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71. 发明授权

US5051355A Anti-human gastric cancer monoclonal antibody 失效
标题翻译：抗人胃癌单克隆抗体
公开(公告)号：US5051355A
公开(公告)日：1991-09-24
申请号：US445160
申请日：1989-12-06
申请人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
发明人： Hajime Yoshida , Nobuo Hanai , Akiko Furuya
IPC分类号： A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号： C07K16/303 , C07K16/3046 , Y10S436/813 , Y10S530/809
摘要： An anti-human gastric cancer monoclonal antibody, AMC-462, which belongs to the class IgG.sub.1, reacts with human digestive system cancer, and recognizes sialylated glycoproteins or glycolipids as the antigen is disclosed. It is effective for diagnosis of digestive system cancer, especially pancreatic cancer.
摘要翻译：属于IgG1类的抗人胃癌单克隆抗体AMC-462与人类消化系统癌症反应，并公开了唾液酸化糖蛋白或糖脂作为抗原。对于消化系统癌症，特别是胰腺癌的诊断是有效的。

72. 发明授权

US4970070A Protective monoclonal antibody compositions for infections due to group B streptococcus 失效
标题翻译：用于B组链球菌感染的保护性单克隆抗体组合物
公开(公告)号：US4970070A
公开(公告)日：1990-11-13
申请号：US189359
申请日：1988-05-02
申请人： Howard V. Raff
发明人： Howard V. Raff
IPC分类号： A61K38/00 , C07K16/12 , G01N33/569
CPC分类号： G01N33/569 , C07K16/12 , A61K38/00 , Y10S424/802 , Y10S424/803 , Y10S424/808 , Y10S435/948 , Y10S530/808 , Y10S530/809 , Y10S530/865
摘要： Immortalized cell lines have been produced that secrete human monoclonal antibodies capable of binding to bacterial species which are a major cause of neonatal sepsis and meningitis. These antibodies have been found to be protective against lethal challenges of these bacteria, which include group B streptococcus, E. coli, K1, and Neisseria meningitidis group B. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal anitbodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.
摘要翻译：已经产生了永生化的细胞系，其分泌能够结合细菌物种的人单克隆抗体，这些是新生儿败血症和脑膜炎的主要原因。已经发现这些抗体可以防止这些细菌的致命挑战，这些细菌包括B族链球菌，大肠杆菌，K1和脑膜炎奈瑟球菌B组。含有这些抗体的药物组合物，其可以与其它单克隆抗体组合，血液包括血浆级分和抗微生物剂，以及这些组合物在感染管理中的预防和治疗用途。

73. 发明授权

US4956452A Monoclonal antibody which neutralizes multiple strains of infectious bursal disease virus 失效
标题翻译：中和多种传染性法氏囊病病毒的单克隆抗体
公开(公告)号：US4956452A
公开(公告)日：1990-09-11
申请号：US61083
申请日：1987-06-12
申请人： David B. Snyder , Warren W. Marquardt , Sammy L. Gorham , Dolores P. Lana
发明人： David B. Snyder , Warren W. Marquardt , Sammy L. Gorham , Dolores P. Lana
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , Y10S530/806 , Y10S530/809 , Y10S530/826
摘要： Monoclonal antibodies effective in preventing infectious bursal disease in chickens, by neutralizing one or more virus strains thereof, have been isolated and obtained from deposited hybridomas. Vaccination of an entire poultry population with a vaccine prepared from these monoclonal antibodies gives a uniform level of protection against all strains of infectious bursal disease tested. The monoclonal antibodies were effective in inducing priming for an active anti-viral response in a heterologous host.
摘要翻译：已经从沉积的杂交瘤中分离并获得了通过中和其中一种或多种病毒株而有效预防鸡传染性法氏囊病的单克隆抗体。使用由这些单克隆抗体制备的疫苗对整个家禽人群进行疫苗接种，为所有感染性法氏囊病病毒株提供了一致的保护水平。单克隆抗体在异源宿主中有效诱导启动活性抗病毒反应。

