专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20040265369A1 Compounds that inhibit caspase activity for treating glaucoma 审中-公开
标题翻译：抑制半胱天冬酶活性治疗青光眼的化合物
公开(公告)号：US20040265369A1
公开(公告)日：2004-12-30
申请号：US10839434
申请日：2004-05-05
发明人： Stuart A. Lipton
IPC分类号： A61K048/00 , A61K038/54 , A61K009/127
CPC分类号： A61K9/0048 , A61K9/127 , A61K31/04 , A61K31/122 , A61K31/34 , A61K31/353 , A61K31/401 , A61K31/455 , A61K38/063 , A61K38/08 , A61K38/385 , A61K38/4873 , A61K38/488 , A61K38/49 , A61K38/556 , Y02A50/414
摘要： Compounds that inhibit caspase activity, particularly those that bind a caspase substrate and protect it, are combined with a vector such as liposomes or an antennapeida peptide to treat glaucoma.
摘要翻译：抑制半胱天冬酶活性的化合物，特别是结合半胱天冬酶底物并保护其的那些化合物与载体例如脂质体或天疱疮肽组合以治疗青光眼。

2. 发明申请

US20040146495A1 Method for assisting in differential diagnosis and treatment of autistic syndromes 失效
标题翻译：协助自闭症综合征鉴别诊断和治疗的方法
公开(公告)号：US20040146495A1
公开(公告)日：2004-07-29
申请号：US10327591
申请日：2002-12-20
申请人： Repligen Corporation, a Delaware corporation
发明人： Victoria Beck , Karoly Horvath
IPC分类号： A61K038/54
CPC分类号： G01N33/6893 , A61K31/045 , A61K31/047 , A61K31/12 , A61K31/121 , A61K31/201 , A61K31/495 , A61K31/575 , A61K36/48 , A61K36/484 , A61K38/2235 , G01N2333/645 , G01N2800/28 , G01N2800/38 , A61K2300/00
摘要： A novel relationship between pancreatico-biliary secretion and autistic syndrome is disclosed. This relationship enables a novel therapy for the treatment of the symptoms of autistic syndromes, comprising the administration of a therapeutically effective, preferably intravenous, dose of secretin to an individual with autistic syndrome. The relationship further enables a differential diagnosis for autistic syndrome, comprising an analysis of an individual's blood and/or intestinal tissue for the presence of secretin and comparison of the level of secretin to known norms.
摘要翻译：公开了胰胆汁分泌与自闭症综合征之间的新颖关系。这种关系使得能够进行治疗自闭症综合征的症状的新疗法，其包括向具有自闭症综合征的个体施用治疗有效的，优选静脉内的剂量的促胰液素。该关系进一步使自闭症综合征的鉴别诊断，包括对个体血液和/或肠组织的分析以了解胰液素的存在以及分泌素水平与已知规范的比较。

3. 发明申请

US20030099626A1 Nutrient absorption enhancing compositions and methods 审中-公开
标题翻译：营养吸收增强组合物和方法
公开(公告)号：US20030099626A1
公开(公告)日：2003-05-29
申请号：US09989980
申请日：2001-11-20
申请人： Health Education Corporation
发明人： Tracy Gibbs
IPC分类号： A61K038/54
CPC分类号： A61K36/062 , A23L29/06 , A23L31/00 , A23L33/105 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： The present invention provides a nutrient absorption enhancing composition that contains a mixture of various Aspergillus derived enzymes and mineral cofactors. In one aspect, the enzymes of the formulation may include protease, lipase, amylase, and cellulase. In another aspect, the mineral cofactors of the formulation may include calcium compounds, zinc compounds, manganese compounds, and magnesium compounds.
摘要翻译：本发明提供了含有各种曲霉衍生酶和矿物辅因子的混合物的营养吸收增强组合物。一方面，制剂的酶可以包括蛋白酶，脂肪酶，淀粉酶和纤维素酶。在另一方面，制剂的矿物辅因子可以包括钙化合物，锌化合物，锰化合物和镁化合物。

