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71. 发明申请

US20030206896A1 Cosmetic method 审中-公开
标题翻译：化妆方法
公开(公告)号：US20030206896A1
公开(公告)日：2003-11-06
申请号：US10388018
申请日：2003-03-12
发明人： Conor James O'Prey , Marina Trani , David John Weisgerber
IPC分类号： A61K038/48 , C12N009/50 , A61K031/525 , A61K031/07
CPC分类号： A61K8/66 , A61K8/345 , A61K31/07 , A61K31/525 , A61K2800/884 , A61Q19/00
摘要： A cosmetic method for providing improved skin hydration is provided comprising the steps of topically applying to the skin a protease enzyme, and simultaneously or sequentially, topically applying to the skin a polyhydric alcohol. Also provided is a cosmetic method for providing improved skin hydration comprising topically applying to the skin a polyhydric alcohol, and simultaneously or sequentially, topically applying to the skin a protease enzyme.
摘要翻译：提供了一种用于提供改善的皮肤水合作用的美容方法，其包括以下步骤：向皮肤局部施用蛋白酶，同时或依次地向皮肤施加多元醇。还提供了一种用于提供改善的皮肤水合的美容方法，其包括向皮肤局部施用多元醇，同时或顺序地向皮肤施用蛋白酶。

72. 发明申请

US20030148417A1 Cacao endoproteinases and production of cocoa flavor from same 失效
标题翻译：可可内蛋白酶和可可风味来自同一品种
公开(公告)号：US20030148417A1
公开(公告)日：2003-08-07
申请号：US10339351
申请日：2003-01-10
发明人： Peter Bucheli , Maryse Laloi , James McCarthy
IPC分类号： C12P021/06 , C07H021/04 , C12N009/50 , C12P021/02 , C12N005/06 , A23G001/00
CPC分类号： A23G1/02 , A23L27/28 , C12N9/50
摘要： The present invention pertains to novel aspartic endoproteinases from Th. cacao which are involved in the production of cocoa flavor and DNA sequences coding for them. These enzymes are advantageously used in the manufacture of cocoa flavor.
摘要翻译：本发明涉及来自Th的新型天冬氨酸内蛋白酶。参与生产可可风味的可可粉和编码它们的DNA序列。这些酶有利地用于制造可可味。

73. 发明申请

US20030108908A1 Hansenula polymorpha mutants and process for the preparation of recombinant proteins using the same 审中-公开
标题翻译：汉逊酵母多形汉逊酵母突变体及其制备方法
公开(公告)号：US20030108908A1
公开(公告)日：2003-06-12
申请号：US10206619
申请日：2002-07-26
发明人： Sangki Rhee , Euisung Choi , Hyunah Kang , Junghoon Sohn , Junghoon Bae , Moowoong Kim , Michael Agaphonov , Myungkuk Kim
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/50 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12N9/50 , C12N15/815
摘要： Disclosed are Hansenula polymorpha mutants useful as host cells through which various proteins can be produced as being intact at high yield and a process for preparing recombinant proteins using the host cells. Using various vectors, Hansenula polymorpha is made to be a mutant which is deprived of methanol assimilating ability and incapable of utilizing methanol as a carbon source. This Hansenula polymorpha mutant is used as a high yield host to produce recombinant proteins without continuous feeding of methanol, with the aid of an expression at a cassette carrying a promoter capable of inducing the expression at a low concentration of methanol. Further, the mutant is also lacking in carboxypeptidase Y, protease Y and/or carboxypeptidase null activity, so the recombinant protein of interest is not degraded at its carboxyl terminal when being expressed in the cell. Thus, intact recombinant protein can be obtained. Also, there is disclosed a pop-out technique in which a recombinant protein expression cassette is inserted into a MOX gene site of the mutant and is allowed to pop out therefrom, thereby utilizing the mutant as a host for general use in producing various proteins of interest.
摘要翻译：公开了可用作宿主细胞的汉逊酵母多形汉逊酵母突变体，通过该宿主细胞可以以高产量产生各种蛋白质完整的蛋白质，以及使用宿主细胞制备重组蛋白质的方法。使用各种载体，多形汉逊酵母被认为是一种被剥夺了甲醇同化能力并且不能利用甲醇作为碳源的突变体。这种汉逊酵母多形突变体用作高产量宿主以产生重组蛋白，而不用连续进料甲醇，借助于携带能够在低浓度甲醇下诱导表达的启动子的盒中的表达。此外，突变体也缺乏羧肽酶Y，蛋白酶Y和/或羧肽酶α活性，因此当在细胞中表达时，其目的重组蛋白在其羧基末端不降解。因此，可以获得完整的重组蛋白。此外，公开了一种突变技术，其中将重组蛋白表达盒插入到突变体的MOX基因位点，并从其中突出出来，从而利用突变体作为一般用于产生各种蛋白质的各种蛋白质的宿主利益。

