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71. 发明申请

US20070031474A1 Implantable preparations 失效
标题翻译：可植入的制剂
公开(公告)号：US20070031474A1
公开(公告)日：2007-02-08
申请号：US11499723
申请日：2006-08-07
申请人： Jean Tayot
发明人： Jean Tayot
IPC分类号： A61F13/02 , A61K38/40
CPC分类号： A61L27/227 , A61K38/39 , A61K38/42 , A61L15/32 , A61L24/108 , A61L26/0047 , A61L31/047
摘要： Implantable preparation comprising a material which can be obtained from globin that has been modified, especially chemically, to be, at least partially, soluble at physiological pH, the material being biocompatible, and biodegradable in the organism. The material may be soluble at physiological pH, or insoluble at that pH. The preparation may be in the form of a solution, suspension, paste, gel, film, sponge, powder or granules, or a solid implant. Application in particular to the healing, protection or filling of external skin wounds, the filling of wrinkles and skin flaws, the filling of tissue, as means for fixing prostheses or biomaterials, or means for preventing adhesion.
摘要翻译：可植入制剂，其包含可从球形蛋白获得的材料，所述珠蛋白经生物相容性改变，特别是在化学上至少部分地在生理pH下可溶解，并且可生物降解。该物质可能在生理pH下可溶，或在该pH下不溶。制剂可以是溶液，悬浮液，糊剂，凝胶，薄膜，海绵，粉末或颗粒或固体植入物的形式。尤其适用于皮肤外伤的愈合，保护或填充，皱纹和皮肤瑕疵的填充，组织的填充，固定假体或生物材料的手段，或防止粘连的手段。

72. 发明授权

US07129210B2 Tissue adhesive sealant 失效
标题翻译：组织胶粘剂
公开(公告)号：US07129210B2
公开(公告)日：2006-10-31
申请号：US10894609
申请日：2004-07-20
申请人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David A. Browdie
发明人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David A. Browdie
IPC分类号： A01N37/18 , A61K38/38 , A61K38/39 , A61F13/00 , A61F13/02
CPC分类号： A61L24/102 , A61L24/108
摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
摘要翻译：组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。密封剂非常适合单独粘合组织或与贴片组合。醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

73. 发明申请

US20060088565A1 Device having osteoinductive and osteoconductive properties 失效
标题翻译：具有骨诱导和骨传导性能的装置
公开(公告)号：US20060088565A1
公开(公告)日：2006-04-27
申请号：US10496399
申请日：2002-03-27
申请人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
发明人： Ulrich Kohnert , Sylke Pohling , Klaus Hellerbrand , Peter Happersberger
IPC分类号： A61K38/17 , A61K8/96 , A61K31/7012
CPC分类号： A61L27/227 , A61L24/02 , A61L24/108 , A61L27/12 , A61L27/34
摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
摘要翻译：本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中所述载体均匀地涂覆有所述蛋白质。此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，并且涉及所述装置用于制备用于骨增大的药物组合物用于治疗骨缺损的用途用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

74. 发明授权

US06960352B2 Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent 有权
公开(公告)号：US06960352B2
公开(公告)日：2005-11-01
申请号：US10241717
申请日：2002-09-12
申请人： Antoine Noujaim , Roland H. Person , Michael W. Stewart
发明人： Antoine Noujaim , Roland H. Person , Michael W. Stewart
IPC分类号： A61K9/00 , A61B17/12 , A61F2/82 , A61K9/16 , A61K31/16 , A61K38/36 , A61K38/37 , A61K38/43 , A61K45/00 , A61K47/48 , A61L24/10 , A61L27/00 , A61L31/00 , A61L31/04 , A61L31/16 , A61P35/00 , A61F2/00
CPC分类号： A61L24/108 , A61K9/167 , A61K31/16 , A61K38/36 , A61K38/37 , A61K47/62 , A61K47/6921 , A61K47/6927 , A61L31/047 , A61L31/16 , A61L2300/252 , A61L2300/418
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.

