在期望的闭塞部位。本发明还涉及接头本身。本发明还包括用于引入和电解分离该装置的方法。

7. 发明授权

US6066158A Mechanical clot encasing and removal wire 失效
标题翻译：机械凝块包裹和去除线
公开(公告)号：US6066158A
公开(公告)日：2000-05-23
申请号：US686304
申请日：1996-07-25
申请人： Erik T. Engelson , Gene Samson
发明人： Erik T. Engelson , Gene Samson
IPC分类号： A61B17/22 , A61F2/958 , A61M29/00 , A61M29/02
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320725 , A61B17/32075 , A61B2017/22034 , A61B2017/22061 , A61B2017/2212 , A61M2025/1095 , A61M25/10 , A61M29/02
摘要： This is a surgical device usually delivered through an intravascular catheter. It is designed to pierce and remove emboli often found in tortuous vasculature. The device includes several sections. The device has a core element. Placed around the distal end of the core wire is a collapsible but self expanding embolism collection assembly. That collector assembly is typically joined to the core wire at its distal end. The collector assembly may have a generally conical distal portion when expanded and may have a proximal section having varied purposes, e.g. for centering the collector assembly in the vascular lumen. The assembly further may have an actuator which permits the collector assembly to expand after deployment.
摘要翻译：这是通常通过血管内导管递送的手术装置。它旨在刺穿和去除经常在弯曲脉管系统中发现的栓子。该设备包括几个部分。该设备具有核心元件。放置在芯线远端的是可折叠但自膨胀的栓塞收集组件。该集电器组件通常在其远端处连接到芯线。收集器组件可以在膨胀时具有大致锥形的远侧部分，并且可以具有不同目的的近端部分，例如，用于将收集器组件对准在血管腔中。组件还可以具有致动器，其允许收集器组件在展开之后膨胀。

8. 发明授权

US6030369A Micro catheter shaft 失效
标题翻译：微导管轴
公开(公告)号：US6030369A
公开(公告)日：2000-02-29
申请号：US887950
申请日：1997-07-03
申请人： Erik T. Engelson , Mark Carter
发明人： Erik T. Engelson , Mark Carter
IPC分类号： A61M25/00 , A61M25/16 , A61M5/00
CPC分类号： A61M25/0045 , A61M2025/0042 , A61M25/0009
摘要： This is a catheter having a shaft, the layers of which are coextruded in an intermittently changing pattern that produces particular mechanical and frictional properties in the structure. The outer layer of the catheter shaft is comprised of a material which has greater flexibility than the material which comprises the inner layer of the catheter shaft. The stiffer material which comprises the inner layer has frictional properties which facilitate guidewire passage and control. The invention includes the substituent shaft per se and a method of making the shaft.
摘要翻译：这是具有轴的导管，其轴线以间歇变化的图案共挤出，在结构中产生特定的机械和摩擦特性。导管轴的外层由与包括导管轴的内层的材料相比具有更大柔性的材料构成。包含内层的更硬的材料具有促进导丝通过和控制的摩擦性能。本发明包括取代轴本身以及制造轴的方法。

9. 发明授权

US5984929A Fast detaching electronically isolated implant 失效
标题翻译：快速分离电子隔离植入物
公开(公告)号：US5984929A
公开(公告)日：1999-11-16
申请号：US941458
申请日：1997-09-30
申请人： Mehran Bashiri , Michael P. Wallace , Pete Phong Pham , Cong Thach , Chad C. Roue , Erik T. Engelson
发明人： Mehran Bashiri , Michael P. Wallace , Pete Phong Pham , Cong Thach , Chad C. Roue , Erik T. Engelson
IPC分类号： A61B17/12 , A61F2/01 , A61F2/02 , A61F2/06 , A61F2/84 , A61B17/00
CPC分类号： A61F2/95 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61F2/01 , A61B2017/12063 , A61F2002/011 , A61F2002/016 , A61F2002/9505 , A61F2230/0006 , A61F2230/005 , A61F2230/0069 , A61F2230/0091
摘要： This is an implant for placement in the human body and an assembly for so placing that implant. Most desirably, it is an implant for use in the vasculature of the human body and is used to occlude some space in that vasculature as a portion of a treatment regimen. The implant itself is preferably a component of a deployment device using an electrolytically severable joint. The implant is electrically isolated from the electrolytically severable joint by a highly resistive or insulative layer. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of the electrolytic joint to quick erosion and detachment of the implant from the deployment media. Although the implant itself is preferably a vaso-occlusive device, it may instead be a stent, a vena cava filter, or other implant which may be installed in this manner.
摘要翻译：这是用于放置在人体中的植入物和用于使得植入物放置的组件。最理想的是，它是用于人体脉管系统的植入物，并且用于封闭该脉管系统中的一些空间作为治疗方案的一部分。植入物本身优选是使用电解可分割接头的展开装置的部件。植入物通过高电阻或绝缘层与电解可分离的接头电隔离。从放置装置到身体的流体的导电通路的这种隔离和最小化似乎增强了电解接头对植入物从展开介质的快速侵蚀和分离的敏感性。虽然植入物本身优选为血管闭塞装置，但它可以是支架，腔静脉过滤器或可以以这种方式安装的其它植入物。

10. 发明授权

US5749849A Variable stiffness balloon catheter 失效
标题翻译：可变刚度球囊导管
公开(公告)号：US5749849A
公开(公告)日：1998-05-12
申请号：US557075
申请日：1996-08-12
申请人： Erik T. Engelson
发明人： Erik T. Engelson
IPC分类号： A61M25/00 , A61M29/02 , A61M31/00
CPC分类号： A61M29/02 , A61M25/0045 , A61M25/0054 , A61M2025/0079 , A61M2025/1063
摘要： This invention is a single-lumen balloon catheter and assembly having a variable stiffness shaft that allows for greater guidewire trackability and proximal pushability than previous designs. The catheter has an elongate tubular body that is made of inner and outer coaxial tubes, the inner tube being made of proximal and distal sections, the proximal section being stiffer than the distal section and the distal section being stiffer than the outer tube.
摘要翻译： PCT No.PCT / US94 / 05679 Sec。 371日期：1996年8月12日 102（e）日期1996年8月12日PCT 1994年5月20日PCT公布。公开号WO94 / 27668 日期1994年12月8日本发明是具有可变刚度轴的单腔气囊导管和组件，其允许比以前的设计更大的导丝跟踪性和近端推挤性。导管具有由内外同轴管制成的细长管状体，内管由近端和远端部分制成，近端部分比远端部分更硬，远端部分比外管更硬。

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