74. 发明申请

US20030104502A1 Two-component system that controls bacterial membrane synthesis 有权
公开(公告)号：US20030104502A1
公开(公告)日：2003-06-05
申请号：US10288986
申请日：2002-11-05
申请人： University of Iowa Research Foundation
发明人： Michael A. Apicella , Andrew Preston
IPC分类号： G01N033/554 , G01N033/569 , C07H021/04 , C12N009/50 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12R1/36 , C07K14/22 , G01N33/56911 , G01N33/571 , G01N2333/22 , Y10S435/871
摘要： The present invention discloses a mutant Neisseria having extensive membrane blebbing, both an indicium and a cause of virulence in the gonococcus and meningococcus. Methods are disclosed for making and characterizing the mutant, bmrRS. Methods are disclosed for isolating bmrRS membranes for use as a vaccine. Methods are also disclosed for the use of the mutant for determining the virulence of clinical samples of N. gonorrhoeae and N. meningitidis. Methods are also disclosed for the screening of antibiotics targeted to virulent Neisseria.

75. 发明申请

US20030092128A1 Nucleic acid encoding RNA ligase of bacteriophage RM 378 审中-公开
标题翻译：编码噬菌体RM 378的RNA连接酶的核酸
公开(公告)号：US20030092128A1
公开(公告)日：2003-05-15
申请号：US10270710
申请日：2002-10-11
申请人： Prokaria ltd.
发明人： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC分类号： C12P021/02 , C12N005/06 , C12N001/21 , C07H021/04 , C12N007/00 , C12N015/86 , C12N015/09 , C12N009/50 , C12N007/01 , C12N001/20 , C12N005/00 , C12N005/02 , C07K001/00 , C07K014/00 , C07K017/00
CPC分类号： C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
摘要： A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
摘要翻译：描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。

76. 发明申请

US20030087785A1 Modified polypeptides 审中-公开
标题翻译：修饰的多肽
公开(公告)号：US20030087785A1
公开(公告)日：2003-05-08
申请号：US10209812
申请日：2002-08-01
申请人： Novozymes A/S
发明人： Arne Agerlin Olsen , Claus von der Osten , Kim Vilbour Andersen , Steffen Ernst , Erwin Ludo Roggen
IPC分类号： C11D003/386 , C07H021/04 , C12N009/24 , C12N009/50 , C12P021/02 , C12N001/21 , C12N015/74
CPC分类号： C12N9/242 , A61K47/54 , A61K47/60 , A61K47/646 , C11D3/3719 , C11D3/38 , C12N9/54
摘要： The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of the polypeptide for reducing the immunogenicity and allergenicity and compositions comprising the polypeptide.
摘要翻译：本发明涉及具有降低的免疫应答的多肽，包括具有一个或多个氨基酸残基被其它氨基酸残基取代的降低的变应原性和/或在多肽金属结合位点附近具有偶联的一个或多个聚合物分子的方法，制备本发明的修饰多肽，多肽用于降低免疫原性和变应原性的用途以及包含该多肽的组合物。

77. 发明申请

US20030084477A1 Genes enhancing disease resistance in plants 审中-公开
标题翻译：增加植物抗病性的基因
公开(公告)号：US20030084477A1
公开(公告)日：2003-05-01
申请号：US10122822
申请日：2002-04-15
发明人： Gregory B. Martin , Jian-Min Zhou
IPC分类号： A01H005/00 , C12N001/21 , C12N009/50
CPC分类号： C07K14/415 , C12N15/8279
摘要： The present invention relates to methods and materials for the protection of plants against pathogens through plant genetic engineering; and more particularly to genes which enhance disease resistance in plants by encoding proteins that physically interact with R gene products involved in activation of plant defense mechanisms. The invention further relates to three nucleotide sequences which have been cloned, isolated and sequenced, three amino acid sequences encoded thereby and a transgenic plant and methods for making the same, the genome of the plant having incorporated therein a foreign nucleotide sequence selected in accordance with the invention which functions to enhance the plant's ability to resist pathogens.
摘要翻译：本发明涉及通过植物遗传工程保护植物免受病原体的方法和材料; 更具体地涉及通过编码与参与植物防御机制活化的R基因产物物理相互作用的蛋白质来增强植物抗病性的基因。本发明还涉及已经克隆，分离和测序的三个核苷酸序列，由此编码的三个氨基酸序列和转基因植物及其制备方法，植物的基因组中掺入了根据本发明选择的外源核苷酸序列本发明的作用是提高植物抵抗病原体的能力。

