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1. 发明申请

US20100291080A1 COMPOSITIONS AND METHODS FOR TISSUE REPAIR 有权
标题翻译：组织修复的组合物和方法
公开(公告)号：US20100291080A1
公开(公告)日：2010-11-18
申请号：US12601522
申请日：2008-05-30
申请人： Randall J. Lee , Shirley Mihardja , Manley Huang , James W. Larrick
发明人： Randall J. Lee , Shirley Mihardja , Manley Huang , James W. Larrick
IPC分类号： A61K39/395 , A61K38/12 , A61K38/16 , A61K38/10 , A61K38/08 , A61P9/10
CPC分类号： A61K47/48415 , A61K38/00 , A61K47/48538 , A61K47/48561 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K2039/505 , C07K7/08 , C07K14/4716 , C07K14/4721 , C07K14/52 , C07K14/70525 , C07K14/70542 , C07K14/70553 , C07K14/70564 , C07K14/7151 , C07K14/78 , C07K16/2833 , C07K2318/00 , C07K2319/00 , C12N9/6475
摘要： The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.
摘要翻译：本发明提供了组合物和方法，其主要靶向受损组织的细胞外基质衍生（EMD）肽，与体内未受损组织相反。靶向的EMD肽通过提供用于细胞附着和生长的表面来促进损伤组织的修复和/或再生，从而促进损伤组织的修复和/或再生。

2. 发明授权

US07326730B2 Aminoadamantane derivatives as therapeutic agents 有权
标题翻译：氨基金刚烷衍生物作为治疗剂
公开(公告)号：US07326730B2
公开(公告)日：2008-02-05
申请号：US11283241
申请日：2005-11-17
申请人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stemler , Stuart A. Lipton
发明人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stemler , Stuart A. Lipton
IPC分类号： A01N37/00
CPC分类号： C07C233/23 , C07C219/24 , C07C2603/74
摘要： The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions There are a variety of neurological disorders that can be treated using the present invention, including, for example, the following: neurological disorders arising from trauma, ischemic or hypoxic conditions that can be treated include stroke, hypoglycemia, cerebral ischemia, cardiac arrest, spinal cord trauma, head trauma, perinatal hypoxia, cardiac arrest and hypoglycemic neuronal damage; neurodegenerative disorders such as epilepsy, Alzheimer's disease, Huntington's disease Parkinsonism, and amyotrophic lateral sclerosis; other diseases or disorders such as convulsion, pain, depression, anxiety, schizophrenia, muscle spasms, migraine headaches, urinary incontinence, nicotine withdrawal, opiate tolerance and withdrawal, emesis, brain edema, tardive dyskinesia, AIDS-induced dementia, ocular damage, retinopathy, cognitive disorders, and neuronal injury associated with HIV-infection such as dysfunction in cognition, movement and sensation.
摘要翻译：本发明提供了新的氨基金刚烷衍生物，制备衍生物的方法，包括新型氨基金刚烷衍生物的组合物，以及使用该衍生物和组合物治疗和预防神经疾病的方法。存在可以使用本发明治疗的多种神经障碍发明，包括例如：由外伤，缺血或缺氧条件引起的神经系统疾病，可治疗包括中风，低血糖症，脑缺血，心跳骤停，脊髓创伤，头部创伤，围产期缺氧，心脏骤停和降血糖神经元损伤; 神经变性疾病如癫痫，阿尔茨海默病，亨廷顿病帕金森综合征和肌萎缩性侧索硬化; 其他疾病或障碍，如惊厥，疼痛，抑郁，焦虑，精神分裂症，肌肉痉挛，偏头痛，尿失禁，尼古丁戒断，阿片剂耐受和戒断，呕吐，脑水肿，迟发性运动障碍，艾滋病诱导的痴呆，眼部损伤，视网膜病变，认知障碍和与HIV感染相关的神经元损伤，如认知，运动和感觉功能障碍。

3. 发明授权

US5567611A Multifunctional M-CSF proteins and genes encoding therefor 失效
公开(公告)号：US5567611A
公开(公告)日：1996-10-22
申请号：US354456
申请日：1994-12-12
申请人： Peter Ralph , George Martin , Michael Piatak , James W. Larrick
发明人： Peter Ralph , George Martin , Michael Piatak , James W. Larrick
IPC分类号： C07K14/52 , C07K14/53 , C12N15/19 , C12N15/00 , C12N15/20 , C12N15/24 , C12N15/27
CPC分类号： C07K14/52 , C07K14/53 , C07K2319/00 , C07K2319/036 , C07K2319/75
摘要： Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are also described. These multifunctional M-CSF proteins have increased therapeutic potential.