4. 发明申请

US20030026795A1 Methods and compositions for controlling insects 审中-公开
公开(公告)号：US20030026795A1
公开(公告)日：2003-02-06
申请号：US10005530
申请日：2001-10-26
申请人： MONSANTO TECHNOLOGY LLC
发明人： Barbara G. Isaac , John T. Greenplate , John P. Purcell , Charles P. Romano
IPC分类号： A61K038/54 , A61K038/44 , A01N025/00
CPC分类号： C12N15/8286 , A01N63/00 , C12N9/00 , C12N9/0022 , C12N9/0024 , Y02A40/162 , A01N2300/00
摘要： Compositions and methods for controlling insects by co-expressing an amino acid oxidase and a second enzyme that provides insecticidal activity when present in a mixture with the amino acid oxidase are disclosed. Also disclosed are DNA and protein sequences, and transformed microorganisms and plants useful for achieving such insect control.

5. 发明申请

US20020182696A1 Stabilized enzyme compositions 审中-公开
标题翻译：稳定的酶组合物
公开(公告)号：US20020182696A1
公开(公告)日：2002-12-05
申请号：US10132344
申请日：2002-04-25
申请人： COSMOFERM B.V.
发明人： Luppo Edens , Luc Van der Heijden , Albert Jon Vis
IPC分类号： C12N009/96 , A61K038/54
CPC分类号： A61K8/66 , A61K8/345 , A61K8/8158 , A61K47/26 , A61K2800/52
摘要： A stabilized enzyme composition comprising an amount of at least one enzyme, an amount of a polyol for stabilizing the enzyme and an amount of an acrylamide polymer thickening agent, characterized in that as the acrylamide polymer use is made of a null(CH2CR(CONH2)null polymer, in which R is either hydrogen or a methyl group. The concentration of the polyacrylamide in the composition varies from 0.05 to 15 wt %.
摘要翻译：一种稳定的酶组合物，其包含一定量的至少一种酶，一定量的用于稳定酶的多元醇和一定量的丙烯酰胺聚合物增稠剂，其特征在于，作为丙烯酰胺聚合物，使用 - （CH 2 CR（CONH 2） - 聚合物，其中R是氢或甲基。组合物中聚丙烯酰胺的浓度为0.05至15重量％。

6. 发明申请

US20020146403A1 Method for the treatment of bacterial eye infections 失效
标题翻译：治疗细菌性眼感染的方法
公开(公告)号：US20020146403A1
公开(公告)日：2002-10-10
申请号：US10135824
申请日：2002-05-01
发明人： Vincent Fischetti , Lawrence Loomis
IPC分类号： A61K038/54
CPC分类号： A61K9/00 , A61K38/00 , C12N9/503 , Y02A50/473 , Y02A50/481 , Y10S514/937 , Y10S514/948
摘要： A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
摘要翻译：公开了一种用于治疗眼睛细菌感染的组合物，其包含对感染细菌特异性的溶解酶组合物和用于递送所述溶解酶的载体。将至少一种裂解酶递送至眼睛的载体可以是但不限于使用等渗溶液。

7. 发明申请

US20040109852A1 METHODS FOR ELIMINATING THE FORMATION OF BIOFILM 失效
标题翻译：消除生物膜形成的方法
公开(公告)号：US20040109852A1
公开(公告)日：2004-06-10
申请号：US09885379
申请日：2001-06-19
申请人： Novozymes Biotech, Inc.
发明人： Feng Xu
IPC分类号： A61K038/54 , A61K038/46
CPC分类号： C02F1/50 , A61L2/18 , B08B7/00
摘要： The present invention relates to methods for preventing or removing biofilm on a surface, comprising contacting the surface with an effective amount of a composition comprising one or more acylases and a carrier to degrade a lactone produced by one or more microorganisms, wherein the degradation of the lactone prevents or removes the biofilm.
摘要翻译：本发明涉及用于在表面上预防或去除生物膜的方法，包括使表面与有效量的包含一种或多种酰基转移酶和载体的组合物接触以使由一种或多种微生物产生的内酯降解，其中，内酯防止或去除生物膜。