78. 发明申请

US20030082521A1 Polypeptide inducing antibodies neutralizing HIV 失效
标题翻译：多肽诱导中和HIV的抗体
公开(公告)号：US20030082521A1
公开(公告)日：2003-05-01
申请号：US10040349
申请日：2002-01-07
发明人： Robert Brasseur , Benoit Charloteaux , Michel Chevalier , Raphaelle El Habib , Tino Krell , Regis Sodoyer
IPC分类号： C12Q001/70 , C07H021/04 , A61K039/21 , C12N009/50 , C12P021/02 , C12N005/06
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2740/16122 , Y10S530/826
摘要： The present invention thus provides a polypeptide capable of forming a structure corresponding to or mimicking the intermediate of gp41 as well as its use in a vaccine for treating or preventing HIV infections.
摘要翻译：因此，本发明提供了能够形成对应于或模拟gp41中间体的结构的多肽，以及其在疫苗中用于治疗或预防HIV感染的用途。

79. 发明申请

US20030059912A1 Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof 失效
标题翻译：用于抑制肥大细胞脱颗粒的杂交蛋白及其用途
公开(公告)号：US20030059912A1
公开(公告)日：2003-03-27
申请号：US10064903
申请日：2002-08-27
申请人： BioteCon Gesellschaft fur biotechnologische Entwicklung und consulting mbH
发明人： Hans Bigalke , Jurgen Frevert
IPC分类号： C12N009/50 , C07K016/40 , A61K039/40
CPC分类号： C07K16/00 , A61K38/00 , A61K47/62 , C07K16/283 , C07K2317/52 , Y02A50/469
摘要： A hybrid protein contains a protein that binds to a receptor of mastocytes and basophils and is endocyted by them. The protein can be IgE; IgE fragment; IgE Fc fragment; antibody against IgE receptor of mastocytes and basophils; fragment of the antibody against the IgE receptor of mastocytes and basophils; antibody against mastocyte specific potassium channel; and mast cell degranulating peptide. The hybrid protein also contains a protease cleaving proteins of the secretion process of the mastocytes and basophils so as to inhibit the secretion process without killing the mastocytes and basophils. The protease can be light chain Clostridium botulinum toxin; proteolytically active fragment of the light chain of a Clostridium botulinum toxin containing an amino acid sequence His-Xaa-Xaa-Xaa-His-Xaa-Xaa-His wherein Xaa is an amino acid; light chain of the tetanus toxin; proteolytically active fragment of the light chain of the tetanus toxin containing His-Asp-Leu-Ile-His-Val-Leu-His; IgA protease of Neisseria gonorrhoeae; and proteolytic domain of the IgA protease of Neisseria gonorrhoeae.
摘要翻译：杂交蛋白质含有与乳腺细胞和嗜碱性粒细胞受体结合并被它们内吞的蛋白质。蛋白质可以是IgE; IgE片段; IgE Fc片段; 针对肥大细胞和嗜碱性粒细胞的IgE受体的抗体; 针对肥大细胞和嗜碱性粒细胞的IgE受体的抗体片段; 抗乳腺特异性钾通道抗体; 和肥大细胞脱粒肽。杂交蛋白还含有蛋白酶切割乳腺细胞和嗜碱性粒细胞分泌过程的蛋白质，以抑制分泌过程而不杀死乳腺细胞和嗜碱性粒细胞。蛋白酶可以是轻链肉毒梭菌毒素; 含有氨基酸序列His-Xaa-Xaa-Xaa-His-Xaa-Xaa-His的肉毒杆菌毒素的轻链的蛋白水解活性片段，其中Xaa是氨基酸; 破伤风毒素轻链; 含有His-Asp-Leu-Ile-His-Val-Leu-His的破伤风毒素轻链的蛋白水解活性片段; 淋病奈瑟菌IgA蛋白酶; 和淋病奈瑟氏菌IgA蛋白酶的蛋白水解结构域。

80. 发明申请

US20030045438A1 Proteases from gram positive organisms 失效
公开(公告)号：US20030045438A1
公开(公告)日：2003-03-06
申请号：US10188586
申请日：2002-07-02
发明人： David A. Estell
IPC分类号： C11D007/42 , C12N009/50 , C12N001/21
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , D06M16/003
摘要： The present invention relates to the identification of a novel metalloprotease in gram positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the metalloprotease. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding the metalloprotease. The present invention provides host cells which further comprises a nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides cleaning compositions, animal feeds and compositions used to treat a textile that include the metalloprotease of the present invention.

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