74. 发明授权

US4954434A Isoferritin as a marker for pathological pregnancy 失效
标题翻译：异铁蛋白作为病理性怀孕的标志物
公开(公告)号：US4954434A
公开(公告)日：1990-09-04
申请号：US210601
申请日：1988-06-23
申请人： Chaya Moroz
发明人： Chaya Moroz
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： G01N33/68 , C07K16/18 , C07K16/3015 , C07K16/3061 , G01N33/57415 , G01N33/57476 , G01N33/689 , G01N2800/368 , Y10S435/81 , Y10S436/80 , Y10S436/801 , Y10S436/804 , Y10S436/808 , Y10S436/811 , Y10S436/813 , Y10S436/814 , Y10S530/808 , Y10S530/809 , Y10S530/828 , Y10S530/838 , Y10S530/846 , Y10S530/85 , Y10S530/866
摘要： The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a pregnant woman. Diagnosis may also be achieved by observation of percentages of PLF-bearing lymphocytes in the pregnant female. Detection of PLF levels is achieved by immunoassay with a PLF-specific anitbody. Also described is a method of treating or preventing pathological pregnancies and transplant or graft rejection by administration of effective amounts of PLF and/or a PLF-specific antibody in combination with immunization.

75. 发明授权

US4950598A Process for making T cell hybridomas 失效
标题翻译：制备T细胞杂交瘤的方法
公开(公告)号：US4950598A
公开(公告)日：1990-08-21
申请号：US777947
申请日：1985-09-19
申请人： Edgar G. Engleman , James W. Larrick , Andrew A. Raubitschek , Steven K. Foung
发明人： Edgar G. Engleman , James W. Larrick , Andrew A. Raubitschek , Steven K. Foung
IPC分类号： C07K14/55 , C12N5/16
CPC分类号： C07K14/55 , C12N5/163 , C12N2510/02 , Y10S530/809
摘要： Human T-T hybridomas are made by fusing an azaserine-hypoxanthine (AH) sensitive T leukemia cell line, preferably the AH-sensitive mutant of the Jurkat leukemia line identified as J3R7, with normal T cells and culturing the fusion product in a selective AH medium. Stable, interleukin-2 (IL-2)-producing human T-T hybridomas were made by this process.
摘要翻译：人T-T杂交瘤通过将正义T细胞与正常T细胞融合，将嗜惟细胞 - 次黄嘌呤（AH）敏感性T白血病细胞系，优选Jurkat白血病系的AH敏感突变体与正常T细胞融合，并在选择性AH培养基中培养融合产物。通过该方法制备稳定的白细胞介素-2（IL-2）产生的人T-T杂交瘤。

76. 发明授权

US4945057A Monoclonal antibodies to crystal protein of Bacillus thuringiensis subspecies israelensis 失效
标题翻译：苏云金芽孢杆菌亚种的晶体蛋白单克隆抗体以色列
公开(公告)号：US4945057A
公开(公告)日：1990-07-31
申请号：US50451
申请日：1987-05-18
申请人： Kevin B. Temeyer , Maurice Haufler , John H. Pruett
发明人： Kevin B. Temeyer , Maurice Haufler , John H. Pruett
IPC分类号： C07K16/12 , C12N5/20
CPC分类号： C07K16/1278 , Y10S435/832 , Y10S435/948 , Y10S530/809 , Y10S530/825
摘要： Murine hybridomas are disclosed which were constructed by fusing spleen cells from BALB/c mice immunized with soluble crystal protein from Bacillus thuringiensis subsp. israelensis (B.t.i.) to the murine myeloma cell line SP2/0-AG14. An ELISA (enzyme-linked immunosorbent assay) method for detection of antibodies specific for crystal protein of B.t.i. was modified to produce 100- to 1,000-fold increased sensitivity and was used to identify hybridomas secreting monoclonal antibody specific for the B.t.i. crystal protein. Analysis of the hybridoma culture supernatant fluid indicated production of monoclonal IgG3 antibodies, specific for the 68,000 dalton protein presumed to be the insecticidal delta-endotoxin of B.t.i.
摘要翻译：公开了通过将来自苏云金芽孢杆菌亚种可溶性晶体蛋白免疫的BALB / c小鼠的脾细胞融合而构建的鼠杂交瘤。以色列（B.t.i.）至鼠骨髓瘤细胞系SP2 / 0-AG14。用于检测特异于B.t.i的结晶蛋白的抗体的ELISA（酶联免疫吸附测定）方法。被修饰以产生100倍至1,000倍增加的灵敏度，并用于鉴定分泌针对B.t.i.特异性的单克隆抗体的杂交瘤。晶体蛋白。杂交瘤培养上清液的分析表明产生单克隆IgG3抗体，特异于推定为B.t.i的杀虫δ-内毒素的68,000道尔顿蛋白质。