8. 发明申请

US20030103955A1 Diclofenac pharmaceutical composition based on vitamin-e, papain and hyaluronidase 审中-公开
标题翻译：基于维生素e，木瓜蛋白酶和透明质酸酶的双氯芬酸药物组合物
公开(公告)号：US20030103955A1
公开(公告)日：2003-06-05
申请号：US10204464
申请日：2002-11-14
发明人： Cristiano A.R. Santana , Gilberto De Nucci , Marcio Falci
IPC分类号： A61K038/54 , A61K031/355 , A61K031/16
CPC分类号： A61K9/0014 , A61K31/196 , A61K38/4873 , A61K38/51 , A61K45/06 , A61K47/42 , A61K2300/00
摘要： The present application refers to a new pharmaceutical composition of diclofenac comprising the following formulation: PAPAIN . . . 0.1 to 15%, HYALURONIDASE . . . 50 to 900 utr/mg, VITAMIN E . . . 10 to 2000 mg.
摘要翻译：本申请是指包含以下配方的双氯芬酸新药物组合物：PAPAIN。。。 0.1〜15％，HYALURONIDASE。。。 50至900 utr / mg，VITAMIN E。。。 10至2000毫克。

9. 发明申请

US20030026796A1 Method for treating a subject suffering from conditions associated with an extracellular zinc sphingomyelinase 失效
公开(公告)号：US20030026796A1
公开(公告)日：2003-02-06
申请号：US09518805
申请日：2000-03-03
发明人： Ira Tabas , Scott L. Schissel , Kevin Jon Williams
IPC分类号： A61K038/43 , A61K038/54 , A61K038/46
CPC分类号： C07K16/40 , A61K38/465 , C07K2317/77 , C12Q1/025 , C12Y301/04012 , G01N2333/916 , G01N2500/02
摘要： The present invention provides for a method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase activity which comprises administering to the subject an amount of a zinc sphingomyelinase inhibitor effective to decrease extracellular zinc sphingomyelinase activity in the subject and thereby treat the subject. The present invention also provides for a method for determining whether a compound inhibits an activity of an extracellular zinc sphingomyelinase involving ceramide formation which comprises: (a) contacting a sample containing zinc sphingomyelinase under acidic pH conditions known to be associated with the activity of such zinc sphingomyelinase, with: (i) a substrate of the zinc sphingomyelinase enzyme, and (ii) the compound being evaluated; (b) measuring the ceramide in the sample from (a); (c) determining the amount of zinc sphingomyelinase activity in the sample based on the concentration of ceramide measured in step (b); and (d) comparing the amount of sphingomyelinase activity determined in step (c) with the amount of sphingomyelinase activity determined in the absence of the compound, so as to determine whether the compound inhibits the activity of zinc sphingomyelinase.

10. 发明申请

US20030026794A1 Selective enzyme treatment of skin conditions 审中-公开
标题翻译：选择性酶处理皮肤状况
公开(公告)号：US20030026794A1
公开(公告)日：2003-02-06
申请号：US09919102
申请日：2001-07-31
发明人： Howard Fein
IPC分类号： A61K038/54 , A61K038/46 , A61K038/48
CPC分类号： A61Q19/08 , A61K8/66 , A61K38/4826 , A61K38/4873 , A61K2800/28 , A61Q19/00 , A61K2300/00
摘要： A method of treating skin conditions by providing compositions containing enzymes to selectively remove specific layers of skin. The depth of skin removed (that is, vertical surface treated) is regulated by the type and concentration of enzyme or enzymes in the composition. The surface area of skin removed (that is, radial surface treated) is regulated by the area of topical application. Conditions treatable by the method include, but are not limited to, age-related conditions such as lines and wrinkles, infections, pigmentary disorders, follicular disorders such as acne, and hyperkeratotic disorders such as warts. The inventive method and composition thus achieves the specificity and efficacy of more invasive methods such as surgery, while providing a composition that may be topically applied and is easy to use.
摘要翻译：通过提供含有酶的组合物来选择性去除特定的皮肤层来治疗皮肤病症的方法。去除皮肤的深度（即垂直表面处理）由组合物中酶或酶的类型和浓度调节。去除皮肤的表面积（即径向表面处理）由局部施用的面积来调节。通过该方法可治疗的病症包括但不限于与年龄相关的病症，例如线条和皱纹，感染，色素障碍，滤泡性疾病如痤疮，以及角化过度症状如疣。因此，本发明的方法和组合物在提供可局部施用并且易于使用的组合物的同时实现诸如外科手术的更多侵入性方法的特异性和功效。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式