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71. 发明授权

US5445736A Device and filter element for processing blood for human transfusion 失效
标题翻译：装置和过滤元件，用于处理用于输血的血液
公开(公告)号：US5445736A
公开(公告)日：1995-08-29
申请号：US231914
申请日：1994-04-25
申请人： David B. Pall , Thomas C. Gsell , Brian T. Muellers
发明人： David B. Pall , Thomas C. Gsell , Brian T. Muellers
IPC分类号： A61M1/02 , A61M1/36 , B01D39/16 , B01D29/00 , B01D35/00
CPC分类号： B01D39/1623 , A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439
摘要： A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.
摘要翻译：用于处理捐赠血液的装置包括介于收集袋和卫星袋之间的多孔介质，其中通过离心分离的组分可以表达在该卫星袋中，所述过滤元件优选具有约70至约115达因/厘米3的CWST。多孔介质阻止红细胞，但允许血小板通过。

72. 发明授权

US5403272A Apparatus and methods for generating leukocyte free platelet concentrate 失效
标题翻译：用于产生无白血球的血小板浓缩物的装置和方法
公开(公告)号：US5403272A
公开(公告)日：1995-04-04
申请号：US890980
申请日：1992-05-29
申请人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
发明人： Jose C. Deniega , Daniel H. Duff , Donald W. Schoendorfer , William R. Miller
IPC分类号： A61M1/02 , A61K35/14 , A61M1/26 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/262 , A61M1/265 , A61M1/302 , A61M1/303 , A61M1/3603 , A61M1/3693 , A61M2202/0427 , A61M2202/0439
摘要： Methods and devices for separating leukocytes from a leukocyte contaminated blood fraction by use of a rotating membrane filter apparatus. The invention includes methods/devices for preparing substantially leukocyte free platelet concentrate for therapeutic use. The devices of the invention include a rotating membrane filter apparatus for leukocyte separation as well as tubing harness/component systems (FIGS. 2a, 2b, 2c) useable in connection with automated apheresis instruments.
摘要翻译：通过使用旋转的膜过滤装置从白细胞污染的血液分数中分离白细胞的方法和装置。本发明包括用于制备基本上无白血球的血小板浓缩物用于治疗用途的方法/装置。本发明的装置包括用于白细胞分离的旋转膜过滤装置以及可用于与自动取样仪器相关联的管线束/部件系统（图2a，2b，2c）。

73. 发明授权

US5322620A Centrifugation system having an interface detection surface 失效
标题翻译：具有界面检测面的离心系统
公开(公告)号：US5322620A
公开(公告)日：1994-06-21
申请号：US748244
申请日：1991-08-21
申请人： Richard I. Brown , Sidney Smith , David E. Cerny , John T. Foley
发明人： Richard I. Brown , Sidney Smith , David E. Cerny , John T. Foley
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B13/00 , B01D33/00
CPC分类号： B01D17/0217 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , B01D21/2405 , B01D21/2472 , B01D21/262 , B01D21/34 , B04B13/00 , B04B5/0442 , A61M1/025 , A61M1/30 , A61M2202/0439 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis. The platelet rich plasma is separated from the residual red blood cells in a first part. The platelet rich plasma flows into the second part and is separated into platelet poor plasma and platelets. The platelet poor plasma can be drawn off and returned to a donor or collected. The platelet concentrate can then be accumulated in a separate container.
摘要翻译：治疗成分与血液分离的系统和方法。该系统包括双组分离心机和一次性单次使用的流体输送装置。该组件包括细长的柔性分离室，其具有输入端口，分离的部件输出端口和残余流体输出端口。输入端口和分离的部件输出端口位于细长分离室的相对端。离心机包括其中具有选择性地形成的环形槽的容纳室。分离室定位在环形槽中并以预定的旋转速度旋转。诸如全血的流体流过分离室并分离成各种治疗成分，例如富含血小板的血浆和残留的浓缩红细胞。血小板富集血浆可作为分离的治疗成分被排出。替代的两部分转移组提供了高效血小板凝固。在第一部分中将富含血小板的血浆与剩余的红细胞分离。富含血小板的血浆流入第二部分，并分离成血小板不足的血浆和血小板。可以将血小板质量差的血浆抽出并返回给供体或收集。然后可以将血小板浓缩物积聚在单独的容器中。