77. 发明授权

US4935496A Mouse-human chimaeric immunoglobulin heavy chain specific for the call antigen 失效
标题翻译：特异于呼叫抗原的小鼠 - 人类嵌合免疫球蛋白重链
公开(公告)号：US4935496A
公开(公告)日：1990-06-19
申请号：US805381
申请日：1985-12-04
申请人： Akira Kudo , Yushi Nishimura , Yataro Ichikawa , Takeshi Watanabe
发明人： Akira Kudo , Yushi Nishimura , Yataro Ichikawa , Takeshi Watanabe
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , C07H21/04 , C07K16/30 , C07K16/46 , C12P21/08 , C12R1/91
CPC分类号： C07K16/462 , C07K16/3061 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S530/808 , Y10S530/809 , Y10S530/828 , Y10S530/866 , Y10S530/867
摘要： A mouse-human chimaeric immunoglobulin heavy chain comprising (a) the amino acid sequence of a mouse immunoglobulin heavy chain variable region and (b) the amino acid sequence of a human immunoglobulin heavy chain constant region and reacting specifically with human common acute lympohocytic leukemia antigen and a chimaeric DNA fragment which encodes the amino acid sequence of the above mouse-human chimaeric immunoglobulin heavy chain.
摘要翻译：一种小鼠 - 人类嵌合免疫球蛋白重链，其包含（a）小鼠免疫球蛋白重链可变区的氨基酸序列和（b）人免疫球蛋白重链恒定区的氨基酸序列，并与人常见的急性淋巴细胞白血病抗原以及编码上述小鼠 - 人嵌合免疫球蛋白重链的氨基酸序列的嵌合DNA片段。

78. 发明授权

US4923813A Monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde or acrolein 失效
标题翻译：用于通过暴露于巴豆醛或丙烯醛引起的环状DNA加合物的基于单克隆抗体的免疫测定
公开(公告)号：US4923813A
公开(公告)日：1990-05-08
申请号：US144490
申请日：1988-01-15
申请人： Stephen S. Hecht , Peter G. Foiles , Fung-Lung Chung
发明人： Stephen S. Hecht , Peter G. Foiles , Fung-Lung Chung
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6804 , G01N33/5308 , Y10S435/948 , Y10S436/813 , Y10S436/822 , Y10S530/809
摘要： Monoclonal antibodies specific for the 8R,6R- and 8S,6S-stereoisomers of 3-(2-deoxy-.beta.-D-erythropentofuransyl)-5,6,7,8-tetrahydro-8-hydroxy-6-methylpyrimido[1,2-a]purine-10(3H)one were produced. These cyclic 1,N.sup.2 -propanodeoxyguanosines are formed in DNA exposed to crotonaldehyde in vitro. Three of the four antibodies were most specific for one stereoisomer while the fourth was most specific for the other stereoisomer. Fifty % inhibition of binding in an enzyme-linked immunoabsorbent assay could be achieved with 0.2 picomol of either stereoisomer. A high-pressure liquid chromatography-enzyme-linked immunoabsorbent assay using two of these antibodies and capable of detecting 0.5 .mu.mol of 1,N.sup.2 -propanodeoxyguanosine per mol of deoxyguanosine was developed. The method was validated by comparison to results obtained with fluorescence assay.
摘要翻译：对3-（2-脱氧-β-D-赤式呋喃基）-5,6,7,8-四氢-8-羟基-6-甲基嘧啶并[1,2-d]嘧啶的8R，6R和8S，6S立体异构体特异性的单克隆抗体， 2-a]嘌呤-10（3H）。这些环状1，N 2 - 丙酮脱氧鸟苷在体外在巴豆醛暴露的DNA中形成。四种抗体中的三种对于一种立体异构体最具特异性，而第四种是其他立体异构体最特异的。可以用0.2皮摩尔的立体异构体实现在酶联免疫吸附测定中50％的结合抑制。开发了高压液相色谱 - 酶联免疫吸附测定法，其使用这些抗体中的两种并且能够检测每摩尔脱氧鸟苷的0.5微摩尔的1，N 2 - 丙酮脱氧鸟苷。通过与荧光测定获得的结果进行比较，验证了该方法。