75. 发明申请

US20030082224A1 Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent 有权
标题翻译：使用固相血小板结合剂产生血管闭塞的组合物和方法
公开(公告)号：US20030082224A1
公开(公告)日：2003-05-01
申请号：US10241717
申请日：2002-09-12
发明人： Antoine Noujaim , Roland H. Person , Michael W. Stewart
IPC分类号： A61K038/36 , A61F002/00
CPC分类号： A61L24/108 , A61K9/167 , A61K31/16 , A61K38/36 , A61K38/37 , A61K47/62 , A61K47/6921 , A61K47/6927 , A61L31/047 , A61L31/16 , A61L2300/252 , A61L2300/418
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
摘要翻译：本发明一般涉及靶向和递送固相血小板依赖性血管阻塞剂的方法和组合物。特别地，涂覆有血小板结合剂的颗粒或线圈或支架被引导到目标脉管系统，例如实体肿瘤块的血管系统或AV畸形或动脉瘤或内漏; 然后固相剂结合并激活血小板，血小板又结合并激活其他血小板。该过程导致关于导致血管闭塞的固相剂快速形成血小板介导的血栓。

76. 发明授权

US06503539B2 Matrix protein compositions for wound healing 有权
标题翻译：用于伤口愈合的基质蛋白组合物
公开(公告)号：US06503539B2
公开(公告)日：2003-01-07
申请号：US09258613
申请日：1999-02-26
申请人： Stina Gestrelius , Lars Hammarström , Petter Lyngstadaas , Christer Andersson , Ivan Slaby , Tomas Hammargren
发明人： Stina Gestrelius , Lars Hammarström , Petter Lyngstadaas , Christer Andersson , Ivan Slaby , Tomas Hammargren
IPC分类号： A61K3532
CPC分类号： A61K8/19 , A61K8/64 , A61K8/981 , A61K38/39 , A61L15/32 , A61L24/108 , A61L26/0047 , A61L27/227 , A61Q11/00 , A61Q17/005 , A61Q19/00 , Y10S977/906
摘要： Active enamel substances may be used for the preparation of a pharmaceutical or cosmetic composition for healing of a wound, improving healing of a wound, soft tissue regeneration or repair, or for preventing or treating infection or inflammation.
摘要翻译：活性搪瓷物质可用于制备用于愈合伤口，改善伤口愈合，软组织再生或修复，或用于预防或治疗感染或炎症的药物或化妆品组合物。

77. 发明授权

US06423333B1 Sealing or filling tissue defects using polyfunctional crosslinking agents and protein polymers 失效
标题翻译：使用多官能交联剂和蛋白质聚合物密封或填充组织缺陷
公开(公告)号：US06423333B1
公开(公告)日：2002-07-23
申请号：US09451206
申请日：1999-11-29
申请人： Erwin R. Stedronsky , Joseph Cappello
发明人： Erwin R. Stedronsky , Joseph Cappello
IPC分类号： A61K31785
CPC分类号： A61L27/227 , A61K38/00 , A61L24/106 , A61L24/108 , C07K14/001 , Y10S530/81
摘要： Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesive compositions for bonding together separated tissue, and for sealing or filling tissue defects by injecting the compositions into the defects. Particularly, block copolymers having repeating units of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents such as glutaraldehyde, activated diolefins, diisocyanates, acid anhydrides or diamines. The protein polymer contains at least 40 weight percent of repetitive units of 3 to 30 amino acids, preferably 3 to 15 amino acids, of at least one naturally occurring structural protein and at least two amino acids containing a functional group capable of reacting with the crosslinking agent. The protein polymer generally has a molecular weight of at least about 30 kD and not more than 250 kD. A preferred protein polymer contains at least 70 weight percent of repetitive units of Gly-Ala-Gly-Ala-Gly-Ser and Gly-Val-Gly-Val-Pro, where in at least two units an amino acid is substituted with one of lysine or arginine, and the protein polymer has a lysine and arginine equivalent weight in the range of 1 to 20 kD and contains at least two amino acids having a functional group capable of reacting with at least one of aldehyde, isocyanate, thioisocyanate and activated carboxy. The protein polymer is produced by recombinant DNA technology, and a kit may be formed containing the crosslinking agent and protein polymer.
摘要翻译：具有来自天然存在的结构蛋白质的重复单元的蛋白质聚合物用作用于交联的官能团的主链，以提供用于将分离的组织粘合在一起的强粘附组织粘合剂组合物，以及通过将组合物注入缺陷中来密封或填充组织缺陷。特别地，使用具有弹性蛋白和丝心蛋白重复单元的嵌段共聚物，其间隔开的单元具有赖氨酸取代，其中氨基可以使用双功能交联剂如戊二醛，活化的二烯烃，二异氰酸酯，酸酐或二胺进行交联。蛋白质聚合物含有至少40重量％的3至30个氨基酸，优选3至15个氨基酸的至少一种天然存在的结构蛋白的重复单元和至少两个含有能够与交联反应的官能团的氨基酸代理商蛋白质聚合物通常具有至少约30kD且不超过250kD的分子量。优选的蛋白质聚合物含有至少70重量％的Gly-Ala-Gly-Ala-Gly-Ser和Gly-Val-Gly-Val-Pro的重复单元，其中在至少两个单元中氨基酸被赖氨酸或精氨酸，并且蛋白质聚合物的赖氨酸和精氨酸当量的重量在1至20kD的范围内并且包含至少两个具有能够与醛，异氰酸酯，硫代异氰酸酯和活化羧基中的至少一种反应的官能团的氨基酸。蛋白质聚合物通过重组DNA技术生产，并且可以形成含有交联剂和蛋白质聚合物的试剂盒。