74. 发明授权

US5269946A Systems and methods for removing undesired matter from blood cells 失效
标题翻译：从血细胞中去除不想要的物质的系统和方法
公开(公告)号：US5269946A
公开(公告)日：1993-12-14
申请号：US704063
申请日：1991-05-22
申请人： Richard Goldhaber , Daniel F. Bischof
发明人： Richard Goldhaber , Daniel F. Bischof
IPC分类号： A61J3/00 , A61J1/05 , A61J1/10 , A61M1/02 , A61M1/36 , B01D37/00
CPC分类号： A61M1/0231 , A61M1/0222 , A61M1/3643 , A61M2202/0429 , A61M2202/0439
摘要： Systems and methods of collecting blood cells use a first container connected to at least three transfer containers. A filtration system is provided with one transfer container, which ultimately serves as the storage container for red blood cells free of white blood cells. The two other transfer containers are connected to each other, one of which is empty and one of which contains and additive solution for storage of red blood cells. The empty transfer container is used for storage of platelet concentrate, while the container that originally contained the additive solution is ultimately used to store the platelet-poor plasma component. A portion of the additive solution may be separately passed through the filtration system after filtration of the red cells to flush additional red blood cells from the filtration device.
摘要翻译：收集血细胞的系统和方法使用连接至少三个转运容器的第一容器。过滤系统设置有一个转运容器，其最终用作不含白细胞的红细胞的储存容器。另外两个转运容器彼此连接，其中一个是空的，其中一个包含用于储存红细胞的添加剂溶液。空转移容器用于储存血小板浓缩物，而最初含有添加剂溶液的容器最终用于储存贫血小板血浆成分。过滤红细胞后，一部分添加剂溶液可以分开通过过滤系统，以从过滤装置冲洗附加的红细胞。

75. 发明授权

US5128048A Systems and methods for removing undesired matter from blood cells 失效
标题翻译：从血细胞中去除不想要的物质的系统和方法
公开(公告)号：US5128048A
公开(公告)日：1992-07-07
申请号：US704029
申请日：1991-05-22
申请人： Mary A. Stewart , Kenneth Johnson
发明人： Mary A. Stewart , Kenneth Johnson
IPC分类号： A61J3/00 , A61M1/02 , B01D37/00
CPC分类号： A61M1/0209 , A61M1/0222 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439
摘要： Systems and methods of collecting blood cells use a first container connected to initially collect blood. A filtration system is provided that uses two flow paths, the first being a dual purpose path that is initially used to convey plasma and platelets to a pair of transfer/storage containers. A second flow path leads to a temporary transfer container through a filtration device. The dual purpose fluid path is next used to convey blood cells, now substantially free of undesired matter, from the temporary storage container to a storage container. The filtration system is then detached from the blood collection system.
摘要翻译：收集血细胞的系统和方法使用连接到最初收集血液的第一容器。提供了一种使用两个流动路径的过滤系统，第一个是最初用于将血浆和血小板输送到一对转运/储存容器的双重目的路径。第二流路通过过滤装置通向临时转移容器。双重目的流体路径接下来用于将现在基本上不需要的物质的血细胞从临时存储容器传送到储存容器。然后将过滤系统与采血系统分离。

76. 发明授权

US4943287A Red blood cell storage system 失效
标题翻译：红细胞储存系统
公开(公告)号：US4943287A
公开(公告)日：1990-07-24
申请号：US380949
申请日：1989-07-17
申请人： Raleigh A. Carmen
发明人： Raleigh A. Carmen
IPC分类号： A61J1/10 , A61K35/18 , A61M1/02 , A61M39/22
CPC分类号： A61K35/18 , A61M1/0209 , A61M1/0218 , A61M2039/222 , A61M2202/0429 , A61M2202/0439
摘要： Closed blood bag system for long term storage of red blood cells (RBCs) without contamination due to storage. System comprises the combination of a white blood cell (WBC) filter in sterile communication with a plastic bag made from a film substantially free of blood extractable plasticizers. In use, an RBC preservative solution (preferably from within the closed system) is added to a mixture of RBCs and WBCs and the mixture is then passed through the filter to remove at least 98% of the WBCs. The filtered RBCs and preservative solution pass into the attached bag and can then be stored in the attached bag for up to 42 days.
摘要翻译：封闭式血袋系统可长期储存红血球（RBC），不会因储存而受到污染。系统包括与由基本上不含可提取血液的增塑剂的薄膜制成的塑料袋无菌连通的白血球（WBC）过滤器的组合。在使用中，将RBC防腐剂溶液（优选从封闭系统内）加入到RBC和WBC的混合物中，然后使混合物通过过滤器以除去至少98％的WBC。过滤的红细胞和防腐剂溶液进入附着的袋子中，然后可以存放在附着的袋子中长达42天。