79. 发明授权

US4918163A Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria 失效
标题翻译：特异于革兰氏阴性菌的脂质A决定簇的单克隆抗体
公开(公告)号：US4918163A
公开(公告)日：1990-04-17
申请号：US855878
申请日：1986-04-24
申请人： Lowell S. Young
发明人： Lowell S. Young
IPC分类号： C12N15/02 , A61K38/00 , A61K39/02 , C07K14/005 , C07K14/195 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/569 , G01N33/577
CPC分类号： G01N33/56916 , C07K16/1203 , C07K16/1214 , A61K38/00 , C07K2317/77 , G01N2333/21 , G01N2400/50 , Y10S530/809 , Y10S530/825 , Y10S530/864
摘要： The present invention provides novel hybridoma cell lines which produce monoclonal antibodies (MoAbs) that bind epitopes found on lipopolysaccharide most commonly associated with the endotoxin core of gram negative bacteria and exhibit broad cross-reactivity with gram negative bacteria of different genera and effectively neutralize endotoxin. At least one of the MoAbs disclosed (XMMEN-J5D) binds an epitope also found on gram positive bacteria. The hybridomas are produced by fusing an immortal cell, a cell having the ability to replicate indefinitely in myeloma cell culture, and an effector immune cell following immunization of the immune cell host with a preparation of a gram negative bacteria. While several individual hybridoma cell lines producing monoclonal antibodies to lipopolysaccharide are described, the present invention adds to the state of the art an entire family of hybridoma producing monoclonal antibodies to lipopolysaccharide-associated epitopes.The monoclonal antibodies produced by the hybridoma cell lines of the present invention are useful in the detection of bacterial infections, therapy and prophylaxis of bacterial endotoxemia and infection caused by gram negative bacteria.
摘要翻译：本发明提供了产生单克隆抗体（MoAb）的新型杂交瘤细胞系，所述单克隆抗体（MoAb）结合了与通常与革兰氏阴性细菌的内毒素核心最相关的脂多糖上发现的表位，并且表现出与不同属的革兰氏阴性细菌的广泛的交叉反应性并有效中和内毒素。所公开的至少一种MoAb（XMMEN-J5D）结合在革兰氏阳性细菌上也发现的表位。杂交瘤通过将具有无限期复制骨髓瘤细胞培养物的能力的永生细胞，具有革兰氏阴性细菌制剂免疫免疫细胞宿主的效应免疫细胞融合而产生。虽然描述了产生针对脂多糖的单克隆抗体的几种单独的杂交瘤细胞系，但是本发明使得产生针对脂多糖相关表位的单克隆抗体的全部杂交瘤家族成为现有技术。由本发明的杂交瘤细胞系产生的单克隆抗体可用于细菌感染的检测，治疗和预防细菌内毒素血症和由革兰氏阴性细菌引起的感染。

80. 发明授权

US4916070A Fibrin-specific antibodies and method of screening for the antibodies 失效
标题翻译：纤维蛋白特异性抗体和筛选抗体的方法
公开(公告)号：US4916070A
公开(公告)日：1990-04-10
申请号：US851514
申请日：1986-04-14
申请人： Gary R. Matsueda , Edgar Haber
发明人： Gary R. Matsueda , Edgar Haber
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61K38/48 , A61K39/395 , A61K45/00 , A61K49/00 , A61K49/16 , A61K51/00 , A61K51/10 , A61P7/02 , C07H21/04 , C07K16/00 , C07K16/18 , C07K16/36 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/58 , G01N33/86
CPC分类号： A61K51/1018 , A61K49/16 , C07K16/18 , G01N33/58 , G01N33/86 , A61K2123/00 , G01N2333/75 , Y10S530/808 , Y10S530/809
摘要： The invention relates to a method of screening for fibrin clot-specific monoclonal antibodies and to the monoclonal antibodies screened by this method. The invention also relates to immundiagnostic and immunotherapeutic applications of the screened fibrin clot-specific monoclonal antibodies.
摘要翻译：本发明涉及筛选纤维蛋白凝块特异性单克隆抗体的方法和通过该方法筛选的单克隆抗体。本发明还涉及筛选的纤维蛋白凝块特异性单克隆抗体的无证和免疫治疗应用。

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