4. 发明授权

US08889140B2 Compositions and methods for tissue repair 有权
标题翻译：组织修复的组成和方法
公开(公告)号：US08889140B2
公开(公告)日：2014-11-18
申请号：US12601522
申请日：2008-05-30
申请人： Randall J. Lee , Shirley Mihardja , Manley Huang , James W. Larrick
发明人： Randall J. Lee , Shirley Mihardja , Manley Huang , James W. Larrick
IPC分类号： A61K39/00 , A61K39/44 , C07K16/00 , C07K14/715 , C07K14/705 , A61K47/48 , C07K14/78 , C12N9/64 , C07K14/47 , C07K14/52 , C07K16/28
CPC分类号： A61K47/48415 , A61K38/00 , A61K47/48538 , A61K47/48561 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K2039/505 , C07K7/08 , C07K14/4716 , C07K14/4721 , C07K14/52 , C07K14/70525 , C07K14/70542 , C07K14/70553 , C07K14/70564 , C07K14/7151 , C07K14/78 , C07K16/2833 , C07K2318/00 , C07K2319/00 , C12N9/6475
摘要： The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.
摘要翻译：本发明提供了组合物和方法，其主要靶向受损组织的细胞外基质衍生（EMD）肽，与体内未受损组织相反。靶向的EMD肽通过提供用于细胞附着和生长的表面来促进损伤组织的修复和/或再生，从而促进损伤组织的修复和/或再生。

5. 发明授权

US06291431B1 Methods and compositions for the treatment and prevention of Staphylococcal infections 失效
标题翻译：用于治疗和预防葡萄球菌感染的方法和组合物
公开(公告)号：US06291431B1
公开(公告)日：2001-09-18
申请号：US09054331
申请日：1998-04-02
申请人： Naomi Balaban , James W. Larrick , Susan C. Wright
发明人： Naomi Balaban , James W. Larrick , Susan C. Wright
IPC分类号： A61K3800
CPC分类号： C07K16/1271 , A61K38/164 , A61K39/00 , A61K39/085 , C07K14/31
摘要： Methods and compositions are provided for the treatment of staphylococcal infections.
摘要翻译：提供了用于治疗葡萄球菌感染的方法和组合物

6. 发明授权

US5843937A DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents 失效
标题翻译： DNA结合吲哚衍生物，其前药和免疫缀合物作为抗癌剂
公开(公告)号：US5843937A
公开(公告)日：1998-12-01
申请号：US652883
申请日：1996-05-23
申请人： Yuqiang Wang , Susan C. Wright , James W. Larrick
发明人： Yuqiang Wang , Susan C. Wright , James W. Larrick
IPC分类号： C12P21/08 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/407 , A61K31/415 , A61K31/4164 , A61K31/4188 , A61K31/545 , A61K31/546 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61P35/00 , C07D209/60 , C07D403/06 , C07D403/14 , C07D405/14 , C07D487/04 , C07D495/04 , C07D501/00 , C07D501/22 , C07D501/34 , C07H15/04 , C07H15/24 , C07K16/30
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D495/04 , C07D501/00 , C07H15/24
摘要： The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomeric constituents are derived from monocyclic or bicyclic heterocyclic aromatic residues.
摘要翻译：本发明涉及可用作抗肿瘤剂和DNA标记试剂的新型DNA烷基化剂和这些药物的前药。该化合物是羟基二氢苯并吲哚寡肽及其前体药物，其中单体组分衍生自单环或双环杂环芳族残基。

7. 发明授权

US4624921A Human lymphoblastold cell line and hybridomas derived therefrom 失效
标题翻译：人类淋巴细胞增生细胞系和由其衍生的杂交瘤
公开(公告)号：US4624921A
公开(公告)日：1986-11-25
申请号：US604068
申请日：1984-04-26
申请人： James W. Larrick , Andrew R. Raubitschek , Kenneth E. Truitt
发明人： James W. Larrick , Andrew R. Raubitschek , Kenneth E. Truitt
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61K39/40 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/12 , C07K16/34 , C12N5/10 , C12N5/16 , C12N15/02 , C12P21/08 , C12R1/91 , C12N15/00 , C12N5/00
CPC分类号： C07K16/34 , C07K16/1282 , C12N5/163 , A61K38/00 , Y10S435/948
摘要： A 6-thioguanine-resistant subvariant of the EBV-transformed human lymphoblastoid B cell line WI-L2 is described. The subvariant line, designated LTR228, fuses efficiently with human cells. Human.times.human hybridomas derived from LTR228 that produce monoclonal antibodies against tetanus toxin and blood group A are exemplified.
摘要翻译：描述了EBV转化的人类淋巴母细胞样B细胞系WI-L2的6-硫鸟嘌呤抗性亚变异体。指定为LTR228的亚变体线与人体细胞有效融合。衍生自产生针对破伤风毒素和血型A的单克隆抗体的LTR228的人类人类杂交瘤被列举。