77. 发明授权

US4920738A Apparatus for winding optical fiber on a bobbin 失效
标题翻译：用于将光纤缠绕在线轴上的装置
公开(公告)号：US4920738A
公开(公告)日：1990-05-01
申请号：US407713
申请日：1989-09-14
申请人： James C. White , George T. Pinson
发明人： James C. White , George T. Pinson
IPC分类号： B65H54/10 , B65H55/04 , G02B6/44
CPC分类号： B65H54/10 , B65H55/04 , G02B6/4457 , A61M2202/0439
摘要： The apparatus for winding optical fiber on a bobbin in axially compact coils includes a bobbin mount reciprocably driven along the fiber deployment axis, a winding arm for receiving optical fiber being fed along the deployment axis, and a supply reel for feeding optical fiber along the deployment axis with the reel being mounted on a twist arm, with the reel axis orthogonal to the deployment axis, for rotating the reel a preselected amount for each turn of the winding arm. An optical time domain reflectometer continuously monitors optical signal attenuation through the free start end of the fiber, and an optical scanner continuously scans the formed coils for the presence of gaps and overlaps. A controller is used to automatically stop, rewind, and adjust the winding apparatus when excessive signal attenuation, gaps or overlaps are detected.
摘要翻译：用于将光纤卷绕在轴向紧凑线圈上的线轴上的装置包括沿着光纤展开轴可往复驱动的筒管架，用于接收沿展开轴线馈送的光纤的卷绕臂和用于沿着展开供给光纤的供应卷轴所述卷轴安装在扭转臂上，所述卷轴与所述展开轴线正交，用于使所述卷轴旋转卷绕臂的每一圈的预选量。光时域反射计通过光纤的自由起始端连续监测光信号衰减，并且光扫描器连续地扫描形成的线圈以存在间隙和重叠。当检测到过多的信号衰减，间隙或重叠时，控制器用于自动停止，倒带和调整卷绕装置。

78. 发明授权

US4917799A Filtering device for blood platelets 失效
标题翻译：血小板过滤装置
公开(公告)号：US4917799A
公开(公告)日：1990-04-17
申请号：US263757
申请日：1988-10-28
申请人： Kazuhiko Masuda , Masami Ohnishi
发明人： Kazuhiko Masuda , Masami Ohnishi
IPC分类号： A61M1/16 , A61M1/22 , A61M1/36 , B01D39/04 , B01D39/16 , B01D67/00 , B01D71/48 , D01F6/62
CPC分类号： B01D39/1623 , A61M1/3633 , B01D39/04 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439
摘要： A filtering device for blood platelets comprises polyester fibers having an average cross-sectional diameter of 0.1 to 5 .mu.m, wherein there is formed electro-microscopic roughness on the surface of the polyester fibers. According to the present invention, there can be realized a filtering device for blood platelets having simple construction, wherein blood platelets are caught efficiently and the removal of blood platelets is carried out in a short time.

79. 发明授权

US4915848A Red blood cell filtering system 失效
标题翻译：红细胞过滤系统
公开(公告)号：US4915848A
公开(公告)日：1990-04-10
申请号：US304133
申请日：1989-01-31
申请人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
发明人： Raleigh A. Carmen , Chiyong Chong , Barry S. Leng
IPC分类号： A61M1/02 , A61M1/36
CPC分类号： A61M1/0209 , A61M1/0218 , A61M1/3633 , A61M2202/0439
摘要： Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with preservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.
摘要翻译：用于从红细胞混合物中相对快速有效地除去白细胞的封闭过滤系统。系统包括通过中间过滤器组件彼此密封连通的至少两个血袋，所述中间过滤器组件包括含有连续过滤纤维的壳体。优选的壳体是锥形的并且纤维优选地具有大致Y形的横截面积，并且其适于允许当用防腐剂溶液稀释混合物时从红细胞混合物中显着除去白细胞，同时具有最小的红细胞溶血并以相对高的流量从一个袋子传递到另一个袋子。过滤在全血献血的24小时内，最好在6小时内完成。

80. 发明授权

US4130642A Method of separating blood cells components 失效
标题翻译：分离血细胞成分的方法
公开(公告)号：US4130642A
公开(公告)日：1978-12-19
申请号：US846369
申请日：1977-10-28
申请人： Kiyomi Kikugawa , Kyoko Minoshima
发明人： Kiyomi Kikugawa , Kyoko Minoshima
IPC分类号： G01N33/48 , A61K35/14 , A61M1/02 , B01D15/00 , A61K35/18
CPC分类号： B01D15/00 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M2202/0429 , A61M2202/0439
摘要： A method of separating blood cell components, characterized in that a blood cells suspension containing red cells and at least one of leucocytes and blood platelets is passed through a processing column packed with an Egyptian cotton which has been de-fatted and bleached, thereby allowing the blood cells components other than the red cells to be adsorbed substantially completely on the Egyptian cotton and permitting the red cells portion alone to be isolated.
摘要翻译：一种分离血细胞成分的方法，其特征在于，将含有红细胞和白细胞和血小板中的至少一种的血细胞悬浮液通过填充有脱脂和漂白的埃及棉的加工柱，从而允许红细胞以外的血细胞成分基本上完全吸收在埃及棉上，并允许单独的红细胞部分被分离。

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