78. 发明申请

US20010033837A1 Thrombin preparations and process for their production 有权
标题翻译：凝血酶制剂及其生产工艺
公开(公告)号：US20010033837A1
公开(公告)日：2001-10-25
申请号：US09809021
申请日：2001-03-16
申请人： Aventis Behring GmbH.
发明人： Hubert Metzner , Scheider Heinrich
IPC分类号： A61K038/54
CPC分类号： A61L24/108 , A61K38/4833 , A61K47/02 , A61K47/183 , A61K47/26 , A61L24/043 , A61L24/106 , C08L89/00
摘要： The production of a thrombin preparation which is obtained from prothrombin which is, after activation to thrombin without the addition of thromboplastin, purified by a hydrophobic interaction chromatography, it being possible subsequently also to inactivate or remove viruses, is described. Before or after the hydrophobic interaction chromatography it is also possible in addition to carry out a cation exchange chromatography. A thrombin preparation which contains as stabilizer a noncovalently binding inhibitor and to which further stabilizers can be added for stabilization in the liquid state is additionally described.
摘要翻译：描述了从凝血酶原获得的凝血酶制剂的制备，其在通过疏水相互作用色谱法纯化的活化凝血酶而不加入凝血激酶之后，随后也可以灭活或除去病毒。在疏水相互作用层析之前或之后，除了进行阳离子交换层析之外，还可以进行。另外描述了一种凝血酶制剂，其包含作为稳定剂的非共价结合抑制剂，并且可以加入其它稳定剂以稳定液体状态。

79. 发明授权

US06274090B1 Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby 有权
标题翻译：从其形成的血浆和凝血酶制备稳定的长期凝血酶的装置和方法
公开(公告)号：US06274090B1
公开(公告)日：2001-08-14
申请号：US09129988
申请日：1998-08-05
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
IPC分类号： B01L1100
CPC分类号： G01N33/86 , A61J3/002 , A61K35/16 , A61L24/108 , C12N9/6429 , C12Y304/21005 , G01N33/4905 , G01N2333/974
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译：一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

80. 发明授权

US6048964A Compositions and therapeutic methods using morphogenic proteins and stimulatory factors 失效
标题翻译：使用形态发生蛋白和刺激因子的组合物和治疗方法
公开(公告)号：US6048964A
公开(公告)日：2000-04-11
申请号：US570752
申请日：1995-12-12
申请人： John C. Lee , Lee-Chuan C. Yeh
发明人： John C. Lee , Lee-Chuan C. Yeh
IPC分类号： C12N15/09 , A61K31/00 , A61K31/20 , A61K31/202 , A61K31/565 , A61K31/57 , A61K31/573 , A61K31/59 , A61K38/00 , A61K38/18 , A61K38/27 , A61K38/28 , A61K38/30 , A61L24/10 , A61L27/00 , A61L27/22 , A61P19/00 , A61P43/00 , C12N5/10 , C12N7/00 , C12P21/02
CPC分类号： A61L27/227 , A61K38/1875 , A61K38/30 , A61L24/108
摘要： The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.
摘要翻译：本发明提供包含形态发生蛋白质刺激因子（MPSF）的药物组合物，用于改善形态发生蛋白质，特别是属于BMP蛋白质家族的组织诱导活性。提供了使用这些组合物改善哺乳动物中形态发生蛋白的组织诱导活性的方法。本发明还提供了可植入形态发生装置，其包含形态发生蛋白和设置在载体内的MPSF，其能够诱导同种异体和异种植入物中的组织形成。还提供了使用这些装置从哺乳动物的祖细胞诱导局部组织形成的方法。提供了使用形态发生装置促进哺乳动物同种异体移植修复的方法。本发明还提供了一种假体装置，其包括涂覆有形态发生蛋白质和MPSF的假体，以及用于促进可植入假体装置的体内整合以增强假体和接合部位的现有靶组织之间的结合强度的方法。还提供了使用药物组合物治疗哺乳动物的组织退行病症的方法。

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