8. 发明授权

US08541014B2 Gamma-tocopherol therapy for restenosis prevention 失效
标题翻译：伽马生育酚治疗预防再狭窄
公开(公告)号：US08541014B2
公开(公告)日：2013-09-24
申请号：US13357208
申请日：2012-01-24
申请人： James W. Larrick , James C. Peacock, III
发明人： James W. Larrick , James C. Peacock, III
IPC分类号： A61F2/02
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： The present invention is directed to a drug eluting stent system, including: a stent; a tocopherol agent coupled to the stent; wherein the stent is adapted to elute the tocopherol agent into a surrounding lumenal wall tissue when implanted along the lumen within a body of a patient.
摘要翻译：本发明涉及一种药物洗脱支架系统，包括：支架; 连接到支架的生育酚剂; 其中所述支架适于当沿着患者体内的内腔植入时将所述生育酚剂洗脱到周围的腔壁组织中。

9. 发明申请

US20100015143A1 Compositions and Methods Relating to Modulation of Immune System Components 审中-公开
标题翻译：关于免疫系统组分调制的组成和方法
公开(公告)号：US20100015143A1
公开(公告)日：2010-01-21
申请号：US12225459
申请日：2007-03-22
申请人： Tracy Hussell , James W. Larrick , George L. Foltin
发明人： Tracy Hussell , James W. Larrick , George L. Foltin
IPC分类号： A61K39/395 , A61K38/16
CPC分类号： A61K39/39 , A61K2039/55516
摘要： A composition comprising a molecular blockade agent to a costimulatory molecule which costimulatory molecule satisfies the following criteria: a. absent in naÊve or resting T-lymphocytes; b. inducible; c. expressed; and d. prominent at the height of an immunopathological response, such as a disease/condition response. Preferably, the costimulatory molecule is OX40 and the molecular blockade agent is an antibody or antibody fragment having antibody activity to OX40. Further, the system may involve modulation of the molecular signal pathway of the aforesaid costimulatory molecule.
摘要翻译：包含共刺激分子的分子阻断剂的组合物满足以下标准：a。缺乏或休息的T淋巴细胞; b。诱导型 C。表达; 和d。在免疫病理反应的高度突出，例如疾病/病症反应。优选地，共刺激分子是OX40，分子阻断剂是对OX40具有抗体活性的抗体或抗体片段。此外，该系统可以涉及上述共刺激分子的分子信号通路的调节。

10. 发明申请

US20080183003A1 AMINOADAMANTANE DERIVATIVES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：氨基甲酸衍生物作为治疗剂
公开(公告)号：US20080183003A1
公开(公告)日：2008-07-31
申请号：US12025622
申请日：2008-02-04
申请人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stamler , Stuart A. Lipton
发明人： Yuqiang Wang , Wenqing Ye , James W. Larrick , Jonathan S. Stamler , Stuart A. Lipton
IPC分类号： C07C271/06 , C07C211/33 , C07C61/12
CPC分类号： C07C233/23 , C07C219/24 , C07C2603/74
摘要： The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions. There are a variety of neurological disorders that can be treated using the present invention, including, for example, the following: neurological disorders arising from trauma, ischemic or hypoxic conditions that can be treated include stroke, hypoglycemia, cerebral ischemia, cardiac arrest, spinal cord trauma, head trauma, perinatal hypoxia, cardiac arrest and hypoglycemic neuronal damage; neurodegenerative disorders such as epilepsy, Alzheimer's disease, Huntington's disease Parkinsonism, and amyotrophic lateral sclerosis; other diseases or disorders such as convulsion, pain, depression, anxiety, schizophrenia, muscle spasms, migraine headaches, urinary incontinence, nicotine withdrawal, opiate tolerance and withdrawal, emesis, brain edema, tardive dyskinesia, AIDS-induced dementia, ocular damage, retinopathy, cognitive disorders, and neuronal injury associated with HIV-infection such as dysfunction in cognition, movement and sensation.
摘要翻译：本发明提供了新的氨基金刚烷衍生物，制备衍生物的方法，包括新的氨基金刚烷衍生物的组合物，以及使用该衍生物和组合物治疗和预防神经疾病的方法。存在可以使用本发明治疗的各种神经障碍，包括例如以下：由可以治疗的创伤，缺血或缺氧状况引起的神经障碍包括中风，低血糖，脑缺血，心跳停止，脊髓脐带创伤，头部创伤，围产期缺氧，心脏骤停和降血糖神经元损伤; 神经退行性疾病如癫痫，阿尔茨海默病，亨廷顿病帕金森综合征和肌萎缩性侧索硬化; 其他疾病或障碍，如惊厥，疼痛，抑郁，焦虑，精神分裂症，肌肉痉挛，偏头痛，尿失禁，尼古丁戒断，阿片剂耐受和戒断，呕吐，脑水肿，迟发性运动障碍，艾滋病诱导的痴呆，眼部损伤，视网膜病变，认知障碍和与HIV感染相关的神经元损伤，如认知，运动和感觉功能障碍。

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